隔日禁食对中年大鼠体重、氧化应激和代谢健康的性别特异性影响

Özgen Kılıç Erkek, G. Gündoğdu
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引用次数: 0

摘要

目的:本研究旨在评估隔日禁食(ADF)对性别的影响及其在与衰老相关的全身和组织水平氧化应激改变中的功能。材料和方法:将42只雌性(n=21)和雄性(n=21)Wistar大鼠(年龄16个月)分为6组(每组n=7):第1组(对照组-雄性)、第2组(1个月,ADF-雄性)、第3组(2个月,ADF-雄性)、第4组(对照组-雌性)、第5组(1个月,ADF-雌性)和第6组(2个月,ADF-雌性)。ADF方案每隔一天实施一次,禁食24小时(每周三天)。通过 ELISA 分析血清样本以测量总氧化-抗氧化状态(TOS-TAS),并计算氧化应激指数(OSI)。结果:与对照组相比,ADF 治疗 2 个月可降低体重(P
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Gender-Specific Effects of Alternate-Day Fasting on Body Weight, Oxidative Stress, and Metabolic Health in Middle-Aged Rats
Purpose: The purpose of this study was to assess the effect of alternate-day fasting (ADF) concerning sex as well as its function in systemic and tissue-level oxidative stress alterations associated with aging. Materials and methods: Forty-two female (n=21) and male (n=21) Wistar rats (aged 16 months) were separated into six groups (n=7 each):Group-1 (control-male), Group-2 (1-month,ADF-male), Group-3 (2-month,ADF-male), Group-4 (control-female), Group-5 (1-month,ADF-female), and Group-6 (2-month,ADF-female). The ADF protocol was applied every other day for 24-h of fasting (three days/week). Serum samples were analyzed via ELISA to measure total oxidant-antioxidant status (TOS-TAS), and the oxidative stress index (OSI) was calculated. Results: 2-months of ADF treatment reduced body weight (BW) compared compliance control groups (P
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