Pharmaceutisch weekblad. Scientific edition最新文献

Drug transport across the blood-brain barrier. II. Experimental techniques to study drug transport. 通过血脑屏障的药物运输。2研究药物转运的实验技术。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1992-12-11 DOI: 10.1007/BF01970169

J B Van Bree, A G De Boer, M Danhof, D D Breimer

引用次数: 7

Administration of oral chloral hydrate to paediatric patients undergoing magnetic resonance imaging. 小儿核磁共振成像患者口服水合氯醛的应用。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1992-12-11 DOI: 10.1007/BF01970170

C L Ronchera, L Martí-Bonmatí, C Poyatos, J Vilar, N V Jiménez

{"title":"Administration of oral chloral hydrate to paediatric patients undergoing magnetic resonance imaging.","authors":"C L Ronchera, L Martí-Bonmatí, C Poyatos, J Vilar, N V Jiménez","doi":"10.1007/BF01970170","DOIUrl":"https://doi.org/10.1007/BF01970170","url":null,"abstract":"Sedation is frequently required in children undergoing magnetic resonance imaging (MRI). 172 Paediatric patients (82 female and 90 male, age 42 +/- 26 months, weight 14.7 +/- 5.6 kg) entered an open, non-comparative, prospective study to assess the utilization of oral chloral hydrate. Chloral hydrate syrup (70 mg/ml) was administered 20-30 min prior to the procedure. Effective sedation was reached in 80.3% with an average initial dose of 55 mg/kg and in 93.6% with an average total dose of 65 mg/kg. Significant differences in effectivity were correlated with the dose (54 +/- 11 mg/kg in failure cases versus 66 +/- 16 mg/kg in effective cases; p < 0.05) and diagnosis (effectivity falls to 62.5% and 76.0% in children with medullar tumours and encephalic white matter alterations, respectively; p < 0.01). Average sleep induction time was 30 +/- 19 min, and average duration of sleep was 62 +/- 24 min. Adverse reactions occurred in 4.7%, with nausea, vomiting and stomach pain being the most common side-effects (3.5%). Multivariate statistical analysis selects total dose and age into the discriminant function, with a 100% relative percentage of correct classification. A simple method for optimizing the chloral hydrate dose in children is proposed: the dose in mg/kg is calculated as half the age in months + 50.","PeriodicalId":19804,"journal":{"name":"Pharmaceutisch weekblad. Scientific edition","volume":"14 6","pages":"349-52"},"PeriodicalIF":0.0,"publicationDate":"1992-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF01970170","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12644967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Clinical Pharmacological Meeting. Nieuwegein, The Netherlands, 9 October 1992. Abstracts. 临床药理学会议。1992年10月9日，荷兰新韦格因。摘要。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1992-12-11

引用次数: 0

Home-based chemotherapy confronts pharmacists with stability and compatibility problems. 家庭化疗给药师带来了稳定性和相容性问题。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1992-12-11 DOI: 10.1007/BF01970167

J H Beijnen

引用次数: 8

Antimicrobial screening of essential oils and extracts of some Humulus lupulus L. cultivars. 部分葎草品种精油及提取物的抗菌筛选。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1992-12-11 DOI: 10.1007/BF01970171

C R Langezaal, A Chandra, J J Scheffer

引用次数: 53

Stability and compatibility of four anthracyclines: doxorubicin, epirubicin, daunorubicin and pirarubicin with PVC infusion bags. 阿霉素、表阿霉素、柔红霉素、比阿霉素四种蒽环类药物与PVC输注袋的稳定性及相容性研究。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1992-12-11 DOI: 10.1007/BF01970174

T Dine, J C Cazin, B Gressier, M Luyckx, C Brunet, M Cazin, F Goudaliez, M L Mallevais, I Toraub

{"title":"Stability and compatibility of four anthracyclines: doxorubicin, epirubicin, daunorubicin and pirarubicin with PVC infusion bags.","authors":"T Dine, J C Cazin, B Gressier, M Luyckx, C Brunet, M Cazin, F Goudaliez, M L Mallevais, I Toraub","doi":"10.1007/BF01970174","DOIUrl":"https://doi.org/10.1007/BF01970174","url":null,"abstract":"A rapid isocratic technique was developed for the analysis of four anthracyclines (doxorubicin, epirubicin, daunorubicin and pirarubicin) in parenteral solutions using high pressure liquid chromatography (HPLC) with fluorescence detection and a C18 Hypersil ODS column. The availability and compatibility of these drugs from solutions infused via PVC infusion bags through PVC administration sets have been examined. No significant drug loss was observed during simulated infusions (n = 4) for 24 h using PVC infusion bags and administration sets. No significant difference was found between infusion solutions (5% glucose or 0.9% NaCl), except for pirarubicin. The reconstitution of pirarubicin in 0.9% NaCl was impossible, because we observed a precipitation of the compound in solution. The stability of the drugs was also studied in solution, in PVC bags after storage at 4 degrees C with protection from light. The results show the stability of doxorubicin, epirubicin and daunorubicin during 7 days of storage to be satisfactory, irrespective of the infusion solution (5% glucose or 0.9% NaCl). In the case of pirarubicin, the stability of the drug was satisfactory during 5 days of storage in 5% glucose, but beyond, we observed a degradation of the compound with formation of doxorubicin in the infusion solution.","PeriodicalId":19804,"journal":{"name":"Pharmaceutisch weekblad. Scientific edition","volume":"14 6","pages":"365-9"},"PeriodicalIF":0.0,"publicationDate":"1992-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF01970174","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12644911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Drug Utilization Research and Pharmacoepidemiology Meeting. Utrecht, The Netherlands, 27 November 1992. Abstracts. 药物利用研究与药物流行病学会议。乌得勒支，荷兰，1992年11月27日。摘要。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1992-12-11

引用次数: 0

Comparison of costs linked to the preparation and administration of fluorouracil as a continuous infusion based on three techniques. 基于三种技术的氟尿嘧啶连续输注制备和给药成本比较。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1992-12-11 DOI: 10.1007/BF01970172

P Larrouturou, J L Rebischung, M C Taugourdeau, J Sauvaget, J Huchet

引用次数: 0

Symposium on Enzyme Inhibition and Drug Discovery. Antwerp, Belgium, 6 November 1992. Abstracts. 酶抑制与药物发现研讨会。1992年11月6日，比利时安特卫普。摘要。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1992-12-11

引用次数: 0

Pharmacological Meeting. Lunteren, The Netherlands, 14-15 December 1992. Abstracts. 药理会议。荷兰《Lunteren》，1992年12月14-15日。摘要。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1992-12-11

引用次数: 0