诊断难题：BP180 酶联免疫吸附试验呈阴性的幼年大疱性类天疱疮。

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-08-21 DOI:10.1111/pde.15741

Janet A Fairley, Kristen G Berrebi, Andrew M Poggemiller, Afshin Varzavand, Kelly N Messingham

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引用次数: 0

摘要

大疱性类天疱疮（BP）是一种自身免疫性水疱病，主要影响老年人，而幼年BP病例则很少见。这两种类型的大疱性类天疱疮通常都是由针对 BP180 的 NC16A 区域的自身抗体介导的；但也有一小部分成年患者的血清会对该蛋白的其他区域产生反应。类似情况在幼年 BP 中的发生率尚不清楚。这例BP180酶联免疫吸附试验阴性的幼年BP病例凸显了诊断上的误区，这些误区可能导致儿科患者延误正确诊断。

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Diagnostic challenge: Juvenile bullous pemphigoid with a negative BP180 ELISA.

Bullous pemphigoid (BP) is an autoimmune blistering disease primarily affecting the elderly, whereas cases of juvenile BP are rare. Both types of BP are typically mediated by autoantibodies targeting the NC16A region of BP180; however, a small subset of adult patient sera react to other regions of the protein. The incidence of a similar occurrence in juvenile BP is unknown. This case of juvenile BP with a negative BP180 ELISA highlights diagnostic pitfalls that can lead to a delay in the correct diagnosis in the pediatric population.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.