发布求助
文献互助 智能选刊 最新文献

Pharmaceutisch weekblad. Scientific edition最新文献

筛选
英文 中文
Hydrocortisone anaphylaxis: a new case report. 氢化可的松过敏反应1例新报告。
Pharmaceutisch weekblad. Scientific edition Pub Date : 1992-06-19 DOI: 10.1007/BF01962693
N Corominas, J M Mañé, C Codina, M A Paz, J Ribas
{"title":"Hydrocortisone anaphylaxis: a new case report.","authors":"N Corominas,&nbsp;J M Mañé,&nbsp;C Codina,&nbsp;M A Paz,&nbsp;J Ribas","doi":"10.1007/BF01962693","DOIUrl":"https://doi.org/10.1007/BF01962693","url":null,"abstract":"<p><p>In this report we describe a case of a nonatopic patient who developed an anaphylactoid reaction immediately after receiving intravenous hydrocortisone. The patient recovered after reanimation techniques and intravenous administration of atropine, epinephrine and plasma expanders. Although allergic reactions to corticosteroids appear to be rare there are a few case reports in the literature. This case is presented to draw the attention of clinicians to the occasional hazard of intravenous corticosteroid preparations, specially hydrocortisone.</p>","PeriodicalId":19804,"journal":{"name":"Pharmaceutisch weekblad. Scientific edition","volume":"14 3","pages":"93-4"},"PeriodicalIF":0.0,"publicationDate":"1992-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF01962693","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12797510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Neural tube defects in association with epilepsy and its treatment. 与癫痫相关的神经管缺陷及其治疗。
Pharmaceutisch weekblad. Scientific edition Pub Date : 1992-06-19 DOI: 10.1007/BF01962702
D Chadwick
{"title":"Neural tube defects in association with epilepsy and its treatment.","authors":"D Chadwick","doi":"10.1007/BF01962702","DOIUrl":"https://doi.org/10.1007/BF01962702","url":null,"abstract":"","PeriodicalId":19804,"journal":{"name":"Pharmaceutisch weekblad. Scientific edition","volume":"14 3A","pages":"126"},"PeriodicalIF":0.0,"publicationDate":"1992-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF01962702","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12670714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Differentiation between valproate-induced anticonvulsant effect, teratogenicity and hepatotoxicity. Aspects of species variation, pharmacokinetics, metabolism and implications of structural specificity for the development of alternative antiepileptic agents such as delta 2-valproate. 丙戊酸诱导的抗惊厥作用、致畸性和肝毒性的鉴别。物种变异、药代动力学、代谢和结构特异性对开发替代抗癫痫药物如2-丙戊酸三角洲的影响。
Pharmaceutisch weekblad. Scientific edition Pub Date : 1992-06-19 DOI: 10.1007/BF01962697
H Nau, H Siemes
{"title":"Differentiation between valproate-induced anticonvulsant effect, teratogenicity and hepatotoxicity. Aspects of species variation, pharmacokinetics, metabolism and implications of structural specificity for the development of alternative antiepileptic agents such as delta 2-valproate.","authors":"H Nau,&nbsp;H Siemes","doi":"10.1007/BF01962697","DOIUrl":"https://doi.org/10.1007/BF01962697","url":null,"abstract":"<p><p>Valproate is metabolized into a large number of compounds via various metabolic routes. Metabolic profiles depend on species and age. Hepatotoxicity may be correlated with abnormal metabolism, especially in young age. Teratogenicity is associated with specific structural requirements: a free carboxyl atom connected to a carbon atom which also carries a hydrogen, and two carbon chains. This provides a clue for the development of alternative antiepileptic agents.</p>","PeriodicalId":19804,"journal":{"name":"Pharmaceutisch weekblad. Scientific edition","volume":"14 3A","pages":"101-7"},"PeriodicalIF":0.0,"publicationDate":"1992-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF01962697","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12671626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Direct measurement of probenecid and its glucuronide conjugate by means of high pressure liquid chromatography in plasma and urine of humans. 高压液相色谱法直接测定人血浆和尿液中丙戊酸及其葡萄糖醛酸偶联物的含量。
Pharmaceutisch weekblad. Scientific edition Pub Date : 1992-06-19 DOI: 10.1007/BF01962691
T B Vree, E W Beneken Kolmer
{"title":"Direct measurement of probenecid and its glucuronide conjugate by means of high pressure liquid chromatography in plasma and urine of humans.","authors":"T B Vree,&nbsp;E W Beneken Kolmer","doi":"10.1007/BF01962691","DOIUrl":"https://doi.org/10.1007/BF01962691","url":null,"abstract":"<p><p>Probenecid with its phase-I metabolites, and phase-II glucuronide conjugate can be analysed by a gradient high pressure liquid chromatographic method. Probenecid glucuronide in plasma with pH 7.4 is not stable and declines to 10% of the original value within 6 h (t1/2 approximately 1 h). Probenecid glucuronide is stable in urine with pH 5.0, moderately unstable at pH 6.0 (t1/2 approximately 10 h), and unstable at pH 8.0 (t1/2 approximately 0.5 h). Probenecid glucuronide is stable in water and 0.01 mol/l phosphoric acid in the autosampler of the high pressure liquid chromatograph. The decrease in concentration in water is 5.5% during 9 h and 0% in diluted acid. Probenecid glucuronide and the phase-I metabolites were not detectable in plasma. The main compound in fresh urine is the phase-II conjugate probenecid glucuronide (62% of a 500 mg dose); the phase-I metabolites are present and only a trace of probenecid is present. The percentage of the dose of the phase-I metabolites varies between 5 and 10, while hardly any probenecid is excreted unchanged (0.33%).</p>","PeriodicalId":19804,"journal":{"name":"Pharmaceutisch weekblad. Scientific edition","volume":"14 3","pages":"83-7"},"PeriodicalIF":0.0,"publicationDate":"1992-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF01962691","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12797508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Valproate hepatotoxicity syndrome: hypotheses of pathogenesis. 丙戊酸肝毒性综合征:发病机制假说。
Pharmaceutisch weekblad. Scientific edition Pub Date : 1992-06-19 DOI: 10.1007/BF01962700
J R Stephens, R H Levy
{"title":"Valproate hepatotoxicity syndrome: hypotheses of pathogenesis.","authors":"J R Stephens,&nbsp;R H Levy","doi":"10.1007/BF01962700","DOIUrl":"https://doi.org/10.1007/BF01962700","url":null,"abstract":"<p><p>Therapeutic use of the anticonvulsant valproate (VPA) has been associated with a rare, but severe and often fatal hepatotoxicity. Cases usually present with lethargy, anorexia, and vomiting with rapid progression to coma. Liver histopathology is characterized by steatosis with and without necrosis. In some instances only necrosis was present. Several hypotheses of pathogenesis have been postulated. These deal mainly with biochemical systems that are known to be affected by VPA, or with the possible idiosyncratic production of toxic VPA metabolites, especially delta 4-VPA. At present, no hypothesis entirely explains the diverse characteristics of the disorder.</p>","PeriodicalId":19804,"journal":{"name":"Pharmaceutisch weekblad. Scientific edition","volume":"14 3A","pages":"118-21"},"PeriodicalIF":0.0,"publicationDate":"1992-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF01962700","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12670712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 21
Centralized preparation of hazardous drugs. A choice between isolator and laminar airflow. 危险药品的集中配制。在隔离器和层流之间进行选择。
Pharmaceutisch weekblad. Scientific edition Pub Date : 1992-06-19 DOI: 10.1007/BF01962692
P Larrouturou, J Huchet, M C Taugourdeau
{"title":"Centralized preparation of hazardous drugs. A choice between isolator and laminar airflow.","authors":"P Larrouturou,&nbsp;J Huchet,&nbsp;M C Taugourdeau","doi":"10.1007/BF01962692","DOIUrl":"https://doi.org/10.1007/BF01962692","url":null,"abstract":"<p><p>In 1987, the manager of the Saint-Joseph Hospital (Paris, France) requested a reorganization of cytotoxic drug preparation. Protection for staff who handle hazardous drugs was the main concern. The conclusions drawn from a first analysis emphasize the advantages of a centralized reconstitution unit against a decentralized system. Subsequently, a workload study and an economic study (investment, maintenance, supplies, staff costs, comparative balance sheet and a 5-year simulation) were carried out, but to choose between a laminar airflow in aseptic room and an isolator in a conventional room. The selected isolator is the first of the conception: the central half-suit uses as a server, and four sleeves located on one side allow two technicians to work in a sterile and closed area without sterile garments.</p>","PeriodicalId":19804,"journal":{"name":"Pharmaceutisch weekblad. Scientific edition","volume":"14 3","pages":"88-92"},"PeriodicalIF":0.0,"publicationDate":"1992-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF01962692","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12797509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Clinical and pharmaceutical aspects in acute poisoning. 急性中毒的临床和药物方面。
Pharmaceutisch weekblad. Scientific edition Pub Date : 1992-06-19 DOI: 10.1007/BF01962690
R G Van Kesteren, D R Uges
{"title":"Clinical and pharmaceutical aspects in acute poisoning.","authors":"R G Van Kesteren,&nbsp;D R Uges","doi":"10.1007/BF01962690","DOIUrl":"https://doi.org/10.1007/BF01962690","url":null,"abstract":"<p><p>Today there are several methods for treating intoxicated patients. If these patients arrive in hospital in time, the diagnosis is correct and appropriate therapy is instituted, nearly all survive without any physical damage. This is best achieved by team-work between the hospital pharmacist and the physician treating the patient. Both should have a sound knowledge of the toxicological properties of drugs and other poisons and the clinical features which they produce. This article emphasizes the need for close co-operation between the pharmacist and the physician and discusses specific therapeutic measures, such as prevention of absorption, acceleration of elimination, symptomatic therapy and administration of antagonists.</p>","PeriodicalId":19804,"journal":{"name":"Pharmaceutisch weekblad. Scientific edition","volume":"14 3","pages":"78-82"},"PeriodicalIF":0.0,"publicationDate":"1992-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF01962690","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12797506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Recent developments on valproate and its metabolites. Proceedings of a workshop. Nijmegen, The Netherlands, 25 January 1991. 丙戊酸及其代谢物的最新研究进展。研讨会记录。奈梅亨，荷兰，1991年1月25日。
Pharmaceutisch weekblad. Scientific edition Pub Date : 1992-06-19
{"title":"Recent developments on valproate and its metabolites. Proceedings of a workshop. Nijmegen, The Netherlands, 25 January 1991.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":19804,"journal":{"name":"Pharmaceutisch weekblad. Scientific edition","volume":"14 3A","pages":"97-160"},"PeriodicalIF":0.0,"publicationDate":"1992-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12527492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Delta 2-valproate biotransformation using human liver microsomal fractions. 利用人肝微粒体组分进行2-丙戊酸三角洲生物转化。
Pharmaceutisch weekblad. Scientific edition Pub Date : 1992-06-19 DOI: 10.1007/BF01962707
G Fabre, C Briot, E Marti, J P Montseny, M Bourrié, D Massé, Y Berger, J P Cano
{"title":"Delta 2-valproate biotransformation using human liver microsomal fractions.","authors":"G Fabre,&nbsp;C Briot,&nbsp;E Marti,&nbsp;J P Montseny,&nbsp;M Bourrié,&nbsp;D Massé,&nbsp;Y Berger,&nbsp;J P Cano","doi":"10.1007/BF01962707","DOIUrl":"https://doi.org/10.1007/BF01962707","url":null,"abstract":"<p><p>The metabolism of 2-n-propyl-2-pentenoate (delta 2-VPA) was evaluated in human hepatic microsomal fractions. Two biotransformation pathways have been particularly investigated. In the presence of the cytochrome P-450 co-factor, NADPH, the main metabolites recovered were delta 3-VPA, delta 2,4-VPA and VPA. The glucuronidation of delta 2-VPA was also studied on various hepatic microsomal fractions using Brij 35 as activator and UDP-glucuronic acid as co-factor. A large interindividual variability occurred in this metabolic pathway. Km and Vmax were 0.85 mmol/l and 1.75 nmol.min-1.mg-1, respectively, for delta 2-VPA and 1.11 mmol/l and 5.71 nmol.min-1.mg-1 for VPA, respectively. The good correlation (r = 0.82; p less than 0.001) observed between the glucuronidation of VPA and delta 2-VPA as well as the mutual inhibition of each other's glucuronidation strongly suggests that (a) common single UDP-glucuronosyltransferase isoenzyme(s) was (were) involved in this glucuronidation step. The glucuronidation of specific substrates for various UDP-glucuronosyltransferase isoenzymes showed a good relationship between the glucuronidations of delta 2-VPA and morphine, a substrate for UDP-glucuronosyltransferase-2B. Moreover, morphine competitively inhibits delta 2-VPA glucuronidation. It seems the same isoenzyme or, at least, (a) very closely related isoenzyme(s) belonging to UDP-glucuronosyltransferase-2 isoenzyme, is involved in delta 2-VPA glucuronidation.</p>","PeriodicalId":19804,"journal":{"name":"Pharmaceutisch weekblad. Scientific edition","volume":"14 3A","pages":"146-51"},"PeriodicalIF":0.0,"publicationDate":"1992-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF01962707","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12670718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Influence of co-medication on the metabolism of valproate. 联合用药对丙戊酸代谢的影响。
Pharmaceutisch weekblad. Scientific edition Pub Date : 1992-06-19 DOI: 10.1007/BF01962698
F Pisani
{"title":"Influence of co-medication on the metabolism of valproate.","authors":"F Pisani","doi":"10.1007/BF01962698","DOIUrl":"https://doi.org/10.1007/BF01962698","url":null,"abstract":"<p><p>Valproate is extensively metabolized in the liver and at least six main pathways which produce about 50 metabolites have been identified in man. The enzyme-inducing antiepileptic drugs phenobarbital, primidone, phenytoin and carbamazepine increase total valproate clearance by 30-85%, whereas cimetidine and the new anticonvulsant compound striripentol display a small inhibitory effect (10-20%). Both carbamazepine and phenytoin induce a two-fold increase in the formation of delta 4-valproate and stimulate omega-oxidation and omega-1-oxidation. Acetylsalicylic acid causes a fall of 60-70% in the content in the urine of the metabolites of the beta-oxidative pathway, i.e. delta 2-valproate, 3-OH-valproate and 3-oxo-valproate, and an increase of glucuronidation (approximately 30%) and delta-dehydrogenation (approximately 20%). Stiripentol inhibits the formation clearance of delta 4-valproate by 30%. In the light of the possible therapeutic and toxic effects of some valproate metabolites, drug interactions with valproate at metabolic level may have important clinical implications.</p>","PeriodicalId":19804,"journal":{"name":"Pharmaceutisch weekblad. Scientific edition","volume":"14 3A","pages":"108-13"},"PeriodicalIF":0.0,"publicationDate":"1992-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF01962698","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12671627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 21
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信