Synthesis, Characterization and Biological Evaluation of Novel Benzimidazole Derivatives against Candida albicans

Abstract

In heterocyclic chemistry, benzimidazole is recognized as a “privileged structure” due to its association with a wide range of biological activities. In this present research work, we included the synthesis, characterization and biological evaluation of substituted derivatives. The designated derivatives were synthesized by the condensation method. ortho-Phenylenediamine was used as the starting material. The designated benzimidazole derivatives were synthesized using different acids and aldehydes. Further, the in-vitro antifungal-activity-synthesized compounds were evaluated against Candida albicans using the agar well diffusion method and the culture tube method. It was concluded that all the designated derivatives of benzimidazole exhibited prominent antifungal activity and can be considered as potent leads in future antifungal research.