M M Tjoeng, P H Hogeman, H Kapelle, M L De Ridder, H Verhaar
{"title":"氯喹直肠和口服制剂的比较生物利用度。","authors":"M M Tjoeng, P H Hogeman, H Kapelle, M L De Ridder, H Verhaar","doi":"10.1007/BF01957742","DOIUrl":null,"url":null,"abstract":"<p><p>The relative bioavailability of chloroquinone in Witepsol H15 suppositories can vary between 10 and 53% of the bioavailability of a tablet formulation in adults. Therefore, it is therapeutically not sound to replace chloroquine tablets by a rectal formulation with the same dose.</p>","PeriodicalId":19804,"journal":{"name":"Pharmaceutisch weekblad. Scientific edition","volume":"13 4","pages":"176-8"},"PeriodicalIF":0.0000,"publicationDate":"1991-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF01957742","citationCount":"4","resultStr":"{\"title\":\"Comparative bioavailability of rectal and oral formulations of chloroquine.\",\"authors\":\"M M Tjoeng, P H Hogeman, H Kapelle, M L De Ridder, H Verhaar\",\"doi\":\"10.1007/BF01957742\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The relative bioavailability of chloroquinone in Witepsol H15 suppositories can vary between 10 and 53% of the bioavailability of a tablet formulation in adults. Therefore, it is therapeutically not sound to replace chloroquine tablets by a rectal formulation with the same dose.</p>\",\"PeriodicalId\":19804,\"journal\":{\"name\":\"Pharmaceutisch weekblad. Scientific edition\",\"volume\":\"13 4\",\"pages\":\"176-8\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1991-08-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1007/BF01957742\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pharmaceutisch weekblad. Scientific edition\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/BF01957742\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmaceutisch weekblad. Scientific edition","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/BF01957742","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Comparative bioavailability of rectal and oral formulations of chloroquine.
The relative bioavailability of chloroquinone in Witepsol H15 suppositories can vary between 10 and 53% of the bioavailability of a tablet formulation in adults. Therefore, it is therapeutically not sound to replace chloroquine tablets by a rectal formulation with the same dose.
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