Malignancy smells in the air: widespread eroded, hemorrhagic, and lichenified plaques in an older man

Rashad Ismayilov, O. A. Uyaroğlu, Berkay Kapar, M. Özdede, D. Ates Ozdemir
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引用次数: 0

Abstract

Paraneoplastic pemphigus (PNP) is a rare autoimmune mucocutaneous disease associated with underlying neoplasia. It is typically characterized by painful mucosal erosions and dark, patchy skin eruptions. A 66-year-old male was admitted to the internal medicine outpatient clinic with complaints of suddenly started rashes, loss of appetite, dyspepsia, weakness, and unexplained gross weight loss. The patient was cachectic and physical examination revealed widespread eroded, erythematous, thick-middle, yellow-pitted, lichenified plaques on bilateral arms and legs and the hands and feet dorsum. Scattered seborrheic keratosis lesions on the trunk were also detected. He had microcytic anemia with elevated CA 19-9 measures. Abdomen computed tomography showed a malignant mass in the antrum. Endoscopic biopsy of the gastric mass revealed poorly differentiated adenocarcinoma composed of discohesive signet ring cells and skin punch biopsy was compitable with paraneoplastic pemphigus. In patients with rapidly developing skin lesions with constitutional symptoms, underlying malignancies should be kept in mind.
空气中弥漫着恶性肿瘤的气味:一名老年男子身上出现大面积糜烂、出血和苔藓化斑块
副肿瘤性丘疹性荨麻疹(PNP)是一种罕见的自身免疫性粘膜皮肤病,与潜在的肿瘤有关。其典型特征是疼痛性粘膜糜烂和深色斑块状皮肤糜烂。一名 66 岁的男性因主诉突然出现皮疹、食欲不振、消化不良、乏力和不明原因的体重大幅下降而被送入内科门诊。体格检查显示,患者双侧手臂、双腿、手背和足背广泛出现糜烂、红斑、中间厚、黄坑状、苔藓化斑块。躯干上也有散在的脂溢性角化病病变。他患有小细胞性贫血,CA 19-9指标升高。腹部计算机断层扫描显示,胃窦有一个恶性肿块。胃部肿块的内镜活检显示,由盘状标志环细胞组成的腺癌分化较差,皮肤打孔活检与副肿瘤性丘疹性荨麻疹相符。对于皮肤病变迅速发展并伴有全身症状的患者,应注意潜在的恶性肿瘤。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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