Zahraa Neamah Abbas, Hanaa N. Abdullah, Zahra Hallaji, Bijan Ranjbar
{"title":"氧化锌量子点对耐甲氧西林金黄色葡萄球菌的抗菌和抗生物膜活性","authors":"Zahraa Neamah Abbas, Hanaa N. Abdullah, Zahra Hallaji, Bijan Ranjbar","doi":"10.1002/ppsc.202400048","DOIUrl":null,"url":null,"abstract":"Antimicrobial resistance occurs mostly through the ineffective and unauthorized use of antibiotics in both the environment and health care. Biofilms are a new target in the search for new antibacterial agents. Here, the sol‐gel method is used to produce zinc oxide quantum dots (ZnO‐QDs). The ZnO‐QDs show yellow emission at 526 nm under 360 nm excitation. After that, the ability of ZnO‐QDs as an antibacterial and antibiofilm agent against methicillin‐resistant <jats:italic>Staphylococcus aureus</jats:italic> (MRSA) is examined. The 100 samples are collected from patients with hospital‐acquired infections between December 2020 and October 2021 from Imamen Kadhmiyan Teaching Hospital in Baghdad (Iraq). Out of these 100 samples, 63 are <jats:italic>S. aureus</jats:italic> and 20 out of 63 are MRSA. The minimum inhibitory concentration assay demonstrates the antibacterial activity of ZnO‐QDs on MRSA strains. Also, results show that 80, 5, and 15% of isolated MRSA strains produce strong, moderate, and weak or very weak biofilm, respectively. The effect of ZnO‐QDs on strong and moderate biofilms reveal that QDs could also inhibit and destroy biofilm produced by MRSA. In addition, the antibiofilm effect of ZnO‐QDs is greater than their antibacterial effect. Generally, this work offers new insights into the development of antibacterial and antibiofilm nanomaterials.","PeriodicalId":19903,"journal":{"name":"Particle & Particle Systems Characterization","volume":null,"pages":null},"PeriodicalIF":2.7000,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Antibacterial and Antibiofilm Activity of Zinc Oxide Quantum Dots against Methicillin‐resistant Staphylococcus aureus\",\"authors\":\"Zahraa Neamah Abbas, Hanaa N. Abdullah, Zahra Hallaji, Bijan Ranjbar\",\"doi\":\"10.1002/ppsc.202400048\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Antimicrobial resistance occurs mostly through the ineffective and unauthorized use of antibiotics in both the environment and health care. Biofilms are a new target in the search for new antibacterial agents. Here, the sol‐gel method is used to produce zinc oxide quantum dots (ZnO‐QDs). The ZnO‐QDs show yellow emission at 526 nm under 360 nm excitation. After that, the ability of ZnO‐QDs as an antibacterial and antibiofilm agent against methicillin‐resistant <jats:italic>Staphylococcus aureus</jats:italic> (MRSA) is examined. The 100 samples are collected from patients with hospital‐acquired infections between December 2020 and October 2021 from Imamen Kadhmiyan Teaching Hospital in Baghdad (Iraq). Out of these 100 samples, 63 are <jats:italic>S. aureus</jats:italic> and 20 out of 63 are MRSA. The minimum inhibitory concentration assay demonstrates the antibacterial activity of ZnO‐QDs on MRSA strains. Also, results show that 80, 5, and 15% of isolated MRSA strains produce strong, moderate, and weak or very weak biofilm, respectively. The effect of ZnO‐QDs on strong and moderate biofilms reveal that QDs could also inhibit and destroy biofilm produced by MRSA. In addition, the antibiofilm effect of ZnO‐QDs is greater than their antibacterial effect. Generally, this work offers new insights into the development of antibacterial and antibiofilm nanomaterials.\",\"PeriodicalId\":19903,\"journal\":{\"name\":\"Particle & Particle Systems Characterization\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2024-06-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Particle & Particle Systems Characterization\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://doi.org/10.1002/ppsc.202400048\",\"RegionNum\":4,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, PHYSICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Particle & Particle Systems Characterization","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1002/ppsc.202400048","RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
Antibacterial and Antibiofilm Activity of Zinc Oxide Quantum Dots against Methicillin‐resistant Staphylococcus aureus
Antimicrobial resistance occurs mostly through the ineffective and unauthorized use of antibiotics in both the environment and health care. Biofilms are a new target in the search for new antibacterial agents. Here, the sol‐gel method is used to produce zinc oxide quantum dots (ZnO‐QDs). The ZnO‐QDs show yellow emission at 526 nm under 360 nm excitation. After that, the ability of ZnO‐QDs as an antibacterial and antibiofilm agent against methicillin‐resistant Staphylococcus aureus (MRSA) is examined. The 100 samples are collected from patients with hospital‐acquired infections between December 2020 and October 2021 from Imamen Kadhmiyan Teaching Hospital in Baghdad (Iraq). Out of these 100 samples, 63 are S. aureus and 20 out of 63 are MRSA. The minimum inhibitory concentration assay demonstrates the antibacterial activity of ZnO‐QDs on MRSA strains. Also, results show that 80, 5, and 15% of isolated MRSA strains produce strong, moderate, and weak or very weak biofilm, respectively. The effect of ZnO‐QDs on strong and moderate biofilms reveal that QDs could also inhibit and destroy biofilm produced by MRSA. In addition, the antibiofilm effect of ZnO‐QDs is greater than their antibacterial effect. Generally, this work offers new insights into the development of antibacterial and antibiofilm nanomaterials.
期刊介绍:
Particle & Particle Systems Characterization is an international, peer-reviewed, interdisciplinary journal focusing on all aspects of particle research. The journal joined the Advanced Materials family of journals in 2013. Particle has an impact factor of 4.194 (2018 Journal Impact Factor, Journal Citation Reports (Clarivate Analytics, 2019)).
Topics covered include the synthesis, characterization, and application of particles in a variety of systems and devices.
Particle covers nanotubes, fullerenes, micelles and alloy clusters, organic and inorganic materials, polymers, quantum dots, 2D materials, proteins, and other molecular biological systems.
Particle Systems include those in biomedicine, catalysis, energy-storage materials, environmental science, micro/nano-electromechanical systems, micro/nano-fluidics, molecular electronics, photonics, sensing, and others.
Characterization methods include microscopy, spectroscopy, electrochemical, diffraction, magnetic, and scattering techniques.