Modern Approaches to Mathematical Modeling of the Process of Direct Pressing of Tablets

IF 0.8 4区医学 Q4 CHEMISTRY, MEDICINAL

Pharmaceutical Chemistry Journal Pub Date : 2024-08-27 DOI:10.1007/s11094-024-03194-y

V. B. Markeev, E. V. Blynskaya, S. V. Tishkov, K. V. Alekseev, V. K. Alekseev

引用次数: 0

Abstract

The Heckel and Kawakita equations are the most common mathematical models used in modern studies of the pressing process to evaluate the mechanical properties of tablets. However, these classical models do not take into account the whole spectrum of processes occurring during interparticle interaction, which necessitates the development of new approaches to modeling the tableting process. For this reason, a rather large number of direct- pressing models have now been developed. The choice of the optimal equation for each specific case has become a nontrivial problem. Currently used mathematical descriptions of the direct-pressing process were analyzed in the present study.

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直接压片工艺数学建模的现代方法

Heckel 和 Kawakita 方程是现代压片工艺研究中最常用的数学模型，用于评估片剂的机械性能。然而，这些经典模型并没有考虑到颗粒间相互作用的全部过程，因此有必要开发新的方法来模拟压片过程。因此，目前已开发出大量直接压片模型。为每种特定情况选择最佳方程已成为一个非难解决的问题。本研究对目前使用的直接压片工艺数学描述进行了分析。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pharmaceutical Chemistry Journal CHEMISTRY, MEDICINAL-PHARMACOLOGY & PHARMACY

CiteScore

1.30

自引率

22.20%

发文量

226

审稿时长

3-8 weeks

期刊介绍： Pharmaceutical Chemistry Journal is a monthly publication devoted to scientific and technical research on the creation of new drugs and the improvement of manufacturing technology of drugs and intermediates. International contributors cover the entire spectrum of new drug research, including: methods of synthesis; results of pharmacological, toxicological, and biochemical studies; investigation of structure - activity relationships in prediction of new compounds; methods and technical facilities used; and problems associated with the development of ecologically safe and economically feasible methods of industrial production. In addition, analytical reviews of the international literature in the field provide coverage of the most recent developments around the world. Pharmaceutical Chemistry Journal is a translation of the Russian journal Khimiko-Farmatsevticheskii Zhurnal. The Russian Volume Year is published in English from April. All articles are peer-reviewed.