Pediatric Dermatology最新文献

Hypopigmented Patch in a Pediatric Patient. 一名儿科患者的低色素斑块。

IF 1.2 4区医学

Pediatric Dermatology Pub Date : 2025-07-21 DOI: 10.1111/pde.16020

Terri Chiong, Ho Sheun Ling Madeline, Mark Jean Ann Koh

引用次数: 0

Trichostasis Spinulosa: A Case Report of an Unusual Presentation in the Groin of a Pediatric Patient on Clonidine. 棘滴虫病：小儿服用可乐定后腹股沟异常表现的病例报告。

IF 1.2 4区医学

Pediatric Dermatology Pub Date : 2025-07-19 DOI: 10.1111/pde.16016

Katherine Aw, S Dresden Glockler-Lauf, Dina El Demellawy, Carmen Liy-Wong

引用次数: 0

Cutaneous Juvenile Xanthogranuloma With MRC1::PDGFRB Gene Fusion: A Case Report. 皮肤幼年黄色肉芽肿伴MRC1: PDGFRB基因融合1例报告。

IF 1.2 4区医学

Pediatric Dermatology Pub Date : 2025-07-19 DOI: 10.1111/pde.16037

Angelina Labib, Xochitl Longstaff, Maria Gnarra Buethe, Allison M Han, Katayoon Shayan, Jennifer Picarsic, Somak Roy, Dawn Z Eichenfield

引用次数: 0

Pigmented Birthmarks and Spinal Neurofibromas in KRAS Mosaicism-Not to Be Confused With NF1. KRAS嵌合性中的色素胎记和脊髓神经纤维瘤-不要与NF1混淆。

IF 1.2 4区医学

Pediatric Dermatology Pub Date : 2025-07-19 DOI: 10.1111/pde.16018

Karina M Forde, Nicole Knöpfel, Ulrike Loebel, Veronica A Kinsler

引用次数: 0

Anifrolumab in Refractory Juvenile Dermatomyositis. 难治性幼年皮肌炎的无瘤细胞抗体研究。

IF 1.2 4区医学

Pediatric Dermatology Pub Date : 2025-07-17 DOI: 10.1111/pde.16012

Amaia Barrutia-Etxebarria, Rosa María Escribano De La Torre, Jone Lopez Martinez, Juan Ramón De Dios Jimenez de Aberasturi, Zuriñe Martinez de Lagrán Álvarez de Arcaya

{"title":"Anifrolumab in Refractory Juvenile Dermatomyositis.","authors":"Amaia Barrutia-Etxebarria, Rosa María Escribano De La Torre, Jone Lopez Martinez, Juan Ramón De Dios Jimenez de Aberasturi, Zuriñe Martinez de Lagrán Álvarez de Arcaya","doi":"10.1111/pde.16012","DOIUrl":"https://doi.org/10.1111/pde.16012","url":null,"abstract":"Juvenile dermatomyositis (JDM) is a rare, idiopathic inflammatory myopathy of childhood and first-line therapy typically includes corticosteroids and immunosuppressive agents, but complete and sustained remission of the disease is not always achieved. This case report describes an 8-year-old girl with refractory JDM who failed multiple therapies, including corticosteroids, disease-modifying agents, and JAK inhibitors. After the introduction of anifrolumab, a monoclonal antibody targeting the type I interferon receptor, the patient experienced significant improvement in both skin and muscle symptoms. Her disease activity scores decreased markedly, and the response was sustained over six months with no adverse effects. This is the third reported case of JDM treated with anifrolumab, highlighting the potential of targeting the type 1 interferon pathway as a promising therapeutic strategy for patients with refractory disease. The case underscores the importance of IFN-I dysregulation in dermatomyositis and the value of blocking this pathway in difficult-to-treat cases.","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144650059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regional Infantile Hemangiomas Associated With Raynaud Phenomenon. 与雷诺现象相关的婴幼儿区域性血管瘤。

IF 1.2 4区医学

Pediatric Dermatology Pub Date : 2025-07-17 DOI: 10.1111/pde.16006

Racquel A Bitar, Sarah E Servattalab, Lauren A Henderson, Megan M Perron, Amir H Taghinia, Marilyn G Liang

引用次数: 0

Systematic Review of the Epidemiology and Risk Factors for Nonsexual Transmission of Warts and Molluscum in Children. 儿童疣和软疣非性传播的流行病学和危险因素的系统评价。

IF 1.2 4区医学

Pediatric Dermatology Pub Date : 2025-07-17 DOI: 10.1111/pde.16002

Nicolás Exequiel Guillermo Montyn Lücher, Uchechukwu J Okoh, Nanette B Silverberg

{"title":"Systematic Review of the Epidemiology and Risk Factors for Nonsexual Transmission of Warts and Molluscum in Children.","authors":"Nicolás Exequiel Guillermo Montyn Lücher, Uchechukwu J Okoh, Nanette B Silverberg","doi":"10.1111/pde.16002","DOIUrl":"https://doi.org/10.1111/pde.16002","url":null,"abstract":"Background/objective: There is limited literature examining cutaneous warts (CW) and molluscum contagiosum (MC) together to identify common risk factors for their transmission in the pediatric population, and the epidemiological findings vary significantly among authors. This work aims to identify the determinants contributing to the spread of these diseases among children and to consolidate epidemiological data from multiple articles into a single, comprehensive overview.Methods: English literature publications in PubMed were reviewed. Works related to sexual, oral, or vertical transmission were included only in the introduction, while the focus on risk factors and epidemiology centered on nonsexual transmission of CW and MC. The literature review is summarized in a table.Results: The epidemiological data vary; however, all show that CW and molluscum infections are more common in children. Two strongly associated risk factors were identified: skin-to-skin contact with affected individuals (classmates, siblings, other family members) and shared fomites (shoes, clothing, towels, bath sponges, razors, brushes, combs, bar soap). Additional minor risk factors in the pediatric population included gender, swimming in pools, sharing bathtubs/showers, immunocompromise (immunodeficiency, organ transplantation, chemotherapy) and a history of cutaneous illnesses that impair skin barrier function.Conclusions: There are similarities in the transmission of both infections. Gaining a deeper understanding of how these infections spread will contribute to developing more effective prevention measures for the pediatric population. This research serves as a starting point for future studies.","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144650061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dupilumab Treatment for Atopic Dermatitis Is Associated With Decreased Risk of Otitis Media and Related Surgical Procedures: A Retrospective Cohort Study. 杜匹单抗治疗特应性皮炎与中耳炎及相关外科手术风险降低相关：一项回顾性队列研究

IF 1.2 4区医学

Pediatric Dermatology Pub Date : 2025-07-16 DOI: 10.1111/pde.16008

Matthew H Lanehart, Breanne Hayes, Zachary Zinn, David P Skoner

{"title":"Dupilumab Treatment for Atopic Dermatitis Is Associated With Decreased Risk of Otitis Media and Related Surgical Procedures: A Retrospective Cohort Study.","authors":"Matthew H Lanehart, Breanne Hayes, Zachary Zinn, David P Skoner","doi":"10.1111/pde.16008","DOIUrl":"https://doi.org/10.1111/pde.16008","url":null,"abstract":"Objective: To evaluate the risk of otitis media (OM) and related surgical procedures among population-based, propensity score-matched cohorts of patients with atopic dermatitis (AD) treated with dupilumab compared to those treated with pimecrolimus.Methods: The TriNetX research network was used to conduct a retrospective cohort study estimating the risk of all OM, nonsuppurative OM, suppurative OM, and subsequent surgical intervention in patients with AD treated with dupilumab compared to those treated with pimecrolimus, including an age-stratified analysis focused on pediatric patients. Cohorts were propensity score matched by age at index, current age, sex, race, other atopies, and exposure to tobacco smoke. 5-year Cox proportional hazards models with 95% confidence intervals were analyzed.Results: This study demonstrates that compared to those treated with pimecrolimus, AD patients treated with dupilumab have a significantly decreased 5-year risk of all OM (HR, 0.60; 95% CI, 0.54-0.67; p < 0.001), nonsuppurative OM (HR, 0.60; 95% CI, 0.52-0.70; p < 0.001), suppurative OM (HR, 0.61; 95% CI, 0.55-0.69; p < 0.001), and related surgical procedures (HR, 0.73; 95% CI, 0.58-0.90; p = 0.004), with similar results found among those < 18 years old.Conclusions: Overall, reduced risk of OM and related surgical procedures is observed in patients with AD treated with dupilumab compared to those treated with pimecrolimus.","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expanding the Cutaneous Presentation of Blau Syndrome, Response to Treatment, and Correlation With Genetics. 扩大Blau综合征的皮肤表现，对治疗的反应及其与遗传学的相关性。

IF 1.2 4区医学

Pediatric Dermatology Pub Date : 2025-07-16 DOI: 10.1111/pde.15994

Nessa Aghazadeh Mohandesi, Setu Mittal, Amir B Orandi, Wendy M Smith, Nila S Khan, Dawn Marie Davis

{"title":"Expanding the Cutaneous Presentation of Blau Syndrome, Response to Treatment, and Correlation With Genetics.","authors":"Nessa Aghazadeh Mohandesi, Setu Mittal, Amir B Orandi, Wendy M Smith, Nila S Khan, Dawn Marie Davis","doi":"10.1111/pde.15994","DOIUrl":"https://doi.org/10.1111/pde.15994","url":null,"abstract":"Background: Blau syndrome is a rare, autosomal dominant granulomatous disease caused by mutations in the NOD2/CARD15 gene. While the classic triad of arthritis, dermatitis, and uveitis is well known, the full range of cutaneous manifestations remains underexplored.Objective: To expand the understanding of cutaneous findings in Blau syndrome, correlate these findings with NOD2 variants, and evaluate treatment outcomes across organ systems.Methods: A retrospective review of medical records from January 1999 to January 2024 identified 14 patients with Blau syndrome supported by the presence of NOD2 variants. Clinical data on dermatological features, genetics, and treatment responses were analyzed and categorized into specific and non-specific cutaneous findings.Results: Of the 14 patients with Blau syndrome, 85% (12/14) demonstrated skin involvement. Specific findings included lichenoid or granulomatous papules and nodules (50%, 6/12), while non-specific findings (83%, 10/12) were more diverse, including dermatitis (6/10), chronic urticaria (5/10), ichthyosiform eruptions (4/10), vasospastic disorders (5/10), and oral/genital ulcers (2/10). Skin biopsies in three patients with specific findings revealed non-caseating granulomas. Genetic analysis identified multiple NOD2 variants, though no clear genotype-phenotype correlation was observed. TNF-alpha inhibitors demonstrated efficacy in controlling ocular and joint disease.Conclusion: Blau syndrome presents with a broader spectrum of cutaneous findings than previously recognized. These findings highlight the importance of dermatological evaluation and a multidisciplinary approach to optimize diagnosis and management.","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Localized Morphea in a Pediatric Patient Successfully Treated With Topical Ruxolitinib. 局部Ruxolitinib成功治疗小儿局部睡眠不足。

IF 1.2 4区医学

Pediatric Dermatology Pub Date : 2025-07-13 DOI: 10.1111/pde.16025

Grace Rabinowitz, Nicholas Gulati, Saakshi Khattri, Justine Fenner

引用次数: 0