使用乙基纤维素吸附剂制备含水杨酸的多组分药物样品

IF 0.8 4区医学 Q4 CHEMISTRY, MEDICINAL

Pharmaceutical Chemistry Journal Pub Date : 2024-09-16 DOI:10.1007/s11094-024-03215-w

M. N. Kachalkin, A. V. Voronin, V. A. Kurkin

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引用次数: 0

摘要

使用乙基纤维素基吸附剂进行固相萃取（SPE）制备样品，用紫外分光光度法测定了几种多组分药物中的水杨酸，结果表明这种方法具有良好的选择性。分析物与吸附剂活性位点的选择性结合，以及在固相萃取过程中连续使用纯化水和 NaOH 溶液（0.1 M）进行分步洗脱，消除了紫外分光光度法鉴定和定量水杨酸时多成分药物中其他活性药物成分的干扰。使用乙基纤维素吸附剂可以改善计量参数，使定量程序的系统误差平均降低 47%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Use of Ethylcellulose-Based Sorbent for Sample Preparation of Multicomponent Drugs Containing Salicylic Acid

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Use of Ethylcellulose-Based Sorbent for Sample Preparation of Multicomponent Drugs Containing Salicylic Acid

UV spectrophotometric determination of salicylic acid in several multicomponent drugs using an ethylcellulose-based sorbent for solid-phase extraction (SPE) for sample preparation was shown to be selective. Selective binding of the analyte to sorbent active sites and stepwise elution successively with purified water and NaOH solution (0.1 M) during SPE eliminated interference of other active pharmaceutical ingredients of multicomponent drugs during identification and quantitation of salicylic acid by UV spectrophotometry. Use of the ethylcellulose sorbent made it possible to improve the metrological parameters and decrease systematic error of the quantitative procedure by an average of 47%.

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来源期刊

Pharmaceutical Chemistry Journal CHEMISTRY, MEDICINAL-PHARMACOLOGY & PHARMACY

CiteScore

1.30

自引率

22.20%

发文量

226

审稿时长

3-8 weeks

期刊介绍： Pharmaceutical Chemistry Journal is a monthly publication devoted to scientific and technical research on the creation of new drugs and the improvement of manufacturing technology of drugs and intermediates. International contributors cover the entire spectrum of new drug research, including: methods of synthesis; results of pharmacological, toxicological, and biochemical studies; investigation of structure - activity relationships in prediction of new compounds; methods and technical facilities used; and problems associated with the development of ecologically safe and economically feasible methods of industrial production. In addition, analytical reviews of the international literature in the field provide coverage of the most recent developments around the world. Pharmaceutical Chemistry Journal is a translation of the Russian journal Khimiko-Farmatsevticheskii Zhurnal. The Russian Volume Year is published in English from April. All articles are peer-reviewed.