Pharmaceutisch weekblad. Scientific edition最新文献_第4页

Delivery of hormones: some new concepts. 激素输送:一些新概念。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1992-08-21 DOI: 10.1007/BF01962547

W A Hermens

引用次数: 2

Comparative study on protective gloves for handling cytotoxic medicines: a model study with carmustine. 细胞毒性药物防护手套的比较研究:卡莫司汀模型研究。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1992-08-21 DOI: 10.1007/BF01962535

H Dinter-Heidorn, G Carstens

引用次数: 6

Drugs in the pipeline. Proceedings of the scientific meeting of the Dutch Association of Hospital Pharmacists. Valkenburg, 13-14 September 1991. 药物正在研发中。荷兰医院药剂师协会科学会议记录。1991年9月13日至14日，瓦尔肯堡。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1992-08-21

引用次数: 0

New cytotoxic drugs and targets in oncology. 新的肿瘤细胞毒药物和靶点。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1992-08-21 DOI: 10.1007/BF01962548

J H Beijnen

引用次数: 1

Clearance of indomethacin occurs predominantly by renal glucuronidation. 吲哚美辛的清除主要通过肾糖醛酸化发生。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1992-08-21 DOI: 10.1007/BF01962537

F Moolenaar, S Crancrinus, J Visser, D De Zeeuw, D K Meijer

引用次数: 8

Future directions in antimicrobial chemotherapy. 抗菌化疗的未来方向。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1992-08-21 DOI: 10.1007/BF01962545

R Janknegt

引用次数: 0

New developments in the pharmacotherapy of inflammatory bowel disease. 炎症性肠病药物治疗的新进展。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1992-08-21 DOI: 10.1007/BF01962550

J W Harting

引用次数: 4

Dealing with sadness, madness and hostility. New psychotropic drug remedies for the future. 处理悲伤、疯狂和敌意。未来新的精神药物疗法。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1992-08-21 DOI: 10.1007/BF01962542

A J Loonen

{"title":"Dealing with sadness, madness and hostility. New psychotropic drug remedies for the future.","authors":"A J Loonen","doi":"10.1007/BF01962542","DOIUrl":"https://doi.org/10.1007/BF01962542","url":null,"abstract":"The objective of this article is to present an overview of new forms of psychotropic drug therapy that may be expected to play a role in psychiatric practice in the 1990s. In predicting these future developments, three lines of approach have been followed. Firstly, progress in elucidating basic neuronal mechanisms is described. The radioligand receptor binding technique has proved to be an especially powerful tool in the search for novel psychoactive compounds. Secondly, those mental health problems most likely to undergo intensive study are discussed. It is likely that special attention will be devoted to organic mental disorders related to aging (dementia) or chronic exposure to toxic substances. In addition, research will be aimed at explaining and reducing the occurrence of auto-aggressive and hetero-aggressive behaviour. Thirdly, the types of newly designed agents and treatment strategies currently under investigation are outlined. In particular, the development of pharmacological agents that interfere with serotonergic molecular mechanisms has opened the way to improving existing psychotropic drugs, to inventing drugs that achieve known clinical effects via different mechanisms of action, and even to discovering entirely new categories of psychotropic drugs.","PeriodicalId":19804,"journal":{"name":"Pharmaceutisch weekblad. Scientific edition","volume":"14 4A","pages":"206-20"},"PeriodicalIF":0.0,"publicationDate":"1992-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF01962542","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12608051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Immunomodulators. Future prospects. 免疫调制剂。未来的前景。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1992-08-21 DOI: 10.1007/BF01962546

B C Takx-Köhlen

{"title":"Immunomodulators. Future prospects.","authors":"B C Takx-Köhlen","doi":"10.1007/BF01962546","DOIUrl":"https://doi.org/10.1007/BF01962546","url":null,"abstract":"The future role of the immunomodulators in medical practice is yet to be defined. The key question is whether these new substances will bring remarkable progress in transplantation or in the treatment of such conditions as cancer, AIDS, and autoimmune diseases, or whether they will be of only minor adjunctive importance. As background to the discussion of immunomodulating agents, the immune system is explained, with emphasis on the roles of T and B lymphocytes, macrophages, phagocytes, human leukocyte antigen and the complement system. Special attention is given to the cytokines, particularly the lymphokines. The immunomodulators can be divided into three main groups: immunosuppressive agents, such as FK 506 and rapamycin; immunostimulating agents, of which BCG vaccine is most important; and the remaining immunomodulators, which include the biological response modifiers. The last group, which encompasses the colony-stimulating factors (GM-CSF, G-CSF, and M-CSF), the interleukins, the interferons, and the tumour necrosis factors, is described in detail. Innovative research and medical applications of these cytokines, including indications, contraindications, and adverse reactions, are discussed. The role of monoclonal antibodies against endotoxins is also described.","PeriodicalId":19804,"journal":{"name":"Pharmaceutisch weekblad. Scientific edition","volume":"14 4A","pages":"245-52"},"PeriodicalIF":0.0,"publicationDate":"1992-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF01962546","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12608053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Strategies for identifying and developing new anticonvulsant drugs. 新抗惊厥药物的鉴定和开发策略。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1992-06-19 DOI: 10.1007/BF01962704

H J Kupferberg

{"title":"Strategies for identifying and developing new anticonvulsant drugs.","authors":"H J Kupferberg","doi":"10.1007/BF01962704","DOIUrl":"https://doi.org/10.1007/BF01962704","url":null,"abstract":"The identification of new anticonvulsant drugs depends on the use of different animal models of epilepsy. The models should be mechanism-independent, able to screen a large number of compounds, at limited cost and technical expertise. Primary screening models include genetic or reflex models of epilepsy and electrically and chemically induced seizures. Once active compounds have been identified, more advanced mechanistic and seizure-specific models are needed to refine the choice of a lead compound. These can be either in vivo or in vitro models. Models known to interact with specific receptors or the production of the putative neurotransmitters of neural excitability or inhibition are valuable in assessing possible mechanisms of action. In vitro models have evolved as important tools in correlating changes in electrical phenomena and therapeutic spectrum. The use of the hippocampal slice and the cultured neuron permits classification of anticonvulsant activity based on cellular actions of the drug. Interactions by the experimental drugs with specific subcellular fractions of the central nervous system augment information on possible mechanisms of action. The final choice of compounds for development requires synthesizing and comparing all of the pharmacodynamic information with the pharmacokinetic and toxicologic data. In the final analysis, no single animal model of epilepsy known today can assure the development of better drugs for all treatment of the epilepsies.","PeriodicalId":19804,"journal":{"name":"Pharmaceutisch weekblad. Scientific edition","volume":"14 3A","pages":"132-8"},"PeriodicalIF":0.0,"publicationDate":"1992-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF01962704","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12670716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7