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Clinicogenetic Characterization of H Syndrome in a South African Child. 一名南非儿童H综合征的临床遗传学特征。
IF 1.2 4区 医学
Pediatric Dermatology Pub Date : 2026-10-19 DOI: 10.1111/pde.70393
Tshimogo Tswelopele Sathekge, Claude Bailly
{"title":"Clinicogenetic Characterization of H Syndrome in a South African Child.","authors":"Tshimogo Tswelopele Sathekge, Claude Bailly","doi":"10.1111/pde.70393","DOIUrl":"https://doi.org/10.1111/pde.70393","url":null,"abstract":"<p><p>H syndrome is a rare autosomal recessive genodermatosis caused by loss-of-function SLC29A3 variants, combining hyperpigmented indurated plaques and hypertrichosis with life-threatening autoinflammation. We report a 5-year-old South African girl of first-cousin parents who presented with hyperinflammation mimicking macrophage activation syndrome, progressing to purpura fulminans with digital gangrene and autoamputation of fingertips and toes, myocarditis, flexion contractures, flat feet, and enlarged cheeks. Next-generation sequencing identified a homozygous SLC29A3 variant, c.7G>A (p.Val3Ile), of uncertain significance, though the phenotype fulfills published criteria. Recognizing H syndrome's cutaneous, musculoskeletal, and vascular hallmarks can shorten a potentially fatal delay in diagnosis.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vascular Patterning in Morphea Mimicking a Capillary Malformation: Case Report and Review of the Literature. 模仿毛细血管畸形的Morphea血管模式：病例报告和文献回顾。
IF 1.2 4区 医学
Pediatric Dermatology Pub Date : 2026-10-13 DOI: 10.1111/pde.70366
Hannah Kolarik, Ashley Ng, Donglin Zhang, Beth Drolet, Kristen M Kelly, Yvonne E Chiu, Daniel D Bennett, Lisa M Arkin
{"title":"Vascular Patterning in Morphea Mimicking a Capillary Malformation: Case Report and Review of the Literature.","authors":"Hannah Kolarik, Ashley Ng, Donglin Zhang, Beth Drolet, Kristen M Kelly, Yvonne E Chiu, Daniel D Bennett, Lisa M Arkin","doi":"10.1111/pde.70366","DOIUrl":"https://doi.org/10.1111/pde.70366","url":null,"abstract":"<p><p>Early, inflammatory morphea can rarely mimic an acquired capillary malformation (CM), and emerging evidence suggests that endothelial injury may precede fibrosis in morphea, with vascular abnormalities driving immune recruitment and fibroblast activation. We present a pediatric case of inflammatory linear morphea initially misdiagnosed as an acquired CM. Dynamic optical coherence tomography (OCT) demonstrated a dense, superficial vascular network, resembling that seen in genetically confirmed capillary malformations. This case highlights the key clinical and morphologic features of morphea, with clinical pearls to differentiate from acquired CMs. Early recognition of this clinical mimic is critical to prevent irreversible atrophy and fibrosis.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149183671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interim Update on Reactive Infectious Mucocutaneous Eruption (RIME). 反应性感染性皮肤粘膜爆发（RIME）的中期进展。
IF 1.2 4区 医学
Pediatric Dermatology Pub Date : 2026-10-12 DOI: 10.1111/pde.70367
Michele Ramien, Yvonne E Chiu, Sarah D Cipriano, Sadaf Hussain, A Yasmine Kirkorian, Minnelly Luu, Erin F Mathes, Vikash S Oza, Martin Theiler, James R Treat, Patrick M Meyer Sauteur, Irene Lara-Corrales
{"title":"Interim Update on Reactive Infectious Mucocutaneous Eruption (RIME).","authors":"Michele Ramien, Yvonne E Chiu, Sarah D Cipriano, Sadaf Hussain, A Yasmine Kirkorian, Minnelly Luu, Erin F Mathes, Vikash S Oza, Martin Theiler, James R Treat, Patrick M Meyer Sauteur, Irene Lara-Corrales","doi":"10.1111/pde.70367","DOIUrl":"https://doi.org/10.1111/pde.70367","url":null,"abstract":"<p><p>Reactive infectious mucocutaneous eruption (RIME), a term describing blistering skin and mucosal lesions, is a term coined by a group of Pediatric Dermatology Research Alliance (PeDRA) researchers and first published in 2021. Since that time, the literature has grown with reports of diverse infectious triggers, management strategies, and complications. This expert opinion PeDRA perspective, developed by a group conducting a consensus process on management of RIME, is an interim update on the current state of diagnosis and management of RIME with a focus on practical information for the busy clinician.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149170975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Injection-Related Pain During Nemolizumab Treatment With Standardized Vibration-and-Cooling Analgesia in Children With Atopic Dermatitis: A Real-World Observational Study. 奈莫单抗治疗与标准振动和冷却镇痛对特应性皮炎儿童的注射相关疼痛：一项真实世界的观察研究
IF 1.2 4区 医学
Pediatric Dermatology Pub Date : 2026-10-12 DOI: 10.1111/pde.70387
Tomoaki Kunitsu, Kana Hamanaka, Midori Tagaya, Kazuo Nonomura
{"title":"Injection-Related Pain During Nemolizumab Treatment With Standardized Vibration-and-Cooling Analgesia in Children With Atopic Dermatitis: A Real-World Observational Study.","authors":"Tomoaki Kunitsu, Kana Hamanaka, Midori Tagaya, Kazuo Nonomura","doi":"10.1111/pde.70387","DOIUrl":"https://doi.org/10.1111/pde.70387","url":null,"abstract":"<p><strong>Background/objectives: </strong>Injection pain and needle-related anxiety may limit acceptance and continuation of biologic therapy in children with atopic dermatitis (AD). Real-world data on injection pain during nemolizumab treatment is limited. We aimed to longitudinally quantify injection pain during nemolizumab treatment under standardized vibration-and-cooling analgesia and evaluate early clinical outcomes.</p><p><strong>Methods: </strong>This retrospective observational cohort study enrolled children aged 6-12 years with moderate-to-severe AD who had completed 16 weeks of nemolizumab treatment (30 mg every 4 weeks) between June 2024 and July 2025. All injections were administered with standardized vibration-and-cooling analgesia. Injection pain was assessed immediately after each injection using the Wong-Baker FACES Pain Rating Scale (0-10). Secondary outcomes included the Peak Itch Numeric Rating Scale (NRS), Patient-Oriented Eczema Measure (POEM), and Eczema Area and Severity Index (EASI) scores.</p><p><strong>Results: </strong>The 13 children provided 62 of 65 planned pain ratings. Injection pain was consistently minimal (median 0; interquartile range [IQR] 0-2); no child reported severe pain (score ≥ 8). At Week 16, the median EASI reduction was 87.5% (IQR, 73.7-90.3); EASI-75 was achieved by 9 of 13 (69.2%) participants. Median peak itch NRS improved by 5.0 points (IQR, 3.0-6.0), and median POEM improved by 7.0 points (IQR, 4.0-12.0). No serious adverse events occurred.</p><p><strong>Conclusion: </strong>Under standardized vibration-and-cooling analgesia, nemolizumab administration was associated with minimal injection pain and substantial early clinical improvement; these findings do not represent the intrinsic injection pain of nemolizumab without analgesia.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149168629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Itch to Read. 阅读之痒。
IF 1.2 4区 医学
Pediatric Dermatology Pub Date : 2026-10-12 DOI: 10.1111/pde.70369
Kayla Tran, Lauren Rausch, Anna Tappel, JiaDe Yu
{"title":"The Itch to Read.","authors":"Kayla Tran, Lauren Rausch, Anna Tappel, JiaDe Yu","doi":"10.1111/pde.70369","DOIUrl":"https://doi.org/10.1111/pde.70369","url":null,"abstract":"<p><p>Bibliotherapy in pediatric dermatology can be a useful tool for addressing the emotional and social impact of skin conditions in children. Current publication trends across 110 children's books on eczema, birthmarks, vitiligo, alopecia, psoriasis, ichthyosis, and acne show that the number of publications, eBook availability, and skin of color representation has increased over the last 20 years. However, this progress is not evenly distributed across ages or diagnoses. Future published works could be geared towards adolescents and discuss less commonly represented skin conditions like ichthyosis, acne, and alopecia. Additional work is also needed to assess the impact of bibliotherapy in children with skin disease.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149168301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modern Day "Enfreakment" in Pediatric Dermatology. 儿童皮肤病学的现代“启蒙”。
IF 1.2 4区 医学
Pediatric Dermatology Pub Date : 2026-10-12 DOI: 10.1111/pde.70383
Neha Kinariwalla
{"title":"Modern Day \"Enfreakment\" in Pediatric Dermatology.","authors":"Neha Kinariwalla","doi":"10.1111/pde.70383","DOIUrl":"https://doi.org/10.1111/pde.70383","url":null,"abstract":"<p><p>Dermatology is inherently a visual field that requires careful physical exam and observation skills; however, this may have unintended effects during patient encounters. This paper reviews the history of \"freak shows\" and how dermatological conditions were portrayed in the past. It also outlines how dermatologists can be mindful of this history in the context of medical education in an effort to treat patients with respect and dignity.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149171890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pediatric Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Hospitalizations in the United States. 美国儿童史蒂文斯-约翰逊综合征和中毒性表皮坏死松解症的住院治疗。
IF 1.2 4区 医学
Pediatric Dermatology Pub Date : 2026-10-09 DOI: 10.1111/pde.70362
Shazli Razi, Priya Agarwal, Gaurav N Pathak, Christian Kaunzinger, Aaron Morgan, Babar K Rao
{"title":"Pediatric Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Hospitalizations in the United States.","authors":"Shazli Razi, Priya Agarwal, Gaurav N Pathak, Christian Kaunzinger, Aaron Morgan, Babar K Rao","doi":"10.1111/pde.70362","DOIUrl":"https://doi.org/10.1111/pde.70362","url":null,"abstract":"<p><p>Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare life-threatening mucocutaneous reactions that remain poorly characterized in pediatric populations. Using the Healthcare Cost and Utilization Project (HCUP) Kids' Inpatient Database (KID), the prevalence of SJS/TEN hospitalizations declined from 0.02% in 2016 to 0.009% in 2022, with an overall prevalence of 0.014%. Mortality rates among hospitalized patients remained relatively stable, ranging from 1.8% in 2016 to 1.1% in 2019 and 2022. These findings suggest encouraging trends in pediatric SJS/TEN prevalence and survival while emphasizing the importance of comprehensive supportive management.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149149302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Psoriasiform Plaques as a Cutaneous Clue to Persistent Inflammation in Infantile Kawasaki Disease. 牛皮癣样斑块作为婴儿川崎病持续炎症的皮肤线索。
IF 1.2 4区 医学
Pediatric Dermatology Pub Date : 2026-10-08 DOI: 10.1111/pde.70370
Khadija Al Wahaybi, Mazoon Al Saadi, Mahadev Mal, Eman Al Masroori, Buthaina Al Musalhi, Marwa Al Riyami, Reem Abdwani
{"title":"Psoriasiform Plaques as a Cutaneous Clue to Persistent Inflammation in Infantile Kawasaki Disease.","authors":"Khadija Al Wahaybi, Mazoon Al Saadi, Mahadev Mal, Eman Al Masroori, Buthaina Al Musalhi, Marwa Al Riyami, Reem Abdwani","doi":"10.1111/pde.70370","DOIUrl":"https://doi.org/10.1111/pde.70370","url":null,"abstract":"<p><p>Kawasaki disease is typically associated with a polymorphous exanthem, but persistent psoriasiform or pustular plaques during the acute illness may be mistaken for infection, drug eruption, or a separate inflammatory dermatosis. We report a 4-month-old boy with Kawasaki disease who developed erythematous scaly plaques with pustules during the acute phase, in temporal association with recurrent mucosal inflammation and evolving coronary artery dilation requiring repeat intravenous immunoglobulin. Skin biopsy showed psoriasiform epidermal hyperplasia with parakeratosis, loss of the granular layer, neutrophilic exocytosis, papillary dermal edema, and dilated capillaries, supporting psoriasiform dermatitis in the setting of Kawasaki disease. This case highlights the value of clinicopathologic correlation when atypical plaques arise in Kawasaki disease and suggests that such eruptions should prompt careful assessment for ongoing systemic inflammation and coronary involvement.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149137911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
White Nodes on the Hair Shaft of a 16-Year-Old Swimmer. 16岁游泳运动员发干上的白色结节。
IF 1.2 4区 医学
Pediatric Dermatology Pub Date : 2026-10-08 DOI: 10.1111/pde.70376
Sarah Hallowell, Michelle Oboite
{"title":"White Nodes on the Hair Shaft of a 16-Year-Old Swimmer.","authors":"Sarah Hallowell, Michelle Oboite","doi":"10.1111/pde.70376","DOIUrl":"https://doi.org/10.1111/pde.70376","url":null,"abstract":"","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149137855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pediatric Lichen Planus Pemphigoides in a Child With Sickle Cell Disease: Cyclosporine Induction and Dupilumab Maintenance. 镰状细胞病儿童扁平苔藓类天疱疮：环孢素诱导和杜匹单抗维持。
IF 1.2 4区 医学
Pediatric Dermatology Pub Date : 2026-10-08 DOI: 10.1111/pde.70360
Yumeng T Engelking, Laura Correa Ferrer, Jazmin Newton, Kristen G Berrebi
{"title":"Pediatric Lichen Planus Pemphigoides in a Child With Sickle Cell Disease: Cyclosporine Induction and Dupilumab Maintenance.","authors":"Yumeng T Engelking, Laura Correa Ferrer, Jazmin Newton, Kristen G Berrebi","doi":"10.1111/pde.70360","DOIUrl":"https://doi.org/10.1111/pde.70360","url":null,"abstract":"<p><p>Lichen planus pemphigoides (LPP) is a rare autoimmune subepidermal blistering disorder that combines lichenoid lesions of lichen planus with immunopathologic features of pemphigoid disease. We report an 8-year-old boy with homozygous sickle cell disease and severe atopic dermatitis who developed diffuse pruritic violaceous papules followed by tense bullae; subsequent histopathologic, immunofluorescence, and serologic findings confirmed LPP. The patient was initially treated with cyclosporine, with marked clinical improvement within 2-3 weeks. Dupilumab was subsequently initiated during the cyclosporine taper, and no recurrent bullae were observed through approximately 8 months of follow-up.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149137880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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