YÜKSEK FRUKTOZLA BESLENEN SIÇANLARDA QUERCETİN’İN PERİRENAL YAĞ DOKUSUNDAKİ ADİPONEKTİN VE REZİSTİN DÜZEYLERİNE ETKİSİ

Abstract

Obesity is defined as the accumulation of adipose tissue to excess and to an extent that impairs both physical and psychosocial health and well-being. The increase in adipose tissue observed in obesity causes proinflammatory and anti-inflammatory cytokine imbalance. Accumulating evidence on quercetin, one of the antioxidants frequently used in obesity treatment, suggests that quercetin has significant anti-obesity and lipid-lowering effects simultaneously. We hypothesized that quercetin supplementation could improve obesity parameters and restore adipokine balance in obese mice. Sprague Dawley rats, 8-10 weeks of age, were divided into 4 groups, including a control group (C), high fructose (HF) group, quercetine (Q) group, and high fructose+quercetin (HF+Q) group. Fructose was administered to HF groups as a 20% solution in drinking water for 6 weeks. The rats in the Q groups were given 50 mg quercetin per kg BW by gavage for the next 4 weeks. The body weight, lee index, TG, HDL, fasting insülin, fasting glucose, and HOMA-IR were determined in rats. ADP and resistin levels were determined by ELISA assay from perirenal adipose tissue homogenates. We showed that quercetin acts to improve TG, fasting glucose and insulin resistance in high fructose-fed rats. In this study, we found no effect of quercetin on perirenal adipose tissue ADP and resistin levels. These results showed that high fructose could induce obesity in rats, while quercetin could favorably affect these parameters.