Pediatric Dermatology最新文献

{"title":"Ten-Year Epidemiology and Antimicrobial Susceptibility of Pediatric Staphylococcal Scalded Skin Syndrome: A Retrospective Study From a Tertiary Referral Center.","authors":"Mahsa Soti Khiabani, Sanaz Mohamadaghayi Talari, Mahmoud Khodabandeh","doi":"10.1111/pde.70287","DOIUrl":"10.1111/pde.70287","url":null,"abstract":"<p><strong>Background/objectives: </strong>Staphylococcal scalded skin syndrome (SSSS) is a toxin-mediated dermatologic emergency that predominantly affects infants and young children. Despite its characteristic clinical presentation, data on long-term epidemiologic patterns and antimicrobial susceptibility in pediatric SSSS remain limited. This study aimed to describe demographic features, microbiological findings, and antimicrobial susceptibility trends in children with SSSS over a 10-year period preceding the COVID-19 pandemic.</p><p><strong>Methods: </strong>We retrospectively reviewed children diagnosed with SSSS who were admitted to a tertiary pediatric referral center between 2009 and 2018. Demographic, clinical, and microbiological data were collected, and antimicrobial susceptibility results were interpreted according to Clinical and Laboratory Standards Institute (CLSI) criteria, with methicillin susceptibility assessed using oxacillin or cloxacillin, and inducible clindamycin resistance excluded by D-test.</p><p><strong>Results: </strong>A total of 120 children were included, the majority of whom were infants. Cases demonstrated a clear seasonal variation, with higher incidence during warmer months, although Winter represented the second most frequent season. Staphylococcus aureus was the predominant organism isolated from secretion cultures, while blood cultures were infrequently positive. No phenotypically confirmed methicillin-resistant S. aureus was identified. Susceptibility to first-line β-lactam antibiotics remained high, and clindamycin susceptibility was preserved without evidence of inducible resistance. Clinical outcomes were favorable, with short hospital stays and no in-hospital mortality.</p><p><strong>Conclusions: </strong>Methicillin-susceptible S. aureus continues to be the principal pathogen in pediatric SSSS, with sustained susceptibility to first-line β-lactam agents. These findings support current empiric treatment strategies and provide a robust regional baseline for future antimicrobial resistance surveillance.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":"1120-1125"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148138633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Evaluation of Pediatric Dermatology Fellowship Websites: Content Analysis and Perspectives of Fellows and Program Directors.","authors":"Cathleen Huang, Vivian C Iloabuchi, Jacob Breinholt, Micah Starghill, Austin Todd, Bryan Witt, Jordan R Pollock, Joyce Chen, Dawn Marie R Davis","doi":"10.1111/pde.70271","DOIUrl":"10.1111/pde.70271","url":null,"abstract":"<p><strong>Background/objectives: </strong>Prospective applicants for pediatric dermatology fellowships often use program websites as a source of information. This study evaluated the content of pediatric dermatology fellowship websites to identify potential areas of improvement including website accessibility and information found on websites. In addition, this study also surveyed current pediatric dermatology fellows and program directors (PDs) to determine priorities in website content across different stakeholders.</p><p><strong>Methods: </strong>Using the Society for Pediatric Dermatology's (SPD) list of fellowship programs, two independent evaluators assessed the same 40 total programs, with 29 of the same websites included for analysis, against 27 criteria across four domains. In addition, an electronic survey was disseminated via the SPD's mailing list to current pediatric dermatology fellows and fellowship PDs.</p><p><strong>Results: </strong>On average between both evaluators, of the 29 included fellowship websites, 9 educational criteria were included 47.8% of the time across the websites, compared to 46.0% of 10 recruitment criteria, 30.7% of 5 social criteria, and 31.6% of 3 other criteria. Fellows were significantly more likely than PDs to consider several website components as highly valuable.</p><p><strong>Conclusions: </strong>These findings reveal variable and incomplete content across pediatric dermatology fellowship websites, as well as differing expectations for fellowship websites between pediatric dermatology fellowship applicants and PDs, which may help provide suggestions to optimize future website development to enhance applicant engagement.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":"1098-1103"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148016740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Cross-Sectional Study on Quality of Life and Family Quality of Life of Infants, Toddlers, and Preschoolers With Acute and Chronic Urticaria.","authors":"Pavel V Chernyshov, Servando E Marron, Talia Kakourou, Alexis Alexopoulos, Dimitra Koumaki, Tetiana Svyatenko, Tetiana Pochynok, Tetiana Umanets, Kateryna Skriabina, Maksym Zapolskiy, Lucia Tomas-Aragones","doi":"10.1111/pde.70283","DOIUrl":"10.1111/pde.70283","url":null,"abstract":"<p><strong>Background/objectives: </strong>Infants and Toddlers Dermatology Quality of Life (InToDermQoL) questionnaire makes it possible to assess QoL in the youngest children with acute (AU) and chronic urticaria (CU). The aim of this study was to assess the impact of AU and CU on QoL and family QoL of children from birth to 4 years.</p><p><strong>Methods: </strong>The data were collected in Spain, Greece, and Ukraine. Parents of children with AU and CU were asked to complete the InToDermQoL, Family Dermatology Life Quality Index (FDLQI), and Family Reported Outcome Measure (FROM-16). Disease severity was measured by the global severity and Urticaria Activity Score 7 (UAS7).</p><p><strong>Results: </strong>Among 108 children with AU 44.44% had severe and 28.70% had moderate effect on their QoL. Eight of eleven children with CU had a severe effect on their lives. The InToDermQoL correlated with FDLQI (r = 0.78-0.88), global disease severity (r = 0.68-0.76), UAS7 (r = 0.77) and FROM-16 (r = 0.82). FDLQI was well correlated with FROM-16 (r = 0.83) and global disease severity (r = 0.63). UAS7 was well correlated with the FDLQI (r = 0.77) and FROM-16 (r = 0.73). In children with CU, there was more severe impact on itching or scratching, bleeding, sleep, bathing, physical activity, and problems with treatment. Their families noted more impact on personal relationships, leisure activities, looking after relative, extra housework, affected job, and expenditure.</p><p><strong>Conclusions: </strong>AU and CU have a significant impact on children's QoL and family QoL. InToDermQoL, FDLQI, and FROM-16 well reflected QoL and family QoL impairment in young children with urticaria. More active educational work with their parents is needed.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":"1104-1110"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148033986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistent Hemorrhagic Lip Crusts as the Presenting Sign of Pediatric FIP1L1-PDGFRA-Positive Hypereosinophilic Syndrome: A Case Report and Review of the Literature.","authors":"Yi-Kuan Chiang, Yi-Hsin Ho","doi":"10.1111/pde.70233","DOIUrl":"10.1111/pde.70233","url":null,"abstract":"<p><p>FIP1-like-1-platelet-derived growth factor receptor-α (FIP1L1-PDGFRA)-positive hypereosinophilic syndrome (HES) is a rare myeloproliferative neoplasm characterized by persistent eosinophilia and occurs predominantly in middle-aged adults. We report a 15-year-old boy with FIP1L1-PDGFRA-associated chronic eosinophilic leukemia who initially presented with persistent hemorrhagic crusts on the lower lip, an uncommon mucocutaneous manifestation resulting from thrombotic aggregates of eosinophil granule proteins. This case is followed by a systematic literature review of pediatric FIP1L1-PDGFRA-positive HES to further characterize its clinical features and outcomes in children.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":"1204-1208"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dermatological Diseases in Indigenous Children and Adolescents in Polycrisis: A Scoping Review.","authors":"Ana María Valencia-Castaño, Ana María Vargas-Gallego, Felipe Agudelo-Hernández","doi":"10.1111/pde.70308","DOIUrl":"10.1111/pde.70308","url":null,"abstract":"<p><strong>Background: </strong>Polycrisis refers to interacting social, economic, environmental, institutional, cultural, political, and health-system crises that amplify one another. In Indigenous children and adolescents, dermatological diseases may indicate not only a clinical skin condition but also overlapping vulnerabilities involving housing, water and sanitation, nutrition, environmental exposure, territorial disruption, discrimination, and barriers to culturally safe care.</p><p><strong>Aims: </strong>To map evidence on how polycrisis is related to dermatological diseases among Indigenous children and adolescents, and to describe the dermatological conditions most frequently reported in these populations.</p><p><strong>Methods: </strong>This scoping review considered records published between 2010 and 2025, without language restrictions. Eligible records included quantitative, qualitative, review, perspective, editorial, secondary-analysis, and gray-literature sources when they addressed dermatological disease in Indigenous children or adolescents and overlapping crisis-related determinants. The review followed Joanna Briggs Institute guidance and PRISMA-ScR reporting standards.</p><p><strong>Results: </strong>Eight studies were included. The evidence does not establish causality, but it maps recurrent pathways through which environmental exposure, poverty, overcrowding, limited water and sanitation, geographic isolation, fragmented services, cultural safety barriers, stigma, and under-documentation converge with pediatric skin disease. Atopic dermatitis/eczema and infectious dermatoses, including bacterial skin infections, scabies, fungal infections, and pediculosis, were the most frequent categories.</p><p><strong>Conclusions: </strong>Pediatric skin health in Indigenous communities should be understood as a clinical and public health indicator of intersecting environmental, socioeconomic, institutional, cultural, and political crises. Dermatological care in these settings requires accurate diagnosis and treatment, but also intercultural, rights-based, and social-determinants-informed responses.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":"1017-1026"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148536664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sun Safety Intervention for Elementary School Students.","authors":"Camille Moeckel, Rachel Anderson, Laurie Krnajic, Amy Longenecker, Elizabeth M Billingsley, Andrea L Zaenglein, Charlene Lam","doi":"10.1111/pde.70234","DOIUrl":"10.1111/pde.70234","url":null,"abstract":"<p><p>This study evaluated the impact of an elementary school-based intervention that aimed to improve sun safety knowledge and behaviors among third- and fourth-grade students in Pennsylvania through an educational video, t-shirt design contest, and interactive assembly. From pre-survey (n = 88) to post-survey (n = 86), students showed significant improvements in awareness of the link between sun exposure and skin cancer (p < 0.001). Between pre-survey and 6-month follow-up (n = 67), no significant changes were found in reported sunscreen use and reapplication, hat-wearing, or sunburn incidence, but knowledge of skin cancer risk from the sun remained high (p < 0.001). In summary, the intervention significantly increased awareness of the link between sun exposure and skin cancer, with knowledge remaining high at 6-month follow-up, but sustained behavioral change was not observed, suggesting a need for continued reinforcement or different intervention.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":"1163-1166"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13617170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147869315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Line-Field Confocal Optical Coherence Tomography (LC-OCT) of Pilomatricoma.","authors":"Gerardo Palmisano, Simone Cappilli, Daniele Omar Traini, Enrico Bocchino, Lyna Mtimet, Lucas Boussingault, Mariano Suppa, Ketty Peris, Alessandro Di Stefani","doi":"10.1111/pde.70244","DOIUrl":"10.1111/pde.70244","url":null,"abstract":"<p><p>Pilomatricoma is a benign cutaneous tumor of hair matrix origin, often presenting in children as a slow-growing, firm, colored nodule. Line-field confocal optical coherence tomography (LC-OCT) is a novel imaging method that enables non-invasive, quasi-histologic visualization of the skin. We report the case of a 12-year-old patient in whom LC-OCT allowed the in vivo identification of histological features of pilomatricoma.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":"1250-1252"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13617166/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147869240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Efficacy and Safety of Oleogel-S10 (Birch Triterpenes) for Pediatric Patients With Epidermolysis Bullosa.","authors":"Eli Sprecher, Mauricio Torres-Pradilla, Maria Florencia Fernandez, Christine Bodemer, Anna L Bruckner, Silvia Maria de Macedo Barbosa, Andrea Diociaiuti, Anna E Martinez, Francis Palisson, Miloš Nikolić, Asunción Vicente, Raúl de Lucas, Noemi Toiber Temin, Sandra Löwe, Johannes S Kern, Dédée F Murrell","doi":"10.1111/pde.70224","DOIUrl":"10.1111/pde.70224","url":null,"abstract":"<p><strong>Background/objectives: </strong>Pediatric patients with epidermolysis bullosa (EB) experience lifelong complications, and wound healing is an important treatment goal. In the phase III EASE study (NCT03068780), Oleogel-S10 accelerated wound healing in EB. This prespecified subgroup analysis evaluated the long-term efficacy and safety of Oleogel-S10 in patients aged < 18 years from EASE.</p><p><strong>Methods: </strong>EASE comprised a 90-day double-blind phase (DBP) and 24-month open-label phase (OLP). In the DBP, patients were randomized 1:1 to receive Oleogel-S10 or control gel; all patients could enter the OLP and receive Oleogel-S10. Endpoints in this analysis included wound healing, total body wound burden, dressing change burden, and safety.</p><p><strong>Results: </strong>Overall, 156 pediatric patients were enrolled into the DBP (Oleogel-S10: n = 74; Control gel: n = 82); 147 entered the OLP. Oleogel-S10 resulted in 44.6% of pediatric patients with first complete target wound closure within 45 days, versus 25.6% with control gel (relative risk [95% CI]: 1.70 [1.11, 2.60], p = 0.012). Mean absolute body surface area percentage scores were 12.5% at DBP baseline and 5.3% at OLP Month 24 for the Oleogel-S10 group. Significantly more patients treated with Oleogel-S10 (38%) no longer required daily dressing changes versus control gel (9%) at DBP Day 90. Similar proportions of patients experienced adverse events in the Oleogel-S10 and control gel groups in the DBP, with most mild or moderate.</p><p><strong>Conclusions: </strong>These analyses of pediatric patients demonstrated accelerated wound healing, reduced frequency of dressing changes, and sustained reduction in wound burden up to 27 months. Long-term safety was consistent with the overall EASE population.</p><p><strong>Trial registration: </strong>NCT03068780, EudraCT 2016-002066-32; registered 3 March 2017; https://clinicaltrials.gov/study/NCT03068780 and https://www.clinicaltrialsregister.eu/ctr-search/trial/2016-002066-32/GB.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":"1111-1119"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13617162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148043291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment Patterns in Pediatric Hidradenitis Suppurativa: Time to Treatment Initiation, Initial Treatment, and Time to Switching.","authors":"Shaliz Aflatooni, Andrea Ure, Kimberly Smart, Julian A Cortes, Gabriela Palma, Nicole Johnsen, Yvonne Nong, April W Armstrong","doi":"10.1111/pde.70214","DOIUrl":"10.1111/pde.70214","url":null,"abstract":"<p><strong>Background: </strong>Hidradenitis suppurativa (HS) causes significant morbidity in children. Treatment patterns across sex, race, and ethnicity in pediatric HS have not been thoroughly evaluated. We aim to characterize treatment patterns in pediatric HS, including (1) time to treatment initiation, (2) first prescribed HS treatment, and (3) time to switching following initial therapy across demographic factors.</p><p><strong>Methods: </strong>We conducted a real-world, retrospective cohort study of patients < 18 years with a HS diagnosis, using a large U.S. national electronic health record database (2005-2025). Treatments prescribed within 1 year after HS diagnosis were categorized as systemic antibiotics, topicals, hormonal therapies, retinoids, biologics, or procedures.</p><p><strong>Results: </strong>The cohort included 6659 children with HS (mean age 12.8 ± 2.8 years at diagnosis), 74.9% female, 37.7% White, and 56.5% non-Hispanic/Latino. Overall, 3.2% of children received biologics. Following HS diagnosis, the mean time to treatment initiation was 15 days. The most common initial treatment was systemic antibiotics plus topical therapies. The mean time on the initial treatment regimen prior to switching was 386 days. Multivariable analyses demonstrated that girls were more likely than boys to receive any treatments, including biologics, except major procedures. Non-White children initiated treatment sooner than White children (1 vs. 17 days, p < 0.0001). Regardless of demographic subgroup, most children remained on their initial HS treatment for a mean duration of approximately a year before switching therapies.</p><p><strong>Conclusion: </strong>Pediatric HS care is characterized by delayed treatment escalation, antibiotic-dominant initial therapy, and variation in treatment initiation timing across demographic groups.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":"1037-1043"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13617171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147675661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unilateral Forearm Ulceration in a Newborn: Thinking Outside the Box (Compartment).","authors":"Carson Bair, Elizabeth Warbasse, Sharon Albers","doi":"10.1111/pde.70289","DOIUrl":"10.1111/pde.70289","url":null,"abstract":"<p><p>This case details a neonate with unilateral forearm ulceration and motor weakness diagnosed with neonatal limb compartment syndrome (NLCS) following interdisciplinary collaboration. NLCS is a rare cause of congenital extremity ulceration. Due to low clinical suspicion, it is easily misdiagnosed, leading to delayed treatment and preventable complications including motor deficits, or in severe cases, amputation. NLCS is sparsely recognized in dermatologic literature, although dermatologists may be the first point of contact as consultants.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":"1244-1246"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148144113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}