Pamukkale Medical Journal最新文献

{"title":"Perkütan nefrolitotomi esnasinda sol renal vene kalkül migrasyonu: nadir bir komplikasyon ve literatür taraması","authors":"Eser Ördek, Fatih Gokalp, Bilal Kulak, Ferhat Uçurmak, S. Görür","doi":"10.31362/patd.1415784","DOIUrl":"https://doi.org/10.31362/patd.1415784","url":null,"abstract":"Percutaneous nephrolithotomy (PCNL) has long been the standard treatment of choice for the management of large and complex renal calculi. PCNL is a safe and well-tolerated surgical procedure when performed systematically and correctly; however, as with any surgical intervention, although mild complications may occur in this surgery, serious complications may also occur. In this article, we report a rare case of migration of residual calculi into the renal vein during PCNL surgery and aim to present its presentation, treatment and management in a tertiary care center.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140251993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kanser Hastalarında Hipokalsemi","authors":"Seval Akay, Olcun Umit Unal","doi":"10.31362/patd.1404919","DOIUrl":"https://doi.org/10.31362/patd.1404919","url":null,"abstract":"This review evaluates the causes, extent and management of hypocalcaemia in cancer patients, with special emphasis on treatment-related (iatrogenic) hypocalcaemia. It is important for physicians to recognise these conditions well in treatment management.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140265791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential effects of parietin on apoptosis and cell cycle related genes in SH-SY5Y neuroblastoma cells","authors":"Y. Dodurga, Mücahit Seçme, L. Elmas, G. Gündoğdu, Ayşe Çeki̇n, Nur Selvi Günel","doi":"10.31362/patd.1392275","DOIUrl":"https://doi.org/10.31362/patd.1392275","url":null,"abstract":"Background: Ingredients obtained from natural products have been used in cancer treatments for years. High diversity and non-toxicity compared to chemotherapeutic agents are the main reasons for their preference. Lichens having potential for treatment of cancer consist of fungus and 1-2 species of algae. Under the name of lichen substances, many of them have also been synthesized as specific substances. The secondary metabolites in lichens are generally insoluble in water, and have many biological activities such as antiviral, antitumor, antibacterial, and antioxidant; they store in the fungal cell or on the surface of the hyphae and can only be extracted with organic solvents. Parietin extracted from lichen species such as xanthoria parietina is an anthraquinone pigment and a secondary metabolite. In our study, the effects of parietin on cytotoxicity, gene expression, migration, invasion, and colony formation in neuroblastoma cells treated with parietin were investigated. The SH-SY5Y neuroblastoma (NB), which is not treated with parietin, was administered as a control group. Methods: The IC50 value of the parietin was determined using XTT assay. The total RNA extractions were performed from the cells using the Tri-Reagent kit. The expressions of BCL-XL, BCL-2, MMP2, MMP9, P21, CYCLIN D1, CASAPASE-3, CASAPASE-9, BAX, P53, PUMA, and NOXA genes were investigated by Lightcycler 480 (Roche) using SYBR Green dye. Migration analysis of the control and the dose group cells were performed in accordance with the Wound-healing assay protocol. Invasion activities were determined using the “Invasion Chamber” (BD Biosciences) protocol. The colony assay was treated with crystal violet and the cells were observed under the light microscope. Results: The IC50 value of the parietin used for 48-hour treatment on the cells was determined as 35 µM. It was found that the expression levels of BCL-XL, BCL-2, MMP2, MMP9, P21, and CYCLIN D1 mRNA were downregulated, and it was also shown the expression levels of CASAPASE-3, CASAPASE-9, BAX, P53, PUMA, and NOXA to be upregulated. It was determined that parietin suppressed both cell invasion and migration, and colony formation in the neuroblastoma cells. Conclusions: Thus, it can be possible parietin to be used as an alternative, complementary, and supportive agent together with the other drugs in the treatment of neuroblastoma. However, more comprehensive studies supporting these significant effects of parietin will increase its potential in the application.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139154860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TOTAL DİZ ARTROPLASTİSİ UYGULANAN HASTALARDA POST-OP TRAMADOL ETKİNLİĞİNİN CYP2D6*17 GENOMU İLİŞKİSİ","authors":"Nusret Ök, Muhammet Erdi Gürbüz, Aylin Koseler","doi":"10.31362/patd.1351539","DOIUrl":"https://doi.org/10.31362/patd.1351539","url":null,"abstract":"Objective: In our study where we examined the effect of tramadol maintenance on VAS score in geriatric patients, we observed until the post-op 60th minute. Investigation of the incidence of pain in patients who underwent knee arthroplasty in the study. We aimed to examine the effect of the *17 allele of the CYP2D6 genome on the post-op tramadol activity. Methods: 110 patients who underwent total knee arthroplasty in our service in Pamukkale University Faculty of Medicine, Department of Orthopedics and Traumatology, and 100 healthy individuals without complaints as the control group were included in this study. Tramadol 100 mg (contramal) was administered intravenously to each patient. The port-op 0-15-30-45-60.min VAS scores of the patients were recorded. Results: The mean age of the patients was 62.36 years. While 86.4% of the patients in our study were female, this rate was 46% in the control group. We found 3.65% (n=14) *17 carriers with the presence of *17 allele in the patient (n=7) and control groups (n=7). The VAS score of the patients in the *1/*1 group at VAS post-op 0th minute was 91.07. The VAS score of the patients in the *1/*17 group was 95.0. There was no statistically significant difference between genomes (p>0.050). Similarly post-op 15., 30., 45. And 60. Min There was no statistically significant difference between the genomes per (p>0.050). We observed a statistically significant decrease in the postoperative VAS score between 0-60 minutes in both groups in time-dependent variation (p=0.000). Conclusion: When we examine the studies with different results in the literature in which tramadol is classified as IM or EM in relation to the *17 allele, according to the results of our study: We think that the *17 allele should be evaluated as EM and NM.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139157535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psoriasis'te Biyolojik Tedavi Öncesi Latent Tüberküloz Enfeksiyonunun Değerlendirilmesi: Web Tabanlı Yorumlayıcı ile Yeni Bir Tanı Yaklaşımı","authors":"Zuhal Meti̇n, Kemal Özyurt, Mustafa Atasoy, Efşan Gürbüz Yontar, Ragıp Ertaş, Ozkan Gorgulu","doi":"10.31362/patd.1393540","DOIUrl":"https://doi.org/10.31362/patd.1393540","url":null,"abstract":"Purpose: The use of biological agents, particularly anti-TNF-alpha treatments, is associated with an elevated risk of tuberculosis (TB). Hence, a comprehensive assessment of latent tuberculosis infection (LTBI) before biologic therapies is imperative. The objective of this study was to evaluate the utility of an online tuberculin skin test (TST)/ interferon-γ release assay (IGRA) interpreter (OI-TST/IGRA) in assessing the risk of LTBI prior to initiating biological therapies in psoriasis patients. Materials and methods: 116 psoriasis patients who were previously evaluated for TB by a pulmonologist before being treated with a biologic agent were re-evaluated retrospectively with OI-TST/IGRA (tstin3d.com). Mean positive predictive value (PPV), mean annual risk of development of active tuberculosis (ARDATB), and mean cumulative risk of active tuberculosis (CRATB) values were calculated with OI-TST/IGRA and compared with previous results. Chi-square, Fisher-Freeman-Halton exact tests, Cohen's Kappa, and Mann-Whitney U-test were used in comparisons of groups. Results: The PPV of the LTBI-positive group was significantly higher than the LTBI-negative group. The PPV, ARDATB and CRATB values of the TST size of >15 mm group were significantly higher than the TST size of 5-9 mm and TST size of 10-15 mm groups. The PPV, ARDATB, and CRATB values of the QuantiFERON-TB Gold In-tube test (QFT-GIT)-positive group were significantly higher than the QFT-GIT-negative group. And the same values of the chest X-ray (CXR)-positive group were significantly higher than the CXR-negative group. The PPV, ARDATB, and CRATB values were positively correlated with QFT-GIT and CXR results. In addition, the PPV was positively correlated with previous LTBI decisions and TSTs. Conclusion: OI-TST/IGRA in which many factors are questioned and PPV, ARDATB, and CRATB values are evaluated together, may be a valuable tool for assessing the risk of active TB in psoriasis patients and preventing overdiagnosis and unnecessary prophylaxis.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139157432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Üroloji polikliniğine başvuran hastaların üriner inkontinans farkındalığı ve tutumlarına etkisi.","authors":"Mahinur DURMUŞ İSKENDER, Sıla Gül","doi":"10.31362/patd.1406978","DOIUrl":"https://doi.org/10.31362/patd.1406978","url":null,"abstract":"Purpose: This study was conducted to determine the effect of urinary incontinence on the awareness and attitudes of patients applying to urology outpatient policlinics. Materials and methods: The data of this descriptive and cross-sectional study were collected between 07/09/2023-08/10/2023 with Personal Information Form, Urinary Incontinence Awareness Attitude Scale data collection tools from 180 people who applied to urology outpatient clinic by face-to-face interview method. Data were analyzed with the SPSS 25.0 package program. In all analyses, p","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139156511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Ischemic Priapism in a 14 Year Old Patient","authors":"Alper Şi̇mşek, S. Bütün, M. Duran, Kürşat Küçüker, S. Çelen, Yusuf Özlülerden","doi":"10.31362/patd.1389523","DOIUrl":"https://doi.org/10.31362/patd.1389523","url":null,"abstract":"Introduction: Priapism can occur in all age groups, including neonatales, children and adolescents. Pediatric priapism treatment is similar to adult priapism treatment, but there are no guidelines for the management of priapism, which is not common in children. \u0000Case presentation: We present a pediatric low-flow priapism case who was unresponsive to conservative methods and underwent T-shunt operation \u0000Conclusions: In the present case, we wanted to emphasize when distal shunt surgery, which is rarely performed in pediatric patients, is necessary and how it is managed.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138947092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malignancy smells in the air: widespread eroded, hemorrhagic, and lichenified plaques in an older man","authors":"Rashad Ismayilov, O. A. Uyaroğlu, Berkay Kapar, M. Özdede, D. Ates Ozdemir","doi":"10.31362/patd.1357970","DOIUrl":"https://doi.org/10.31362/patd.1357970","url":null,"abstract":"Paraneoplastic pemphigus (PNP) is a rare autoimmune mucocutaneous disease associated with underlying neoplasia. It is typically characterized by painful mucosal erosions and dark, patchy skin eruptions. A 66-year-old male was admitted to the internal medicine outpatient clinic with complaints of suddenly started rashes, loss of appetite, dyspepsia, weakness, and unexplained gross weight loss. The patient was cachectic and physical examination revealed widespread eroded, erythematous, thick-middle, yellow-pitted, lichenified plaques on bilateral arms and legs and the hands and feet dorsum. Scattered seborrheic keratosis lesions on the trunk were also detected. He had microcytic anemia with elevated CA 19-9 measures. Abdomen computed tomography showed a malignant mass in the antrum. Endoscopic biopsy of the gastric mass revealed poorly differentiated adenocarcinoma composed of discohesive signet ring cells and skin punch biopsy was compitable with paraneoplastic pemphigus. \u0000In patients with rapidly developing skin lesions with constitutional symptoms, underlying malignancies should be kept in mind.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138951979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dijital Çıkarma Anjiyografisinde Komplikasyonlar: İlk Üç Yıllık Deneyim","authors":"Serkan Ci̇vlan, Berk Burak Berker, Fatih Yakar, Eylem Teke, Erdal Çoşkun","doi":"10.31362/patd.1404483","DOIUrl":"https://doi.org/10.31362/patd.1404483","url":null,"abstract":"Purpose: In this study, we describe the complications we encountered during digital subtraction angiographies (DSA) in our initial three years of experience and evaluate the risk factors in our patient population. \u0000Materials and methods: A series of 507 patients with different pathological processes were diagnosed via digital subtraction angiography (DSA) in our institution from April 2019 through May 2022 and were retrospectively evaluated. During the angiography, the date of the procedure, patient age, gender, comorbidities, catheter types, number of catheters used, and all procedure-related complications were recorded, even if they did not cause any neurological sequelae. Complications were categorized as neurological, non-neurological, or local. \u0000Results: Our study included a total of 507 patients. Of these, 256 (50.5%) were male, and 251 (49.5%) were female. The mean age of patients was 49.2 years (range 5-91). The most preexisting comorbidity in patients was hypertension (22.5%). Of 507 patients, a total of 10 patients had either a neurological complication, radiological complication, or angio-site-related complication, and the overall rate of complications was 0.02%. In 6 patients with neurological complications, 3 (0.6%) had permanent neurological deficits, and 3 (0.6%) had transient deficits. In 4 patients with non-neurological complications, asymptomatic vasospasms were encountered in two cases; internal carotid artery (ICA) dissection was experienced in one case, and scrotal hematoma was observed in one case. \u0000Conclusion: Complications following DSA are rare but must be minimized with knowledge of the characteristics of the patients and determining the proper indication. Although the risk is low, complications such as thromboembolism can cause permanent neurological deficits and even death.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138954293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fractal analysis and radiomorphometric indices: comparison of mandibular bone structure changes on digital panoramic radiographs of smokers","authors":"B. Çelik, Zeynep Betül Arslan","doi":"10.31362/patd.1333987","DOIUrl":"https://doi.org/10.31362/patd.1333987","url":null,"abstract":"Purpose: The purpose of the study was to assess how smoking affected the mandibular bone structure using a variety of radiomorphometric indices and fractal dimension (FD) analysis. \u0000 \u0000Materials and methods: 56 patients (28 smokers and 28 non-smokers) were included in this retrospective study. In the trabecular bone of the mandible, eight areas of interest of 45x45 pixels were chosen, and fractal dimension analysis was carried out. All digital panoramic radiographs were used to measure the mandibular index and mandibular cortical width. All values were compared between groups. Utilizing the Shapiro-Wilk and Mann-Whitney U tests, collected data were evaluated. \u0000 \u0000Results: There was a statistically significant difference between the groups in ROI4 and ROI8, but not in the mean FD values of ROI1, ROI2, ROI3, ROI5, ROI6 and ROI7 in the mandibular trabecular bone. No statistically significant differences between groups were seen for PMI and MCW measures (p > .05). The intraclass correlation coefficient (ICC) values for the FD, PMI and MCW measurements were excellent. \u0000 \u0000Conclusion: The trabecular bone structures of the anterior of the mental foramen and the condyle were different in smokers. There was no difference in cortical bone structures.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138997318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}