Pediatric Dermatology最新文献

{"title":"Basiliximab for IL-2-Associated Inflammatory Disorder With Atopic Dermatitis.","authors":"Sarah L Becker, Liza Kenny, Alison Small","doi":"10.1111/pde.15913","DOIUrl":"10.1111/pde.15913","url":null,"abstract":"<p><p>Options for pediatric patients with severe atopic dermatitis who do not respond to biologics remain limited. We report the case of a 10-year-old boy with severe, recalcitrant atopic dermatitis associated with episodic fever, joint pains, and elevated serum IL-2R, which responded to basiliximab. To our knowledge, this is the first reported use of basiliximab for atopic dermatitis in a pediatric patient. This case highlights the potential for basiliximab as a therapy for severe cases of atopic dermatitis and the potential for precision medicine in dermatology.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":"1047-1050"},"PeriodicalIF":1.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143502554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the Current Landscape of Educational Workload Among Pediatric Dermatologists Involved in Teaching Primary Care Residents.","authors":"Final Patel, Samantha Epstein, Sonal D Shah, Leah Lalor","doi":"10.1111/pde.15960","DOIUrl":"10.1111/pde.15960","url":null,"abstract":"<p><p>Many pediatric dermatologists train pediatric residents to diagnose and manage common skin conditions. Our study assesses the educational burden and workload pediatric dermatologists face in training pediatric residents (N = 65). Although most pediatric dermatologists (68.2%) agree that their efforts are valued by their department and consider the teaching important (93%), only 12.7% feel they are fairly compensated for this, and 27% attribute teaching pediatric residents to burnout. Our study highlights the need for systemic changes to support teaching efforts through compensation, protected time, or alternative educational models.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":"1037-1039"},"PeriodicalIF":1.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sun-Safety Understanding Among Canadian Elementary Students: A Survey-Based Cohort Study Across Racial/Ethnic Groups.","authors":"Aliyah King, Russell Leong, Reetesh Bose","doi":"10.1111/pde.16034","DOIUrl":"10.1111/pde.16034","url":null,"abstract":"<p><strong>Background: </strong>Early promotion of sun-protective behavior may play a pivotal role in skin cancer prevention. School-based interventions have shown effectiveness in increasing sun-safety knowledge, yet few studies assess children's baseline perceptions before formal education.</p><p><strong>Objective: </strong>To assess elementary students' baseline sun-safety perceptions before an educational session.</p><p><strong>Methods: </strong>Elementary students completed online surveys before sun-safety presentations (May 2023-April 2024). Race/ethnicity data were collected for subgroup analyses.</p><p><strong>Results: </strong>Among 260 respondents (mean age 12; 51.2% female), the race/ethnicity distribution included White (53.9%), Asian (13.9%), Mixed race (7.7%), and Black (6.9%) students, with smaller proportions of Hispanic, Arab, and Indigenous students (each 1.9%). While most students had positive attitudes toward photoprotection and negative perceptions of tanning, notable differences emerged. Regular sunscreen use was more challenging for Black, Hispanic, and Indigenous respondents. Pressure to tan was highest among Indigenous and Asian respondents, and Arab respondents most associated tanning with aging. Indigenous and Hispanic respondents had the highest tanning rates, while Indigenous and White respondents had the highest sunburn rates.</p><p><strong>Conclusions: </strong>Sun-safety perceptions and behaviors varied across racial/ethnic groups. Most students understood that sun exposure contributes to skin cancer, recognized the importance of sunscreen, and acknowledged that darker skin can benefit from sun protection. However, misconceptions remained about sun-protection factor (SPF) meaning, sunscreen use on cloudy days, and the belief that sunscreen fully prevents tanning-related damage. Future studies should explore how sun-safety education can be better tailored for diverse populations.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":"985-992"},"PeriodicalIF":1.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12459399/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144848244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperpigmented Streaks on the Sole of a 12-Year-Old Girl.","authors":"Shanmathi Sethumadhavan, Raman C Varsha, Saritha Mohanan, Dhayalini Raj, Raj R Remya","doi":"10.1111/pde.15889","DOIUrl":"10.1111/pde.15889","url":null,"abstract":"","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":"1073-1075"},"PeriodicalIF":1.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How to Make a Wick: A Controlled and Accurate Cryotherapy Technique for Benign Lesions.","authors":"Molly Thapar, Isabella Plumptre, Karen Wiss, Mark Scharf","doi":"10.1111/pde.15915","DOIUrl":"10.1111/pde.15915","url":null,"abstract":"<p><p>Several cryotherapy techniques are used to treat benign conditions in pediatric dermatology. These include a long-tipped cotton swab, portable sprayer can (\"cryo gun\"), and forceps, amongst others. However, all modalities result in peri-procedural pain and often emotional distress. We present a modification of the cotton swab cryotherapy technique by making a wick from a rayon-tipped OB/GYN swab. This technique may minimize patient emotional distress, while achieving a controlled and efficacious freeze.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":"1105-1107"},"PeriodicalIF":1.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What Matters Most to Minoritized Families in Pediatric Dermatology Care: A Qualitative Study.","authors":"Molly Thapar, Elizabeth Garcia-Creighton, Sandra Garcia-Hernandez, Caroline Tietbohl, Lucinda L Kohn","doi":"10.1111/pde.16021","DOIUrl":"10.1111/pde.16021","url":null,"abstract":"<p><strong>Background: </strong>Limited access to pediatric dermatology care is a well-recognized issue for racially and/or ethnically minoritized (Black, Hispanic, American Indian/Alaska Native [AI/AN]) communities. Little is known about their experiences utilizing dermatology care. Understanding the perspectives of affected families will aid healthcare systems in reducing disparities.</p><p><strong>Objective: </strong>To identify racially and/or ethnically minoritized families' values regarding their children's dermatology care, opinions regarding racial concordance between the patient and healthcare clinicians, and perceptions of how pediatric dermatologists can improve their practice.</p><p><strong>Methods: </strong>English- or Spanish-speaking parents and/or guardians of children receiving care at a pediatric dermatology clinic identifying as Black, Hispanic, or AI/AN were interviewed from November 2, 2023, to January 23, 2024. Thematic analysis was conducted using a reflexive, team-based inductive approach.</p><p><strong>Results: </strong>Thirty-two parents were interviewed. Four major themes were identified: Being Heard, Patient-Clinician Racial and/or Ethnic Concordance, Patient-Clinician Gender Concordance, and Pediatric Patient-Clinician Relationship. Being heard was the most important factor, defined as experiencing validation, empathy, patience, and respect for patient autonomy from their child's clinician. Racial and/or ethnic concordance between the patient and clinician was another commonly identified theme from interviews. Parents valued comparable minority backgrounds over racial and/or ethnic concordance with their child's clinician. Many parents expressed preferences for gender concordance, clinician familiarity with the patient, and specific clinician communication styles when engaging children.</p><p><strong>Conclusions: </strong>Black, Hispanic, and AI/AN families shared that racial and/or ethnic concordance does matter, but being heard matters more. Assessing patient priorities through interpersonal skills training should be a core competency in dermatology residency education to enhance the care of our diverse and underserved patients and their families.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":"971-977"},"PeriodicalIF":1.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144619682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute Generalized Exanthematous Pustulosis Associated With Human Parvovirus B19 in an 11-Year-Old Girl.","authors":"Saniye Yasemin Yilmaz, İlknur Külhaş Çelik, Gülsüm Alkan, İsmail Harmankaya, Hasibe Artaç","doi":"10.1111/pde.15928","DOIUrl":"10.1111/pde.15928","url":null,"abstract":"<p><p>Acute generalized exanthematous pustulosis (AGEP) is a severe adverse cutaneous reaction characterized by the rapid development of nonfollicular sterile pustules on an erythematous base. AGEP is drug induced in 90% of cases but has been associated with viral infections. This report describes a rare case of AGEP induced by parvovirus B19 infection in a pediatric patient.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":"1095-1096"},"PeriodicalIF":1.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dupilumab Treatment for Atopic Dermatitis Is Associated With Decreased Risk of Otitis Media and Related Surgical Procedures: A Retrospective Cohort Study.","authors":"Matthew H Lanehart, Breanne Hayes, Zachary Zinn, David P Skoner","doi":"10.1111/pde.16008","DOIUrl":"10.1111/pde.16008","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the risk of otitis media (OM) and related surgical procedures among population-based, propensity score-matched cohorts of patients with atopic dermatitis (AD) treated with dupilumab compared to those treated with pimecrolimus.</p><p><strong>Methods: </strong>The TriNetX research network was used to conduct a retrospective cohort study estimating the risk of all OM, nonsuppurative OM, suppurative OM, and subsequent surgical intervention in patients with AD treated with dupilumab compared to those treated with pimecrolimus, including an age-stratified analysis focused on pediatric patients. Cohorts were propensity score matched by age at index, current age, sex, race, other atopies, and exposure to tobacco smoke. 5-year Cox proportional hazards models with 95% confidence intervals were analyzed.</p><p><strong>Results: </strong>This study demonstrates that compared to those treated with pimecrolimus, AD patients treated with dupilumab have a significantly decreased 5-year risk of all OM (HR, 0.60; 95% CI, 0.54-0.67; p < 0.001), nonsuppurative OM (HR, 0.60; 95% CI, 0.52-0.70; p < 0.001), suppurative OM (HR, 0.61; 95% CI, 0.55-0.69; p < 0.001), and related surgical procedures (HR, 0.73; 95% CI, 0.58-0.90; p = 0.004), with similar results found among those < 18 years old.</p><p><strong>Conclusions: </strong>Overall, reduced risk of OM and related surgical procedures is observed in patients with AD treated with dupilumab compared to those treated with pimecrolimus.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":"966-970"},"PeriodicalIF":1.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expanding the Cutaneous Presentation of Blau Syndrome, Response to Treatment, and Correlation With Genetics.","authors":"Nessa Aghazadeh Mohandesi, Setu Mittal, Amir B Orandi, Wendy M Smith, Nila S Khan, Dawn Marie Davis","doi":"10.1111/pde.15994","DOIUrl":"10.1111/pde.15994","url":null,"abstract":"<p><strong>Background: </strong>Blau syndrome is a rare, autosomal dominant granulomatous disease caused by mutations in the NOD2/CARD15 gene. While the classic triad of arthritis, dermatitis, and uveitis is well known, the full range of cutaneous manifestations remains underexplored.</p><p><strong>Objective: </strong>To expand the understanding of cutaneous findings in Blau syndrome, correlate these findings with NOD2 variants, and evaluate treatment outcomes across organ systems.</p><p><strong>Methods: </strong>A retrospective review of medical records from January 1999 to January 2024 identified 14 patients with Blau syndrome supported by the presence of NOD2 variants. Clinical data on dermatological features, genetics, and treatment responses were analyzed and categorized into specific and non-specific cutaneous findings.</p><p><strong>Results: </strong>Of the 14 patients with Blau syndrome, 85% (12/14) demonstrated skin involvement. Specific findings included lichenoid or granulomatous papules and nodules (50%, 6/12), while non-specific findings (83%, 10/12) were more diverse, including dermatitis (6/10), chronic urticaria (5/10), ichthyosiform eruptions (4/10), vasospastic disorders (5/10), and oral/genital ulcers (2/10). Skin biopsies in three patients with specific findings revealed non-caseating granulomas. Genetic analysis identified multiple NOD2 variants, though no clear genotype-phenotype correlation was observed. TNF-alpha inhibitors demonstrated efficacy in controlling ocular and joint disease.</p><p><strong>Conclusion: </strong>Blau syndrome presents with a broader spectrum of cutaneous findings than previously recognized. These findings highlight the importance of dermatological evaluation and a multidisciplinary approach to optimize diagnosis and management.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":"956-960"},"PeriodicalIF":1.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cantharidin: Its Role in Dermatology Revisited.","authors":"Yolanka Lobo, Jessica Zhuang, Heba Jibreal","doi":"10.1111/pde.16000","DOIUrl":"10.1111/pde.16000","url":null,"abstract":"<p><p>Dermatologists have been using cantharidin as a vesicant for the treatment of molluscum contagiosum and warts since the 1950s. In experienced hands, treatment with cantharidin is safe, effective, and rarely associated with significant complications. There are varying methods of application and treatment regimens among practitioners; a consensus standard of care has yet to be established. This article provides an overview of cantharidin and its role in dermatology with an emphasis on mechanism of action, adverse effects, limitations of use, and how it compares with alternative treatment options. Instructions for topical application and other important considerations surrounding its use are also discussed.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":"913-926"},"PeriodicalIF":1.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144789642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}