Pediatric Dermatology最新文献

{"title":"Response to \"Letter to the Editor Regarding 'Prospective Study to Assess the Utility and Validity of a Chromameter in the Assessment of Infantile Hemangiomas'\".","authors":"Luis Fernando Sánchez-Espino, Bahar Bahrani, Alexandra Pennal, Elena Pope","doi":"10.1111/pde.70363","DOIUrl":"https://doi.org/10.1111/pde.70363","url":null,"abstract":"","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149025412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Characteristics, Management, and Complications of Infantile Hemangiomas Involving the Ear and Periauricular Region.","authors":"Bayan Matarneh, Nicole Stefanko, Anthony J Mancini, Sarah L Chamlin, Catherine C McCuaig, Julie Powell, Maxine Joly-Chevrier, Erin F D Mathes, Ilona J Frieden, Mitchell Braun, Maria C Garzon, Kimberly D Morel, Christine T Lauren, Kimberly A Horii, Brandon Newell, Sonal D Shah, Amy Buros-Stein, Esteban Fernandez Faith","doi":"10.1111/pde.70359","DOIUrl":"https://doi.org/10.1111/pde.70359","url":null,"abstract":"<p><strong>Background: </strong>Despite advances in IH research across various anatomical sites, studies focusing on IH involving the ear and periauricular areas remain scarce.</p><p><strong>Objective: </strong>To analyze the clinical characteristics, management, and outcomes of IH involving the ear and periauricular area.</p><p><strong>Methods: </strong>Multicenter, retrospective study of patients with IH involving the ear and periauricular area across seven tertiary referral centers between 2001 and 2021. Data analyzed included patient demographics, IH location, management practices, Hemangioma Severity Scale (HSS) scores, and American Academy of Pediatrics (AAP) IH risk categories.</p><p><strong>Results: </strong>A total of 305 patients met the inclusion criteria. Management decision information was available in 250 patients. Active intervention was pursued in 80% of the patients with available management information. The risk of anatomic deformity was the most common indication for treatment (72%), followed by ulceration (18%) and the risk of functional impairment (17%). Systemic beta-blockers were used in 48% of patients, followed by topical corticosteroids (46%) and topical timolol (32%). Treatment with a systemic beta-blocker was associated with a significantly higher HSS score (median 15.5, IQR: 12-20) compared to patients treated with topical therapy (median 10, IQR: 8-12).</p><p><strong>Conclusions: </strong>Given their location and potential for anatomic deformity and functional impairment, ear and periauricular IH may require intervention. A majority of patients in this cohort required treatment, most commonly for risk of anatomic deformity. The study is limited by the retrospective design and inclusion of patients seen before beta-blockers were available for IH management.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148991053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Cost of the Curl: Wig-Induced Hair Loss in Pediatric Irish Dancers.","authors":"Sara N Bilimoria, May Madi Han, Alexa G Ries, Joree Ruiz, Valerie M Carlberg, Katherine E Kondratuk","doi":"10.1111/pde.70347","DOIUrl":"https://doi.org/10.1111/pde.70347","url":null,"abstract":"<p><p>Traction alopecia is a well-described cause of hair loss associated with high-tension hairstyles but is rarely reported in children related to wig use. We describe three pediatric patients aged 7-8 years who developed focal vertex scalp alopecia after wearing traditional Irish dancing wigs during high-energy dances. Clinical findings and trichoscopy were consistent with traction alopecia, with partial or complete regrowth following wig avoidance. These cases highlight an underrecognized form of pediatric alopecia caused by prolonged wig use during Irish dancing, emphasizing the importance of early recognition and preventive modification of wig practices.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148970620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triggers, Clinical Manifestations, and Management of Pediatric Erythema Nodosum: A Systematic Review.","authors":"Florence Lagacé-Thomassin, Hannah Nguyen, Justin Gervais, Imane Labzagui, Anya Bussière-Filion, Kerlysha-Danielle Guerrier, Carolina Lucena Fernandes, Elio Kechichian","doi":"10.1111/pde.70346","DOIUrl":"https://doi.org/10.1111/pde.70346","url":null,"abstract":"<p><strong>Background/objectives: </strong>Erythema nodosum (EN) is a septal panniculitis clinically characterized by bilateral erythematous tender subcutaneous nodules typically found on the shins. While recognized as the most common form of panniculitis, it is less frequently documented in children and infants. Currently, there are no established guidelines to diagnose and manage EN in children. This review aims to consolidate current data on triggers, clinical manifestations, and treatment options, and propose a management algorithm for pediatric erythema nodosum (PEN).</p><p><strong>Methods: </strong>A systematic literature review of published PEN cases up to April 22, 2024, was conducted using PubMed, Embase, Cochrane, and MEDLINE databases.</p><p><strong>Results: </strong>After full-text article review, 239 articles were included, representing 959 patients. The mean age was 10.2 years, ranging from 0.58 to 17.5 years. Infections were the main triggers: bacterial infections in 302 patients (31.5%), predominantly streptococcal; tuberculosis in 193 patients (20.1%); followed by idiopathic cases in 80 patients (8.3%); inflammatory bowel diseases (IBD) in 66 patients (6.9%); Behçet's disease in 61 patients (6.4%); leprosy in 38 patients (4.0%); drug related in 28 patients (2.9%); and to a lesser extent various other infectious agents, genetic diseases, vaccines, autoimmune and inflammatory conditions, and malignancies. Diagnosis relied mainly on clinical assessment, with only 111 patients (11.6%) undergoing skin biopsy. Most patients received supportive care, including NSAIDs, along with treatment of the underlying cause.</p><p><strong>Conclusions: </strong>Erythema nodosum affects children. It is mainly triggered by infections. The diagnosis is primarily clinical. Supportive care is the mainstay of treatment along with addressing the underlying cause.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148970646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concomitant PLACK Syndrome, MYBPC3-Related Cardiomyopathy, and Nutritional Deficiency.","authors":"Nisrine Kawa, Tessa M LeWitt, Katharina W Horn, Elaine M Pereira, Mythily Ganapathi, Kimberly D Morel","doi":"10.1111/pde.70343","DOIUrl":"https://doi.org/10.1111/pde.70343","url":null,"abstract":"<p><p>PLACK syndrome is a rare genodermatosis that features peeling skin, leukonychia, acral punctal keratoses, cheilitis, and knuckle pads. We report a case of a 6-year-old female with PLACK syndrome, attributed to a homozygous variant in CAST, and concurrent dilated cardiomyopathy, explained by a heterozygous variant in MYBPC3. She also had severe protein calorie malnutrition. Although the patient's cardiomyopathy is attributable to her MYBPC3 variant, this case adds to the growing list of reports describing PLACK syndrome with coinciding cardiomyopathy and highlights a unique presentation featuring both CAST and MYBPC3 variants.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148970699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic Review and Meta-Analysis of Thyroid Disease in Children With Vitiligo.","authors":"Minu Jose Chiramel, Alyce Kuo, Mabel Yau, Nanette B Silverberg","doi":"10.1111/pde.70277","DOIUrl":"https://doi.org/10.1111/pde.70277","url":null,"abstract":"<p><strong>Background: </strong>Vitiligo is a common dermatologic disease in children with a prevalence of around 1% in the general pediatric population. The co-occurrence of thyroid disease and vitiligo has been established, which can affect growth and development. However, this association in the pediatric population has not been systematically evaluated.</p><p><strong>Methods: </strong>This systematic review included studies from PubMed and Cochrane databases with data on children ≤ 18 years of age with a documented diagnosis of vitiligo where information on thyroid disease could be obtained from the study based on history, examination, or testing. Studies were screened by two independent reviewers. Covidence systematic review software was used for study screening, abstract and full-text reviews, and data extraction.</p><p><strong>Results: </strong>A total of 37 studies were identified, including 6291 children with vitiligo. There was a significant amount of heterogeneity in thyroid testing performance. Among all patients, 571 patients had thyroid disease or abnormal test results with a per-study range of 0%-55.3%. Positive antithyroid antibodies (13.5%) and elevated thyroid-stimulating hormone (TSH) (6.3%) were the most common abnormalities. Most patients with thyroid disease had non-segmental vitiligo. There was no correlation between age, sex, disease duration, disease activity, and family history of vitiligo or thyroid disease, with much heterogeneity in reporting.</p><p><strong>Discussion: </strong>Most studies showed an increased prevalence of thyroid disease in children with vitiligo, indicating that screening for thyroid disease with antithyroid antibodies and TSH may be warranted at baseline and periodically.</p><p><strong>Trial registration: </strong>PROSPERO 2025 CRD420251059494.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148963727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric ALK-Negative Anaplastic Large Cell Lymphoma With Recurrent Cutaneous Relapses: Diagnostic Challenges.","authors":"Kayla Coffman, Emily Saurborn, Dylan Maldonado, Paul Finch, Shane Cook","doi":"10.1111/pde.70361","DOIUrl":"https://doi.org/10.1111/pde.70361","url":null,"abstract":"<p><p>We present the case of a 10-year-old female with anaplastic lymphoma kinase protein (ALK) negative systemic anaplastic large cell lymphoma (ALCL) with cutaneous manifestations that achieved complete remission after multi-agent chemotherapy. Approximately 6 months after remission, the patient experienced a relapse of ALK-negative ALCL confined exclusively to the skin. Four months after completing salvage therapy, she developed a second isolated cutaneous relapse. This case highlights the diagnostic challenge of distinguishing systemic ALCL from primary cutaneous ALCL and other primary cutaneous CD30+ lymphoproliferative disorders.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148963708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Germline Missense Variant in the NSDHL Gene Underlies Inflammatory Linear Verrucous Epidermal Nevus.","authors":"Janan Mohamad, Kiril Malovitski, Moshe Giladi, Eylon Sharoni, Nabih Elias, Yarden Feller, Jacob Mashiah, Moran Furman, Ofer Sarig, Eli Sprecher, Liat Samuelov","doi":"10.1111/pde.70355","DOIUrl":"https://doi.org/10.1111/pde.70355","url":null,"abstract":"<p><p>Inflammatory linear verrucous epidermal nevus (ILVEN) is a rare skin disorder characterized by pruritic, erythematous, and scaly plaques following Blaschko's lines. Known genetic causes include somatic variants in CARD14 and GJA1. In addition, a similar phenotype of congenital hemidysplasia with ichthyosiform nevus and limb defects (CHILD) nevus has been associated with germline pathogenic variants in NSDHL encoding a NAD(P)-dependent steroid dehydrogenase-like protein essential for cholesterol biosynthesis. Here we report a case of ILVEN caused by a previously unreported germline pathogenic variant in NSDHL.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148944188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of Active and Passive Smoke Exposure and Hidradenitis Suppurativa in the Pediatric Population: A Case-Control Study.","authors":"Rachel L Ziebart, Asfia Numani, Austin Todd, Afsaneh Alavi, Dawn M Davis, Nessa Aghazadeh Mohandesi","doi":"10.1111/pde.70101","DOIUrl":"10.1111/pde.70101","url":null,"abstract":"<p><strong>Background: </strong>Hidradenitis suppurativa (HS) is an inflammatory condition associated with cysts of the folliculopilosebaceous unit primarily affecting intertriginous areas. HS has been correlated with smoke exposure in the adult population, but there is a knowledge gap in understanding its effect in pediatric and adolescent patients. This study assesses correlations between active and passive smoke exposure and the development of HS in the pediatric and adolescent population.</p><p><strong>Methods: </strong>A retrospective case-control study was conducted at Mayo Clinic (2010-2023) of patients diagnosed with HS before the age of 18 years who were age-, sex-, and race-matched to healthy controls in a 1:3 ratio, analyzed using Fisher exact for categorical variables and Kruskal-Wallis for continuous.</p><p><strong>Results: </strong>One hundred and seventy-four cases and 522 controls met inclusion criteria. The prevalence of active and passive smoke exposure was significantly higher in patients with HS compared to controls (p = 0.001), with passive smoke accounting for 64.6% (N = 31/48) of smoke exposure in patients with HS. Smoke exposure was associated with a significant increase in the odds of an HS diagnosis, with an odds ratio of 4.8 (95% CI: 3.06-7.61) for passive and/or active exposure, and 1.64 (95% CI: 1.01-2.61) for passive exposure alone. Smoke exposure was associated with a later age of diagnosis than those with no smoke exposure (p < 0.001).</p><p><strong>Conclusion: </strong>Prevalence of active and passive smoke exposure was higher in pediatric and adolescent patients with HS compared to age, sex, and race-matched healthy controls. Smoke exposure increased the odds of having HS and was associated with a later age at diagnosis.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13639880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148913011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ustekinumab as an Effective Therapeutic Option in Papillon-Lefèvre Syndrome: Long-Term Follow-Up.","authors":"Ozlem Apti Sengkioun, Deniz Yücelten, Tülin Ergun","doi":"10.1111/pde.70351","DOIUrl":"https://doi.org/10.1111/pde.70351","url":null,"abstract":"<p><p>Papillon-Lefèvre syndrome (PLS) is a rare autosomal recessive genodermatosis characterized by palmoplantar hyperkeratosis and severe periodontitis, leading to premature loss of both primary and permanent teeth, and treatment responses are often unsatisfactory. We report a 20-year-old female patient with PLS who presented with extensive palmoplantar hyperkeratosis and widespread psoriasiform plaques refractory to multiple conventional therapies. Treatment with ustekinumab resulted in marked clinical improvement by the sixth month after three subcutaneous injections. The patient has remained in sustained clinical remission during 6 years of continuous therapy, with only mild and intermittent recurrent plaques on the knees, suggesting that biologic therapy may represent a sustainable option in selected cases of PLS.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148875387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}