Antibacterial and Antibiofilm Activity of Zinc Oxide Quantum Dots against Methicillin‐resistant Staphylococcus aureus

IF 2.7 4区材料科学 Q3 CHEMISTRY, PHYSICAL

Particle & Particle Systems Characterization Pub Date : 2024-06-25 DOI:10.1002/ppsc.202400048

Zahraa Neamah Abbas, Hanaa N. Abdullah, Zahra Hallaji, Bijan Ranjbar

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引用次数: 0

Abstract

Antimicrobial resistance occurs mostly through the ineffective and unauthorized use of antibiotics in both the environment and health care. Biofilms are a new target in the search for new antibacterial agents. Here, the sol‐gel method is used to produce zinc oxide quantum dots (ZnO‐QDs). The ZnO‐QDs show yellow emission at 526 nm under 360 nm excitation. After that, the ability of ZnO‐QDs as an antibacterial and antibiofilm agent against methicillin‐resistant Staphylococcus aureus (MRSA) is examined. The 100 samples are collected from patients with hospital‐acquired infections between December 2020 and October 2021 from Imamen Kadhmiyan Teaching Hospital in Baghdad (Iraq). Out of these 100 samples, 63 are S. aureus and 20 out of 63 are MRSA. The minimum inhibitory concentration assay demonstrates the antibacterial activity of ZnO‐QDs on MRSA strains. Also, results show that 80, 5, and 15% of isolated MRSA strains produce strong, moderate, and weak or very weak biofilm, respectively. The effect of ZnO‐QDs on strong and moderate biofilms reveal that QDs could also inhibit and destroy biofilm produced by MRSA. In addition, the antibiofilm effect of ZnO‐QDs is greater than their antibacterial effect. Generally, this work offers new insights into the development of antibacterial and antibiofilm nanomaterials.

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氧化锌量子点对耐甲氧西林金黄色葡萄球菌的抗菌和抗生物膜活性

抗菌药耐药性的产生主要是由于在环境和医疗保健中未经授权无效使用抗生素造成的。生物膜是寻找新型抗菌剂的新目标。本文采用溶胶-凝胶法生产氧化锌量子点（ZnO-QDs）。在 360 纳米的激发下，氧化锌量子点在 526 纳米处发出黄色荧光。然后，研究了 ZnO-QDs 作为抗菌剂和抗生物膜剂对耐甲氧西林金黄色葡萄球菌（MRSA）的抗菌能力。这 100 份样本是 2020 年 12 月至 2021 年 10 月期间从巴格达（伊拉克）Imamen Kadhmiyan 教学医院的医院感染患者身上采集的。在这 100 份样本中，63 份为金黄色葡萄球菌，20 份为 MRSA。最小抑菌浓度测定证明了 ZnO-QDs 对 MRSA 菌株的抗菌活性。结果还显示，在分离出的 MRSA 菌株中，分别有 80%、5% 和 15%的菌株会产生强、中、弱或极弱的生物膜。ZnO-QDs 对强生物膜和中等生物膜的作用表明，QDs 也能抑制和破坏 MRSA 产生的生物膜。此外，ZnO-QDs 的抗生物膜效果大于其抗菌效果。总之，这项研究为开发抗菌和抗生物膜纳米材料提供了新的思路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Particle & Particle Systems Characterization 工程技术-材料科学：表征与测试

CiteScore

5.50

自引率

0.00%

发文量

114

审稿时长

3.0 months

期刊介绍： Particle & Particle Systems Characterization is an international, peer-reviewed, interdisciplinary journal focusing on all aspects of particle research. The journal joined the Advanced Materials family of journals in 2013. Particle has an impact factor of 4.194 (2018 Journal Impact Factor, Journal Citation Reports (Clarivate Analytics, 2019)). Topics covered include the synthesis, characterization, and application of particles in a variety of systems and devices. Particle covers nanotubes, fullerenes, micelles and alloy clusters, organic and inorganic materials, polymers, quantum dots, 2D materials, proteins, and other molecular biological systems. Particle Systems include those in biomedicine, catalysis, energy-storage materials, environmental science, micro/nano-electromechanical systems, micro/nano-fluidics, molecular electronics, photonics, sensing, and others. Characterization methods include microscopy, spectroscopy, electrochemical, diffraction, magnetic, and scattering techniques.