诊断难题：BP180 酶联免疫吸附试验呈阴性的幼年大疱性类天疱疮。

IF 1.2 4区医学 Q3 DERMATOLOGY

Pediatric Dermatology Pub Date : 2024-08-21 DOI:10.1111/pde.15741

Janet A Fairley, Kristen G Berrebi, Andrew M Poggemiller, Afshin Varzavand, Kelly N Messingham

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引用次数: 0

摘要

大疱性类天疱疮（BP）是一种自身免疫性水疱病，主要影响老年人，而幼年BP病例则很少见。这两种类型的大疱性类天疱疮通常都是由针对 BP180 的 NC16A 区域的自身抗体介导的；但也有一小部分成年患者的血清会对该蛋白的其他区域产生反应。类似情况在幼年 BP 中的发生率尚不清楚。这例BP180酶联免疫吸附试验阴性的幼年BP病例凸显了诊断上的误区，这些误区可能导致儿科患者延误正确诊断。

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Diagnostic challenge: Juvenile bullous pemphigoid with a negative BP180 ELISA.

Bullous pemphigoid (BP) is an autoimmune blistering disease primarily affecting the elderly, whereas cases of juvenile BP are rare. Both types of BP are typically mediated by autoantibodies targeting the NC16A region of BP180; however, a small subset of adult patient sera react to other regions of the protein. The incidence of a similar occurrence in juvenile BP is unknown. This case of juvenile BP with a negative BP180 ELISA highlights diagnostic pitfalls that can lead to a delay in the correct diagnosis in the pediatric population.

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来源期刊

Pediatric Dermatology 医学-皮肤病学

CiteScore

3.20

自引率

6.70%

发文量

269

审稿时长

1 months

期刊介绍： Pediatric Dermatology answers the need for new ideas and strategies for today''s pediatrician or dermatologist. As a teaching vehicle, the Journal is still unsurpassed and it will continue to present the latest on topics such as hemangiomas, atopic dermatitis, rare and unusual presentations of childhood diseases, neonatal medicine, and therapeutic advances. As important progress is made in any area involving infants and children, Pediatric Dermatology is there to publish the findings.