Effects of boric acid on oxidant-antioxidant, proinflammatory cytokine levels, and biochemical parameters in aged rats

Mehmet Başeğmez, Muhammed Fatih Doğan
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引用次数: 0

Abstract

Purpose: As a result of the literature studies, it was seen that boric acid was the subject of many studies, and its effects on living things were investigated and examined. The aim of this study was to investigate the effects of oral boric acid supplementation at pharmacologic doses on physiological and biochemical systems in aged rats. Material and methods: A total of 32 Wistar Albino male-aged rats were randomly and equally divided into the following four groups: 1st; Control=1 ml saline; 2nd; Low-dose boric acid (L-BA)=10 mg/kg; 3rd; Medium-dose boric acid (M-BA)=20 mg/kg; 4th; High-dose boric acid (H-BA)=40 mg/kg. Boric acid was given orally to aged rats for 28 days. Blood, liver, and kidney samples of rats were collected on day 29 to be analyzed for oxidants, antioxidants, proinflammatory cytokines, and biochemical changes. Result: Boric acid significantly increased albumin, total protein, calcium levels equally in all boric acid groups compared to the control group (p
硼酸对老龄大鼠氧化抗氧化剂、促炎细胞因子水平和生化指标的影响
目的:通过文献研究,我们发现硼酸是许多研究的主题,并对其对生物的影响进行了调查和研究。本研究旨在探讨药理剂量口服硼酸对老年大鼠生理生化系统的影响。材料和方法将 32 只 Wistar Albino 雄性老年大鼠随机平均分为以下四组:第一组;对照组=1 ml 生理盐水;第二组;低剂量硼酸(L-BA)=10 mg/kg;第三组;中剂量硼酸(M-BA)=20 mg/kg;第四组;高剂量硼酸(H-BA)=40 mg/kg。给老龄大鼠口服硼酸 28 天。第 29 天采集大鼠的血液、肝脏和肾脏样本,分析氧化剂、抗氧化剂、促炎细胞因子和生化变化。结果与对照组相比,所有硼酸组的白蛋白、总蛋白和钙水平均有明显提高(p
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