Pamukkale Medical Journal最新文献

Gender-Specific Effects of Alternate-Day Fasting on Body Weight, Oxidative Stress, and Metabolic Health in Middle-Aged Rats 隔日禁食对中年大鼠体重、氧化应激和代谢健康的性别特异性影响

Pamukkale Medical Journal Pub Date : 2024-06-12 DOI: 10.31362/patd.1487708

Özgen Kılıç Erkek, G. Gündoğdu

引用次数: 0

An Effective Treatment for Progressive Keratoconus with Two-Year Outcomes: Accelerated Epithelium-on Corneal Cross-Linking 一种治疗进展性角膜炎的有效方法，疗效可达两年：加速角膜上皮交联术

Pamukkale Medical Journal Pub Date : 2024-06-12 DOI: 10.31362/patd.1460362

Muhammet Kaim, Murat Okutucu, H. Fındık, Feyzahan Uzun

引用次数: 0

The influence of anesthesia type on recurrence of the non-muscle invasive bladder tumor according to risk groups: 3 year follow up 按风险组别划分的麻醉类型对非肌层浸润性膀胱肿瘤复发的影响：3 年随访

Pamukkale Medical Journal Pub Date : 2024-06-05 DOI: 10.31362/patd.1443444

S. Çelen, Aslı Mete, Yusuf Özlülerden, M. Duran, Kürşat Küçüker, Alper Şimşek, A. Başer, Yunus Yaz, Kadir Ömür Günseven

{"title":"The influence of anesthesia type on recurrence of the non-muscle invasive bladder tumor according to risk groups: 3 year follow up","authors":"S. Çelen, Aslı Mete, Yusuf Özlülerden, M. Duran, Kürşat Küçüker, Alper Şimşek, A. Başer, Yunus Yaz, Kadir Ömür Günseven","doi":"10.31362/patd.1443444","DOIUrl":"https://doi.org/10.31362/patd.1443444","url":null,"abstract":"Purpose: Many risk factors affecting bladder cancer recurrence, such as genetic and environmental factors, have been previously identified. It has been stated that risk factors that cause immunosuppression play a role in the spread of cancer cells. Anesthetic agent, which is a perioperative factor, may affect the risk of cancer recurrence by disrupting the immune system. The aim of this study was to compare the effect of regional anesthesia (RA) and general anesthesia (GA) on non-muscle invasive bladder cancers (NMIBC) recurrence. \u0000Materials and methods: A total of one hundred seventy-eight patients who underwent transurethral bladder tumor resection (TURBT) for NMIBC and underwent surgery under GA or RA between 2011 and 2016 in the urology departments of Pamukkale University and Uludağ University were included in the study. In the first group, 80 patients had RA. In the second group, 98 patients underwent GA during TURBT for NMIBC. \u0000Results: The recurrence time was shorter in the GA group (5.5 months) than in the RA group (11 months) (p=0.015). First-year relapse was higher in the GA group than in the RA group (p=0.048), but there was no difference in third-year relapse between groups (p=0.810). The mean recurrence time was 11 months (95% CI; 9.058 - 12.942) in the RA group and 5 months (95% CI; 2.090 - 7.910) in the GA group (p=0.031). \u0000Conclusion: During transurethral resection of the bladder tumor, an increase in the recurrence time was observed in patients with intermediate-risk NMIBC who received RA compared to patients who received GA. RA provided a 7-month benefit in relapse delay.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141385695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does vitamin D deficiency affect ventricular repolarization in the elderly? 维生素 D 缺乏会影响老年人心室的再极化吗？

Pamukkale Medical Journal Pub Date : 2024-03-22 DOI: 10.31362/patd.1382849

I. Akbulut, Busra Yurumez Korkmaz, Volkan Atmış, M. Varlı

{"title":"Does vitamin D deficiency affect ventricular repolarization in the elderly?","authors":"I. Akbulut, Busra Yurumez Korkmaz, Volkan Atmış, M. Varlı","doi":"10.31362/patd.1382849","DOIUrl":"https://doi.org/10.31362/patd.1382849","url":null,"abstract":"Introduction: The aim of the current study is to establish whether vitamin D deficiency interacts with the electrocardiographic indices of abnormal ventricular repolarization in elderly patients. Material and Methods: 138 patients were divided into three groups: patients with vitamin D deficiency, patients with vitamin D insufficiency, and patients with adequate vitamin D levels. 12-lead electrocardiography and laboratory data were collected. Results: The resting heart rate, PR interval, QRS duration, QTd, and Tp-e dispersion were similar among the groups. However, the QTc interval was significantly prolonged in patients with vitamin D deficiency, when compared to patients with sufficient vitamin D levels. Vitamin D level was found as the only independent predictor of the QTc interval. The cut-off value of Vitamin D level determining the significant prolongation of QTc interval was found to be 20 ng/ml on ROC analysis (Area Under Curve: 0,629±0.051 (95% CI: 0,530-0.728, p=0.013). Conclusion: Low vitamin D levels are associated with QTc prolongation in the elderly. Vitamin D-deficient elderly patients may benefit from routine ECG screening. Timely diagnosis and treatment of vitamin D deficiency may aid in reducing the rate of arrhythmias in this patient population.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140215253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current Approaches, Significance and Prognostic Impact of Lumbar Ligament Flavum Preserving Surgeries 保留腰椎韧带手术的当前方法、意义和预后影响

Pamukkale Medical Journal Pub Date : 2024-03-20 DOI: 10.31362/patd.1420935

B. C. Alpergin, Murat Zaimoğlu, Ömer Mert Özpi̇şki̇n, Elif Gokalp, Murat Buyuktepe, F. Yakar, Ümit Eroğlu

{"title":"Current Approaches, Significance and Prognostic Impact of Lumbar Ligament Flavum Preserving Surgeries","authors":"B. C. Alpergin, Murat Zaimoğlu, Ömer Mert Özpi̇şki̇n, Elif Gokalp, Murat Buyuktepe, F. Yakar, Ümit Eroğlu","doi":"10.31362/patd.1420935","DOIUrl":"https://doi.org/10.31362/patd.1420935","url":null,"abstract":"Objectives: The aim of this study is to evaluate the use of flavum-preserving surgeries in lumbar disc herniation surgery, compare their clinical outcomes with standard microdiscectomy techniques, and demonstrate the transflaval microdiscectomy technique. \u0000Material and Methods: Between 2020 and 2023, a total of 48 patients who underwent transflaval microdiscectomy and 48 patients who underwent standard microdiscectomy at a single center were included in the study. Epidemiologic characteristics of the groups were described, and preoperative and postoperative visual analoge scale scores for leg pain (LPVAS) and back pain (BPVAS) were retrospectively analyzed. \u0000Results: There is no significant difference between the groups in preoperative mean LPVAS scores (p=0,474) and there is no significant difference between the groups in postoperative mean LPVAS scores (p=0,598). There is no significant difference between the groups in preoperative mean BPVAS scores (p=0,608). However there is a significant difference between the groups in postoperative mean BPVAS scores (p","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140224192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of boric acid on oxidant-antioxidant, proinflammatory cytokine levels, and biochemical parameters in aged rats 硼酸对老龄大鼠氧化抗氧化剂、促炎细胞因子水平和生化指标的影响

Pamukkale Medical Journal Pub Date : 2024-03-19 DOI: 10.31362/patd.1438593

Mehmet Başeğmez, Muhammed Fatih Doğan

引用次数: 0

YÜKSEK FRUKTOZLA BESLENEN SIÇANLARDA QUERCETİN’İN PERİRENAL YAĞ DOKUSUNDAKİ ADİPONEKTİN VE REZİSTİN DÜZEYLERİNE ETKİSİ 槲皮素对高果糖喂养大鼠肾周脂肪组织中脂肪连素和抵抗素水平的影响

Pamukkale Medical Journal Pub Date : 2024-03-15 DOI: 10.31362/patd.1398168

Emine KILIÇ TOPRAK, Melek TUNÇ-ATA

{"title":"YÜKSEK FRUKTOZLA BESLENEN SIÇANLARDA QUERCETİN’İN PERİRENAL YAĞ DOKUSUNDAKİ ADİPONEKTİN VE REZİSTİN DÜZEYLERİNE ETKİSİ","authors":"Emine KILIÇ TOPRAK, Melek TUNÇ-ATA","doi":"10.31362/patd.1398168","DOIUrl":"https://doi.org/10.31362/patd.1398168","url":null,"abstract":"Obesity is defined as the accumulation of adipose tissue to excess and to an extent that impairs both physical and psychosocial health and well-being. The increase in adipose tissue observed in obesity causes proinflammatory and anti-inflammatory cytokine imbalance. Accumulating evidence on quercetin, one of the antioxidants frequently used in obesity treatment, suggests that quercetin has significant anti-obesity and lipid-lowering effects simultaneously. We hypothesized that quercetin supplementation could improve obesity parameters and restore adipokine balance in obese mice. Sprague Dawley rats, 8-10 weeks of age, were divided into 4 groups, including a control group (C), high fructose (HF) group, quercetine (Q) group, and high fructose+quercetin (HF+Q) group. Fructose was administered to HF groups as a 20% solution in drinking water for 6 weeks. The rats in the Q groups were given 50 mg quercetin per kg BW by gavage for the next 4 weeks. The body weight, lee index, TG, HDL, fasting insülin, fasting glucose, and HOMA-IR were determined in rats. ADP and resistin levels were determined by ELISA assay from perirenal adipose tissue homogenates. We showed that quercetin acts to improve TG, fasting glucose and insulin resistance in high fructose-fed rats. In this study, we found no effect of quercetin on perirenal adipose tissue ADP and resistin levels. These results showed that high fructose could induce obesity in rats, while quercetin could favorably affect these parameters.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140239698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Künt Çoklu Travmalı Hastalarda Mortalite Belirleyicisi Olarak Laboratuvar Parametrelerinin Araştırılması 实验室参数作为多处钝性创伤患者死亡率预测指标的研究

Pamukkale Medical Journal Pub Date : 2024-03-15 DOI: 10.31362/patd.1435793

Mümin Murat Yazici, Nurullah Parça, Utku Sarp Ceri̇t, Özlem Bi̇li̇r

{"title":"Künt Çoklu Travmalı Hastalarda Mortalite Belirleyicisi Olarak Laboratuvar Parametrelerinin Araştırılması","authors":"Mümin Murat Yazici, Nurullah Parça, Utku Sarp Ceri̇t, Özlem Bi̇li̇r","doi":"10.31362/patd.1435793","DOIUrl":"https://doi.org/10.31362/patd.1435793","url":null,"abstract":"Purpose: In trauma patients, vital signs may not be beneficial in patient management. Therefore, evaluating vital signs, some laboratory parameters, and imaging methods is essential in managing trauma patients. Based on the hypothesis that lactate and base excess (BE) is an early marker of morbidity and mortality in the evaluation in blunt multi-trauma patients, we aimed to investigate the value of lactate albumin ratio and lactate dehydrogenase (LDH) albumin ratio in addition to lactate and BE in predicting mortality in blunt multi-trauma patients. \u0000Materials and methods: This was a single-centre, retrospective study. Prior to data collection, approval was obtained from the local ethics committee (decision no. 2024/29). Patients admitted with multi-trauma to the emergency department of a tertiary education and research hospital in Turkey between January 1, 2018, and December 31, 2021, who did not meet the exclusion criteria, were included in the study. This study was he predictive value of Lactate, BE, Lactate to albumin ratio, and LDH to albumin ratio in predicting mortality in blunt multi-trauma patients. \u0000Results: The lactate cut-off value for mortality was 4.2, exhibiting 73.3% sensitivity and 89.2% specificity. The BE cut-off value for mortality was -3, exhibiting 80.0% sensitivity and 76.9% specificity. The lactate albumin ratio cut-off value for mortality was 0.11, exhibiting 73.3% sensitivity and 90.8% specificity. The LDH albumin ratio cut-off value for mortality was 7.2, exhibiting 86.7% sensitivity and 58.5% specificity. \u0000Conclusion: Lactate albumin ratio was more specific in predicting mortality than lactate and BE, while LDH albumin ratio was more sensitive in predicting mortality than lactate and BE.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140241099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Türkiye’de Doğu Anadolu bölgesinde spinal travmaların tanımlayıcı özellikleri: 3 yıllık retrospektif analiz. 土耳其东安纳托利亚地区脊柱创伤的描述性特征：三年回顾性分析

Pamukkale Medical Journal Pub Date : 2024-03-14 DOI: 10.31362/patd.1443672

Mürteza Çakir, Fatma Tortum, Kamber Kaşali̇

{"title":"Türkiye’de Doğu Anadolu bölgesinde spinal travmaların tanımlayıcı özellikleri: 3 yıllık retrospektif analiz.","authors":"Mürteza Çakir, Fatma Tortum, Kamber Kaşali̇","doi":"10.31362/patd.1443672","DOIUrl":"https://doi.org/10.31362/patd.1443672","url":null,"abstract":"Purpose: \u0000Understanding the descriptive characteristics of traumatic spinal injuries such as etiology, epidemiology, mortality and their associations with mortality may facilitate the diagnosis and management of spinal traumas. Moreover, its incidence can be reduced through eliminating preventable causes. The present study aimed to assess the descriptive characteristics of spinal traumas and the conditions associated with mortality in our country. \u0000Materials and methods: \u0000Our study was conducted retrospectively in the emergency service of a tertiary care hospital. Data of patients visiting to our hospital’s emergency room between 2020 and 2023 with spinal trauma, were obtained from the hospital information management system by scanning electronic patient records for inclusion in the study. \u0000Results: \u0000A total of 1835 patients were included in our study, of which 427 (23.3%) were female and 1408 (76.7%) were male. The most common complaint of the included patients who presented to the emergency room was observed as falls (n꞊1112). 52.8% (n=968) of those patients with special traumas had other concomitant injury. 3.7% (n=68) of the included patients resulted in death. \u0000Conclusion: \u0000Falls are the most common cause of special traumas in our country and concomitant head trauma and thoracic trauma are closely associated with mortality. While men are more frequently presented to the emergency room with special trauma, there has been no difference between both sexes in terms of mortality rate. Moreover, the most common vertebral fractures after spinal trauma occur in the parts of the corpus and spinous processes of the lumbar vertebrae.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140243369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Cardiometabolic Control and Malnutrition on the Prevalence and Prognosis of Diabetic Retinopathy in Type 2 Diabetes 心血管代谢控制和营养不良对 2 型糖尿病视网膜病变患病率和预后的影响

Pamukkale Medical Journal Pub Date : 2024-03-11 DOI: 10.31362/patd.1419095

Melek Özdemi̇r, Yaşar Dağ, Mehmet Uzunlulu, A. Oguz, Aylin Ardagi̇l, Ömer Acar, Bensu Selbest

引用次数: 0