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Dupilumab as Add-On Therapy for JAK Inhibitor-Relapsed Pediatric Alopecia Areata: A Case Series. Dupilumab作为JAK抑制剂-复发性儿童斑秃的附加治疗：一个病例系列。
IF 1.2 4区 医学
Pediatric Dermatology Pub Date : 2026-10-08 DOI: 10.1111/pde.70379
Shengke Fang, Xuesong Wang, Honglei Wang, Guoyan Liu
{"title":"Dupilumab as Add-On Therapy for JAK Inhibitor-Relapsed Pediatric Alopecia Areata: A Case Series.","authors":"Shengke Fang, Xuesong Wang, Honglei Wang, Guoyan Liu","doi":"10.1111/pde.70379","DOIUrl":"https://doi.org/10.1111/pde.70379","url":null,"abstract":"<p><p>A retrospective case series evaluated dupilumab as add-on therapy in 15 children with severe alopecia areata who relapsed after achieving SALT80 with Janus kinase inhibitors. At Week 12, the median improvement in SALT score from baseline was 59.0%. Among the 13 patients who completed 24 weeks of treatment, 84.6% achieved complete hair regrowth (SALT100). Dupilumab add-on therapy demonstrated efficacy and acceptable safety, suggesting it may be a promising option for pediatric alopecia areata patients who relapse during JAK inhibitor treatment.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149137943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Biologic Therapy on Emergency Department Utilization in Pediatric Hidradenitis Suppurativa Patients. 生物治疗对小儿化脓性汗腺炎急诊科应用的影响。
IF 1.2 4区 医学
Pediatric Dermatology Pub Date : 2026-10-08 DOI: 10.1111/pde.70364
Kenan Kherallah, Claire S Chung, Meagan Hughes, Vivian Y Shi, Jennifer L Hsiao, Katrina H Lee
{"title":"Impact of Biologic Therapy on Emergency Department Utilization in Pediatric Hidradenitis Suppurativa Patients.","authors":"Kenan Kherallah, Claire S Chung, Meagan Hughes, Vivian Y Shi, Jennifer L Hsiao, Katrina H Lee","doi":"10.1111/pde.70364","DOIUrl":"https://doi.org/10.1111/pde.70364","url":null,"abstract":"<p><p>Hidradenitis suppurativa (HS) is a chronic inflammatory condition that often begins in adolescence and is associated with substantial morbidity and increased healthcare utilization, including emergency department (ED) visits. Using the TriNetX Global Network, a retrospective cohort study was conducted comparing pediatric HS patients who received biologic therapy before adulthood with biologic-naïve pediatric HS controls. Biologic exposure was associated with a lower cumulative incidence of 1 or more all-cause ED visits at 5 years (RR: 0.75, 95% CI: 0.58-0.97; p = 0.0250), 10 years (RR: 0.65, 95% CI: 0.51-0.84; p = 0.0002), and at any time after index (RR: 0.61, 95% CI: 0.48-0.77; p < 0.0001; NNT, 10). These findings suggest that biologic exposure during pediatric years is associated with lower subsequent all-cause ED utilization among patients with HS.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149127963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Successful Treatment of Inflammatory Dermatitis Associated With ALOXE3 Nonsyndromic Epidermal Differentiation Disorder Using Dupilumab. Dupilumab成功治疗与ALOXE3非综合征性表皮分化障碍相关的炎性皮炎。
IF 1.2 4区 医学
Pediatric Dermatology Pub Date : 2026-10-07 DOI: 10.1111/pde.70350
Hsing-Jou Su, Rosalynn M Nazarian, Elena B Hawryluk
{"title":"Successful Treatment of Inflammatory Dermatitis Associated With ALOXE3 Nonsyndromic Epidermal Differentiation Disorder Using Dupilumab.","authors":"Hsing-Jou Su, Rosalynn M Nazarian, Elena B Hawryluk","doi":"10.1111/pde.70350","DOIUrl":"https://doi.org/10.1111/pde.70350","url":null,"abstract":"<p><p>Dupilumab has emerged as a promising treatment for inflammatory dermatitis in some epidermal differentiation disorders (EDDs, formerly known as ichthyosis). We report a 5-month-old female with recurrent generalized skin peeling and erythematous plaques since birth that were refractory to multiple topical therapies; she was diagnosed with ALOXE3-associated nonsyndromic epidermal differentiation disorder (ALOXE3-nEDD) by whole exome sequencing. Following initiation of dupilumab, she experienced near-complete resolution of erythematous plaques within 9 months and improvement of pruritus, with sustained response over 2 years of treatment. This case highlights dupilumab as a potential treatment for inflammatory dermatitis associated with ALOXE3-nEDD and similar EDDs.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149128123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Persistent Annular Eruptions in a 2-Year-Old Girl. 2岁女童持续性肺环喷发。
IF 1.2 4区 医学
Pediatric Dermatology Pub Date : 2026-10-07 DOI: 10.1111/pde.70358
Harisankeerth Mummareddy, Lauryn Reid, Robert E Ruiz, Crystal Y Pourciau
{"title":"Persistent Annular Eruptions in a 2-Year-Old Girl.","authors":"Harisankeerth Mummareddy, Lauryn Reid, Robert E Ruiz, Crystal Y Pourciau","doi":"10.1111/pde.70358","DOIUrl":"https://doi.org/10.1111/pde.70358","url":null,"abstract":"","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149128125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oral Sirolimus for Infantile Hemangioma: A Series of Six Patients. 口服西罗莫司治疗婴幼儿血管瘤：6例临床观察。
IF 1.2 4区 医学
Pediatric Dermatology Pub Date : 2026-10-07 DOI: 10.1111/pde.70354
Fiona H Lynch, Meryem Safoine, Esther Zhang, Isabel C Yoon, Denise M Adams, James R Treat, Pierre-Olivier Grenier, Marilyn G Liang
{"title":"Oral Sirolimus for Infantile Hemangioma: A Series of Six Patients.","authors":"Fiona H Lynch, Meryem Safoine, Esther Zhang, Isabel C Yoon, Denise M Adams, James R Treat, Pierre-Olivier Grenier, Marilyn G Liang","doi":"10.1111/pde.70354","DOIUrl":"https://doi.org/10.1111/pde.70354","url":null,"abstract":"<p><p>A minority of patients with infantile hemangioma (IH) are refractory or intolerant to systemic beta-blockers. Adjunctive sirolimus was clinically beneficial in six patients with IH who were refractory or intolerant to beta-blockade and at risk of complications including disfigurement, ulceration, visual obstruction, and/or airway obstruction. Improvements were seen in both cutaneous and extracutaneous IH following the addition of sirolimus to propranolol therapy, with variable use of systemic corticosteroids. Laboratory abnormalities prompted early sirolimus withdrawal in two patients. Concurrent therapies and natural involution are important confounders that limit the ability to attribute improvements solely to sirolimus.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149128088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neonatal Urticaria as the First Manifestation of Neonatal Onset Multisystem Inflammatory Disease Treated Empirically With Anakinra. 新生儿荨麻疹是新生儿起病多系统炎性疾病的第一表现。
IF 1.2 4区 医学
Pediatric Dermatology Pub Date : 2026-10-07 DOI: 10.1111/pde.70356
Adrienne Conza, Shauna M Rice, Isabella Plumptre, Maria C Bryant, Mary Beth F Son, Leah Belazarian
{"title":"Neonatal Urticaria as the First Manifestation of Neonatal Onset Multisystem Inflammatory Disease Treated Empirically With Anakinra.","authors":"Adrienne Conza, Shauna M Rice, Isabella Plumptre, Maria C Bryant, Mary Beth F Son, Leah Belazarian","doi":"10.1111/pde.70356","DOIUrl":"https://doi.org/10.1111/pde.70356","url":null,"abstract":"<p><p>Urticarial eruptions in neonates, especially within hours to days of birth, should prompt workup for cryopyrin-associated periodic syndrome (CAPS) disorders. This report details a 9-h-old neonate with urticaria as the first manifestation of neonatal onset multisystem inflammatory disease (NOMID), also known as chronic infantile neurologic cutaneous and articular syndrome. Empiric anakinra was started on Day 3 of life, prior to genetic confirmation of a de novo pathogenic variant of NLRP3, due to high clinical suspicion for CAPS and in the absence of an infectious source. As early treatment reduces morbidity and mortality, this case highlights the importance of having a low threshold for empiric anti-IL-1 therapy in neonatal urticaria with clinical suspicion for NOMID.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149113344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Operative Management of Phakomatosis Pigmentokeratotica Sequelae: Surgical Techniques and Procedural Pearls. 色素性角化斑病后遗症的手术治疗：手术技术及手术要点。
IF 1.2 4区 医学
Pediatric Dermatology Pub Date : 2026-10-07 DOI: 10.1111/pde.70372
Helen Chen, Brooke Walterscheid, Michelle Tarbox, Alba Posligua
{"title":"Operative Management of Phakomatosis Pigmentokeratotica Sequelae: Surgical Techniques and Procedural Pearls.","authors":"Helen Chen, Brooke Walterscheid, Michelle Tarbox, Alba Posligua","doi":"10.1111/pde.70372","DOIUrl":"https://doi.org/10.1111/pde.70372","url":null,"abstract":"<p><p>Phakomatosis pigmentokeratotica (PPK) is a rare variant of epidermal nevus syndrome, classically characterized by the coexistence of nevus sebaceus and nevus spilus. Secondary neoplasms arising within nevus sebaceus, including syringocystadenoma papilliferum (SPAP), can cause persistent irritation, discomfort, and bleeding that negatively impact quality of life, particularly in patients with extensive disease. Due to the rarity of this condition, no standardized management protocol exists for symptomatic SPAPs, which poses a therapeutic challenge for this patient population. Herein, we present a case of multiple SPAPs in a patient with PPK successfully managed using multimodal therapy involving dermatologic surgery and ablative CO<sub>2</sub> laser, adding to the limited literature on the management of recalcitrant SPAPs.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149128106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multidisciplinary Support for Children With Genodermatoses in Brazil: A RE-AIM Evaluation of Casa Santa Teresinha's Community-Based Model. 巴西对遗传性皮肤病儿童的多学科支持：圣特雷西哈之家社区模式的RE-AIM评估
IF 1.2 4区 医学
Pediatric Dermatology Pub Date : 2026-10-07 DOI: 10.1111/pde.70368
Izadora Lapenda, Alreem Al-Nabti, Natalia Campacci, Zilda Najjar Prado de Oliveira, Luciana Paula Samorano, Lais Lopes Almeida Gomes, Magda Carneiro-Sampaio, Regia Patriota
{"title":"Multidisciplinary Support for Children With Genodermatoses in Brazil: A RE-AIM Evaluation of Casa Santa Teresinha's Community-Based Model.","authors":"Izadora Lapenda, Alreem Al-Nabti, Natalia Campacci, Zilda Najjar Prado de Oliveira, Luciana Paula Samorano, Lais Lopes Almeida Gomes, Magda Carneiro-Sampaio, Regia Patriota","doi":"10.1111/pde.70368","DOIUrl":"https://doi.org/10.1111/pde.70368","url":null,"abstract":"<p><p>Genodermatoses impose substantial psychosocial and functional burdens on affected children and their families, yet structured community-based support models remain underrepresented in the literature. We describe Casa Santa Teresinha, a Brazilian non-profit organization providing multidisciplinary care for children with genodermatoses and present a programmatic evaluation using the RE-AIM framework (Reach, Effectiveness, Adoption, Implementation, and Maintenance). In 2025, the program engaged 103 patients and their families, delivering 4419 service encounters across psychology, social work, physiotherapy, genetic nursing, nutrition, and socioeducational activities. The model integrates individualized care planning, a genetic nurse acting as patient navigator, and innovative strategies to address social determinants of health, including rideshare-based transportation as a clinical safety measure. Strong engagement and sustained participation highlight the program's relevance in a socioeconomically vulnerable population. While formal outcome measures are being implemented, this evaluation demonstrates a scalable, community-based model that complements hospital care and may inform similar initiatives globally.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149127957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erythematous Pustular Plaques in a Child. 儿童红斑性脓疱斑块。
IF 1.2 4区 医学
Pediatric Dermatology Pub Date : 2026-10-07 DOI: 10.1111/pde.70374
Nicole Kah Mun Yoong, Ian Simpson, Senhong Lee
{"title":"Erythematous Pustular Plaques in a Child.","authors":"Nicole Kah Mun Yoong, Ian Simpson, Senhong Lee","doi":"10.1111/pde.70374","DOIUrl":"https://doi.org/10.1111/pde.70374","url":null,"abstract":"","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149127843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Invisible Waiting Room: How Insurance Status Shapes the Pediatric Dermatology Access Crisis. 看不见的候诊室：保险状况如何影响儿童皮肤科就诊危机。
IF 1.2 4区 医学
Pediatric Dermatology Pub Date : 2026-10-07 DOI: 10.1111/pde.70380
Maria Gnarra Buethe
{"title":"The Invisible Waiting Room: How Insurance Status Shapes the Pediatric Dermatology Access Crisis.","authors":"Maria Gnarra Buethe","doi":"10.1111/pde.70380","DOIUrl":"https://doi.org/10.1111/pde.70380","url":null,"abstract":"<p><p>Children seeking pediatric dermatology care face prolonged waits, and insurance status may impose an additional, undermeasured barrier. Medicaid reimbursement below Medicare rates, combined with lower work relative value units for pediatric encounters, creates financial pressure that disproportionately affects academic centers serving publicly insured children. These barriers contribute to delayed specialty care, emergency department use, and geographic inequities. Sustainable payment parity, payer-stratified access research, teledermatology, and coordinated professional advocacy are needed to improve equitable access.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149128046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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