Pharmaceutisch weekblad. Scientific edition最新文献_第3页

Omeprazole and its use in a university hospital: a comment. 奥美拉唑及其在大学医院的应用:评论。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1992-08-21 DOI: 10.1007/BF01962539

N O Stålhammer

引用次数: 0

Cardiovascular drugs. 心血管药物。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1992-08-21 DOI: 10.1007/BF01962544

P Vermeij

引用次数: 0

Future prospects in antiviral therapy. 抗病毒治疗的未来展望。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1992-08-21 DOI: 10.1007/BF01962549

E H Wiltink

引用次数: 0

Future developments in the pharmacotherapy of lung disease. 肺部疾病药物治疗的未来发展。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1992-08-21 DOI: 10.1007/BF01962543

A Van der Kuy

引用次数: 4

Current status of interferon alpha in the treatment of chronic hepatitis B. 干扰素α治疗慢性乙型肝炎的现状。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1992-08-21 DOI: 10.1007/BF01962533

J B Braken, P P Koopmans, I P Van Munster, F W Gribnau

{"title":"Current status of interferon alpha in the treatment of chronic hepatitis B.","authors":"J B Braken, P P Koopmans, I P Van Munster, F W Gribnau","doi":"10.1007/BF01962533","DOIUrl":"https://doi.org/10.1007/BF01962533","url":null,"abstract":"Interferon alpha is the only available therapy for patients with chronic hepatitis B. With interferon alpha 3-15 MU thrice weekly or 5 MU daily during 3-6 months one-third of the patients achieve seroconversion of HBeAg and HBV-DNA together with normalization of aminotransferases and slight improvement of histology. Loss of HBsAg is reported in a minority of responders during treatment, but increases during follow-up. Patients with baseline alanine aminotransferase of at least twice the upper limit of normal and low HBV-DNA concentration achieve the best response rates. HIV-positive patients with low CD4 counts and Asians are poor responders. As side-effects influenza-like symptoms are experienced by almost all patients. Mild leukopenia, thrombocytopenia and decreased hairgrowth are frequently reported. Severe depression, depersonalization and psychosis are reported in a small number of patients but tend to be poorly recognized in some studies. The decision whether dose reduction is indicated seems strongly related to the opinion of the investigator. Although long-term effects on the occurrence of cirrhosis and the development of hepatocellular carcinoma are not available yet, the achieved results are promising.","PeriodicalId":19804,"journal":{"name":"Pharmaceutisch weekblad. Scientific edition","volume":"14 4","pages":"167-73"},"PeriodicalIF":0.0,"publicationDate":"1992-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF01962533","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12608154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Putative therapeutic applications of calmodulin antagonists. 钙调素拮抗剂的推测治疗应用。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1992-08-21 DOI: 10.1007/BF01962532

R Mannhold, H Timmerman

引用次数: 2

Stability of sufentanil citrate in a portable pump reservoir, a glass container and a polyethylene container. 枸橼酸舒芬太尼在便携式泵储液器、玻璃容器和聚乙烯容器中的稳定性。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1992-08-21 DOI: 10.1007/BF01962538

P J Roos, J H Glerum, J W Meilink

{"title":"Stability of sufentanil citrate in a portable pump reservoir, a glass container and a polyethylene container.","authors":"P J Roos, J H Glerum, J W Meilink","doi":"10.1007/BF01962538","DOIUrl":"https://doi.org/10.1007/BF01962538","url":null,"abstract":"The stability of sufentanil citrate (100 ml, 5 micrograms/ml) in an admixture with sodium chloride 0.9% injection was investigated when filled in a portable pump reservoir with PVC wall, a glass container and a polyethylene container, at 32 degrees C, 4 degrees C and -20 degrees C for up to 21 days. No change in colour was visually observed in any of the samples during the 21-day storage period. A slight precipitation was noticed in three out of nine portable pump reservoirs, one at each storage temperature. There was a slight rise in pH at each storage temperature in all samples. There was approximately 13% loss of sufentanil citrate in the portable pump reservoirs stored at 32 degrees C during 2 days and 60% loss after 21 days, due to absorption of sufentanil citrate in the reservoir wall. No loss of sufentanil citrate could be detected in the portable pump reservoirs when stored at -20 degrees C and 4 degrees C. However, a serious inhomogeneity of the sufentanil citrate solution occurred after thawing at room temperature in the portable pump reservoirs which had been kept at -20 degrees C. The homogeneity could be restored by shaking for approximately 10 min. There was no change in the sufentanil citrate concentrations in the glass containers and polyethylene containers stored at the three temperatures. The portable pump reservoirs stored at 32 degrees C also showed a significant loss of vehicle due to evaporation (1.0 +/- 0.1 ml a week). This could not be detected in any of the other samples.","PeriodicalId":19804,"journal":{"name":"Pharmaceutisch weekblad. Scientific edition","volume":"14 4","pages":"196-200"},"PeriodicalIF":0.0,"publicationDate":"1992-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF01962538","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12608047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Knowledge of medication in hospitalized chronic respiratory patients. 住院慢性呼吸系统患者的用药知识。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1992-08-21 DOI: 10.1007/BF01962534

J Altimiras, J M Borras, E Mendez, E Pastor, T Bassons

{"title":"Knowledge of medication in hospitalized chronic respiratory patients.","authors":"J Altimiras, J M Borras, E Mendez, E Pastor, T Bassons","doi":"10.1007/BF01962534","DOIUrl":"https://doi.org/10.1007/BF01962534","url":null,"abstract":"Object of the study was to assess educative needs in the field of drug therapy among 99 chronic patients with advanced chronic lung disease admitted to the Respiratory Service of the Hospital Sta. Creu i Sant Pau (Barcelona, Spain). The knowledge of the patients about their previous drug treatment, sources of information as well as patients' conception of side-effects, was gathered from medical records and by means of a questionnaire. The majority of patients studied were male (63%), aged over 60 years (average 63 +/- 12), illiterate or with basic education (88%), had a chronic obstructive, pulmonary disease (76%) and with an important degree of chronicity. They had been treated for their condition during a mean of 8.4 years and took an average of 4.6 drugs. 31% Of patients did not answer any question about their medication properly and only 17% gave a correct answer to all the questions. The lower the age and the higher the educational level, the higher the proportion of correct answers to knowledge questions. 35% Of the patients stated not to have been informed about their medication and 55% stated that they had read the patient package inserts.","PeriodicalId":19804,"journal":{"name":"Pharmaceutisch weekblad. Scientific edition","volume":"14 4","pages":"174-9"},"PeriodicalIF":0.0,"publicationDate":"1992-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF01962534","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12608155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Disposition of quinine in rats with induced renal failure. 肾衰竭大鼠对奎宁的处理。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1992-08-21 DOI: 10.1007/BF01962536

C O Onyeji, P A Dixon, N C Ugwu

{"title":"Disposition of quinine in rats with induced renal failure.","authors":"C O Onyeji, P A Dixon, N C Ugwu","doi":"10.1007/BF01962536","DOIUrl":"https://doi.org/10.1007/BF01962536","url":null,"abstract":"Aetiologically different models of experimental acute renal failure were induced in rats by the administration of glycerol, mercuric chloride and gentamicin, respectively, to different groups. Quinine levels in plasma and urine of the rats with induced renal failure were determined and pharmacokinetic parameters (elimination t1/2, CLp, V, CLR AUC0-infinity) of the drug were derived and compared with values obtained from control rats following intraperitoneal administration of a 10 mg/kg body-weight dose of quinine. Results showed that each of the three compounds caused an up to 25-fold increase in the plasma levels of the drug and a marked decrease in the levels of the metabolite 3-hydroxyquinine. All the pharmacokinetic parameters determined for the rats with renal impairment were markedly different when compared to control. The high plasma quinine levels observed in the rats with renal failure could be largely due to the marked decrease in V and reduced metabolism. Also, in the rats with renal impairment, no correlation was observed between the increased plasma urea levels and plasma quinine levels or disposition of the drug. The results of the study suggest that quinine should be used with caution in patients with renal impairment. The plasma urea levels, as a measure of renal function, might not provide a suitable index for determining quinine dosage.","PeriodicalId":19804,"journal":{"name":"Pharmaceutisch weekblad. Scientific edition","volume":"14 4","pages":"185-90"},"PeriodicalIF":0.0,"publicationDate":"1992-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF01962536","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12608157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Quality in Pharmacotherapy. 21st European Symposium on Clinical Pharmacy. Copenhagen, Denmark, 14-17 October 1992. Abstracts. 药物治疗的质量。第21届欧洲临床药学研讨会。1992年10月14日至17日，丹麦哥本哈根。摘要。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1992-08-21

引用次数: 0