Particle & Particle Systems Characterization最新文献

Synthesis of Gold Nanorod@AuAg Hollow Shell Nanostructures with Enhanced Refractive Index Sensitivity and SERS Activity 具有增强折射率灵敏度和SERS活性的金Nanorod@AuAg空心壳纳米结构的合成

4区材料科学

Particle & Particle Systems Characterization Pub Date : 2025-08-28 DOI: 10.1002/ppsc.202500110

Zexiang Shen, Jie Liu, Kun‐Peng Wang, Xuefeng Zhang, Lan Chen, Zhigang Zhou, Tian‐Song Deng

{"title":"Synthesis of Gold Nanorod@AuAg Hollow Shell Nanostructures with Enhanced Refractive Index Sensitivity and SERS Activity","authors":"Zexiang Shen, Jie Liu, Kun‐Peng Wang, Xuefeng Zhang, Lan Chen, Zhigang Zhou, Tian‐Song Deng","doi":"10.1002/ppsc.202500110","DOIUrl":"https://doi.org/10.1002/ppsc.202500110","url":null,"abstract":"Abstract Hollow core‐shell noble metallic nanoparticles have garnered significant attention due to their plasmonic properties, which are markedly enhanced by the hollow structure. However, precisely controlling the size and shape of the shell and cavity in such structures remains a challenge. Here, a novel strategy is reported that eliminates the need for etchants, utilizing monodispersed gold nanorods (AuNRs) as templates to synthesize hollow Au@AuAg core‐shell nanostructures. By precisely regulating the CTAB/CTAC and Au/Ag ratios during the co‐deposition of Au and Ag atoms onto the AuNRs, uniform bimetallic hollow shells are achieved without the use of corrosive etching agents. High‐resolution TEM and EDS characterizations confirm the formation of crystalline AuAg alloy shells surrounding the AuNRs cores, with well‐defined cavities. Compared to pure silver shells, the AuAg alloy shells exhibit superior stability. Furthermore, the resulting Au@AuAg nanostructures with hollow shells demonstrate significantly enhanced refractive index sensitivity and surface‐enhanced Raman scattering (SERS) activity relative to pristine AuNRs, making them highly promising for biomedical applications such as biosensing and bioimaging.","PeriodicalId":19903,"journal":{"name":"Particle & Particle Systems Characterization","volume":"42 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147332243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Titania Doped CDs as Effective CT‐DNA Binders: A Novel Fluorescent Probe via Green Synthesis 掺杂二氧化钛的 CD 作为有效的 CT-DNA 粘合剂：通过绿色合成的新型荧光探针

IF 2.7 4区材料科学

Particle & Particle Systems Characterization Pub Date : 2024-09-10 DOI: 10.1002/ppsc.202400127

Namrata W. N, Neethu Joseph, Nikita Varghese, Meera Varghese, Sreehari K. S, Francis Joy, Yamuna Nair, Manoj B

{"title":"Titania Doped CDs as Effective CT‐DNA Binders: A Novel Fluorescent Probe via Green Synthesis","authors":"Namrata W. N, Neethu Joseph, Nikita Varghese, Meera Varghese, Sreehari K. S, Francis Joy, Yamuna Nair, Manoj B","doi":"10.1002/ppsc.202400127","DOIUrl":"https://doi.org/10.1002/ppsc.202400127","url":null,"abstract":"Carbon dots (CDs), which belong to the class of zero‐dimensional carbon‐based nanomaterials, have garnered significant interest owing to their wide array of applications spanning from the electronics industry to the healthcare sector. This work employs a facile, inexpensive approach to synthesize green luminescent carbon dots (J‐10) from a potential medicinal plant named Justicia Wynaadensis by the one‐step hydrothermal method. A nanocomposite (JT‐10) of the CDs is prepared by adding TiO2 nanoparticles derived from green synthesis of Lavandula leaves. The J‐10 and JT‐10 are further characterized by X‐ray Diffraction spectroscopy (XRD), Transmission Electron Microscopy (TEM), Raman analysis X‐ray Photoelectron Spectroscopy (XPS), and Fourier transform infrared techniques (FTIR), UV–vis spectroscopy, Photoluminescence (PL), and Fluorescence or PL lifetime analysis. The average size of synthesized CDs is 1.85 nm and exhibits an excitation‐dependent fluorescence nature at 320 nm. PL lifetime analysis of J‐10 and JT‐10 is calculated to be 5.80 and 2.84 ns respectively. Offering these unique optical properties and biocompatibility, the synthesised material is suitable for investigating their binding affinity and interaction mechanisms with DNA. The use of JT‐10 in DNA binding studies contributes to the development of sustainable and efficient nanomaterials for applications in biosensors, drug delivery, and gene therapy.","PeriodicalId":19903,"journal":{"name":"Particle & Particle Systems Characterization","volume":"20 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142223458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physical Crosslinking of Aqueous Polymer Dispersions: A Perspective 水性聚合物分散体的物理交联：透视

IF 2.7 4区材料科学

Particle & Particle Systems Characterization Pub Date : 2024-09-10 DOI: 10.1002/ppsc.202400103

Nicholas Ballard, Nerea Jimenez, José M. Asua

引用次数: 0

Fast In Situ Metal Deposition and Removal Under UV and Visible Light Using Polydopamine/TiO2 Composite Surface 利用聚多巴胺/二氧化钛复合表面在紫外和可见光下快速原位沉积和去除金属

IF 2.7 4区材料科学

Particle & Particle Systems Characterization Pub Date : 2024-09-09 DOI: 10.1002/ppsc.202400102

Yanfang Niu, Zhenzhu He, Sen Li, Yi Zeng, Junning Zhang, Keliang Liu, Xin Du, Zhongze Gu

{"title":"Fast In Situ Metal Deposition and Removal Under UV and Visible Light Using Polydopamine/TiO2 Composite Surface","authors":"Yanfang Niu, Zhenzhu He, Sen Li, Yi Zeng, Junning Zhang, Keliang Liu, Xin Du, Zhongze Gu","doi":"10.1002/ppsc.202400102","DOIUrl":"https://doi.org/10.1002/ppsc.202400102","url":null,"abstract":"Metal nanoparticles (MNPs) stand out owing to conspicuous catalytic activity, optical and electromagnetic properties, with applications ranging from photocatalysis to biosensor and photoelectric devices. Although photocatalysis with TiO2 has emerged as a promising technique for preparing MNPs, the low photocatalytic efficiency of TiO2 limits its practical utilization. Herein, a rapid photoreduction approach is presented to prepare MNPs under UV and visible light based on polydopamine (PDA)/TiO2 composite surface. It found that the PDA‐modified TiO2 substrate can greatly enhance the photocatalytic efficiency and stability of MNPs, leading to rapid and highly‐controllable preparation of MNPs. By this method, various Ag, Au, and Pd patterns with controllable metallization degree can be easily fabricated. In addition, the substrate can be effectively recycled through rapid photobleaching. This method will have a promising future in the preparation of MNPs for various applications.","PeriodicalId":19903,"journal":{"name":"Particle & Particle Systems Characterization","volume":"7 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142178342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cobalt Ferrite–Silica–Gold Nanocomposite: Synthesis, Structural Characterization, and Magneto‐Plasmonic Properties 钴铁氧体-二氧化硅-金纳米复合材料：合成、结构表征和磁-质子特性

IF 2.7 4区材料科学

Particle & Particle Systems Characterization Pub Date : 2024-09-06 DOI: 10.1002/ppsc.202400170

Thiago. E. P. Alves, Thatielly F. Almeida, Adolfo Franco, Clemens Burda

{"title":"Cobalt Ferrite–Silica–Gold Nanocomposite: Synthesis, Structural Characterization, and Magneto‐Plasmonic Properties","authors":"Thiago. E. P. Alves, Thatielly F. Almeida, Adolfo Franco, Clemens Burda","doi":"10.1002/ppsc.202400170","DOIUrl":"https://doi.org/10.1002/ppsc.202400170","url":null,"abstract":"Cobalt ferrite–silica–gold nanocomposite (CoFe2O4@SiO2@Au) is synthesized using a new method involving: i) the polyol method for cobalt ferrite nanoparticles (CoFe2O4), ii) the Stober method for silica coating, iii) surface functionalization with 3‐aminopropyl triethoxysilane (APTES), and iv) decoration with gold nanoparticles via tetrakis hydroxy‐methyl‐phosphonium (THPC) reduction. Transmission electron microscopy (TEM) and scanning electron microscopy (SEM) confirm the morphology of the nanoparticles and coatings for the nanocomposites. Ultraviolet–visible (UV–Vis) absorption spectra exhibit plasmon resonance peaks with tuned shifts, discuss in terms of the difference in dielectric permittivity in the core where gold nanoparticles are anchored. Magnetic hysteresis analysis reveals superparamagnetic behavior with reduced saturation magnetization for the nanocomposites. These findings are useful, as superparamagnetic behavior combined with control of plasmonic emission is highly relevant for several magneto‐plasmonic applications.","PeriodicalId":19903,"journal":{"name":"Particle & Particle Systems Characterization","volume":"43 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142178449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Positron Emission Tomography‐Assisted Photothermal Therapy with Gold Nanorods 正电子发射断层扫描辅助金纳米棒光热疗法

IF 2.7 4区材料科学

Particle & Particle Systems Characterization Pub Date : 2024-09-03 DOI: 10.1002/ppsc.202400185

Carlos Renero‐Lecuna, Krishna R. Pulagam, Kepa B. Uribe, Paula Vázquez‐Aristizabal, Vanessa Gómez‐Vallejo, Luis M. Liz‐Marzán, Jordi Llop, Malou Henriksen‐Lacey

{"title":"Positron Emission Tomography‐Assisted Photothermal Therapy with Gold Nanorods","authors":"Carlos Renero‐Lecuna, Krishna R. Pulagam, Kepa B. Uribe, Paula Vázquez‐Aristizabal, Vanessa Gómez‐Vallejo, Luis M. Liz‐Marzán, Jordi Llop, Malou Henriksen‐Lacey","doi":"10.1002/ppsc.202400185","DOIUrl":"https://doi.org/10.1002/ppsc.202400185","url":null,"abstract":"Photothermal anticancer therapy based on plasmonic nanoparticles is proposed to enhance treatment efficacy while mitigating unintended side effects. However, most studies blindly rely on the accumulation of nanoparticles at the tumor site, which may result in inefficient treatment. In this study, the aim is to evaluate relevant parameters to improve plasmonic photothermal therapy. Gold nanorods (AuNRs) with an optimized aspect ratio and either amino or carboxylic acid surface functionalization are selected as photothermal agents. AuNR biocompatibility and photothermal activity in 2D and 3D human MDA‐MB‐231 triple‐negative breast cancer cell models, evaluating localized hyperthermal cell death upon irradiation with resonant near‐infrared (NIR) light, are analyzed first. To ensure reliable tracking of biodistribution in vivo, AuNRs are labeled with the positron emitter copper‐64 (64Cu), and their distribution in a murine MDA‐MB‐231 tumor model is studied via positron emission tomography (PET) imaging. PET images reveal enhanced tumor accumulation of carboxylic acid‐functionalized AuNRs compared to amino‐functionalized AuNRs post‐intravenous administration. Relatively low NIR laser power densities (0.5 W cm−2) are used for controlled heating – keeping local temperature below 50 °C – upon irradiation of intravenously and intratumorally administered AuNRs. As a result, tumor growth is significantly decelerated, even 9 days after application of photothermal therapy.","PeriodicalId":19903,"journal":{"name":"Particle & Particle Systems Characterization","volume":"15 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142178450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

One‐Step Aerosol Synthesis of Thiocyanate Passivated Hybrid Perovskite Microcrystals: Impact of (Pseudo‐)Halide Additives on Crystallization and Access to a Novel Binary Model 一步法气溶胶合成硫氰酸盐钝化混合包晶石微晶：伪）卤化物添加剂对结晶的影响以及新型二元模型的获得

IF 2.7 4区材料科学

Particle & Particle Systems Characterization Pub Date : 2024-09-03 DOI: 10.1002/ppsc.202400132

Ulrich J. Bahnmüller, Yaşar Krysiak, Tobias Seewald, Yenal Yalçinkaya, Denis Pluta, Lukas Schmidt‐Mende, Stefan A. L. Weber, Sebastian Polarz

{"title":"One‐Step Aerosol Synthesis of Thiocyanate Passivated Hybrid Perovskite Microcrystals: Impact of (Pseudo‐)Halide Additives on Crystallization and Access to a Novel Binary Model","authors":"Ulrich J. Bahnmüller, Yaşar Krysiak, Tobias Seewald, Yenal Yalçinkaya, Denis Pluta, Lukas Schmidt‐Mende, Stefan A. L. Weber, Sebastian Polarz","doi":"10.1002/ppsc.202400132","DOIUrl":"https://doi.org/10.1002/ppsc.202400132","url":null,"abstract":"Hybrid Perovskite materials have gone through an astonishing development due to their unique optoelectronic behavior, leading to the creation of a wide range of synthetic strategies. As the materials’ surface is found to play a crucial role with respect to the properties, e.g. hydration, stability and carrier mobilities, considerable efforts have been made to optimize the surface through various approaches. Especially the passivation of the perovskite surface attracted a lot of attention in this field, often resulting in more complex, multi‐step synthetic processes. In this study, a simple one‐step aerosol‐assisted synthetic approach is presented to obtain thiocyanate (SCN) passivated single‐crystal MAPbBr3 microcrystals. To elucidate the role of the additive in the crystallization process, mixed (pseudo‐)halide precursors are systematically investigated. The as processed, passivated microcrystals exhibit enhanced stability and charge carrier lifetimes. Additionally, a decrease in surface photovoltage, attributed to the presence of the SCN additive, is observed. Furthermore, the aerosol process is further developed resulting in a novel binary system containing MAPbBr3‐SCN perovskite microcrystals and Au nanostructures. This system serves as a promising model for further investigations into potential interactions between plasmonic and semiconducting materials, with initial results indicating prolonged charge carrier lifetimes.","PeriodicalId":19903,"journal":{"name":"Particle & Particle Systems Characterization","volume":"4 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142223461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plasmon‐Enhanced Fluorescence of NIR‐Emitting CdxHg1‐xTe Quantum Dots by Ag Nanoprisms 银纳米棱镜对近红外发光 CdxHg1-xTe 量子点的等离子体增强荧光

IF 2.7 4区材料科学

Particle & Particle Systems Characterization Pub Date : 2024-08-26 DOI: 10.1002/ppsc.202400120

Helena Decker, Nadia Metzkow, Vladimir Lesnyak

{"title":"Plasmon‐Enhanced Fluorescence of NIR‐Emitting CdxHg1‐xTe Quantum Dots by Ag Nanoprisms","authors":"Helena Decker, Nadia Metzkow, Vladimir Lesnyak","doi":"10.1002/ppsc.202400120","DOIUrl":"https://doi.org/10.1002/ppsc.202400120","url":null,"abstract":"Near‐infrared (NIR)‐emitting colloidal semiconductor nanocrystals (NCs) draw a lot of attention due to various fields of their potential application, such as bio‐imaging, photovoltaics, photodetectors, light‐emitting diodes, and optical amplifiers for telecommunication. Since they typically suffer from the partial loss of their fluorescence in a solid state, strategies to increase their quantum yields are of outstanding importance. One of the means to improve it is their coupling with structures exhibiting localized surface plasmon resonance (LSPR). As demonstrated for the visible range of light, plasmon‐exciton interactions can enhance the photoluminescence (PL) of CdSe and CdTe NCs. In this work, the influence of the electromagnetic field of plasmonic silver NCs on the PL of CdxHg1–xTe NCs in the NIR region with a special emphasis on tuning the distance between these particle species is studied. In a series of samples prepared by a layer‐by‐layer deposition through polyelectrolytes, a 1.4‐fold PL enhancement at a distance of 9–11 nm between the two layers is observed, while at any other separation emission quenching is a dominating effect. These findings corroborate well with theoretical predictions of an emission increase at these specific distances and can be applied to other types of plasmonic and emitting materials.","PeriodicalId":19903,"journal":{"name":"Particle & Particle Systems Characterization","volume":"11 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142223463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sustainable Wastewater Treatment with Bi2MoO6/Cellulose Acetate Photocatalytic Membranes 利用 Bi2MoO6/醋酸纤维素光催化膜进行可持续废水处理

IF 2.7 4区材料科学

Particle & Particle Systems Characterization Pub Date : 2024-08-26 DOI: 10.1002/ppsc.202400137

Velusamy Sasikala, Sakarapani Sarala, Palani Karthik, Prakash Natarajan, Azhagurajan Mukkannan

{"title":"Sustainable Wastewater Treatment with Bi2MoO6/Cellulose Acetate Photocatalytic Membranes","authors":"Velusamy Sasikala, Sakarapani Sarala, Palani Karthik, Prakash Natarajan, Azhagurajan Mukkannan","doi":"10.1002/ppsc.202400137","DOIUrl":"https://doi.org/10.1002/ppsc.202400137","url":null,"abstract":"A major challenge for modern society is securing quality water for various uses. Membrane water treatment will be crucial for drinking water, desalination, and wastewater reuse. The development of bismuth molybdate (Bi2MoO6) nanoparticles has enabled the production of novel Bi2MoO6‐incorporated cellulose acetate (CA) membrane nanocomposite. The synthesized Bi2MoO6/CA nanocomposites are thoroughly examined for their structural, morphological, and photocatalytic characteristics using X‐ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), X‐ray photoelectron spectroscopy (XPS), and scanning electron microscopy (SEM) with energy dispersive X‐ray spectroscopy (EDX) analysis. The photocatalytic properties are determined by evaluating the degradation of Malachite Green (MG) and Rose Bengal (RB) by the nanocomposite membranes under the illumination of a UV light simulator. Notably, the Bi2MoO6/CA nanocomposite membrane displays exceptional and sustained photocatalytic efficiency (78%) and (84%) in MG and RB dye degradation, respectively. Moreover, the effective loading of the Bi2MoO6 onto the CA membrane enhances electron and hole adsorption while facilitating carrier movement. Furthermore, the stability exhibited by the Bi2MoO6/CA nanocomposite photocatalysts remains impressive even after multiple cycles, demonstrating their durability. This research introduces a cutting‐edge semiconductor‐based hybrid nanocomposite material that proves highly efficient in the photocatalytic degradation of organic dyes, showcasing promising advancements in environmental remediation strategies.","PeriodicalId":19903,"journal":{"name":"Particle & Particle Systems Characterization","volume":"108 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142178451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimizing Formulation Conditions of PLGA Microparticles to Enhance Indomethacin Encapsulation 优化 PLGA 微颗粒的配方条件以提高吲哚美辛的包囊率

IF 2.7 4区材料科学

Particle & Particle Systems Characterization Pub Date : 2024-08-26 DOI: 10.1002/ppsc.202400135

Martina Arabia, Eleonora Maretti, Armita Sedighidarijani, Cecilia Rustichelli, Eliana Leo

{"title":"Optimizing Formulation Conditions of PLGA Microparticles to Enhance Indomethacin Encapsulation","authors":"Martina Arabia, Eleonora Maretti, Armita Sedighidarijani, Cecilia Rustichelli, Eliana Leo","doi":"10.1002/ppsc.202400135","DOIUrl":"https://doi.org/10.1002/ppsc.202400135","url":null,"abstract":"Drug delivery systems can avoid the drawbacks of Indomethacin (IND), a non‐steroidal anti‐inflammatory drug used to treat osteoarthritis and arthritis, which requires high doses to reach therapeutic plasma levels leading to significant systemic side effects. This study aims to optimize poly(lactic‐co‐glycolic acid) (PLGA) microparticles (MPs) for intra‐articular IND administration. MPs are prepared by solvent evaporation and freeze‐dried for stability. Initial formulations with Tween 80 yield rubbery samples with low drug loading (1%); replacement of Tween 80 with Gelatin produces a stable powder with syringable MPs (particles size: 7 µm), although, DL (3%) and EE (30%) remain suboptimal, due to IND polymorphic transformation. Differential Scanning Calorimetry and Fourier‐Transform Infrared spectroscopy demonstrate a molecular dispersion of IND in PLGA. Adjusting the aqueous phase to pH 3 in the formulation process, i.e below IND pKa, significantly enhances EE (90%) due to the reduction of drug solubility in the external aqueous phase. In vitro release study shows prolonged IND release over several days, confirming an effective drug encapsulation. This study provides a foundational framework toward the optimization of the successful encapsulation of IND in PLGA MPs, potentially advancing future clinical applications of such drug delivery systems.","PeriodicalId":19903,"journal":{"name":"Particle & Particle Systems Characterization","volume":"2 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142178462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0