Pharmaceutical Chemistry Journal最新文献_第8页

Prospects for Production of Microencapsulated Medicines Based on Plant Extracts (Review) 基于植物提取物的微囊药物的生产前景（综述）

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-05-13 DOI: 10.1007/s11094-024-03121-1

O. A. Semkina, O. M. Beloshapkina, M. A. Dzhavakhyan

引用次数: 0

Impact of Ultrasonic Vibrations on the Stability of Bovhyaluronidase Azoximer in Solution 超声波振动对溶液中牛醛酸酶氮氧化物稳定性的影响

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-05-13 DOI: 10.1007/s11094-024-03127-9

A. E. Krasheninnikov, V. V. Sepp, K. S. Bakulin, O. I. Arefieva, A. A. Karsanov

{"title":"Impact of Ultrasonic Vibrations on the Stability of Bovhyaluronidase Azoximer in Solution","authors":"A. E. Krasheninnikov, V. V. Sepp, K. S. Bakulin, O. I. Arefieva, A. A. Karsanov","doi":"10.1007/s11094-024-03127-9","DOIUrl":"https://doi.org/10.1007/s11094-024-03127-9","url":null,"abstract":"Changes in the quantitative content and specific activity of hyaluronidase enzyme after ultrasonic treatment of solutions of bovhyaluronidase azoximer were studied. Solutions of the finished dosage form of bovhyaluronidase azoximer (Longidase® lyophilizate for preparation of solution for injection, 3000 IE) and bovhyaluronidase azoximer drug substance (Longidase® substance-lyophilizate) were studied. The aim of the study was to determine the effect of ultrasound (US) on the stability of bovhyaluronidase azoximer determined from the measured quantitative content and enzymatic activity of the substance in solution. US at a radiation intensity of 61.4 W/L during treatment in an ultrasonic bath did not significantly affect the quantitative content of the bovhyaluronidase azoximer drug substance in solution, while the decrease in the enzymatic activity of the active substance in Longidase solution after 20 and 30 min of ultrasonic treatment was statistically significant. At the same time, the enzymatic activity of the active substance determined by a biochemical method differed significantly (residual activity from 99.70% to 59.27%) depending on the design features of the nebulizers and the nebulization time after nebulization of the bovhyaluronidase azoximer solution in mesh nebulizers from various manufacturers. Nebulization times of min were least associated with the risk of significant loss of stability of bovhyaluronidase azoximer.","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":"2014 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140929628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formulating GML-1 Tablets Using the Harrington Desirability Function 利用哈灵顿可取函数配制 GML-1 药片

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-05-13 DOI: 10.1007/s11094-024-03126-w

D. I. Gavrilov, E. V. Blynskaya, S. V. Tishkov, K. V. Alekseev

引用次数: 0

Change in Chromatographic Parameters of Some Phenylpropanoids in Different Mobile Phases Under Reversed-Phase HPLC Conditions 反相高效液相色谱条件下不同流动相中某些苯丙酸类化合物色谱参数的变化

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-05-13 DOI: 10.1007/s11094-024-03128-8

O. K. Abramov, A. F. Ryabukha, I. V. Pletneva

引用次数: 0

Use of Virtual Reality Technology in Pharmacy 虚拟现实技术在药学中的应用

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-05-13 DOI: 10.1007/s11094-024-03125-x

Yu.A. Kolosov, D. V. Kurkin, Yu.V. Gorbunova, D. A. Bakulin, A. I. Robertus, O. V. Ivanova, T. S. Buzina, O. S. Shalina, A. A. Denisov, A. V. Kotelnikova, I. D. Mursalov, I. M. Naryshkin

引用次数: 0

The Role of the HL-10 Peptide in Regulating the Expression of Apoptosis-Related Genes in the HeLa Cancer Cell Line HL-10 肽在调节 HeLa 癌细胞系中凋亡相关基因表达中的作用

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-04-20 DOI: 10.1007/s11094-024-03098-x

Setayesh-Mehr Zahra, Rezavand Maryam, Parsaei Asghar

{"title":"The Role of the HL-10 Peptide in Regulating the Expression of Apoptosis-Related Genes in the HeLa Cancer Cell Line","authors":"Setayesh-Mehr Zahra, Rezavand Maryam, Parsaei Asghar","doi":"10.1007/s11094-024-03098-x","DOIUrl":"https://doi.org/10.1007/s11094-024-03098-x","url":null,"abstract":"Anticancer peptides are among the most important bioactive peptides found in animal sources. The modulation of the molecular process of apoptosis via the genes involved in the signaling pathway is now being studied for cancer treatment. In this study, the anticancer properties of peptide HL-10 extracted from scorpion venom by regulating the apoptosis signaling pathway were investigated. In the present study, the anticancer activity of the HL-10 peptide against the HeLa cancer cell line was assessed using the cytotoxicity assay. The real-time PCR method was used to analyse the expression levels of Bax, p53, caspase-3, PTEN, and Akt genes. The cytotoxicity assay demonstrated that the IC50 value of the HL-10 peptide was 40 μM. The results also showed that the treatment of Hela cells with HL-10 led to an increase in the expression of Bax, p53, caspase-3, and PTEN genes, while it resulted in a significant decrease in the expression level of the Akt gene in a dose-dependent manner (p.05). The flow cytometry analysis also revealed a high number of cells in the secondary apoptotic stage. According to changes in the expression of genes implicated in the apoptosis pathway, the HL-10 peptide appears to play a role in the activation of the intrinsic apoptosis pathway. However, additional research in molecular dimensions and clinical studies is needed. It is suggested to confirm the effectiveness of HL-10 peptide in cancer treatment.","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":"22 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140627864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stereospecificity of the Cytoprotective and Antidepressant-Like Activities of GTS-301, a Dimeric Dipeptide Mimetic of Neurotrophin-3 神经营养素-3 的二聚二肽模拟物 GTS-301 的细胞保护和抗抑郁活性的立体特异性

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-04-18 DOI: 10.1007/s11094-024-03093-2

N. M. Sazonova, A. V. Tarasiuk, M. V. Melnikova, I. A. Zhanataev, I. O. Logvinov, S. V. Nikolaev, D. M. Nikiforov, T. A. Antipova, P. Yu. Povarnina, T. A. Gudasheva, S. B. Seredenin

{"title":"Stereospecificity of the Cytoprotective and Antidepressant-Like Activities of GTS-301, a Dimeric Dipeptide Mimetic of Neurotrophin-3","authors":"N. M. Sazonova, A. V. Tarasiuk, M. V. Melnikova, I. A. Zhanataev, I. O. Logvinov, S. V. Nikolaev, D. M. Nikiforov, T. A. Antipova, P. Yu. Povarnina, T. A. Gudasheva, S. B. Seredenin","doi":"10.1007/s11094-024-03093-2","DOIUrl":"https://doi.org/10.1007/s11094-024-03093-2","url":null,"abstract":"A dimeric dipeptide mimetic based on the β-turn of the 4th loop of neurotrophin-3, bis-(N-monosuccinyl-L-asparaginyl-L-asparagine)hexamethylenediamide (GTS-301LL), was recently designed and synthesized by us. GTS-301, like the full-length neurotrophin, activated TrkC and TrkB receptors and exhibited neuroprotective activity on HT22 cells under oxidative stress conditions in the concentration range 10–5 – 10–12 M and antidepressant-like activity in the forced swimming test in mice (10 – 40 mg/kg, intraperitoneally). The stereospecificity of the pharmacological effects of GTS-301LL was revealed by synthesizing the LD, DL, and DD stereoisomers of GTS-301LL and studying their neuroprotective and antidepressant-like properties under the same conditions as for GTS-301LL. Both activities were found to disappear on going from the LL to the DL and DD stereoisomers and were retained on going to the LD stereoisomer. Thus, the stereospecificity of the neuroprotective and antidepressant-like activities of the dipeptide mimetic of neurotrophin-3 GTS-301LL at the N-terminal asparagine residue was proven, which indicated the key role of that amino-acid residue in the interaction with the receptor.","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":"48 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140614599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Vitro Antioxidant Activity of Asteriscus Graveolens (Forsk.) and Its Protective Effect on Doxorubicin-Induced Hepatotoxicity and Testicular Oxidative Damage in Rats Asteriscus Graveolens（Forsk.）的体外抗氧化活性及其对多柔比星诱导的大鼠肝毒性和睾丸氧化损伤的保护作用

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-04-18 DOI: 10.1007/s11094-024-03102-4

Amira Mecheri, Leila Hammoud, Samia Belahcene, Nassima Boubekri, Mounir Kout, Fadila Benayache, Amel Amrani

{"title":"In Vitro Antioxidant Activity of Asteriscus Graveolens (Forsk.) and Its Protective Effect on Doxorubicin-Induced Hepatotoxicity and Testicular Oxidative Damage in Rats","authors":"Amira Mecheri, Leila Hammoud, Samia Belahcene, Nassima Boubekri, Mounir Kout, Fadila Benayache, Amel Amrani","doi":"10.1007/s11094-024-03102-4","DOIUrl":"https://doi.org/10.1007/s11094-024-03102-4","url":null,"abstract":"Asteriscus graveolens (Asteraceae) is a medicinal herb, used in Algeria to treat diabetes, hypertension, pain, fever, inflammation and gastrointestinal diseases. Doxorubicin (DOX) is an antibiotic antineoplastic drug used to treat many types of cancers; unfortunately, its antitumor activity links toxic effects to several organs including the heart, liver and testis. The appropriate mechanism of its organotoxicity is linked to free reactive oxygen species (ROS) generation and oxidative stress induction. In this study, the antioxidant and protective role of A. graveolens and vitamin E (Vit E) against DOX-induced hepatic and testicular toxicity was assessed. Thirty-five rats were distributed equally into five groups and orally administered with n-butanol extract of A. graveolens (75 mg/kg bw) or Vit E (100 mg/kg bw) for 10 days in the absence or presence of a single intraperitoneal injection of DOX (15 mg/kg bw). The results revealed that DOX toxicity induced a significant elevation in the liver serum marker enzymes and lipid profile levels (cholesterol, triglycerides and LDL). In addition, DOX-induced hepatic and testicular oxidative injury was indicated due to a significant increase of malondialdehyde levels along with a noticeable reduction of the antioxidant system. A. graveolens and Vit E treatment might improve the biochemical and histopathological changes induced by DOX. A. graveolens has antioxidant and hypolipidemic properties and it can reduce DOX-induced oxidative damage in the liver and testis. A. graveolens showed a similar protective effect of Vit E against DOX damage due to the presence of an abundant amount of phenolics such as flavonoids. This protection is mediated by their direct free-radical scavenging activity and their ability to prevent DOX depletion of the hepato-testicular antioxidant defense systems.","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":"10 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140614479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolation, Characterization of Bioactive Compounds from Muntingia calabura – a Pharmacological Study 从 Muntingia calabura 中分离和鉴定生物活性化合物--药理学研究

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-04-17 DOI: 10.1007/s11094-024-03100-6

Siddhartha Marupati, Shashikala Kethireddy, Laxminarayana Eppakayala

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Validation Studies of Some Stages of Drug Production from Equine Blood Plasma Regarding the Reduction of Extraneous Viruses 关于减少外来病毒的马血浆药物生产某些阶段的验证研究

IF 0.9 4区医学

Pharmaceutical Chemistry Journal Pub Date : 2024-04-17 DOI: 10.1007/s11094-024-03106-0

V. V. Mashin, A. N. Sergeev, N. N. Martynova, A. N. Galiullina, O. G. Yakin, A. Yu. Grosheva, T. I. Glotova, V. V. Kataeva, N. V. Zagidullin

引用次数: 0