Pediatric Dermatology最新文献

{"title":"Clinicopathologic Characteristics, Treatment Outcomes of Pediatric Mycosis Fungoides in Turkey: A National Multicenter Retrospective Cohort.","authors":"Dilek Bayramgürler, Dilek Seçkin, Ayşe Deniz Yücelten, Esin Diremsizoğlu, Esra Adışen, Bengü Nisa Akay, Salih Levent Çınar, Pelin Kartal, Aslı Aksu, Burhan Engin, Arzu Ferhatosmanoğlu, Mehmet Melikoğlu, Zeynep Karaca Ural, Tuğba Kevser Uzunçakmak, Serkan Yazıcı, Esma İnan Yüksel, Ayşegül Yalçınkaya İyidal, Özlem Özbağçıvan, Emre Güven, Gizem Nur Öztürk Dönmez, Muhammed Salih Karagöz, Hatice Erdi Şanlı","doi":"10.1111/pde.70349","DOIUrl":"https://doi.org/10.1111/pde.70349","url":null,"abstract":"<p><strong>Background and objectives: </strong>This study aimed to characterize the clinical spectrum, diagnostic delay, treatment patterns, and outcomes of pediatric mycosis fungoides (MF) and to identify predictors of early response.</p><p><strong>Methods: </strong>This national multicenter retrospective study included patients diagnosed with histopathologically confirmed MF before 18 years of age. Demographic, clinical, histopathologic, immunophenotypic, staging, treatment, and follow-up data were collected. Early response at 3-6 months (partial/complete response) was analyzed using logistic regression.</p><p><strong>Results: </strong>A total of 133 patients were included; 60.9% (81/133) were male. Median age at diagnosis was 13 years (IQR, 9-15) and median diagnostic delay was 18 months (IQR, 8-48). Classic morphology was recorded in 78.2% (104/133), and hypopigmented MF in 36.1% (48/133); overlapping morphologies were documented in 42.1% (56/133). Stage IA disease was present in 59.4% (79/133). Phototherapy was used in 60.9% (81/133). Early response occurred in 91.0% (121/133). BSA < 10% was independently associated with higher odds of early response (aOR 8.42, 95% CI 1.71-41.54; p = 0.009), whereas older age at diagnosis predicted lower odds (aOR 0.81 per year, 95% CI 0.67-0.98; p = 0.029). Relapse occurred in 28.5% (37/130) within median follow-up of 22 months (median time to relapse of 8 months); 67.6% (25/37) relapsed within 12 months.</p><p><strong>Conclusion: </strong>In this cohort, pediatric MF presented at an early stage. Despite favorable early responses, relapse occurred in nearly one third, often within the first year, supporting long-term surveillance. Higher BSA involvement and older age at diagnosis were associated with reduced early response.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148875341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Growth Hormone and Insulin-Like Growth Factor 1 in Children With Epidermolysis Bullosa Dystrophica.","authors":"Mohammad El Darouti, Iman Sany Zaki, Noha Mousa, Hagar El Sayed","doi":"10.1111/pde.70113","DOIUrl":"10.1111/pde.70113","url":null,"abstract":"<p><strong>Background: </strong>Epidermolysis bullosa dystrophica (EBD) is characterized by mucocutaneous fragility with blistering, scarring and severe growth retardation attributed to many factors.</p><p><strong>Methods: </strong>This cross-sectional study included 51 patients aged 1-12 years with recessive dystrophic EB (RDEB). Weight and height were measured, with the calculation of weight standard deviation (SD), height SD, and body mass index (BMI), followed by plotting them on Egyptian growth curves. Serum levels of basal growth hormone (GH), insulin-like growth factor 1 (IGF-1), hemoglobin (Hb) level, erythrocyte sedimentation rate (ESR), and thyroid functions (TSH and free T4) were measured. Growth hormone stimulation test was performed in 11 patients.</p><p><strong>Results: </strong>Weight SD and height SD were lower than normal measurements (p < 0.05*). Growth hormone, growth hormone stimulation, and IGF-1 were lower than the normal range (p < 0.05*). Hb levels were lower than normal, whereas ESR levels were elevated (p < 0.001*). A negative correlation was found between ESR and basal GH, and a positive correlation between ESR and IGF-1.</p><p><strong>Conclusion: </strong>Children with generalized RDEB have poor growth and low circulating GH and IGF-1 levels, likely due not only to malnutrition and anemia, but possibly also as a consequence of inflammation that suppresses the GH/IGF-1 axis. Future treatments targeting the correction of GH and IGF-1 levels as well as the chronic inflammatory state should be considered.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov identifier: NCT05390073.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":"1032-1036"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145596954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topical Janus Kinase Inhibitors for Pediatric Atopic Dermatitis: A Systematic Review of Efficacy and Safety.","authors":"Aditi Chokshi, Jennifer Keelin, Valerie Foy, Sourab Choudhury, Daniel Fischer","doi":"10.1111/pde.70298","DOIUrl":"10.1111/pde.70298","url":null,"abstract":"<p><strong>Background: </strong>Atopic dermatitis (AD) is a common inflammatory skin disease affecting up to 20% of children. Long-term topical management is often limited by safety concerns, tolerability issues, and caregiver hesitancy. Topical janus kinase (JAK) inhibitors have emerged as targeted nonsteroidal therapies, with recent pediatric approval of ruxolitinib expanding treatment options. This systematic review synthesizes pediatric-only evidence on topical JAK inhibitors for AD, focusing on efficacy, safety, and treatment strategies for clinical practice.</p><p><strong>Methods: </strong>A PRISMA-guided systematic review of PubMed, Embase, Web of Science, and ClinicalTrials.gov was conducted through November 2025. Eight studies met inclusion criteria, encompassing 541 pediatric patients treated with ruxolitinib or delgocitinib.</p><p><strong>Results: </strong>Across randomized and extension studies, both agents produced rapid, clinically meaningful improvements in both disease severity and pruritus, with benefits observed within the first several weeks of treatment. Ruxolitinib showed consistent efficacy in patients with both limited and extensive disease involvement, while delgocitinib showed sustained disease control with continuous use, including in younger children and infants. Topical JAK inhibitors were generally well tolerated, with adverse event rates comparable to vehicle and few discontinuations. Application-site reactions were uncommon, and no treatment-related serious AEs were reported.</p><p><strong>Conclusions: </strong>Overall, available pediatric data supports topical JAK inhibitors as effective and well-tolerated nonsteroidal options for AD, providing rapid symptom relief and disease control that may help expand steroid-sparing treatment options for children.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":"1126-1130"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148252649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Solitary, Painless Nodule on the Arm of an Adolescent Male.","authors":"Ting Dan Zhang, Peter Pavlidakey, Ravi Hiremagalore","doi":"10.1111/pde.70300","DOIUrl":"10.1111/pde.70300","url":null,"abstract":"","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":"1232-1234"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13617168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148536617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stiff Skin Syndrome: A Diagnostic Challenge and the Role of Complementary Studies.","authors":"Daniela Carvajal, Jorge Cortínez","doi":"10.1111/pde.70241","DOIUrl":"10.1111/pde.70241","url":null,"abstract":"<p><p>Stiff skin syndrome (SSS) is a rare pediatric sclerosing disorder characterized by progressive fibrosis and mobility restriction. We report a 10-year-old girl with progressive skin induration whose diagnosis was supported by histopathology and high-resolution skin ultrasound. Ultrasound demonstrated dermal thickening and prominent hypodermal fibrous septa, findings that correlated with the characteristic hypoinflammatory lattice arrangement seen on histology. This case highlights the diagnostic value of integrating advanced imaging and pathology to ensure accuracy and avoid treatment delays, particularly in resource-limited settings where genetic testing is unavailable.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":"1212-1215"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147778133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conveying Hope in the Face of Uncertainty.","authors":"Neil S Prose","doi":"10.1111/pde.70237","DOIUrl":"10.1111/pde.70237","url":null,"abstract":"","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":"1044-1045"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delayed Newborn Bathing: Exploring Social Media Trends, Cultural Perspectives, and Dermatologic Implications.","authors":"Niayesh Mardmomen, Valerie Foy","doi":"10.1111/pde.70318","DOIUrl":"10.1111/pde.70318","url":null,"abstract":"<p><strong>Background: </strong>Delayed bathing of newborns has gained popularity, particularly on social media platforms, with influencers promoting delays from 24 h to several weeks. While delayed bathing is endorsed by the World Health Organization for at least 24 h after birth, claims of extended delays are largely anecdotal.</p><p><strong>Objective: </strong>To review current evidence on the effects of delayed newborn bathing on skin barrier function and infection risk, and the influence of social media and culture.</p><p><strong>Methods: </strong>Narrative review of peer-reviewed studies on neonatal skin barrier metrics, microbial colonization, and infection outcomes in relation to bathing timing, supplemented by an assessment of prevailing claims on TikTok and cultural practices surrounding newborn bathing.</p><p><strong>Results: </strong>In healthy term infants, delayed bathing up to 24 h preserves vernix caseosa, improves skin hydration, and is associated with higher rates of exclusive breastfeeding, improved thermoregulation, and reduced hypoglycemia. Studies show transient increases in transepidermal water loss after bathing but no lasting disruption of skin maturation. No evidence links delayed bathing with increased rates of staphylococcal scalded skin syndrome, bullous impetigo, or neonatal sepsis. Infection risk is more strongly determined by prematurity, maternal colonization status, and NICU exposures.</p><p><strong>Conclusions: </strong>Delayed bathing for healthy term newborns for at least 24 h is evidence-based, safe, and beneficial for skin barrier development, with no demonstrated increase in infection risk. Data on delays beyond 24 h remain limited. Healthcare providers should proactively counsel families, address online misinformation, and guide them toward evidence-based practices.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":"1027-1031"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148536687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Setmelanotide in Bardet-Biedl Syndrome: A Case Report.","authors":"Shelby Smith, Eric Sanfilippo, Lara Wine Lee","doi":"10.1111/pde.70186","DOIUrl":"10.1111/pde.70186","url":null,"abstract":"<p><p>Setmelanotide is a melanocortin-4-receptor agonist used for the treatment of hyperphagia in the genetic obesity syndrome Bardet-Biedl. Presented is a case of diffuse hyperpigmentation in a patient treated with setmelanotide, which represents the most common side effect of this medication. Herein is a review of the literature for other potential side effects that warrant regular dermatologic screening, including alteration of existing melanocytic lesions. Exact screening guidelines have not been completely defined, though it is recommended that patients receive baseline and annual examinations while undergoing treatment with this agent.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":"1196-1199"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13617176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147699387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric Non-Neural Granular Cell Tumor With Unexpected Molecular Identity: A Case That Challenges Classification.","authors":"Grace S Saglimbeni, Eduardo Zambrano, Sierra Wolter, Nawal Merjaneh, Kristian Schafernak, Brian Keehn, Peaches Ulrich, Maria Epino, Danielle Vargas de Stefano","doi":"10.1111/pde.70324","DOIUrl":"https://doi.org/10.1111/pde.70324","url":null,"abstract":"<p><p>A 7-year-old boy presented with a 3-year history of a slow-growing superficial cutaneous nodule adjacent to the right acromion, with subsequent development of a second subcutaneous mass near the right scapula. Biopsy of the primary lesion revealed a rare non-neural granular cell tumor (NNGCT) lacking S100 expression, distinguishing it from classic granular cell tumors (GCT), and molecular profiling identified a DCTN1::ALK fusion alongside an ATP6AP2 frameshift mutation, the latter reported predominantly in GCT. To our knowledge, this is the first documented NNGCT harboring both alterations, suggesting potential biologic overlap between NNGCT and GCT while expanding the current framework of granular cell tumor classification. This case also highlights the reported potential for recurrence and multifocal disease or regional spread in NNGCT, supporting complete surgical excision with long-term follow-up.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148875366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the Impact of a Mindfulness Program on Anxiety in Pediatric Alopecia Areata.","authors":"Anthony J Gilding, Eden Ventura, Nimrita Sangha, Cathryn Sibbald","doi":"10.1111/pde.70280","DOIUrl":"10.1111/pde.70280","url":null,"abstract":"<p><p>Alopecia areata is an immune-mediated disease resulting in non-scarring hair loss and is associated with significant burden on mental health and quality of life. Mindfulness-based stress-reduction therapies have emerged as a potential intervention and have shown promising results, though studies of efficacy in adolescent populations are lacking. Thus, this pilot study aimed to determine if the daily use of the Breathr mindfulness app would improve anxiety in adolescent patients with AA over a 3-month period. Our results demonstrate that daily use of the app provided limited benefits for a subset of adolescents with AA and anxiety.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":"1179-1182"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148252629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}