实验室参数作为多处钝性创伤患者死亡率预测指标的研究

Mümin Murat Yazici, Nurullah Parça, Utku Sarp Ceri̇t, Özlem Bi̇li̇r
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引用次数: 0

摘要

目的:在创伤患者中,生命体征可能不利于患者的管理。因此,评估生命体征、一些实验室参数和影像学方法对管理创伤患者至关重要。基于乳酸和碱过多(BE)是评估钝性多发创伤患者发病率和死亡率的早期标志物这一假设,我们旨在研究除乳酸和BE外,乳酸白蛋白比值和乳酸脱氢酶(LDH)白蛋白比值在预测钝性多发创伤患者死亡率方面的价值。材料和方法:这是一项单中心回顾性研究。在收集数据之前,已获得当地伦理委员会的批准(第 2024/29 号决定)。研究纳入了 2018 年 1 月 1 日至 2021 年 12 月 31 日期间土耳其一家三级教育研究医院急诊科收治的多重创伤患者,这些患者不符合排除标准。本研究旨在探讨乳酸、BE、乳酸与白蛋白比值、LDH与白蛋白比值在预测钝性多发创伤患者死亡率方面的预测价值。结果:乳酸的死亡率临界值为 4.2,灵敏度为 73.3%,特异度为 89.2%。BE死亡率临界值为-3,灵敏度为80.0%,特异度为76.9%。乳酸白蛋白比率的死亡率临界值为 0.11,灵敏度为 73.3%,特异度为 90.8%。死亡率的 LDH 白蛋白比率临界值为 7.2,显示出 86.7% 的灵敏度和 58.5% 的特异性。结论乳酸白蛋白比值在预测死亡率方面比乳酸和 BE 更特异,而 LDH 白蛋白比值在预测死亡率方面比乳酸和 BE 更敏感。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Künt Çoklu Travmalı Hastalarda Mortalite Belirleyicisi Olarak Laboratuvar Parametrelerinin Araştırılması
Purpose: In trauma patients, vital signs may not be beneficial in patient management. Therefore, evaluating vital signs, some laboratory parameters, and imaging methods is essential in managing trauma patients. Based on the hypothesis that lactate and base excess (BE) is an early marker of morbidity and mortality in the evaluation in blunt multi-trauma patients, we aimed to investigate the value of lactate albumin ratio and lactate dehydrogenase (LDH) albumin ratio in addition to lactate and BE in predicting mortality in blunt multi-trauma patients. Materials and methods: This was a single-centre, retrospective study. Prior to data collection, approval was obtained from the local ethics committee (decision no. 2024/29). Patients admitted with multi-trauma to the emergency department of a tertiary education and research hospital in Turkey between January 1, 2018, and December 31, 2021, who did not meet the exclusion criteria, were included in the study. This study was he predictive value of Lactate, BE, Lactate to albumin ratio, and LDH to albumin ratio in predicting mortality in blunt multi-trauma patients. Results: The lactate cut-off value for mortality was 4.2, exhibiting 73.3% sensitivity and 89.2% specificity. The BE cut-off value for mortality was -3, exhibiting 80.0% sensitivity and 76.9% specificity. The lactate albumin ratio cut-off value for mortality was 0.11, exhibiting 73.3% sensitivity and 90.8% specificity. The LDH albumin ratio cut-off value for mortality was 7.2, exhibiting 86.7% sensitivity and 58.5% specificity. Conclusion: Lactate albumin ratio was more specific in predicting mortality than lactate and BE, while LDH albumin ratio was more sensitive in predicting mortality than lactate and BE.
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