Pharmaceutisch weekblad. Scientific edition最新文献_第10页

The role of medicinal chemistry in drug research. 药物化学在药物研究中的作用。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1991-08-23 DOI: 10.1007/BF01957740

W Soudijn

引用次数: 6

Continuation and maintenance therapy with antidepressive agents. Meta-analysis of research. 抗抑郁药物的继续和维持治疗。研究的荟萃分析。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1991-08-23 DOI: 10.1007/BF01957741

A J Loonen, P G Peer, G J Zwanikken

{"title":"Continuation and maintenance therapy with antidepressive agents. Meta-analysis of research.","authors":"A J Loonen, P G Peer, G J Zwanikken","doi":"10.1007/BF01957741","DOIUrl":"https://doi.org/10.1007/BF01957741","url":null,"abstract":"The purpose of this study was to ascertain the clinical benefits of long-term antidepressant drug treatment in patients with recurrent major depression. Bibliographic reviews of four textbooks and five review articles, literature searches using MEDLINE (1977-1987) and EXCERPTA MEDICA (1974-1987), hand-searching of the bibliographies of identified papers, and a private set were used for data identification. The most informative, definitive research report was selected using explicit criteria for evaluating study design and quality, of each described, randomized, controlled, double-blind trial of long-term antidepressant agent treatment. The trials were started at a specified period after recovery from an affective episode, in patients with major depression. Of the fifty-five originally identified articles, nine were selected that specifically addressed this purpose. The basic data were extracted in the form of 2 x 2 tables comparing the number of patients with an affective relapse to those remaining well and meta-analysed. Six of the selected trials addressed continuation and three addressed maintenance therapy. In two trials of continuation and in one trial of maintenance treatment, antidepressants were significantly more active than a placebo. In none of the trials were antidepressants inferior to a placebo. Continuation therapy with antidepressants (amitriptyline and imipramine) is effective. There are insufficient data to allow any conclusions about the efficacy of maintenance therapy with antidepressants, long-term treatment with antidepressants relative to that with lithium carbonate, or long-term antidepressant treatment in patients with chronic depression.","PeriodicalId":19804,"journal":{"name":"Pharmaceutisch weekblad. Scientific edition","volume":"13 4","pages":"167-75"},"PeriodicalIF":0.0,"publicationDate":"1991-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF01957741","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12996253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Teicoplanin in perspective. A critical comparison with vancomycin. 透视Teicoplanin。与万古霉素的关键性比较。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1991-08-23 DOI: 10.1007/BF01957739

R Janknegt

引用次数: 1

Comparative bioavailability of rectal and oral formulations of chloroquine. 氯喹直肠和口服制剂的比较生物利用度。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1991-08-23 DOI: 10.1007/BF01957742

M M Tjoeng, P H Hogeman, H Kapelle, M L De Ridder, H Verhaar

引用次数: 4

Antibiotic concentrations in the groin wound after vascular prosthetic implantation. 血管假体植入术后腹股沟创面抗生素浓度。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1991-08-23 DOI: 10.1007/BF01957743

A C Van Loenen, H J Martens, A J Mackaay, J A Rauwerda, F C Bakker, G A Vos

引用次数: 1

Clinimetrics and epilepsy care. 临床指标和癫痫护理。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1991-08-23 DOI: 10.1007/BF01957744

D J Wijsman, Y A Hekster, A Keyser, W O Renier, H Meinardi

{"title":"Clinimetrics and epilepsy care.","authors":"D J Wijsman, Y A Hekster, A Keyser, W O Renier, H Meinardi","doi":"10.1007/BF01957744","DOIUrl":"https://doi.org/10.1007/BF01957744","url":null,"abstract":"In order to study the practicability of rating scales in the regular care of people with epilepsy, indices have been developed and tested on their validity. These indices consist of the Index of Seizures, representing seizure activity, and the Composite Index of Impairment concerning the severity of impairment caused by the seizure type and frequency and the side-effects of anti-epileptic drug treatment. The indices have been applied in a retrospective quantitative evaluation of anti-epileptic drug therapy. The medical records of 250 randomly selected patients registered at an adult out-patient clinic have been reviewed. Their seizures have been classified as generalized tonic-clonic, simple partial and/or complex partial. The distribution of this population according to these indices has been studied, which leads us to the following conclusions: the global indices are valid for clinical application; in 18.6% of the patients studied there was severe impairment and unacceptable seizure control; combined types of seizure are difficult to control; no significant difference is demonstrated between monotherapy and polytherapy regarding the amount of neurotoxicity. The indices can be determined rapidly and therefore may become valuable aids for the physician in an out-patient clinic to support a decision whether or not to revise current anti-epileptic drug therapy.","PeriodicalId":19804,"journal":{"name":"Pharmaceutisch weekblad. Scientific edition","volume":"13 4","pages":"182-8"},"PeriodicalIF":0.0,"publicationDate":"1991-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF01957744","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13103842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Meeting of the WHO Drug Utilization Research Group. Verona, Italy, 14-15 June 1991. Abstracts. 世卫组织药物利用研究小组会议。1991年6月14日至15日，意大利维罗纳。摘要。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1991-06-21

引用次数: 0

Immunomodulation by quinones. A model for the use of quinones in the treatment of inflammation. 醌类的免疫调节作用。使用醌类药物治疗炎症的模型。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1991-06-21 DOI: 10.1007/BF01981529

L A 'T Hart

引用次数: 1

European Meeting on Pharmacoepidemiology. Verona, Italy, 11-13 June 1991. Abstracts. 欧洲药物流行病学会议。1991年6月11日至13日，意大利维罗纳。摘要。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1991-06-21

引用次数: 0

Small-scale preparations in Sweden. Extemporaneous preparations and stock preparations at eleven community pharmacies. 瑞典的小规模准备工作。11个社区药房的临时制剂和库存制剂。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1991-06-21 DOI: 10.1007/BF01981531

A Kettis, D Isacson, K Bingefors, G Eriksson

{"title":"Small-scale preparations in Sweden. Extemporaneous preparations and stock preparations at eleven community pharmacies.","authors":"A Kettis, D Isacson, K Bingefors, G Eriksson","doi":"10.1007/BF01981531","DOIUrl":"https://doi.org/10.1007/BF01981531","url":null,"abstract":"Small-scale preparations, i.e. non-registered drugs that are extemporaneously prepared for each patient or made in larger batches for stock keeping, form a small but important group of drugs, especially for patients with rare diseases or allergies. Small-scale preparations are not included in the otherwise comprehensive statistics compiled by the National Corporation of Swedish Pharmacies and this makes knowledge of the use of these drugs limited. The occurrence of small-scale preparations was studied at eleven community pharmacies over a three-year period (1987-1989) by analysis of the orders from the pharmacies to the four production units of the National Corporation of Swedish Pharmacies in the first quarter of each study year. The number of small-scale preparations dispensed were compared with the total sales of drugs at each pharmacy. The proportion of small-scale preparations in the total drug sales was about 1.5% throughout the study period, but there were fluctuations over time at the individual pharmacies. The most common dosage forms were creams, liniments and mixtures. Dermatological drugs in different dosage forms were the most frequent (almost 50%). This was probably because of the necessity for a great variety of different strengths among these drugs.","PeriodicalId":19804,"journal":{"name":"Pharmaceutisch weekblad. Scientific edition","volume":"13 3","pages":"137-41"},"PeriodicalIF":0.0,"publicationDate":"1991-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF01981531","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13082280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0