Pharmaceutisch weekblad. Scientific edition最新文献_第2页

High pressure liquid chromatographic analysis of the serum concentration of cefuroxime after an intravenous bolus injection of cefuroxime in patients with a coronary artery bypass grafting. 冠状动脉旁路移植术患者静脉注射头孢呋辛后血清头孢呋辛浓度的高压液相色谱分析。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1992-12-11 DOI: 10.1007/BF01970173

M J Koot, F N IJdenberg, R M Stuurman, J Poell, L J Bras, J J Langemeijer, L Lie-A-Huen

引用次数: 11

Assessment of trace element compatibility in total parenteral nutrition infusions. 全肠外营养输液中微量元素相容性的评价。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1992-10-16 DOI: 10.1007/BF01977621

M C Allwood, M Greenwood

引用次数: 7

1st European Congress of Pharmaceutical Sciences. Amsterdam, The Netherlands, 7-9 October 1992. Abstracts. 第一届欧洲制药科学大会。1992年10月7日至9日，荷兰阿姆斯特丹。摘要。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1992-10-16

引用次数: 0

Dideoxynucleoside therapy for HIV infection. 双脱氧核苷治疗HIV感染。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1992-10-16 DOI: 10.1007/BF01977615

D M Burger, J H Beijnen

引用次数: 0

Catecholamines in critical care. The commonly used catecholamines: receptor and clinical profile, indications and dosages. 儿茶酚胺在重症监护中的作用。常用儿茶酚胺:受体和临床特点，适应症和剂量。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1992-10-16 DOI: 10.1007/BF01977616

F W Santman

引用次数: 8

Capacity-limited renal glucuronidation of probenecid by humans. A pilot Vmax-finding study. 人丙炔酸肾糖醛酸化能力受限。一个vmax发现的试点研究。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1992-10-16 DOI: 10.1007/BF01977622

T B Vree, E W Van Ewijk-Beneken Kolmer, E W Wuis, Y A Hekster

{"title":"Capacity-limited renal glucuronidation of probenecid by humans. A pilot Vmax-finding study.","authors":"T B Vree, E W Van Ewijk-Beneken Kolmer, E W Wuis, Y A Hekster","doi":"10.1007/BF01977622","DOIUrl":"https://doi.org/10.1007/BF01977622","url":null,"abstract":"Probenecid shows dose-dependent pharmacokinetics. When in one volunteer the dose is increased from 250 to 1,500 mg orally, the t1/2 increased from 3 to 6 h. The Cmax was 14 micrograms/ml with a dosage of 250 mg, 31 micrograms/ml with 500 mg, 70 micrograms/ml with 1,000 mg and 120 micrograms/ml with 1,500 mg. The tmax remained 1 h for all four dosages. The AUC/dose ratio increased with the dose, indicating nonlinear elimination. The total body clearance declined from 64.5 ml/min for 250 mg to 26.0 ml/min for 1,500 mg. The renal clearance of probenecid remained constant, 0.6-0.8 ml/min. Protein binding of probenecid is high (91%) and independent of the dose. The phase I metabolites show lower protein binding values (34-59%). The protein binding of probenecid glucuronide in vitro (spiked plasma) is 75%. Probenecid is metabolized by cytochrome P-450 to three phase I metabolites. Each of the metabolites accounts for less than 10% of the dose administered; the percentage recovered in the urine is independent of the dose. The main metabolite probenecid glucuronide is only present in urine and not in plasma. The renal excretion rate--time profile of probenecid glucuronide shows a plateau value of approximately 700 micrograms/min (46 mg/h) with acidic urine pH. The duration of this plateau value depends on the dose: 2 h at 500 mg, 10 h at 1,000 mg and 20 h at 1,500 mg. It is demonstrated that probenecid glucuronide must be formed in the kidney during its passage of the tubule. The plateau value in the renal excretion rate of probenecid value reflects its Vmax of formation.","PeriodicalId":19804,"journal":{"name":"Pharmaceutisch weekblad. Scientific edition","volume":"14 5","pages":"325-31"},"PeriodicalIF":0.0,"publicationDate":"1992-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF01977622","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12607935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

A drug use review study in patients with obstructive lung disease. Assessment of the quality of drug therapy. 阻塞性肺疾病患者用药回顾研究药物治疗质量评价。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1992-10-16 DOI: 10.1007/BF01977619

G Van den Brink, C W Bollen, O E Van de Wall, L J Hoeve, A J Porsius

引用次数: 2

Drug transport across the blood--brain barrier. I. Anatomical and physiological aspects. 药物通过血脑屏障运输。1 .解剖学和生理学方面。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1992-10-16 DOI: 10.1007/BF01977618

J B Van Bree, A G De Boer, M Danhof, D D Breimer

引用次数: 474

The comprehensiveness of Medline and Embase computer searches. Searches for controlled trials of homoeopathy, ascorbic acid for common cold and ginkgo biloba for cerebral insufficiency and intermittent claudication. Medline和Embase计算机搜索的全面性。搜索顺势疗法的对照试验，抗坏血酸治疗普通感冒，银杏叶治疗脑功能不全和间歇性跛行。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1992-10-16 DOI: 10.1007/BF01977620

J Kleijnen, P Knipschild

{"title":"The comprehensiveness of Medline and Embase computer searches. Searches for controlled trials of homoeopathy, ascorbic acid for common cold and ginkgo biloba for cerebral insufficiency and intermittent claudication.","authors":"J Kleijnen, P Knipschild","doi":"10.1007/BF01977620","DOIUrl":"https://doi.org/10.1007/BF01977620","url":null,"abstract":"Objective: To assess the comprehensiveness of Medline and Embase computer searches for controlled trials.Design: Comparison of articles found after an exhaustive search of the literature with the yield of a Medline or Embase search. This was performed for controlled clinical trials on the efficacy of three interventions: homoeopathy, ascorbic acid for common cold, and ginkgo biloba for intermittent claudication and cerebral insufficiency. The number of controlled trials found by exhaustive search of the literature was 107, 61 and 45, respectively.Results: For homoeopathy, ascorbic acid and ginkgo the proportion of all trials found by Medline was 17%, 36% and 31% respectively and for Embase 13%, 25% and 58% respectively. After checking of the references in the Medline articles 44%, 79% and 76% of all trials were identified. After checking of the references in the Embase articles 42%, 72% and 93% of all trials were identified. About 20% of the articles was not correctly indexed. Of the best trials 68%, 91% and 83% could be found with Medline and 55%, 82% and 92% of the best trials were identified through Embase.Conclusions: For the topics mentioned, Medline and Embase searches are sufficient to get an impression of the evidence from controlled trials, but only if references in the articles are followed for further evidence. If one wants to get a more complete picture, additional search strategies make sense. Of course, this picture may be different for other topics.","PeriodicalId":19804,"journal":{"name":"Pharmaceutisch weekblad. Scientific edition","volume":"14 5","pages":"316-20"},"PeriodicalIF":0.0,"publicationDate":"1992-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF01977620","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12607933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 56

Didanosine, a new antiretroviral drug. A review. 二腺苷，一种新的抗逆转录病毒药物。复习一下。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1992-10-16 DOI: 10.1007/BF01977617

R M Franssen, P L Meenhorst, C H Koks, J H Beijnen

引用次数: 5