Peptide Science最新文献_第6页

Nanomole‐scale photochemical thiol‐ene chemistry for high‐throughput late‐stage diversification of peptide macrocycles 纳米级光化学硫醇烯化学用于肽大环的高通量后期多样化

IF 2.4 4区生物学

Peptide Science Pub Date : 2023-04-26 DOI: 10.1002/pep2.24310

M. Nolan, M. Schüttel, Eoin M. Scanlan, Alexander L. Nielsen

引用次数: 0

Erratum: Current peptide vaccine and immunotherapy approaches against Alzheimer's disease 勘误表：目前针对阿尔茨海默病的肽疫苗和免疫疗法方法

IF 2.4 4区生物学

Peptide Science Pub Date : 2023-04-19 DOI: 10.1002/pep2.24309

引用次数: 0

Membrane permeability and antimicrobial peptides: Much more than just making a hole 膜渗透性和抗菌肽:不仅仅是打一个洞

IF 2.4 4区生物学

Peptide Science Pub Date : 2023-03-31 DOI: 10.1002/pep2.24305

J. C. Espeche, Romina Varas, P. Maturana, A. Cutró, P. Maffía, A. Hollmann

引用次数: 1

Host defense peptides identified in human apolipoprotein B as natural food bio‐preservatives: Evaluation of their biosafety and digestibility 人载脂蛋白B中鉴定的宿主防御肽作为天然食品生物防腐剂：生物安全性和消化率评估

IF 2.4 4区生物学

Peptide Science Pub Date : 2023-03-29 DOI: 10.1002/pep2.24308

Eliana Dell’Olmo, Katia Pane, Martina Schibeci, Angela Cesaro, Maria G De Luca, Shurooq Ismail, R. Gaglione, Angela Arciello

引用次数: 0

Fine‐tuning the antimicrobial activity of β‐hairpin peptides with fluorinated amino acids 用氟化氨基酸微调β -发夹肽的抗菌活性

IF 2.4 4区生物学

Peptide Science Pub Date : 2023-03-08 DOI: 10.1002/pep2.24306

S. Chowdhary, Tim Pelzer, Mareike Saathoff, Elisa Quaas, Johanna Pendl, M. Fulde, B. Koksch

引用次数: 1

Guidelines for designing peptoid structures: Insights from the Peptoid Data Bank peptoid结构设计指南：peptoid数据库的见解

IF 2.4 4区生物学

Peptide Science Pub Date : 2023-03-08 DOI: 10.1002/pep2.24307

James R B Eastwood, Ethan I. Weisberg, Dana Katz, R. Zuckermann, K. Kirshenbaum

{"title":"Guidelines for designing peptoid structures: Insights from the Peptoid Data Bank","authors":"James R B Eastwood, Ethan I. Weisberg, Dana Katz, R. Zuckermann, K. Kirshenbaum","doi":"10.1002/pep2.24307","DOIUrl":"https://doi.org/10.1002/pep2.24307","url":null,"abstract":"The number of structural studies of peptoids has grown dramatically over the past 20 years. To date, over 100 high‐resolution structures have been reported for peptoids, which are typically defined as N‐substituted glycine oligomers. We have collected these structures and standardized their sequence representations to facilitate structural analysis as the dataset continues to grow. These structures are presented online as The Peptoid Data Bank (databank.peptoids.org), which also provides persistent links to the published structural data. This review analyzes the present collection of structures and finds extensive support for grouping side chains by their chemistry at the position adjacent to the backbone nitrogen. Groups of side chains with similar chemistry at this position show similar influences on the conformational preferences of the backbone. We also observe a relationship between the side chain and backbone conformations for many monomers that has not previously attracted significant discussion: the values of the χ1 and ϕ dihedrals are correlated. We outline a general design strategy for attaining a specific backbone conformation based on the patterns seen in the collected structures.","PeriodicalId":19825,"journal":{"name":"Peptide Science","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2023-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47638341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Targeting Peptide-Based Quorum Sensing Systems for the Treatment of Gram-Positive Bacterial Infections. 瞄准基于肽的法定人数感应系统治疗革兰氏阳性细菌感染。

IF 2.4 4区生物学

Peptide Science Pub Date : 2023-03-01 Epub Date: 2022-11-12 DOI: 10.1002/pep2.24298

Tahmina A Milly, Yftah Tal-Gan

{"title":"Targeting Peptide-Based Quorum Sensing Systems for the Treatment of Gram-Positive Bacterial Infections.","authors":"Tahmina A Milly, Yftah Tal-Gan","doi":"10.1002/pep2.24298","DOIUrl":"10.1002/pep2.24298","url":null,"abstract":"Bacteria utilize a cell density-dependent communication system called quorum sensing (QS) to coordinate group behaviors. In Gram-positive bacteria, QS involves the production of and response to auto-inducing peptide (AIP) signaling molecules to modulate group phenotypes, including pathogenicity. As such, this bacterial communication system has been identified as a potential therapeutic target against bacterial infections. More specifically, developing synthetic modulators derived from the native peptide signal paves a new way to selectively block the pathogenic behaviors associated with this signaling system. Moreover, rational design and development of potent synthetic peptide modulators allows in depth understanding of the molecular mechanisms that drive QS circuits in diverse bacterial species. Overall, studies aimed at understanding the role of QS in microbial social behavior could result in the accumulation of significant knowledge of microbial interactions, and consequently lead to the development of alternative therapeutic agents to treat bacterial infectivity. In this review, we discuss recent advances in the development of peptide-based modulators to target QS systems in Gram-positive pathogens, with a focus on evaluating the therapeutic potential associated with these bacterial signaling pathways.","PeriodicalId":19825,"journal":{"name":"Peptide Science","volume":"115 2","pages":""},"PeriodicalIF":2.4,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10127943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The manifold role of octapeptide repeats in prion protein assembly. 八肽重复序列在朊病毒蛋白组装中的多重作用。

IF 1.5 4区生物学

Peptide Science Pub Date : 2023-03-01 Epub Date: 2023-01-30 DOI: 10.1002/pep2.24303

Amy H Guadagno, Scott H Medina

引用次数: 0

Chemical Shifts of Artificial Monomers Used to Construct Heterogeneous-Backbone Protein Mimetics in Random Coil and Folded States. 用于构建随机线圈和折叠状态下异质骨架蛋白模拟物的人工单体的化学位移。

IF 2.4 4区生物学

Peptide Science Pub Date : 2023-03-01 Epub Date: 2022-11-12 DOI: 10.1002/pep2.24297

Shilpa R Rao, Thomas W Harmon, Shelby L Heath, Jacob A Wolfe, Jacqueline R Santhouse, Gregory L O'Brien, Alexis N Distefano, Zachary E Reinert, W Seth Horne

{"title":"Chemical Shifts of Artificial Monomers Used to Construct Heterogeneous-Backbone Protein Mimetics in Random Coil and Folded States.","authors":"Shilpa R Rao, Thomas W Harmon, Shelby L Heath, Jacob A Wolfe, Jacqueline R Santhouse, Gregory L O'Brien, Alexis N Distefano, Zachary E Reinert, W Seth Horne","doi":"10.1002/pep2.24297","DOIUrl":"10.1002/pep2.24297","url":null,"abstract":"The construction of protein-sized synthetic chains that blend natural amino acids with artificial monomers to create so-called heterogeneous-backbones is a powerful approach to generate complex folds and functions from bio-inspired agents. A variety of techniques from structural biology commonly used to study natural proteins have been adapted to investigate folding in these entities. In NMR characterization of proteins, proton chemical shift is a straightforward to acquire, information-rich metric that bears directly on a variety of properties related to folding. Leveraging chemical shift to gain insight into folding requires a set of reference chemical shift values corresponding to each building block type (i.e., the 20 canonical amino acids in the case of natural proteins) in a random coil state and knowledge of systematic changes in chemical shift associated with particular folded conformations. Although well documented for natural proteins, these issues remain unexplored in the context of protein mimetics. Here, we report random coil chemical shift values for a library of artificial amino acid monomers frequently used to construct heterogeneous-backbone protein analogues as well as a spectroscopic signature associated with one monomer class, β3-residues bearing proteinogenic side chains, adopting a helical folded conformation. Collectively, these results will facilitate the continued utilization of NMR for the study of structure and dynamics in protein-like artificial backbones.","PeriodicalId":19825,"journal":{"name":"Peptide Science","volume":"115 2","pages":""},"PeriodicalIF":2.4,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10127938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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IF 2.4 4区生物学

Peptide Science Pub Date : 2023-03-01 DOI: 10.1002/pep2.24274

引用次数: 0