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Off-Label Use of Double-Dose Beremagene Geperpavec (B-VEC) in the Treatment of Recessive Dystrophic Epidermolysis Bullosa: A Promising Clinical Case. 超说明书使用双剂量Beremagene geperpaec （B-VEC）治疗隐性营养不良大疱性表皮松解症：一个有希望的临床病例。
IF 1.2 4区 医学
Pediatric Dermatology Pub Date : 2025-09-30 DOI: 10.1111/pde.70065
Melissa M Yamada, Liza H Siegel
{"title":"Off-Label Use of Double-Dose Beremagene Geperpavec (B-VEC) in the Treatment of Recessive Dystrophic Epidermolysis Bullosa: A Promising Clinical Case.","authors":"Melissa M Yamada, Liza H Siegel","doi":"10.1111/pde.70065","DOIUrl":"https://doi.org/10.1111/pde.70065","url":null,"abstract":"<p><p>Dystrophic epidermolysis bullosa (DEB) is a rare, inherited blistering skin disease with limited treatment options. Beremagene geperpavec (B-VEC) is a herpes simplex virus type 1-based topical gene therapy that is approved by the Food and Drug Administration (FDA) for the treatment of DEB at a fixed weekly dose. While B-VEC has shown significant promise in treating DEB, few studies have examined off-label use of B-VEC at higher dose volumes. We describe the successful off-label use of a temporarily increased B-VEC dose in a patient with recessive DEB (RDEB) with extensive wounds following an episode of acute urticaria, highlighting the potential utility of higher dose B-VEC in managing patients with extensive wound burden.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145192374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment of Short Anagen Syndrome With Low-Dose Oral Minoxidil. 小剂量口服米诺地尔治疗短毛候综合征。
IF 1.2 4区 医学
Pediatric Dermatology Pub Date : 2025-09-26 DOI: 10.1111/pde.70049
Nolan Francis, Brittany G Craiglow
{"title":"Treatment of Short Anagen Syndrome With Low-Dose Oral Minoxidil.","authors":"Nolan Francis, Brittany G Craiglow","doi":"10.1111/pde.70049","DOIUrl":"https://doi.org/10.1111/pde.70049","url":null,"abstract":"<p><p>Short anagen syndrome (SAS) is a rare condition characterized by a shortened anagen phase, resulting in an inability to grow long scalp hair. Low-dose oral minoxidil (LDOM) has recently emerged as an effective treatment for a variety of pediatric hair disorders. This report presents two pediatric patients with SAS who responded favorably to treatment with LDOM.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145150098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Case of a Solitary Angiokeratoma Circumscriptum of the Lower Leg. 下肢单发血管角化瘤1例。
IF 1.2 4区 医学
Pediatric Dermatology Pub Date : 2025-09-25 DOI: 10.1111/pde.70059
Christy Chang, Christine Pak, Marylee Braniecki, Ola Bode Omoleye, Michelle Bain
{"title":"A Case of a Solitary Angiokeratoma Circumscriptum of the Lower Leg.","authors":"Christy Chang, Christine Pak, Marylee Braniecki, Ola Bode Omoleye, Michelle Bain","doi":"10.1111/pde.70059","DOIUrl":"https://doi.org/10.1111/pde.70059","url":null,"abstract":"<p><p>Angiokeratoma circumscriptum (AKC) is a rare congenital vascular malformation that often mimics other skin conditions such as verrucous venous malformation. We report a case of AKC in a 9-year-old male presenting with a pruritic, hyperkeratotic lesion growing proportionally to his body since birth. The diagnosis of AKC was determined based on a constellation of clinical findings, histopathologic examination with immunohistochemistry, and ultrasound technique. This case provides a photo representation of a rarely reported skin condition in a patient with skin of color and highlights the importance of using multiple diagnostic tools to distinguish AKC from other differential diagnoses.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145150053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cutaneous Ciliated Cyst of the Ear. 耳皮纤毛囊肿。
IF 1.2 4区 医学
Pediatric Dermatology Pub Date : 2025-09-25 DOI: 10.1111/pde.70061
Allan Fong, Andrew H Huang, Jonathan Bush
{"title":"Cutaneous Ciliated Cyst of the Ear.","authors":"Allan Fong, Andrew H Huang, Jonathan Bush","doi":"10.1111/pde.70061","DOIUrl":"https://doi.org/10.1111/pde.70061","url":null,"abstract":"<p><p>Cutaneous ciliated cysts are rare benign lesions initially observed exclusively in the lower extremities of young females. Since their first descriptions, there have been numerous case reports of the entity occurring in males and females, in varying anatomical locations. Here, we present a case of cutaneous ciliated cyst reported for the first time in the earlobe of an 11-year-old female.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pediatric Papular Mycosis Fungoides Treated With Phototherapy: A Case Series. 儿童丘疹性真菌病光疗治疗：一个病例系列。
IF 1.2 4区 医学
Pediatric Dermatology Pub Date : 2025-09-24 DOI: 10.1111/pde.70004
Mariana de la Vega, Martha Alejandra Morales-Sánchez, Sonia Torres González, María Antonieta Domínguez Gómez
{"title":"Pediatric Papular Mycosis Fungoides Treated With Phototherapy: A Case Series.","authors":"Mariana de la Vega, Martha Alejandra Morales-Sánchez, Sonia Torres González, María Antonieta Domínguez Gómez","doi":"10.1111/pde.70004","DOIUrl":"https://doi.org/10.1111/pde.70004","url":null,"abstract":"<p><p>Papular mycosis fungoides (PMF) is a rare clinical variant with limited data on long-term outcomes, particularly in children. Our study describes sociodemographic, clinical, therapeutic, and follow-up data in 5 pediatric patients with PMF, all treated with phototherapy (PUVA, PUVAsol or narrowband UVB). Complete remission was achieved by 60% within a median of 6 months (IQR 4.5-7.5 months), and the median follow-up was 19 months (IQR 6-27 months), with no disease progression and 100% overall survival. These findings suggest that papular MF follows a favorable course, similar to early-stage MF or other clinical variants with a positive prognosis.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of Factors Influencing Dermatology Residents' Decisions to Pursue Subspecialty Fellowships: A Cross-Sectional Study. 影响皮肤科住院医师选择专科奖学金的因素分析：一项横断面研究。
IF 1.2 4区 医学
Pediatric Dermatology Pub Date : 2025-09-24 DOI: 10.1111/pde.70053
Sarah Lee, Eun Jae Kim, Jennifer T Huang
{"title":"Analysis of Factors Influencing Dermatology Residents' Decisions to Pursue Subspecialty Fellowships: A Cross-Sectional Study.","authors":"Sarah Lee, Eun Jae Kim, Jennifer T Huang","doi":"10.1111/pde.70053","DOIUrl":"https://doi.org/10.1111/pde.70053","url":null,"abstract":"<p><p>A cross-sectional survey of 101 US dermatology residents examined factors influencing interest in three subspecialty fellowships-pediatric dermatology, dermatopathology, and micrographic surgery and dermatologic oncology-and found that interest often declined during residency, even among those with moderate to strong initial interest, with no significant difference in decline rates across subspecialties. Key deterrents included extended training time, additional year of trainee salary, and for pediatric dermatology, concerns about limited mentorship and lower income potential. Demographic factors such as educational debt and underrepresented status in medicine were not associated with changes in fellowship interest. Targeted interventions focused on structured mentorship and financial considerations may help sustain fellowship interest and will be essential to ensuring an adequately trained subspecialty workforce.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comedogenic Lupus in a 13-Year-Old Female: A Unique Pediatric Case. 13岁女性的粉刺源性狼疮：一个独特的儿科病例。
IF 1.2 4区 医学
Pediatric Dermatology Pub Date : 2025-09-23 DOI: 10.1111/pde.70045
Valeria Olvera-Rodriguez, Ana Cecilia Ortiz-Figueroa, Marion Carolina Aleman-Jimenez, Jorge Ocampo-Candiani, Erika Alba-Rojas
{"title":"Comedogenic Lupus in a 13-Year-Old Female: A Unique Pediatric Case.","authors":"Valeria Olvera-Rodriguez, Ana Cecilia Ortiz-Figueroa, Marion Carolina Aleman-Jimenez, Jorge Ocampo-Candiani, Erika Alba-Rojas","doi":"10.1111/pde.70045","DOIUrl":"https://doi.org/10.1111/pde.70045","url":null,"abstract":"<p><p>Comedogenic lupus (CL) is a rare variant of chronic cutaneous lupus erythematosus, predominantly affecting women in their third and fourth decades of life. We present a case of CL in a pediatric patient, a 13-year-old Hispanic female with a one-year history of an erythematous atrophic plaque on her left cheek, with numerous open comedones. Clinical, dermoscopic, and histopathological findings confirmed the diagnosis. This case highlights the importance of including lupus in the differential diagnosis of atypical or refractory comedonal lesions, particularly in younger patients, to ensure timely diagnosis and effective management.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Successful Treatment of Generalized Pustular Psoriasis With Spesolimab in Two Young Children. Spesolimab成功治疗2例幼儿广泛性脓疱性银屑病。
IF 1.2 4区 医学
Pediatric Dermatology Pub Date : 2025-09-20 DOI: 10.1111/pde.70043
Aisa Longnecker, Cristina M Foschi, Valerie M Carlberg, Lisa Swanson, Kristen E Holland
{"title":"Successful Treatment of Generalized Pustular Psoriasis With Spesolimab in Two Young Children.","authors":"Aisa Longnecker, Cristina M Foschi, Valerie M Carlberg, Lisa Swanson, Kristen E Holland","doi":"10.1111/pde.70043","DOIUrl":"https://doi.org/10.1111/pde.70043","url":null,"abstract":"<p><p>Spesolimab is an IL-36 receptor monoclonal antibody antagonist approved for generalized pustular psoriasis in patients 12 years and older. While it has demonstrated promising results in this population, there is limited literature exploring spesolimab efficacy and dosing in younger patients. We report the cases of a 5-year-old female with generalized pustular psoriasis in the setting of autosomal recessive deficiency of interleukin-36 receptor antagonist (DITRA) as well as a 6-year-old female with generalized pustular psoriasis of unknown genetic status, both successfully treated with spesolimab.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Understanding the Needs and Financial Challenges of Patients With Epidermolysis Bullosa: Insights From Donation Requests. 了解大疱性表皮松解症患者的需求和经济挑战：来自捐赠请求的见解。
IF 1.2 4区 医学
Pediatric Dermatology Pub Date : 2025-09-19 DOI: 10.1111/pde.70047
Elika D Javaheri, Vivian C Iloabuchi, Elizabeth Dupuy, Nessa Aghazadeh Mohandesi
{"title":"Understanding the Needs and Financial Challenges of Patients With Epidermolysis Bullosa: Insights From Donation Requests.","authors":"Elika D Javaheri, Vivian C Iloabuchi, Elizabeth Dupuy, Nessa Aghazadeh Mohandesi","doi":"10.1111/pde.70047","DOIUrl":"https://doi.org/10.1111/pde.70047","url":null,"abstract":"<p><p>Epidermolysis bullosa (EB) is a rare genetic disorder requiring intensive and costly care, often diagnosed in infancy when families are unprepared for the financial burden. We analyzed 160 U.S.-based crowdfunding campaigns for living EB patients, extracting data on demographics and financial needs. 33.8% of patients requested financial support for wound care supplies, 36.9% of patients requested support for travel costs, and 9.4% of patients requested support with special clothing or bedding. These findings highlight persistent, unresolved financial needs for EB-related care.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to "Impact of the Society for Pediatric Dermatology Mentorship Award Program on Careers in Pediatric Dermatology: Workforce Implications". 更正“儿童皮肤病学会指导奖计划对儿童皮肤病职业的影响：劳动力影响”。
IF 1.2 4区 医学
Pediatric Dermatology Pub Date : 2025-09-18 DOI: 10.1111/pde.16048
{"title":"Correction to \"Impact of the Society for Pediatric Dermatology Mentorship Award Program on Careers in Pediatric Dermatology: Workforce Implications\".","authors":"","doi":"10.1111/pde.16048","DOIUrl":"https://doi.org/10.1111/pde.16048","url":null,"abstract":"","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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