Pediatric Dermatology最新文献

{"title":"Orthonyxia as a Noninvasive Treatment for Ingrown Toenails in Pediatric Patients: A Retrospective Study.","authors":"Kadir Atacan Yıldız, Şehribanu Güzel Çiftci, Tuğba Kevser Uzunçakmak","doi":"10.1111/pde.70284","DOIUrl":"10.1111/pde.70284","url":null,"abstract":"<p><strong>Background/objectives: </strong>Ingrown toenail is a painful condition characterized by penetration of the nail plate into the periungual soft tissue. Surgical treatment may provoke stress and delay recovery, increasing interest in noninvasive alternatives. This study aimed to evaluate the clinical outcomes of orthonyxia techniques in children with ingrown toenails and to identify factors associated with healing duration.</p><p><strong>Methods: </strong>This retrospective study included 31 pediatric patients treated with orthonyxia between January 2022 and October 2024. Patients were evaluated clinically and classified according to the Heifetz staging system. Adhesive and wire-based orthonyxia techniques were applied based on clinical presentation. Treatment outcome was defined as complete clinical remission. Logistic regression was used as an exploratory analysis for delayed healing (> 3 months), and multiple linear regression was performed to identify independent predictors of healing duration.</p><p><strong>Results: </strong>The mean age was 14.0 ± 1.9 years, and 71.0% of patients were male. Nearly half of patients presented with Heifetz stage III disease. The mean healing duration was 3.3 ± 2.6 months. Complete remission occurred within ≤ 3 months in 64.5% of patients. Tampon application was associated with faster healing, whereas 3TO brace and silver nitrate applications were associated with delayed healing. Multiple linear regression identified female sex, younger age, higher body weight, and 3TO brace application as independent predictors of prolonged healing duration.</p><p><strong>Conclusions: </strong>Orthonyxia is an effective treatment option for pediatric ingrown toenails. Its practical value in children includes avoidance of surgery and immediate return to daily activities.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":"1145-1151"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148252679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PHOTOQUIZ: Progressive Cervicofacial Nodules in a Young Child.","authors":"Oscar Hidalgo-Mora, Daniel Barquero-Orias, Tatiana Monge-Jiménez, Benjamin Hidalgo-Matlock","doi":"10.1111/pde.70314","DOIUrl":"10.1111/pde.70314","url":null,"abstract":"","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":"1229-1231"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148536673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polypodium leucotomos Gummy Supplementation in the Pediatric Population: A Retrospective Series Demonstrating Safety.","authors":"Cindy Hakim, Alina Galaria, Aamir Hussain, Tina Ho","doi":"10.1111/pde.70278","DOIUrl":"10.1111/pde.70278","url":null,"abstract":"<p><p>Polypodium leucotomos extract (PLE) has been widely studied for its antioxidant, photoprotective, and anti-inflammatory properties, but limited data exist regarding its use in children. This retrospective study evaluated the safety of a gummy-based PLE supplement (Inner Glow Sol Defense, 280 mg) in 77 pediatric patients across three dermatology clinics. Patients took the supplement for a median of 4 months with no documented adverse effects, including in cases of prolonged use and accidental overdose. These findings support the safety of PLE supplementation in the pediatric population.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":"1188-1190"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148252710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Nasal and Inhalant Corticosteroids With Pediatric Perioral Dermatitis: A TriNetX Retrospective Cohort Study.","authors":"Taylor Merkle, Caitlyn Curley, Dylan Wambold, Basira Iginla, Erum N Ilyas","doi":"10.1111/pde.70228","DOIUrl":"10.1111/pde.70228","url":null,"abstract":"<p><p>Although topical corticosteroids are known triggers in the development of perioral dermatitis (PD), investigation into inhalant and nasal corticosteroid preparations, commonly used to manage allergic rhinitis and asthma, remains limited to case series. Using the TriNetX US Collaborative Network, this retrospective cohort study identified pediatric patients (age < 18) with allergic rhinitis or asthma in three groups: corticosteroid nasal/inhalant users, non-steroid nasal/inhalant users, and controls with no nasal/inhalant product use. Patients were propensity score matched 1:1 from 2000 to 2025 with a new diagnosis of PD as the outcome assessed at 6 and 12 months. Corticosteroid nasal/inhalant usage showed an increased association of newly documented PD with the strongest signal occurring within 6 months (RR 3.25, p < 0.0001) remaining persistently elevated although attenuated by 1 year (RR 2.27, p < 0.0001), whereas nonsteroidal preparations showed no such association. Nasal and inhalant containing corticosteroid preparations were clearly associated with PD in this large retrospective database study. They represent a likely underrepresented trigger necessitating clinician attention when encountering new-onset pediatric facial dermatoses.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":"1158-1162"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13617167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147869306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploration of Changes in the Human Skin Microbiome by Mode of Birth and Following First Bath.","authors":"Kimberly Capone, Joanne Kuller, David J Durand, Neena K Tierney, Carolyn Lund","doi":"10.1111/pde.70219","DOIUrl":"10.1111/pde.70219","url":null,"abstract":"<p><strong>Background/objectives: </strong>Microbes colonize the skin soon after birth, and the skin microbiome changes over time. However, the effects of bathing and hygiene products on the infant skin microbiome are not well studied. This randomized, single-center trial analyzed the skin microbiome in neonates born vaginally or via cesarean section (c-section), before and after their first bath with or without a mild baby cleanser.</p><p><strong>Methods: </strong>One hundred healthy full-term neonates were randomized to baths with water alone or with mild baby cleanser, stratified by delivery mode. Volar forearm swabs of neonates (before and after first bath) and their mothers were analyzed by 16S rRNA metagenomic sequencing.</p><p><strong>Results: </strong>At birth, neonates born vaginally had greater overall richness of the skin microbiome versus those born via c-section. Vaginally delivered neonates had similar species richness as their mothers, while neonates delivered via c-section had much lower species richness. Shannon diversity was similar regardless of birth mode, but community structure varied. Species richness was similar before and after bath in vaginally delivered neonates, but those born via c-section had higher species richness after their first bath and showed larger changes in community structures, compared with the vaginal group. Whether water alone or baby cleanser was used for the first bath did not greatly affect skin microbiome composition.</p><p><strong>Conclusions: </strong>The mode of birth had the largest effect on the skin microbiome composition, richness, and structure. Neonates born via c-section showed the largest post-bath changes in the skin microbiome, while the use of water or baby cleanser had little effect.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":"1046-1053"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Hidradenitis Suppurativa in Children: Influence of Neighborhood Socioeconomic Status.","authors":"Maria Elena Sanchez-Anguiano, Krittin Supapannachart, Regina-Celeste Ahmad, Mindy C DeRouen, Stephen Shiboski, Jinoos Yazdany, Aileen Y Chang","doi":"10.1111/pde.70265","DOIUrl":"10.1111/pde.70265","url":null,"abstract":"<p><p>Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition with early onset and disproportionate impact on females and African American youth. In our cross-sectional study of 9695 pediatric HS patients in a single US health system, pediatric patients residing in neighborhoods with lower SES had greater odds of having a new HS diagnosis in unadjusted models and after sequential adjustment for age, sex, and race and ethnicity. Fully adjusted odds ratios (95% confidence intervals) were neighborhood SES quintile, Q1 (lowest): 4.05 (1.76-9.32), Q2: 2.86 (1.13-7.22), Q3: 2.94 (1.22-7.09), Q4: 1.46 (0.55-3.90) (p for linear trend < 0.001), with similar findings in sensitivity analyses. These findings suggest neighborhood factors may contribute to HS diagnosis, highlighting the need to identify and address modifiable, neighborhood factors that influence HS diagnosis.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":"1174-1178"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13189537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147942338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social Media and Direct-to-Consumer Treatments in Pediatric and Young-Adult Patients With Alopecia: Variable Use and Mixed Perceptions.","authors":"Sarah Lee, Adrienne Conza, Itohan Aigbekaen, Jasmine Chang, Yasin Damji","doi":"10.1111/pde.70226","DOIUrl":"10.1111/pde.70226","url":null,"abstract":"<p><strong>Background: </strong>Social media is a common source of health information for children and young adults, yet little is known about how young patients with alopecia engage with hair loss-related content online. Direct-to-consumer (DTC) treatments are also widely marketed for alopecia, but data on their use and perceived effectiveness in pediatric populations remain limited. This study aimed to characterize social media use among patients with alopecia and examine patterns of DTC treatment use.</p><p><strong>Methods: </strong>We conducted a cross-sectional survey of patients aged ≤ 25 years with physician-diagnosed alopecia at Boston Children's Hospital dermatology clinics between November 2024 and September 2025. Surveys collected demographics, social media engagement, and use and perceived effectiveness of DTC treatments.</p><p><strong>Results: </strong>Of 115 respondents, 65% reported social media use, with higher use reported in older age groups (90% ≥ 18 years, 72% 12-17 years, 34% < 12 years; p < 0.001). Among users, 59% encountered hair loss-related content, most often on TikTok, Instagram, and YouTube. Many reported uncertainty regarding the qualifications of content creators, and nearly one-quarter rarely or never questioned the accuracy of information presented. Among respondents exposed to hair loss-related content, 28% reported trying a treatment seen online. These treatments were associated with low satisfaction, variable costs ($0-$500+), and side effects including dryness, itching, and increased shedding. Across all respondents, 60% reported ever using at least one DTC treatment, though only 30% were current users. Perceived effectiveness was inconsistent.</p><p><strong>Conclusions: </strong>Social media exposure and marketing of DTC products appear to shape how youth approach alopecia management, although reported experiences were variable and often unsatisfactory. Dermatologists should inquire about online content exposure and DTC product use in clinical care while guiding families toward evidence-based management.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":"1054-1060"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147778124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unusual Cutaneous and Mucosal Manifestations of Neonatal Inflammatory Skin and Bowel Disease Type 1 due to a Novel Homozygous ADAM17 Mutation.","authors":"Kittu Malhi, Sukhdeep Singh, Pandiarajan Vignesh, Debajyoti Chatterjee, Rahul Mahajan","doi":"10.1111/pde.70235","DOIUrl":"10.1111/pde.70235","url":null,"abstract":"<p><p>Neonatal inflammatory skin and bowel isease type 1 (NISBD1) is a rare autosomal recessive genodermatosis caused by pathogenic variants in ADAM17, a gene essential for epithelial development and cytokine regulation. Affected individuals typically present during infancy with severe cutaneous inflammation, recurrent infections, fragile hair, and variable gastrointestinal involvement. We report a 4-year-old girl with an unusual constellation of mucocutaneous manifestations associated with a novel homozygous ADAM17 mutation (c.436G>A; p.Gln146Lys), thereby expanding the known phenotypic spectrum of NISBD1. This case highlights atypical NISBD1 features, including pyoderma gangrenosum-like ulcerations, pyostomatitis-like mucosal involvement, annular atrophic scarring, and absence of bowel disease.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":"1209-1211"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147778107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating Patient-Reported Outcome Measures in Atopic Dermatitis Clinical Practice: An Analysis of the Patient-Oriented Eczema Measure.","authors":"Chinemelum E Obijiofor, Michael Martinez, Rayvanth Chappidi, Steven Friedman, Soutrik Mandal, Prince Adotama, Vikash Oza","doi":"10.1111/pde.70231","DOIUrl":"10.1111/pde.70231","url":null,"abstract":"<p><p>The Patient-Oriented Eczema Measure (POEM) is a validated patient-reported outcome measure for atopic dermatitis (AD), though its use in routine pediatric dermatology practice remains underexplored. In this cross-sectional study of 297 pediatric patients with AD at a tertiary pediatric dermatology clinic, POEM scores were collected and compared with physician-rated investigator global assessment (IGA) and IGA × body surface area, as well as treatment selection. Older patients (> 12 years) had significantly higher mean POEM scores (17.5 vs. 10.4; p < 0.001) with no significant differences observed by race, ethnicity, or socioeconomic status; total POEM scores correlated strongly with IGA (r = 0.68) and moderately with IGA×BSA (r = 0.54), and higher severity scores were associated with more potent topical corticosteroids and systemic treatments (p < 0.001). POEM detected clinically relevant changes, aligned with physician-rated measures, and correlated with treatment intensity, underscoring its utility in both clinical practice and future predictive modeling applications.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":"1154-1157"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147819475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PHACE(S) Syndrome Minus the H: A Case of Possible PHACE(S) Syndrome Without an Infantile Hemangioma.","authors":"Margaret F Cote, Evan G Stein, Vikash S Oza","doi":"10.1111/pde.70236","DOIUrl":"10.1111/pde.70236","url":null,"abstract":"<p><p>A 4-month-old, full-term girl was referred for evaluation of a supraumbilical raphe and an anomalous aortic arch. Further work up for PHACE(S) syndrome was pursued, despite the absence of a cutaneous infantile hemangioma (IH), which identified hypoplastic and dysplastic cerebral vasculature. We present this case to raise awareness of possible PHACE(S) syndrome even in children without cutaneous IHs and the importance of recognizing supraumbilical raphe as a sentinel finding.</p>","PeriodicalId":19819,"journal":{"name":"Pediatric Dermatology","volume":" ","pages":"1224-1227"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147869263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}