基于纳米颗粒的同时给药植物化学物质和化疗药物的给药平台:癌症治疗的新趋势

IF 2.7 4区 材料科学 Q3 CHEMISTRY, PHYSICAL
Syed M. Kawish, Shwetakshi Sharma, Priya Gupta, Farhan J. Ahmad, Muzaffar Iqbal, Fahad M Alshabrmi, Md. Khalid Anwer, Sonia Fathi‐karkan, Abbas Rahdar, M. Ali Aboudzadeh
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引用次数: 0

摘要

尽管癌症治疗取得了进展,但它仍然是全球死亡的主要原因。目前的化疗常常受到副作用、组织损伤和耐药性的影响。为了克服这些局限性,研究人员正在探索新的方法,以提高化疗疗效并减少其副作用。一种很有前景的策略是将化疗药物与植物化学物质相结合,植物化学物质是从植物中提取的活性化合物。纳米技术在递送这些通常具有疏水性的药物、提高其生物利用度和溶解度方面发挥着至关重要的作用。这一研究领域是纳米技术与传统药物和植物化合物的重要融合。全球越来越多的研究表明,这些组合疗法在实验室和临床前模型中具有抑制癌细胞生长的潜力。这些研究表明,协同或叠加效应可改善治疗效果。本文重点介绍纳米给药系统的最新进展,特别是为同时给药化疗药物和植物化学物质而设计的纳米给药系统。文章探讨了如何根据植物化学物质的抗癌特性对其进行选择,概述了纳米载体设计的注意事项,并讨论了理化特性如何影响药物释放动力学。此外,该综述还探讨了将合成药物与天然成分相结合的纳米制剂,突出了草药油和药物在癌症治疗中的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Nanoparticle‐Based Drug Delivery Platform for Simultaneous Administration of Phytochemicals and Chemotherapeutics: Emerging Trends in Cancer Management
Despite progress in cancer treatments, it remains a leading cause of death worldwide. Current chemotherapy is often hampered by side effects, tissue damage, and drug resistance. To overcome these limitations, research is exploring new approaches to improve chemotherapy efficacy and reduce its side effects. A promising strategy involves combining chemotherapeutic drugs with phytochemicals, which are active compounds derived from plants. Nanotechnology plays a crucial role in delivering these often‐hydrophobic drugs, enhancing their bioavailability and solubility. This research area represents a significant convergence of nanotechnology with both conventional pharmaceuticals and botanical compounds. Global studies are increasingly demonstrating the potential of these combination therapies to inhibit cancer cell growth in laboratory and preclinical models. These studies suggest synergistic or additive effects that lead to improved treatment outcomes. This article focuses on recent advancements in nano‐drug delivery systems, specifically those designed for the simultaneous delivery of chemotherapeutic drugs and phytochemicals. It explores the selection of phytochemicals based on their anticancer properties, outlines the design considerations for nanocarriers, and discusses how physicochemical characteristics influence drug release kinetics. Additionally, the review examines nanoformulations that integrate synthetic drugs with natural components, highlighting the potential of herbal oils and medicines in cancer treatment.
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来源期刊
Particle & Particle Systems Characterization
Particle & Particle Systems Characterization 工程技术-材料科学:表征与测试
CiteScore
5.50
自引率
0.00%
发文量
114
审稿时长
3.0 months
期刊介绍: Particle & Particle Systems Characterization is an international, peer-reviewed, interdisciplinary journal focusing on all aspects of particle research. The journal joined the Advanced Materials family of journals in 2013. Particle has an impact factor of 4.194 (2018 Journal Impact Factor, Journal Citation Reports (Clarivate Analytics, 2019)). Topics covered include the synthesis, characterization, and application of particles in a variety of systems and devices. Particle covers nanotubes, fullerenes, micelles and alloy clusters, organic and inorganic materials, polymers, quantum dots, 2D materials, proteins, and other molecular biological systems. Particle Systems include those in biomedicine, catalysis, energy-storage materials, environmental science, micro/nano-electromechanical systems, micro/nano-fluidics, molecular electronics, photonics, sensing, and others. Characterization methods include microscopy, spectroscopy, electrochemical, diffraction, magnetic, and scattering techniques.
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