Journal of Neuropsychology最新文献_第3页

Hippocampal contributions to semantic memory retrieval: Strategy-specific impairments in transient global amnesia 海马体对语义记忆检索的贡献：短暂性全身性失忆症的策略特异性损伤。

IF 1.8 4区心理学

Journal of Neuropsychology Pub Date : 2025-05-02 DOI: 10.1111/jnp.12430

Vesile Sandikci, Anne Ebert, Annika Marzina, Michael Platten, Kristina Szabo, Carolin Hoyer

{"title":"Hippocampal contributions to semantic memory retrieval: Strategy-specific impairments in transient global amnesia","authors":"Vesile Sandikci, Anne Ebert, Annika Marzina, Michael Platten, Kristina Szabo, Carolin Hoyer","doi":"10.1111/jnp.12430","DOIUrl":"10.1111/jnp.12430","url":null,"abstract":"Transient global amnesia (TGA), a transient memory disorder in clinical neurology, is a unique clinical model for the study of hippocampal dysfunction and its implications for memory processes. While data are rather unequivocal concerning the relevance of the hippocampus for episodic memory, there is considerable dispute about its role for semantic memory. This study aimed at exploring how hippocampal impairment, which underlies the clinical presentation of TGA, affects semantic memory retrieval, particularly with regard to different retrieval strategies. Data from the acute and post-acute phase of 17 TGA patients and 17 healthy controls matched on socio-demographic factors were collected. Categorical word fluency tasks were differentiated into three retrieval strategies: first, with activation of episodic-spatial memory content; second, with novel and flexible linking of semantic memory content and third, with activation of overlearned semantic memory content. We find that hippocampal impairment during TGA significantly restricts semantic word fluency performance, with the degree of impairment depending on the retrieval strategy used and most pronounced when flexible relinking of semantic content is required. Our results suggest an important hippocampal contribution to semantic retrieval, especially in connection with novel and flexible linking of semantic content. They may furthermore be practically relevant for the early differential diagnosis and therapy of memory disorders.","PeriodicalId":197,"journal":{"name":"Journal of Neuropsychology","volume":"19 3","pages":"591-602"},"PeriodicalIF":1.8,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bpspsychub.onlinelibrary.wiley.com/doi/epdf/10.1111/jnp.12430","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

On the complexity of biomarker-driven diagnoses of Alzheimer's disease 关于阿尔茨海默病生物标志物驱动诊断的复杂性。

IF 1.8 4区心理学

Journal of Neuropsychology Pub Date : 2025-05-02 DOI: 10.1111/jnp.12428

Stephanie M. Grasso, Miguel Ángel Santos-Santos, Alexandra Leigh Clark

{"title":"On the complexity of biomarker-driven diagnoses of Alzheimer's disease","authors":"Stephanie M. Grasso, Miguel Ángel Santos-Santos, Alexandra Leigh Clark","doi":"10.1111/jnp.12428","DOIUrl":"10.1111/jnp.12428","url":null,"abstract":"Updated criteria pertaining to the diagnosis of Alzheimer's disease (AD) have sparked debate over the reliance on biomarkers—particularly amyloid-β and phosphorylated tau. While biomarkers promise earlier detection and standardized criteria, the potential extension and interpretation of their use in asymptomatic individuals remains controversial. Many individuals with abnormal biomarker profiles never experience cognitive decline, raising concerns about overdiagnosis, unintended negative psychosocial consequences and the blurring line between risk and definitive diagnosis. We, and others, argue that biomarker positivity should be reframed not as a definitive diagnosis but rather as an indicator of elevated risk, particularly in the absence of cognitive symptoms. Doing so better aligns with current evidence, preserves clarity in diagnosis, and avoids unintended psychosocial consequences. Crucially, the role of cognitive reserve—influenced by education, other life experiences and structural inequities—must be considered, particularly among racially and ethnically diverse populations historically underrepresented in AD research. Biomarker thresholds (as well as neuropsychological tools) derived from predominantly non-Hispanic white cohorts may not generalize across groups, risking misclassification and inequity. As the field moves towards precision medicine and AI-driven risk models, inclusive data and culturally valid frameworks are essential. Ultimately, embracing a risk-based, multifactorial approach respects the complexity of AD and promotes equitable care. This perspective calls for interdisciplinary collaboration to refine diagnostic strategies that are scientifically grounded, socially conscious and responsive to the lived realities of diverse populations. Only then can we responsibly integrate biomarkers into practice without sacrificing nuance.","PeriodicalId":197,"journal":{"name":"Journal of Neuropsychology","volume":"19 2","pages":"176-185"},"PeriodicalIF":1.8,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial introduction to the special issue on biomarker-based diagnosis of Alzheimer's disease: A synthesis of the commentaries 对基于生物标志物的阿尔茨海默病诊断的特刊的编辑介绍：评论的综合。

IF 1.8 4区心理学

Journal of Neuropsychology Pub Date : 2025-04-23 DOI: 10.1111/jnp.12427

Davide Bruno, Jamie Reilly

{"title":"Editorial introduction to the special issue on biomarker-based diagnosis of Alzheimer's disease: A synthesis of the commentaries","authors":"Davide Bruno, Jamie Reilly","doi":"10.1111/jnp.12427","DOIUrl":"10.1111/jnp.12427","url":null,"abstract":"We introduce a special issue of the Journal of Neuropsychology dedicated to a recent paradigm shift in Alzheimer's disease diagnosis. Joint workgroups from the (US) National Institute on Aging and the Alzheimer's Association (NIA-AA) recently issued policy guidelines reclassifying Alzheimer's disease as a biological entity. These guidelines shift the onus of diagnosis in favour of protein biomarkers, relegating cognitive symptoms (e.g. subjective memory and language disorders) as supportive rather than core features. We invited experts in the study of Alzheimer's disease and Related Disorders (ADRDs) to express their views on this paradigmatic shift in dementia management. In this editorial, we synthesize some of the main points advanced in the commentaries. Contributors identified the promise of blood-based biomarker testing for improving equitable detection of dementia in large swathes of the world population. This enthusiasm was tempered by concerns about the biomarker-only diagnostic approach, including the potential for significant harm (e.g. stigma, depression, suicide) caused by labelling asymptomatic older adults who might otherwise never behaviourally express the underlying disease pathology.","PeriodicalId":197,"journal":{"name":"Journal of Neuropsychology","volume":"19 2","pages":"149-153"},"PeriodicalIF":1.8,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional magnetic resonance imaging of taxonomic and thematic processing of abstract and concrete word pairs 抽象和具体词对分类和主题加工的功能磁共振成像。

IF 1.8 4区心理学

Journal of Neuropsychology Pub Date : 2025-03-29 DOI: 10.1111/jnp.12424

Jacquelyn F. Stochel, Chaleece W. Sandberg

{"title":"Functional magnetic resonance imaging of taxonomic and thematic processing of abstract and concrete word pairs","authors":"Jacquelyn F. Stochel, Chaleece W. Sandberg","doi":"10.1111/jnp.12424","DOIUrl":"10.1111/jnp.12424","url":null,"abstract":"This study used fMRI to examine the effect that the abstract-concrete dimension may have on the thematic-taxonomic distinction. The dual hub theory (DHT) posits that left angular gyrus supports thematic relationships and left temporal pole supports taxonomic relationships; however, the DHT is largely based on evidence from concrete words. It is important that theories of semantic organization include abstract words as they are ubiquitous in everyday discourse (Lupyan & Winter, Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 2018, 373, 20170137). Additionally, there is reason to believe that there may bean interaction between the abstract-concrete dimension and the thematic-taxonomic distinction, based on the different representational frameworks (DRF) hypothesis, which posits that abstract concepts are primarily organized by association/theme, and that concrete concepts are primarily organized by similarity/taxonomy. However, there appears to be a mismatch among the DHT, predictions of the DRF hypothesis for brain activation, and existing neuroimaging data for the concreteness effect. Thus, we sought to include abstract words in a test of the DHT and determine whether any interactions exist between the abstract-concrete dimension and the thematic-taxonomic distinction. While we replicated the localization of abstract and concrete word processing, we did not extend the DHT to include abstract words, nor did we find an interaction that would support the DRF hypothesis. Rather, our results align more closely with the hub-and-spoke model (Patterson et al., Nature Reviews Neuroscience, 2007, 8, 976).","PeriodicalId":197,"journal":{"name":"Journal of Neuropsychology","volume":"19 3","pages":"541-558"},"PeriodicalIF":1.8,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bpspsychub.onlinelibrary.wiley.com/doi/epdf/10.1111/jnp.12424","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Learning from missteps: Potential of transcranial electrical stimulation in neuropsychological rehabilitation 从失误中学习：经颅电刺激在神经心理康复中的潜力。

IF 1.8 4区心理学

Journal of Neuropsychology Pub Date : 2025-03-23 DOI: 10.1111/jnp.12425

Carlo Miniussi, Maria Concetta Pellicciari

{"title":"Learning from missteps: Potential of transcranial electrical stimulation in neuropsychological rehabilitation","authors":"Carlo Miniussi, Maria Concetta Pellicciari","doi":"10.1111/jnp.12425","DOIUrl":"10.1111/jnp.12425","url":null,"abstract":"Transcranial electrical stimulation (tES) holds promise for neuropsychological rehabilitation by leveraging the brain's inherent plasticity to enhance cognitive and motor functions. However, early results have been variable due to oversimplified approaches. This manuscript explores the potential and complexities of tES, particularly focusing on a protocol defined transcranial direct current stimulation as a reference model for all tES protocols, emphasising the need for precision in tailoring stimulation parameters to individual characteristics. By integrating intrinsic (i.e. the neuro-physiological system state) and extrinsic factors (i.e. experimental set up), highlighting the critical role of state-dependent effects and the synergy with cognitive tasks, we aim to refine tES protocols. This approach not only addresses the complexity of the brain system (as defined by its current state) but also highlights the importance of collaborative research and data sharing to understand the underlying mechanisms of tES-induced changes and optimising therapeutic efficacy. Emphasising the integration of tES with targeted tasks and clearer hypotheses, this work underscores the potential for more effective neurorehabilitation strategies.","PeriodicalId":197,"journal":{"name":"Journal of Neuropsychology","volume":"19 3","pages":"655-681"},"PeriodicalIF":1.8,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bpspsychub.onlinelibrary.wiley.com/doi/epdf/10.1111/jnp.12425","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial acknowledgement 社论承认

IF 1.8 4区心理学

Journal of Neuropsychology Pub Date : 2025-03-09 DOI: 10.1111/jnp.12402

引用次数: 0

Slowly learned but not forgotten: New learning in a case of childhood-acquired amnesia 慢慢学会但不忘记：儿童获得性失忆症案例中的新学习。

IF 1.8 4区心理学

Journal of Neuropsychology Pub Date : 2025-03-06 DOI: 10.1111/jnp.12423

Kata Pauly-Takacs, Chris J. A. Moulin

引用次数: 0

New onset abnormal eating behaviour following amygdalohippocampal laser ablation for mesial temporal epilepsy 杏仁核海马激光消融术治疗中颞叶癫痫后新出现的异常进食行为。

IF 1.8 4区心理学

Journal of Neuropsychology Pub Date : 2025-02-26 DOI: 10.1111/jnp.12422

Yosefa A. Modiano, Benjamin Eschler, Gabrielle Flores, Kathryn Synder

引用次数: 0

Digit span and Bisyllabic non-word span: Italian norms 数字跨度和双音节非词跨度：意大利标准。

IF 1.8 4区心理学

Journal of Neuropsychology Pub Date : 2025-02-26 DOI: 10.1111/jnp.12420

Konstantinos Priftis, Daphne Gasparre, Denyse Carazzolo, Valeria Vaccaro, Roberta Toffano, Marco Pitteri, Massimo Grassi

{"title":"Digit span and Bisyllabic non-word span: Italian norms","authors":"Konstantinos Priftis, Daphne Gasparre, Denyse Carazzolo, Valeria Vaccaro, Roberta Toffano, Marco Pitteri, Massimo Grassi","doi":"10.1111/jnp.12420","DOIUrl":"10.1111/jnp.12420","url":null,"abstract":"We standardized a new version of the Digit span test and the first version of the Bisyllabic non-word span test, both measuring the phonological loop, in an Italian sample of neurologically healthy adults (n = 225). All stimuli were administered to the participants through a computerized procedure to avoid the influence of the examiner on participants' performance. We used a preliminary test to exclude the presence of sensory-perceptual and articulatory-motor difficulties that might have influenced the results. The results revealed that both Age and Education were significant predictors of participants' performance on the Digit span test. By contrast, only Age predicted significantly participants' performance on the Bisyllabic non-word span test. The average Digit span was approximately twice as large as the average Bisyllabic non-word span, suggesting that the latter might be a strategy-free measure of the phonological loop. The Bisyllabic non-word span is an innovative and specific measure for identifying phonological short-term memory deficits. For all tests, adjusted and equivalent scores are provided to facilitate results interpretation and clinical applicability.","PeriodicalId":197,"journal":{"name":"Journal of Neuropsychology","volume":"19 3","pages":"520-540"},"PeriodicalIF":1.8,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bpspsychub.onlinelibrary.wiley.com/doi/epdf/10.1111/jnp.12420","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143497675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validation of the computerised battery for neuropsychological evaluation of children (BENCI) in a Cuban sample 在古巴样本中验证儿童神经心理评估计算机化电池（BENCI）。

IF 1.8 4区心理学

Journal of Neuropsychology Pub Date : 2025-02-17 DOI: 10.1111/jnp.12418

María Nieves Pérez-Marfil, Manuel Fernández-Alcántara, Elena Navarro, Xiomara García-Navarro, Francisco Cruz-Quintana

{"title":"Validation of the computerised battery for neuropsychological evaluation of children (BENCI) in a Cuban sample","authors":"María Nieves Pérez-Marfil, Manuel Fernández-Alcántara, Elena Navarro, Xiomara García-Navarro, Francisco Cruz-Quintana","doi":"10.1111/jnp.12418","DOIUrl":"10.1111/jnp.12418","url":null,"abstract":"The aim of this research was to analyse the reliability and validity of the Computerised Battery for Neuropsychological Evaluation of Children (BENCI) in a Cuban population of children and adolescents. The study involved 1714 Cuban students between the ages of 6 and 18 who were divided into three groups according to their level of education (Elementary: 6–11 years old; High School: 12–14 years old; and Pre-University: 15–18 years old). All participants were evaluated using the BENCI with some also undergoing additional neuropsychological testing. The BENCI evaluates the following cognitive domains: processing speed, visuomotor coordination, attention, memory, language, and executive functions. The results showed that the BENCI has good test–retest reliability indices and high internal consistency values in Reasoning, Reaction Time, and Working Memory. In terms of validity, the data revealed significant correlations between the BENCI tests and other neuropsychological tests assessing similar cognitive functions. The BENCI also has discriminative validity, as it was found that performance on the tests varies according to the level of education of those being evaluated. In terms of construct validity, confirmatory factor analysis showed that the fit indices for the executive functions dimension of the BENCI are adequate. The data show that the BENCI is a reliable and valid instrument for assessing neurodevelopment in Cuban children and adolescents. Since this is the first neuropsychological test of its kind to be validated in the Cuban population, this finding is of particular importance.","PeriodicalId":197,"journal":{"name":"Journal of Neuropsychology","volume":"19 3","pages":"499-519"},"PeriodicalIF":1.8,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bpspsychub.onlinelibrary.wiley.com/doi/epdf/10.1111/jnp.12418","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0