{"title":"Nanostructures for the Prevention, Diagnosis, and Treatment of COVID‐19: A Review","authors":"Zahra Tavakoli, Faezeh Ranjbar, Saeed Hesami Tackallou, Bijan Ranjbar","doi":"10.1002/ppsc.202400083","DOIUrl":"https://doi.org/10.1002/ppsc.202400083","url":null,"abstract":"Viral infections are a significant cause of death globally, resulting in substantial ethical, social, and economic costs. In recent years, the world has experienced the worst epidemic of the current millennium, caused by the Coronavirus 2019, a severe acute respiratory syndrome. This infection can cause severe complications in various organs, such as the stomach, heart, liver, kidney, and brain. Antimicrobial drugs or vaccines can be a practical approach to combating these pathogens. However, there are drug‐resistant or emerging infections that do not have effective drugs or vaccines. Therefore, it is necessary to explore new approaches for early diagnosis, prevention, and effective therapies. So, nanomaterials are widely considered due to their unique properties. This review employs a practical approach to elucidate the role of nanostructures against COVID‐19. Also, the effects and benefits of various types of nanostructures are discussed that have been used to diagnose, prevent, and treat COVID‐19 in recent years. Furthermore, by evaluating different nanostructures, the utilization of biocompatible nanoparticles consisting of selenium and chitosan derivatives is suggested as a promising candidate for industrial use in the fight against COVID‐19. Ultimately, this study can offer insight into the potential applications of nanomaterials in combating emerging microbial infections.","PeriodicalId":19903,"journal":{"name":"Particle & Particle Systems Characterization","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141786039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lei Shi, Yao‐Jia Ma, Xing‐Hui Ren, Zheng‐Chen Su, Xi‐Wen He, Wen‐You Li, Yu‐Kui Zhang
{"title":"H2O2 Self‐Supplied Chemodynamic Nanosystem Enhanced by Ca2+ Interference and Starvation Strategy for Targeted Cancer Therapy","authors":"Lei Shi, Yao‐Jia Ma, Xing‐Hui Ren, Zheng‐Chen Su, Xi‐Wen He, Wen‐You Li, Yu‐Kui Zhang","doi":"10.1002/ppsc.202400068","DOIUrl":"https://doi.org/10.1002/ppsc.202400068","url":null,"abstract":"Chemodynamic therapy (CDT) has received increasing attention in recent years due to its effectiveness and specificity. However, the limited endogenous hydrogen peroxide (H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub>) concentration and resistance to reactive oxygen species in cancer cells hinder the further application of CDT. Here, an H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub> self‐supplied nanosystem FCaO<jats:sub>2</jats:sub>@ZIF‐67‐2‐DG‐FA (FZDF) is synthesized to achieve efficient CDT improvement by Ca<jats:sup>2+</jats:sup> overload and starvation therapy. Under folic acid‐mediated tumor targeting and endocytosis, the ZIF‐67 layer of FZDF is cleaved in the mildly acidic environment, releasing Co<jats:sup>2+</jats:sup> and 2‐deoxy‐D‐glucose (2‐DG). The decomposition of exposed FCaO<jats:sub>2</jats:sub> generates sufficient H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub>, which further produces abundant <jats:sup>•</jats:sup>OH via the Fenton‐like reaction of Co<jats:sup>2+</jats:sup>. Simultaneously, Ca<jats:sup>2+</jats:sup> overload‐triggered mitochondrial dysfunction couples with glycolysis inhibition via 2‐DG‐induced starvation, which disrupts intracellular adenosine triphosphate (ATP) synthesis and amplifies the efficacy of CDT. Silicon nanoparticles released from FCaO<jats:sub>2</jats:sub> are applied as in vitro fluorescent probes to image tumor cells overexpressing folate receptors. The results have presented that FZDF can actively accumulate in tumor cells, causing the mitochondrial membrane potential abnormality and a decrease in intracellular ATP content, thereby enhancing the self‐supplied CDT with less effect on normal cells and tissues. This work provides a novel strategy for constructing effective CDT nanosystems by hindering intracellular energy supply.","PeriodicalId":19903,"journal":{"name":"Particle & Particle Systems Characterization","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141784228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Efficient Fabrication of CrFeO3‐Based Humidity Sensing Device with Fast Dynamics for Real‐Time Breath Monitoring and Contact‐Less Sensing","authors":"Neeraj Dhariwal, Preety Yadav, Manju Kumari, Vinod Kumar, O.P. Thakur","doi":"10.1002/ppsc.202400072","DOIUrl":"https://doi.org/10.1002/ppsc.202400072","url":null,"abstract":"In this study, a simple and cost‐effective method is presented for developing a metal oxide‐based humidity sensor. CrFeO<jats:sub>3</jats:sub> is synthesized without any precipitating agent and chosen as a model material to study the validity of humidity sensing properties. The surface morphology and structural analysis are provided using field emission scanning electron microscope (FESEM), transmission electron microscope (TEM), X‐ray diffraction (XRD), and Brunauer–Emmett–Teller (BET) analysis. Elemental analysis is provided with the help of X‐ray photoelectron spectroscopy (XPS). Obtained results demonstrate the tunable response of order 860 and stability in a large range of humidity. Also, by controlling the porosity and film uniformity, a fast response time of 1.6 s and a recovery time of 2.6 s are achieved with very low hysteresis. Also, cole–cole plot and Fourier transform infrared spectroscopy (FTIR) spectra in the presence and absence of humidity provide detailed analysis of surface interaction with H<jats:sub>2</jats:sub>O molecules. In addition to this, the developed sensor demonstrates excellent response and reproducibility toward real‐time human respiration monitoring along with non‐contact sensing. This work enables the study of developed sensors in real‐time humidity monitoring for practical applications.","PeriodicalId":19903,"journal":{"name":"Particle & Particle Systems Characterization","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141786234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ruizhi Jin, Ming Zhao, Yumeng Zhang, Bo Wang, Kejun Dong
{"title":"Numerical Study of Air–Vapor–Particle Flow in Gas Cyclone","authors":"Ruizhi Jin, Ming Zhao, Yumeng Zhang, Bo Wang, Kejun Dong","doi":"10.1002/ppsc.202400115","DOIUrl":"https://doi.org/10.1002/ppsc.202400115","url":null,"abstract":"This paper presents a numerical study of the complex multiphase flow of air, vapor, and particles in an innovative gas cyclone called CAP cyclone. The air–vapor flow is modeled as a mixture by the Reynolds‐averaged Navier‐Stokes equations with the mixture species transport and the Eulerian wall film model using FLUENT. Particle flow is modeled by the Lagrangian particle tracking method and the condensational growth of particle droplets is modeled via a user‐defined function. The model is validated by reaching good agreement with experimental results. Flow field analysis shows that the added vapor does not change the major vortex characteristics in the cyclone, but the vapor distribution is not uniform. The vapor concentration is much higher in the upper part than in the lower part of the cyclone, leading to insufficient condensational growth in the lower part. A secondary vapor injection is proposed to improve the vapor concentration in the lower part, which is shown to be effective in improving the collection efficiency. The model and the results are helpful to the understanding and optimization of the CAP cyclone technology, and also the vapor and particle droplet flow in turbulent flows.","PeriodicalId":19903,"journal":{"name":"Particle & Particle Systems Characterization","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141784227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jun Qiu, Jing‐Wei Lyu, Jing‐Lei Yang, Kai‐Bo Cui, Hao‐Ze Liu, Gui‐Fang Wang, Xiao Liu
{"title":"Review on Preparation, Modification and Application of Nano‐Calcium Carbonate","authors":"Jun Qiu, Jing‐Wei Lyu, Jing‐Lei Yang, Kai‐Bo Cui, Hao‐Ze Liu, Gui‐Fang Wang, Xiao Liu","doi":"10.1002/ppsc.202400097","DOIUrl":"https://doi.org/10.1002/ppsc.202400097","url":null,"abstract":"Nano‐calcium carbonate (nano‐CaCO<jats:sub>3</jats:sub>) is a tiny inorganic filler created in the 1980s. It boasts a high specific surface area, excellent biocompatibility, and nontoxicity. As a result, it finds extensive applications in the rubber, plastic, and paper industries. This paper intends to give a general overview of the preparation process, surface modification, and application of nano‐CaCO<jats:sub>3</jats:sub>. In particular, the preparation process conditions, the characteristics of the prepared nano‐CaCO<jats:sub>3</jats:sub>, the method and mechanism of surface modification, and also the main application research progress of nano‐CaCO<jats:sub>3</jats:sub> are described comprehensively. This paper has a good guiding effect for the researchers and related staff engaged in the study of nano‐CaCO<jats:sub>3</jats:sub>.","PeriodicalId":19903,"journal":{"name":"Particle & Particle Systems Characterization","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141739613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Enhanced Antibacterial and Antibiofilm Activities of Actinobacterial Therapeutic Metabolites Mediated Nanosuspension","authors":"Shelly Singh, Shilpa Sharma, Ashok K. Dubey","doi":"10.1002/ppsc.202300196","DOIUrl":"https://doi.org/10.1002/ppsc.202300196","url":null,"abstract":"The escalation in infections from World Health Organization (WHO)‐listed priority pathogens has made development of new antibacterial agents a critical priority. In this context, use of therapeutic secondary metabolites (SMs) from Actinobacteria as new drugs presents a promising avenue. However, majority of them fail to reach market due to low aqueous solubility and hence low bioavailability. Even though nanosuspension technology has been effectively used to address these challenges, use of this technology for nanox02010;listed priority pathogens has made development of new antibacterial agents a critical priority. In thitransformation of crude metabolites from Actinobacteria is still an unattempted area. Herein, for the first time, development of water‐soluble nanosuspension of water‐insoluble therapeutic metabolites produced by <jats:italic>Streptomyces californicus</jats:italic> strain ADR1 to develop a biocompatible material to be used as potential nanomedicine is reported. The nanosuspension (N‐SM) is characterized by UV‐vis spectroscopy, transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), and dynamic light scattering (DLS). The nanosuspension reduces the MIC values by 50% against Gram‐positive priority pathogens and eradicates established biofilms with fivefold efficiency incomparison to SMs. The nanosuspension also displays antioxidant activity. The findings open up future possibilities of using this novel nanosuspension as an effective antibacterial agent in various therapeutic and biomedical applications like wound dressings, coatings on medical equipment, and surgical implants.","PeriodicalId":19903,"journal":{"name":"Particle & Particle Systems Characterization","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141575381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Optical and Structural Properties of Cuprous Oxide Shell Coated Gold Nanoprisms","authors":"Dániel Zámbó, Dávid Kovács, András Deák","doi":"10.1002/ppsc.202400082","DOIUrl":"https://doi.org/10.1002/ppsc.202400082","url":null,"abstract":"Cuprous oxide nanoparticles can be prepared with a great morphological control, and their composites with gold nanostructures are intensively studied owing to their catalytic performance. In this study, cuprous oxide shell growth on nanosized prism‐shaped gold nanoparticles is investigated, where the core‐particle morphology does not match the prototypical cubic or octahedral symmetry of the embedding cuprous oxide particle. It is shown that different shell morphology is obtained depending on the reducing agent used for the shell deposition. Strong reducing agent (hydrazine) leads to a multi‐slab‐like coating with smooth facets, while under milder conditions (hydroxylamine) a multi‐grain coating is obtained. Successful realization of time‐dependent spectroscopic and structural investigations indicate that in this latter case cuprous oxide shell growth is initiated site‐selectively, namely in the highly curved regions of the particle, with a higher growth rate around the tips of the nanoprisms. This is supported by correlative single‐nanoparticle spectroscopy/scanning electron microscopy measurements, that allow to establish the connection between the optical properties and the structure of these plasmonic/semiconductor core/shell nanoparticles.","PeriodicalId":19903,"journal":{"name":"Particle & Particle Systems Characterization","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141549439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Manuel L. Iozzia, Francesco Goto, Alessandro Podestà, Roberta Vecchi, Alberto Calloni, Cristina Lenardi, Gianlorenzo Bussetti, Marcel Di Vece
{"title":"Olivine nanoparticles for Fast Atmospheric CO2 capture at Ambient Conditions","authors":"Manuel L. Iozzia, Francesco Goto, Alessandro Podestà, Roberta Vecchi, Alberto Calloni, Cristina Lenardi, Gianlorenzo Bussetti, Marcel Di Vece","doi":"10.1002/ppsc.202400063","DOIUrl":"https://doi.org/10.1002/ppsc.202400063","url":null,"abstract":"To mitigate climate change, CO<jats:sub>2</jats:sub> sequestration from the atmosphere is being considered as a method to reduce its greenhouse effect and subsequently lower the Earth's surface temperature. A promising approach is the storage of CO<jats:sub>2</jats:sub> in minerals, of which Olivine is a promising candidate due to its Earth abundance and high CO<jats:sub>2</jats:sub> absorption capacity, which is of the order of 50 wt.%. A bottleneck for Olivine carbonation is the slow reaction rate at ambient conditions, which previously resulted in supplying CO<jats:sub>2</jats:sub> at extreme pressures and temperatures to force carbonation. In this study, nanoscale Olivine particles are fabricated, which due to their high surface‐to‐volume ratio, reach a very high carbonation conversion at a time scale of minutes at ambient conditions. The carbonation is measured by X‐ray photoelectron spectroscopy (XPS), which yielded both the presence of carbonates as well as information on the Olivine oxidation state, in agreement with electron diffraction analysis. This work forms the basis for employing Olivine nanoparticles, as fabricated by the relatively simple method of magnetron sputtering, to capture CO<jats:sub>2</jats:sub> from the atmosphere at economic conditions.","PeriodicalId":19903,"journal":{"name":"Particle & Particle Systems Characterization","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141549438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Syed M. Kawish, Shwetakshi Sharma, Priya Gupta, Farhan J. Ahmad, Muzaffar Iqbal, Fahad M Alshabrmi, Md. Khalid Anwer, Sonia Fathi‐karkan, Abbas Rahdar, M. Ali Aboudzadeh
{"title":"Nanoparticle‐Based Drug Delivery Platform for Simultaneous Administration of Phytochemicals and Chemotherapeutics: Emerging Trends in Cancer Management","authors":"Syed M. Kawish, Shwetakshi Sharma, Priya Gupta, Farhan J. Ahmad, Muzaffar Iqbal, Fahad M Alshabrmi, Md. Khalid Anwer, Sonia Fathi‐karkan, Abbas Rahdar, M. Ali Aboudzadeh","doi":"10.1002/ppsc.202400049","DOIUrl":"https://doi.org/10.1002/ppsc.202400049","url":null,"abstract":"Despite progress in cancer treatments, it remains a leading cause of death worldwide. Current chemotherapy is often hampered by side effects, tissue damage, and drug resistance. To overcome these limitations, research is exploring new approaches to improve chemotherapy efficacy and reduce its side effects. A promising strategy involves combining chemotherapeutic drugs with phytochemicals, which are active compounds derived from plants. Nanotechnology plays a crucial role in delivering these often‐hydrophobic drugs, enhancing their bioavailability and solubility. This research area represents a significant convergence of nanotechnology with both conventional pharmaceuticals and botanical compounds. Global studies are increasingly demonstrating the potential of these combination therapies to inhibit cancer cell growth in laboratory and preclinical models. These studies suggest synergistic or additive effects that lead to improved treatment outcomes. This article focuses on recent advancements in nano‐drug delivery systems, specifically those designed for the simultaneous delivery of chemotherapeutic drugs and phytochemicals. It explores the selection of phytochemicals based on their anticancer properties, outlines the design considerations for nanocarriers, and discusses how physicochemical characteristics influence drug release kinetics. Additionally, the review examines nanoformulations that integrate synthetic drugs with natural components, highlighting the potential of herbal oils and medicines in cancer treatment.","PeriodicalId":19903,"journal":{"name":"Particle & Particle Systems Characterization","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141510282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zahraa Neamah Abbas, Hanaa N. Abdullah, Zahra Hallaji, Bijan Ranjbar
{"title":"Antibacterial and Antibiofilm Activity of Zinc Oxide Quantum Dots against Methicillin‐resistant Staphylococcus aureus","authors":"Zahraa Neamah Abbas, Hanaa N. Abdullah, Zahra Hallaji, Bijan Ranjbar","doi":"10.1002/ppsc.202400048","DOIUrl":"https://doi.org/10.1002/ppsc.202400048","url":null,"abstract":"Antimicrobial resistance occurs mostly through the ineffective and unauthorized use of antibiotics in both the environment and health care. Biofilms are a new target in the search for new antibacterial agents. Here, the sol‐gel method is used to produce zinc oxide quantum dots (ZnO‐QDs). The ZnO‐QDs show yellow emission at 526 nm under 360 nm excitation. After that, the ability of ZnO‐QDs as an antibacterial and antibiofilm agent against methicillin‐resistant <jats:italic>Staphylococcus aureus</jats:italic> (MRSA) is examined. The 100 samples are collected from patients with hospital‐acquired infections between December 2020 and October 2021 from Imamen Kadhmiyan Teaching Hospital in Baghdad (Iraq). Out of these 100 samples, 63 are <jats:italic>S. aureus</jats:italic> and 20 out of 63 are MRSA. The minimum inhibitory concentration assay demonstrates the antibacterial activity of ZnO‐QDs on MRSA strains. Also, results show that 80, 5, and 15% of isolated MRSA strains produce strong, moderate, and weak or very weak biofilm, respectively. The effect of ZnO‐QDs on strong and moderate biofilms reveal that QDs could also inhibit and destroy biofilm produced by MRSA. In addition, the antibiofilm effect of ZnO‐QDs is greater than their antibacterial effect. Generally, this work offers new insights into the development of antibacterial and antibiofilm nanomaterials.","PeriodicalId":19903,"journal":{"name":"Particle & Particle Systems Characterization","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141510283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}