D. I. Gavrilov, E. V. Blynskaya, S. V. Tishkov, K. V. Alekseev
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Formulating GML-1 Tablets Using the Harrington Desirability Function
Features of using the generalized Harrington desirability function for the selection of a binder and lubricant for GML-1 (N-benzyl-N-methyl-1-phenylpyrrolo[1,2-a]pyrazine-3-carboxamide) tablets are considered. The factors affecting the characteristics of the finished dosage form are evaluated. Model formulations with different qualitative and quantitative compositions of disintegrant and lubricant excipients were developed. Their pharmaceutical and technological properties were studied. The factors having the greatest impact on indicators such as the mass loss on drying, strength, disintegration, and solubility of the tablets were identified. The type and amount of disintegrant and lubricant in the tablet that could produce a dosage form with the optimal pharmaceutical and technological characteristics were determined.
期刊介绍：
Pharmaceutical Chemistry Journal is a monthly publication devoted to scientific and technical research on the creation of new drugs and the improvement of manufacturing technology of drugs and intermediates. International contributors cover the entire spectrum of new drug research, including:
methods of synthesis;
results of pharmacological, toxicological, and biochemical studies;
investigation of structure - activity relationships in prediction of new compounds;
methods and technical facilities used; and
problems associated with the development of ecologically safe and economically feasible methods of industrial production.
In addition, analytical reviews of the international literature in the field provide coverage of the most recent developments around the world.
Pharmaceutical Chemistry Journal is a translation of the Russian journal Khimiko-Farmatsevticheskii Zhurnal. The Russian Volume Year is published in English from April.
All articles are peer-reviewed.
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