LUMBAR Syndrome State-Of-The-Art Review: Insights Into a Rare and Complex Condition.

Abstract

LUMBAR syndrome is a rare condition with natural history and long-term outcomes that have not been well described. This acronym represents the constellation of features associated with the condition: Lower body hemangiomas with Urogenital anomalies and Ulceration, spinal cord Malformations, Bony defects of the spine and lower extremities, and Anorectal, Arterial, and/or Renal anomalies. The associated infantile hemangioma is the most notable feature, which occurs in a segmental pattern affecting the lower half of the body. Recent publications have described the clinical features of LUMBAR syndrome, its overlap with other lower body syndromes, and, notably, a landmark paper establishing diagnostic criteria through Delphi consensus. This paper aims to provide a comprehensive review of the clinical features, diagnostic criteria, pathophysiology, treatment options, and outcomes associated with LUMBAR syndrome.