Pediatric Dermatology最新文献_第2页

A severe case of reactive infectious mucocutaneous eruption associated with two possible triggers: Coronavirus and group A streptococcus 一例伴有两种可能诱因的反应性传染性粘膜糜烂重症病例：冠状病毒和 A 组链球菌

IF 1.5 4区医学

Pediatric Dermatology Pub Date : 2024-09-10 DOI: 10.1111/pde.15744

Ivan Rodriguez, Andrew T. Kwong, Minnelly Luu, Scott D. Worswick

引用次数: 0

Facial Sebaceous Hyperplasia in an Adolescent With Hypohidrotic Ectodermal Dysplasia. 患有外胚层发育不全的青少年面部皮脂腺增生症。

IF 1.2 4区医学

Pediatric Dermatology Pub Date : 2024-09-08 DOI: 10.1111/pde.15751

Elena Lucía Pinto-Pulido, Lucero Noguera-Morel, Isabel Colmenero, Antonio Torrelo, Ángela Hernández-Martín

引用次数: 0

Recurrent aphthous stomatitis in a child successfully treated with apremilast. 用阿普司特成功治疗一名儿童的复发性口腔炎。

IF 1.2 4区医学

Pediatric Dermatology Pub Date : 2024-09-05 DOI: 10.1111/pde.15711

Alvaro March-Rodríguez, Alejandro Lobato-Berezo, Ramon M Pujol

引用次数: 0

How many is too many? A review of the significant numbers in pediatric skin lesions and their recommended evaluation. 多少才算多？回顾儿科皮损的重要数字及其评估建议。

IF 1.2 4区医学

Pediatric Dermatology Pub Date : 2024-09-05 DOI: 10.1111/pde.15687

Carly Mulinda, Sonora Yun, Justine Fenner, Maria C Garzon, Margaret E Scollan, Laura E Levin

引用次数: 0

Transition of care in adolescents with epidermolysis bullosa: The provider perspective. 表皮松解症青少年的护理过渡：提供者的视角。

IF 1.2 4区医学

Pediatric Dermatology Pub Date : 2024-09-05 DOI: 10.1111/pde.15650

Victoria A Perez, Carly Mulinda, Anna L Bruckner, Lucia Z Diaz, Kristen P Hook, Irene Lara-Corrales, Moise L Levy, Harper N Price, Kimberly D Morel, Laura E Levin

引用次数: 0

Analysis of publicly available adverse events reported for pediatric patients treated with Janus kinase inhibitors. 对公开报道的接受 Janus 激酶抑制剂治疗的儿科患者的不良事件进行分析。

IF 1.2 4区医学

Pediatric Dermatology Pub Date : 2024-09-05 DOI: 10.1111/pde.15721

Sahithi Talasila, Emily Lee, Eric M Teichner, Elaine C Siegfried, Stephanie R Jackson Cullison

{"title":"Analysis of publicly available adverse events reported for pediatric patients treated with Janus kinase inhibitors.","authors":"Sahithi Talasila, Emily Lee, Eric M Teichner, Elaine C Siegfried, Stephanie R Jackson Cullison","doi":"10.1111/pde.15721","DOIUrl":"https://doi.org/10.1111/pde.15721","url":null,"abstract":"Janus kinase inhibitors (JAKi) are drugs that block tyrosine kinases responsible for transducing cytokine signals. The first JAKi was approved by the US Food and Drug Administration (FDA) in 2011 to treat rheumatoid arthritis in adults. A pediatric indication was not approved until 8 years later, for acute graft-versus-host disease. Since then, topical and oral formulations have gained FDA approval for pediatric patients with dermatologic diseases. While increasing evidence supports the safety of these medications in adults, data are limited in children. We sought to determine whether JAKi adverse events (AEs) as reported in clinical trials and via postapproval pharmacovigilance services are comparable in adult and pediatric patients. Pharmacovigilance data were extracted from the FDA's Adverse Event Reporting System and the Canada Vigilance Adverse Reaction Online Database for baricitinib, upadacitinib, abrocitinib, ruxolitinib, and tofacitinib. The pooled data were analyzed to detect the most common AEs for specific JAKi and for the drug class. We assessed 399,649 AEs from 133,216 adults and 2883 AEs from 955 patients under 18 years old and identified slightly different AE profiles for the two age groups. Both populations had increased risk for infections and gastrointestinal AEs. However, pediatric patients reported a higher proportion of blood and lymphatic disorders, while reports of nervous system and musculoskeletal/connective tissue disorders were more common in adults. The spectrum of AEs extracted from pharmacovigilance reports was similar to clinical trials. The JAKi AE profiles we observed may prove helpful in counseling patients and their parents before starting therapy and for monitoring once patients are on therapy.","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142133423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dermatoscopic features of vulvar lichen sclerosus in children: A retrospective study. 儿童外阴硬化性苔藓的皮肤镜特征：回顾性研究。

IF 1.2 4区医学

Pediatric Dermatology Pub Date : 2024-09-03 DOI: 10.1111/pde.15743

Yuyang Han, Runtao Liu, Yuanjun Li

{"title":"Dermatoscopic features of vulvar lichen sclerosus in children: A retrospective study.","authors":"Yuyang Han, Runtao Liu, Yuanjun Li","doi":"10.1111/pde.15743","DOIUrl":"https://doi.org/10.1111/pde.15743","url":null,"abstract":"Objectives: To explore the dermoscopic features of lichen sclerosus in different parts of the external genitalia in children.Methods: A retrospective analysis of the dermoscopic features of 42 female children with vulvar lichen sclerosus treated in the Department of Dermatology of Shanxi Children's Hospital from January 2020 to May 2023.Results: Among the 42 female children, aged 3-14 years (mean: 7.24 ± 2.43 years), the duration of vulvar lichen sclerosus ranged from 3 months to 2 years (mean: 9.83 ± 4.93 months). Clinical lesions occurred in the labia minora in 18 cases (42.9%), labia majora in 38 cases (90.5%), posterior fourchette in 36 cases (85.7%), perianal area in 13 cases (31.0%), anterior fourchette in 17 cases (40.5%), clitoris in seven cases (16.7%), and interlabial sulcus in 11 cases (26.2%). Dermoscopic findings common in the labia majora included follicular keratotic plugs, cloverleaf-like structures, comedo-like openings, and linear vessels (p < .05); however, purple-red globules and patches and white linear streaks were more common in the posterior fourchette (p < .05), whereas dotted vessels were more common in the labia minora (p < .05).Conclusions: Common dermoscopic findings in pediatric vulvar lichen sclerosus were yellow-white structureless areas, white linear streaks, follicular keratotic plugs, and cloverleaf-like structures; yellow-white structureless areas and white linear streaks showed the highest specificity. The dermoscopic findings varied among different affected areas, which provides a basis for further understanding of the characteristics of different sites of vulvar lichen sclerosus in the pediatric population.","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142120414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unusual case of prurigo pigmentosa on the upper extremities in an adolescent female: A rare presentation. 青少年女性上肢色素性瘙痒症的罕见病例：罕见病例。

IF 1.2 4区医学

Pediatric Dermatology Pub Date : 2024-09-03 DOI: 10.1111/pde.15731

Gökçe Işıl Kurmuş, Laden Elkıran, Dilek Menteşoğlu, Ebru Şebnem Ayva, Selda Pelin Kartal

引用次数: 0

Multiple café-au-lait macules, axillary freckling, and hypopigmented macules in a child. 一名儿童身上出现多发性咖啡色斑、腋下雀斑和色素减退斑。

IF 1.2 4区医学

Pediatric Dermatology Pub Date : 2024-09-03 DOI: 10.1111/pde.15729

Kristie Mar, Alison M R Castle, Joseph M Lam

引用次数: 0

Reticulated pigmentary changes and Terry's nails in a patient with a TERT variant-associated telomere biology disorder. 一名 TERT 变异相关端粒生物学紊乱患者的网状色素变化和特里氏指甲。

IF 1.2 4区医学

Pediatric Dermatology Pub Date : 2024-09-03 DOI: 10.1111/pde.15735

Sasan D Noveir, Jayden Galamgam, Deeti Pithadia, Amanda Truong, Marcia Hogeling, Carol E Cheng

引用次数: 0