Pediatric Dermatology最新文献

{"title":"Anagen Effluvium in a Child Misusing Methotrexate: A Case Report With Dermoscopic Findings.","authors":"Fatmanur Hacınecipoğlu, Gökçen Çelik, Selda Pelin Kartal","doi":"10.1111/pde.15927","DOIUrl":"https://doi.org/10.1111/pde.15927","url":null,"abstract":"<p><p>Anagen effluvium is a rare adverse effect of methotrexate therapy, generally associated with high-dose regimens. We report a 12-year-old girl who developed abrupt hair loss 1 week after inadvertently taking methotrexate 15 mg daily for five consecutive days (total 75 mg), without other signs of systemic toxicity. Trichoscopic examination and trichogram findings confirmed methotrexate-induced anagen effluvium, and spontaneous hair regrowth occurred after 2 months. This case underlines the importance of careful methotrexate dose monitoring and awareness that methotrexate toxicity can be associated with anagen effluvium even in the absence of other signs of toxicity.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143615442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gasterophilus: A Rare Cause of Cutaneous Myiasis in the United States.","authors":"Samantha Sun, Sabrina Bennett, Christina Wojewoda, Christopher Attaway, Brittney Boles, Christian D Pulcini, Keith Morley, Joseph Pierson","doi":"10.1111/pde.15929","DOIUrl":"https://doi.org/10.1111/pde.15929","url":null,"abstract":"<p><p>Cutaneous myiasis is most commonly seen in travelers returning to the United States. There are rare reports of US-acquired human myiasis, with Cuterebra larvae being the most common causative organism. Gasterophilus, also known as the horse botfly, however, rarely infests human hosts and typically presents as cutaneous migratory myiasis, unlike this case. We report a cutaneous furuncular myiasis due to Gasterophilus larvae in the neck and cheek of a 4-year-old female after visiting a campground in northern New York.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroichthyosis With a De Novo Variant c.494C>T in ELOVL1 and Severe Pruritus Relieved by Dupilumab.","authors":"Danielle Marcoux, Sophie-Anne Savard, Victor Kokta, Elsa Rossignol, Luis H Ospina","doi":"10.1111/pde.15904","DOIUrl":"https://doi.org/10.1111/pde.15904","url":null,"abstract":"<p><p>We report a patient with neuroichthyosis with an ELOVL1 variant associated with severe pruritus who responded well to dupilumab therapy. Our case is the third known patient reported with this de novo heterozygous dominant variant. The feature of severe progressive pruritus greatly impairing quality of life is unique among these reports. After multiple treatment failures, he responded well clinically and subjectively to the monoclonal antibody dupilumab.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An 11-Year-Old Male With Periorbital Edema and Painful Subcutaneous Nodules.","authors":"Yixin Ally Wang, Michele Khurana, Albert C Yan","doi":"10.1111/pde.15770","DOIUrl":"https://doi.org/10.1111/pde.15770","url":null,"abstract":"","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolated Hypopigmentation on the Upper Lip of a 12-Year-Old Boy.","authors":"Jason Hynes, Niamh Leonard, Maeve Lynch","doi":"10.1111/pde.15829","DOIUrl":"https://doi.org/10.1111/pde.15829","url":null,"abstract":"","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Congenital Perineal Midline Defect in a 3-Month-Old Girl.","authors":"Victor Coste, Yves Turc, Marie-Odile Riou-Gotta, François Aubin, Eve Puzenat","doi":"10.1111/pde.15884","DOIUrl":"https://doi.org/10.1111/pde.15884","url":null,"abstract":"","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enlarging Scalp Lesion in Pediatric Patient.","authors":"Ireland Wayt, Justin Lee, Patrick Tomboc, Zachary Zinn","doi":"10.1111/pde.15831","DOIUrl":"https://doi.org/10.1111/pde.15831","url":null,"abstract":"","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Objective Assessment and Quantification of Skin Color and Melanin in Neonates and Infants: A State-Of-The-Art Review.","authors":"Megha Sharma, Abigail Jo Pickhardt, Madison, Lauren Tong, Megan S Evans","doi":"10.1111/pde.15902","DOIUrl":"10.1111/pde.15902","url":null,"abstract":"<p><p>Neonatal skin color, especially melanin assessment, remains an underexplored topic in neonatology and dermatology literature. Growing concerns about racial bias in pulse oximeters in adults highlight the need for objective assessment of skin color to investigate if skin pigmentation contributes to the inaccuracy. While skin color scales and cutaneous colorimetric devices have been utilized in adult dermatology for various applications, their use and effectiveness in neonates and infants are not well understood. Objective classification and quantification of skin color in these populations are crucial for a better understanding of the inaccuracies of skin transmittance-based devices like pulse oximetry. This state-of-the-art review provides methods and findings from studies assessing neonatal skin color and pigmentation in objective and quantifiable ways, focusing on age-dependent and site-specific effects. Our goal is to provide a comprehensive overview of current knowledge regarding objective assessment of skin pigmentation, particularly melanin. We aim to guide future research efforts aimed at enhancing the accuracy of pigment measurements in medical devices, especially concerning neonates and infants.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Unusual Scrotal Tumor in a Child.","authors":"David Muñoz Castro, Cristina Albanell Fernández, Esmeralda Silva Díaz, Begoña Heras Morán, José María Martín Hernández","doi":"10.1111/pde.15758","DOIUrl":"https://doi.org/10.1111/pde.15758","url":null,"abstract":"","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Congenital Cutaneous Hamartomas With Skeletal Muscle Differentiation Associated With LUMBAR Syndrome.","authors":"Denise W Metry, Dawn H Siegel, Beth A Drolet, Mark S Dias","doi":"10.1111/pde.15898","DOIUrl":"https://doi.org/10.1111/pde.15898","url":null,"abstract":"<p><strong>Background/objectives: </strong>Congenital skin anomalies have been observed in LUMBAR syndrome, but their clinicopathologic significance remains unclear. This study aimed to investigate the congenital, nonvascular skin anomalies in LUMBAR syndrome (lower body infantile hemangiomas, urogenital anomalies and hemangioma ulceration, spinal cord malformations, bony deformities, anorectal/arterial anomalies, and renal anomalies). We hypothesized that an association exists between complex skin hamartomas and LUMBAR syndrome, similar to recent findings in PHACE syndrome (posterior fossa anomalies, hemangioma, cerebrovascular arterial anomalies, cardiovascular anomalies, and eye anomalies).</p><p><strong>Methods: </strong>This IRB-exempt, retrospective study utilized a database of 144 published LUMBAR cases, used to establish diagnostic criteria for the syndrome, to identify individuals with nonhemangioma skin anomalies. Data extracted from identified patients included lesion location and clinical description, lesional histopathology (when available), location of the segmental infantile hemangioma, and the presence of additional congenital anomalies.</p><p><strong>Results: </strong>We discovered 57 individuals with LUMBAR syndrome and nonhemangioma skin anomalies. Of these, 5/57 (9%) presented with lumbosacral or pelvic soft tissue appendages accompanied by histopathological findings. All five exhibited complex skin hamartomas with skeletal muscle differentiation, including four with histopathologic features diagnostic or suggestive of rhabdomyomatous mesenchymal hamartoma and one with a fetal rhabdomyoma.</p><p><strong>Conclusions: </strong>This study reveals a novel association between complex skin hamartomas with skeletal muscle differentiation and LUMBAR syndrome. Our findings suggest that these complex skin hamartomas represent another common link between LUMBAR and PHACE syndromes. Furthermore, this association supports the potential role of abnormal mesodermal tissue migration during early embryogenesis in the shared pathogenesis of these syndromes.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}