{"title":"硼酸对老龄大鼠氧化抗氧化剂、促炎细胞因子水平和生化指标的影响","authors":"Mehmet Başeğmez, Muhammed Fatih Doğan","doi":"10.31362/patd.1438593","DOIUrl":null,"url":null,"abstract":"Purpose: As a result of the literature studies, it was seen that boric acid was the subject of many studies, and its effects on living things were investigated and examined. The aim of this study was to investigate the effects of oral boric acid supplementation at pharmacologic doses on physiological and biochemical systems in aged rats. \nMaterial and methods: A total of 32 Wistar Albino male-aged rats were randomly and equally divided into the following four groups: 1st; Control=1 ml saline; 2nd; Low-dose boric acid (L-BA)=10 mg/kg; 3rd; Medium-dose boric acid (M-BA)=20 mg/kg; 4th; High-dose boric acid (H-BA)=40 mg/kg. Boric acid was given orally to aged rats for 28 days. Blood, liver, and kidney samples of rats were collected on day 29 to be analyzed for oxidants, antioxidants, proinflammatory cytokines, and biochemical changes. \nResult: Boric acid significantly increased albumin, total protein, calcium levels equally in all boric acid groups compared to the control group (p","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effects of boric acid on oxidant-antioxidant, proinflammatory cytokine levels, and biochemical parameters in aged rats\",\"authors\":\"Mehmet Başeğmez, Muhammed Fatih Doğan\",\"doi\":\"10.31362/patd.1438593\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Purpose: As a result of the literature studies, it was seen that boric acid was the subject of many studies, and its effects on living things were investigated and examined. The aim of this study was to investigate the effects of oral boric acid supplementation at pharmacologic doses on physiological and biochemical systems in aged rats. \\nMaterial and methods: A total of 32 Wistar Albino male-aged rats were randomly and equally divided into the following four groups: 1st; Control=1 ml saline; 2nd; Low-dose boric acid (L-BA)=10 mg/kg; 3rd; Medium-dose boric acid (M-BA)=20 mg/kg; 4th; High-dose boric acid (H-BA)=40 mg/kg. Boric acid was given orally to aged rats for 28 days. Blood, liver, and kidney samples of rats were collected on day 29 to be analyzed for oxidants, antioxidants, proinflammatory cytokines, and biochemical changes. \\nResult: Boric acid significantly increased albumin, total protein, calcium levels equally in all boric acid groups compared to the control group (p\",\"PeriodicalId\":19789,\"journal\":{\"name\":\"Pamukkale Medical Journal\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-03-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pamukkale Medical Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.31362/patd.1438593\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pamukkale Medical Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.31362/patd.1438593","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Effects of boric acid on oxidant-antioxidant, proinflammatory cytokine levels, and biochemical parameters in aged rats
Purpose: As a result of the literature studies, it was seen that boric acid was the subject of many studies, and its effects on living things were investigated and examined. The aim of this study was to investigate the effects of oral boric acid supplementation at pharmacologic doses on physiological and biochemical systems in aged rats.
Material and methods: A total of 32 Wistar Albino male-aged rats were randomly and equally divided into the following four groups: 1st; Control=1 ml saline; 2nd; Low-dose boric acid (L-BA)=10 mg/kg; 3rd; Medium-dose boric acid (M-BA)=20 mg/kg; 4th; High-dose boric acid (H-BA)=40 mg/kg. Boric acid was given orally to aged rats for 28 days. Blood, liver, and kidney samples of rats were collected on day 29 to be analyzed for oxidants, antioxidants, proinflammatory cytokines, and biochemical changes.
Result: Boric acid significantly increased albumin, total protein, calcium levels equally in all boric acid groups compared to the control group (p
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
