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Report of Hidradenitis Suppurativa in an Individual Affected by Rubinstein-Taybi Syndrome. 鲁宾斯坦-泰比综合征1例化脓性汗腺炎报告。
IF 1.2 4区 医学
Pediatric Dermatology Pub Date : 2025-04-07 DOI: 10.1111/pde.15906
Erik J Wanberg, Kathleen M Fletcher, Nessa Aghazadeh Mohandesi, Afsaneh Alavi
{"title":"Report of Hidradenitis Suppurativa in an Individual Affected by Rubinstein-Taybi Syndrome.","authors":"Erik J Wanberg, Kathleen M Fletcher, Nessa Aghazadeh Mohandesi, Afsaneh Alavi","doi":"10.1111/pde.15906","DOIUrl":"https://doi.org/10.1111/pde.15906","url":null,"abstract":"<p><p>Rubinstein-Taybi syndrome (RTS) is a rare genetic disorder featuring craniofacial abnormalities, intellectual disability, and multi-organ involvement, including increased risk of keloid formation, pilomatricomas, and hypertrichosis. Hidradenitis suppurativa (HS), a chronic inflammatory skin condition characterized by recurrent abscess formation and draining tunnels, has never been described in a patient affected by RTS. In this report, we detail the history of a 32-year-old male with RTS and refractory Hurley stage III HS and discuss the important considerations and risks of managing this unique patient population.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Evaluation of a Diaper Containing a Shea Butter-Based Emollient and Impact on Diapered Skin Erythema. 含有乳木果黄油润肤剂的纸尿裤的临床评价及其对纸尿裤皮肤红斑的影响。
IF 1.2 4区 医学
Pediatric Dermatology Pub Date : 2025-04-06 DOI: 10.1111/pde.15944
R J O'Connor, Marty O Visscher, Vivek Narendran, Y Wang, F Wiesemann, A N Carr
{"title":"Clinical Evaluation of a Diaper Containing a Shea Butter-Based Emollient and Impact on Diapered Skin Erythema.","authors":"R J O'Connor, Marty O Visscher, Vivek Narendran, Y Wang, F Wiesemann, A N Carr","doi":"10.1111/pde.15944","DOIUrl":"https://doi.org/10.1111/pde.15944","url":null,"abstract":"<p><strong>Background/objectives: </strong>Skin is a baby's first line of defense against mechanical, chemical, enzymatic, and microbial insults. Preventive interventions in the diapered area are important given repetitive, episodic exposures to irritants in urine and feces. For over a century, physicians have utilized petrolatum-based emollients (PBE) prophylactically and retroactively for skin irritation in the diapered area. In this study, a diaper containing an anhydrous, shea butter-based emollient (SBE) was evaluated for its skin effects on adult and baby skin.</p><p><strong>Methods: </strong>A 6-week, randomized, crossover, on-baby study was conducted to compare diapered skin erythema from PBE-, SBE-, or non-emollient-containing diapers. Quantification of emollient transfer from diaper to baby was also determined, and two adult forearm studies evaluated emollient effects to lessen irritation by sodium lauryl sulfate (SLS) or prevent skin overhydration.</p><p><strong>Results: </strong>Babies who transitioned from the PBE-containing diaper to the no emollient diaper exhibited a significant increase in skin erythema, whereas no increase was observed for those transitioning from the PBE to the SBE diaper. Babies wearing the SBE diaper were 2.6x more likely to be free of erythema (score = 0) at the perianal site versus the non-emollient diaper, whereas the proportion of erythema-free babies was similar between PBE and SBE diapers, consistent with their similar protection of skin in the adult forearm models.</p><p><strong>Conclusions: </strong>Collectively, these studies demonstrate a disposable diaper containing an emollient protects diapered skin versus diapers without emollients. SBE was as effective in mitigating erythema, was well-tolerated, and provided similar protection as the PBE in a diaper context.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bullying in Children With Congenital Ichthyosis. 先天性鱼鳞病儿童的欺凌行为。
IF 1.2 4区 医学
Pediatric Dermatology Pub Date : 2025-04-06 DOI: 10.1111/pde.15920
Andrea M Rustad, Hannah Soltani, Lynna J Yang, Jenna E McKenney, Ziyou Ren, Stephanie M Rangel, Amy S Paller
{"title":"Bullying in Children With Congenital Ichthyosis.","authors":"Andrea M Rustad, Hannah Soltani, Lynna J Yang, Jenna E McKenney, Ziyou Ren, Stephanie M Rangel, Amy S Paller","doi":"10.1111/pde.15920","DOIUrl":"https://doi.org/10.1111/pde.15920","url":null,"abstract":"<p><strong>Background/objectives: </strong>Bullying of children with chronic disorders is associated with an increased risk of depression, anxiety, poor self-esteem, and suicidal ideation. Congenital ichthyoses are genodermatoses with extensive visible scaling and inflammation. Bullying is a frequent concern of families with ichthyosis but is rarely discussed or investigated.</p><p><strong>Methods: </strong>Bullying experience and the impact on children with ichthyosis and their caregivers were investigated utilizing survey methodology and validated questionnaires. Correlations were explored between demographic and ichthyosis characteristics, bullying exposure (Child Adolescent Bullying Scale-9), child and caregiver psychosocial functioning (Patient-Reported Outcomes Measurement Information System tools), and family quality of life (Family Dermatology Life Quality Index).</p><p><strong>Results: </strong>Overall, 49 dyads completed the survey, with a mean child age of 12 years, 43% female, and 35% non-white. Lamellar (27%), epidermolytic (16%), and with confetti (12%) ichthyosis subtypes were most common. Child-reported bullying exposure correlated strongly with poor peer relationships (r = -0.63) and moderately with stigma (r = 0.53). Caregiver depression and anxiety scores were moderately correlated with caregiver's perception of child's bullying (r = 0.46 and r = 0.52, respectively). Poor family quality of life (QoL) was moderately correlated with proxy severity, caregiver depression and anxiety, poor peer relationships, and poor mobility.</p><p><strong>Conclusions: </strong>Recognition of bullying and its potential impact on QoL is an important component of exploring the psychosocial impact of ichthyosis and providing holistic care.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Case of Congenital Alopecia Areata Successfully Diagnosed by Integrating Clinical, Trichoscopic, and Scalp Biopsy Findings. 结合临床、毛发镜及头皮活检结果成功诊断先天性斑秃1例。
IF 1.2 4区 医学
Pediatric Dermatology Pub Date : 2025-04-04 DOI: 10.1111/pde.15939
Erina Taniguchi, Hisayoshi Imanishi, Shigeki Inui, Manabu Ohyama, Daisuke Tsuruta
{"title":"A Case of Congenital Alopecia Areata Successfully Diagnosed by Integrating Clinical, Trichoscopic, and Scalp Biopsy Findings.","authors":"Erina Taniguchi, Hisayoshi Imanishi, Shigeki Inui, Manabu Ohyama, Daisuke Tsuruta","doi":"10.1111/pde.15939","DOIUrl":"https://doi.org/10.1111/pde.15939","url":null,"abstract":"<p><p>Congenital alopecia areata is a rare and diagnostically challenging disease. Histopathological findings are helpful for diagnosis; however, patients and their guardians might be reluctant to give consent for skin biopsies due to their concern about the invasiveness of the procedure and potential scar formation at biopsy sites. Herein, we report a case of congenital alopecia areata in which a biopsy procedure was essential for the final diagnosis, even though clinical and trichoscopic findings were suggestive of the condition. Based on a literature review, no non-invasively obtainable and reliable finding exists for diagnosing congenital alopecia areata and, therefore, scalp biopsy still holds diagnostic significance.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Juvenile Intermittent Facial Flushing: A New Entity in Children. 青少年间歇性面部潮红：儿童的一种新现象。
IF 1.2 4区 医学
Pediatric Dermatology Pub Date : 2025-04-03 DOI: 10.1111/pde.15948
Marie-Chantal Caussade, María Trinidad Hasbún Zegpi, Shudeshna Nag, Albert C Yan
{"title":"Juvenile Intermittent Facial Flushing: A New Entity in Children.","authors":"Marie-Chantal Caussade, María Trinidad Hasbún Zegpi, Shudeshna Nag, Albert C Yan","doi":"10.1111/pde.15948","DOIUrl":"https://doi.org/10.1111/pde.15948","url":null,"abstract":"<p><p>The differential diagnosis of flushing is extensive, encompassing benign and malignant entities. In this study, we herein describe three patients under 2 years of age who had similarly striking presentations of recurrent unilateral and bilateral facial flushing of unknown etiology that improved spontaneously over time. We propose the term \"juvenile intermittent facial flushing\" to designate this entity until we better understand its spectrum of underlying causes and determine whether this is a specific disorder or a broader phenotype for a heterogeneous group of disorders.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dental Developmental Anomalies in Facial Segmental Hemangiomas Not Related to PHACES. 面节段血管瘤的牙发育异常与面相无关。
IF 1.2 4区 医学
Pediatric Dermatology Pub Date : 2025-04-03 DOI: 10.1111/pde.15938
Eduardo López-Vera, Javier Del Boz-González, Julia Castro-Ruiz, Francisco Ruiz-Delgado
{"title":"Dental Developmental Anomalies in Facial Segmental Hemangiomas Not Related to PHACES.","authors":"Eduardo López-Vera, Javier Del Boz-González, Julia Castro-Ruiz, Francisco Ruiz-Delgado","doi":"10.1111/pde.15938","DOIUrl":"https://doi.org/10.1111/pde.15938","url":null,"abstract":"<p><p>The dental developmental abnormalities observed in two pediatric patients with segmental infantile hemangiomas (IH) not associated with PHACES syndrome (posterior fossa malformations, hemangiomas, arterial anomalies, cardiac defects, eye abnormalities, sternal cleft, and supraumbilical raphe) are presented. Both patients, treated with oral propranolol, exhibited significant dental complications, including delayed tooth eruption, enamel hypoplasia, and complete tooth agenesis. The findings suggest a potential link between facial segmental IH and dental anomalies that may be underrecognized, particularly in non-PHACES cases. We recommend considering targeted dental screenings and radiographic imaging for patients with segmental IH in high-risk facial regions, particularly those involving the maxillary and mandibular regions, to facilitate early identification and management of potential complications.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prospective Clinical Study of Newborn Fingernails Including Onychoscopy. 新生儿指甲前瞻性临床研究，包括虹膜镜检查。
IF 1.2 4区 医学
Pediatric Dermatology Pub Date : 2025-04-03 DOI: 10.1111/pde.15936
Stephano Cedirian, Francesca Pampaloni, Luca Rapparini, Federico Quadrelli, Francesca Bruni, Iria Neri, Aurora M Alessandrini, Bianca M Piraccini, Michela Starace
{"title":"Prospective Clinical Study of Newborn Fingernails Including Onychoscopy.","authors":"Stephano Cedirian, Francesca Pampaloni, Luca Rapparini, Federico Quadrelli, Francesca Bruni, Iria Neri, Aurora M Alessandrini, Bianca M Piraccini, Michela Starace","doi":"10.1111/pde.15936","DOIUrl":"https://doi.org/10.1111/pde.15936","url":null,"abstract":"<p><p>The literature provides limited information on healthy nail features in newborns, emphasizing a need for comprehensive studies on their physiological characteristics. A prospective observational study was conducted at a single pediatric center in Bologna, Italy. Both clinical and onychoscopic evaluations were performed to assess fingernail dimensions, shapes, colors, and other features. This study highlights key physiological fingernail features in newborns, demonstrating sex variation.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multifocal PIK3CA Related Congenital Hemangioma. 多灶性PIK3CA相关先天性血管瘤。
IF 1.2 4区 医学
Pediatric Dermatology Pub Date : 2025-04-03 DOI: 10.1111/pde.15943
Patricia Andres-Ibarrola, Irune Méndez Maestro, Aitor Fernádez de Larrinoa Santamaría, Cristina Barcelona Alfonso, Estibaliz Solórzano Rodríguez, Ricardo López Alcaraz, María Jose Beato Merino, Lara Rodríguez-Laguna, Victor Martinez-Glez, Juan Carlos López Gutiérrez, Marta Mendieta Eckert, Maria Rosario Gonzalez-Hermosa
{"title":"Multifocal PIK3CA Related Congenital Hemangioma.","authors":"Patricia Andres-Ibarrola, Irune Méndez Maestro, Aitor Fernádez de Larrinoa Santamaría, Cristina Barcelona Alfonso, Estibaliz Solórzano Rodríguez, Ricardo López Alcaraz, María Jose Beato Merino, Lara Rodríguez-Laguna, Victor Martinez-Glez, Juan Carlos López Gutiérrez, Marta Mendieta Eckert, Maria Rosario Gonzalez-Hermosa","doi":"10.1111/pde.15943","DOIUrl":"https://doi.org/10.1111/pde.15943","url":null,"abstract":"<p><p>The case of a newborn with multifocal congenital hemangiomas with an activating pathogenic variant of PIK3CA is presented. This report highlights the difficulty in diagnosing multifocal vascular lesions in newborns. Additionally, this case emphasizes the importance of clinical, histologic, radiographic, and genomic correlation to the best categorize rare vascular lesions and to guide treatment.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Polarized Transilluminating Dermoscopy in Diagnosis of Hair Shaft Disorders. 偏振透射皮肤镜在诊断发轴疾病中的应用。
IF 1.2 4区 医学
Pediatric Dermatology Pub Date : 2025-04-03 DOI: 10.1111/pde.15922
Neha Fogla, Usha N Khemani, Avinash A Sajgane, Gampi Ete, Ratnakar R Kamath
{"title":"Polarized Transilluminating Dermoscopy in Diagnosis of Hair Shaft Disorders.","authors":"Neha Fogla, Usha N Khemani, Avinash A Sajgane, Gampi Ete, Ratnakar R Kamath","doi":"10.1111/pde.15922","DOIUrl":"https://doi.org/10.1111/pde.15922","url":null,"abstract":"<p><strong>Background: </strong>Polarized transilluminating dermoscopy is a novel technique that can be used to diagnose hair shaft disorders. The technique has been used once to describe the findings of trichothiodystrophy, but its use in other hair shaft disorders has not yet been studied.</p><p><strong>Objectives: </strong>To assess the efficacy and utility of polarized transilluminating dermoscopy (PTD) in various hair shaft disorders and describe the observations noted.</p><p><strong>Methods: </strong>Six patients with suspected hair shaft disorder were enrolled based on history and clinical examination. Trichogram, trichoscopy, and PTD were performed in all the cases, and the findings were described.</p><p><strong>Result: </strong>PTD enhances the visualization of hair shaft disorders, including pili torti, trichorrhexis nodosa, trichorrhexis invaginata, pili trianguli et canaliculi, and woolly hair. The utilization of the given method in hair analysis represents a significant advancement in the field, offering distinctive insights into the inner structures of hair shafts.</p><p><strong>Conclusion: </strong>In contrast to simple trichoscopy using a polarizing dermatoscope, PTD revealed detailed defects and was confirmatory for the diagnosis of the respective disorder.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Case of Lipschütz Ulcers in a 13-Year-Old Girl With PFAPA Syndrome. 13岁女孩PFAPA综合征并发lipschschtz溃疡1例。
IF 1.2 4区 医学
Pediatric Dermatology Pub Date : 2025-04-02 DOI: 10.1111/pde.15926
Remi Parker, Hannah Russell Johns, Crystal Pourciau
{"title":"A Case of Lipschütz Ulcers in a 13-Year-Old Girl With PFAPA Syndrome.","authors":"Remi Parker, Hannah Russell Johns, Crystal Pourciau","doi":"10.1111/pde.15926","DOIUrl":"https://doi.org/10.1111/pde.15926","url":null,"abstract":"<p><p>Lipschütz ulcers (LU), also known as reactive non-sexually related acute genital ulcerations, are an uncommon condition that primarily affects sexually inactive girls under the age of 20 years. In this report, we describe a 13-year-old female with a past medical history of periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) in early childhood who presented to the emergency department (ED) for sudden onset of genital ulcerations and labial swelling. Based on her clinical presentation, negative primary infectious workup, unresponsiveness to broad-spectrum antimicrobials, and concurrent viral infection, she was diagnosed with LU.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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