Pamukkale Medical Journal最新文献

{"title":"Geçici neonatal diyabetes mellitus","authors":"Gülay SÖNMEZ DEMİR, Didem YILDIRIM ÇAKAR, Murat Öcal, Ö. Özdemi̇r, Selda Ayça Altincik, Hacer Ergi̇n","doi":"10.31362/patd.1364851","DOIUrl":"https://doi.org/10.31362/patd.1364851","url":null,"abstract":"Neonatal diabetes mellitus (NDM) is defined as hyperglycemia in the first six months of life for at least two weeks and requiring insulin therapy. Although its incidence is 1 in 90000-160000 live births, its frequency rises to 1/30000 in societies such as our country where consanguineous marriages are common. NDM may be seen as transient (50-60%), permanent or as a part of syndromes. Clinical manifestations of NDM are intrauterine growth retardation, growth cessation, excessive urination, dehydration, and ketoacidosis. \u0000Some of the premature or low birth weight infants may develop hyperglycemia due to many different reasons, so there may be difficulties and delay in diagnosis. If the high blood glucose level lasts longer than 7-10 days after excluding other causes of transient hyperglycemia, it is recommended to suspect NDM and perform genetic examination, especially in infants with blood glucose above 250mg/dL. \u0000Herein, a newborn, referred to our neonatal unit due to persistent hyperglycemia on the postnatal 15th day and diagnosed as transient NDM after excluding other causes of hyperglycemia, is presented due to the rarity of the disease.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139008196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disfajisi olan çocukların değerlendirilmesi","authors":"Sevinç Gari̇p","doi":"10.31362/patd.1343219","DOIUrl":"https://doi.org/10.31362/patd.1343219","url":null,"abstract":"Purpose: Difficulty in swallowing; It is a symptom that occurs as a result of mechanical inhibition of the transfer of ingested food from the mouth to the stomach. It can be due to acute and chronic diseases. It is presented because of the limited number of studies comparing the characteristics of both types of oropharyngeal and esophageal dysphagia in healthy and chronically ill children in the pediatric population. \u0000Materials and Methods: 201 pediatric patients admitted with dysphagia between May 2019 and November 2020 were included. They were grouped according to the types of dysphagia. \u0000Results: Group-1 consisted of 80 pediatric patients with oropharyngeal dysphagia, while group-2 consisted of 121 pediatric patients with esophageal dysphagia. 51.7% of the patients were female, mean age was 9.4 years. While all patients in Group-2 had solid food dysphagia, Group-1 had 27% liquid and 53% solid-liquid dysphagia. Percutaneous endoscopic gastrostomy tube for 50 pediatric patients who could not be fed safely; A nasogastric feeding tube was placed in 4 children. Esophagogastroduodenoscopy was performed in 72.6% of the patients, and esophageal pathology was detected in 55.4%. \u0000Conclusions: Although the incidence of dysphagia is high in children with chronic diseases, it should not be forgotten that it can also be seen in healthy children and may be associated with treatable","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139009849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obez hastalarda yapılan laparoskopik tüp mide ameliyatının periodontal duruma etkisi","authors":"Aysan LEKTEMÜR ALPAN, Gizem Torumtay Cin, Muhammed Raşid Aykota","doi":"10.31362/patd.1376207","DOIUrl":"https://doi.org/10.31362/patd.1376207","url":null,"abstract":"Purpose: This study aimed to determine the effects of laparoscopic sleeve gastrectomy surgery on clinical periodontal parameters at 6 months in the postoperative period. Materials and methods: Fifty-four obese patients with periodontitis between 18 and 70 years of age were evaluated for obesity-related parameters and periodontal status before and 6 months after bariatric surgery. Correlations of the changes in periodontal parameters and the total weight loss and body mass index (BMI) loss at 6 months after bariatric surgery were determined with Spearman correlation analysis. p","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139220975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sıçanlarda sirkadiyen ritim bozuklukları ile ilgili çeşitli koşulların plazma ve eritrosit lipidleri üzerindeki etkileri: peroksizomal bir bakış açısı","authors":"Hüsniye Gül Otlu, Yılmaz Uğur, Azibe Yildiz, Selim Erdoğan, Saim Yoloğlu, Nigar Vardi, T. Güldür","doi":"10.31362/patd.1327736","DOIUrl":"https://doi.org/10.31362/patd.1327736","url":null,"abstract":"Purpose: Lipidomics studies of sleep restriction, which is known to be associated with circadian perturbations, revealed alterations in some plasma phospholipid levels including plasmalogens which are partly synthesized in liver peroxisomes. To this end it was aimed to investigate effects of various conditions known to cause circadian rhythm disturbances on various peroxisomal parameters and to compare those effects with that of fenofibrate, a peroxisome proliferator-activated receptor alpha agonist. Materials and Methods: Plasmalogens and some fatty acids in erythrocyte lysates were analyzed by GC. Peroxisomal metabolites including very long chain fatty acids as well as phytanic and pristanic acids in plasma were measured by GC-MS. Immunohistological analyses by catalase antibodies were conducted on liver sections. Results: All the conditions tested exhibited increased catalase immunoreactivity in liver sections compared to that of controls. Both calorie restriction, time-restricted feeding, as well as fenofibrate treatment exhibited lower C18:0 plasmalogen contents of erythrocyte lysates. As plasmalogens are known to be synthesized by peroxisomes, the present results suggest that the peroxisomal lipid content in membranes might be affected by conditions co-occuring with circadian perturbations. Conclusion: Shared effects of conditions associated with circadian rhythm disturbances and peroxisomal induction by fenofibrate on erythrocyte membrane lipids might indicate a link between them.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139224385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HT22 cell differentiation reduces insulin receptor levels","authors":"Melek Tunc-Ata, Fatih Altıntaş","doi":"10.31362/patd.1338766","DOIUrl":"https://doi.org/10.31362/patd.1338766","url":null,"abstract":"Purpose: The brain is an insülin-sensitive organ and has widespread insulin receptor (IR) expression. IR signaling in the brain is essential for neuronal development, feeding behavior, body weight, and cognitive processes such as attention, learning, and memory. HT22 cells, which are derived from parent HT4 cells that are immortalized from primary mouse hippocampal neuronal cells are used in research related to insulin signaling. However, the role of these cells in insulin signaling is not known. In this study, we aimed to examine IR levels in cells differentiated using neurobasal medium. Material and methods: For the study, briefly, the cells were seeded in 6-well plates at 2x105 cells/well for 24 h. After the cells reached 80% confluence, the normal growth medium was replaced with a differentiation medium and the cells were incubated for 72 hours at 37 0C in 5% CO2. Western blot procedure was used to determine the expression of the IR. Result: Our results show that differentiation of HT22 cells stimulates neurite outgrowth. Furthermore, IR protein levels were significantly downregulated in differentiated HT22 cells. Conclusion: This finding may require careful consideration of the use of neurobasal medium in conditions where IR signaling is important.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139229662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of medicolegal death cases sent from abroad to the province of Denizli","authors":"Kemalettin Acar, Ayşe Kurtuluş Dereli, Kamuran Aksoy, Abdülkadir İzci","doi":"10.31362/patd.1359814","DOIUrl":"https://doi.org/10.31362/patd.1359814","url":null,"abstract":"Purpose: In this study, we aimed to contribute to the literature by discussing the difficulties encountered in the approach to suspicious death cases reported abroad and sent to our country. Materials and methods: The findings were obtained by retrospectively reviewing all medico-legal death cases sent from abroad to Denizli province between January 2012 and December 2022, in which death examination and autopsy were performed. Results: Of the 12 cases included in the study, 3 were female and 9 were male, the youngest case was 2 years old and the oldest case was 66 (median 49) years old. Germany was the country to which the most suspicious death cases were sent with nine cases (75%), while one case each was sent from Turkmenistan, the Netherlands and Austria. When the cases were evaluated in terms of origin, it was observed that 5 (41%) cases were of natural origin followed by 4 (33%) cases of suicide origin. Conclusion: : In order to minimize the problems encountered in the re-evaluation of medico-legal death cases from abroad, we think that it would be appropriate for all countries to perform medico-legal autopsy in accordance with international standards for suspicious death cases sent abroad, and to share the report containing the autopsy findings and all documents that may help to clarify the cause of death of the person with the forensic medicine experts in the country of destination.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139252509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kidney transplantation in children and young adults: the initial experience of our center","authors":"U. Ozgen, Murat Özban, İ. H. Akbudak, Selcuk Yuksel, İ. Gi̇ri̇şgen, M. Aykota, E. Mete, Neslihan Yilmaz, Ezgi Doğa Yoran, Osman Uzunlu, Mevlüt Çeri̇, O. Birsen, Çağatay Aydin","doi":"10.31362/patd.1343201","DOIUrl":"https://doi.org/10.31362/patd.1343201","url":null,"abstract":"Abstract \u0000Purpose: Pediatric kidney transplant (PKTx) is one of the most comfortable renal replacement therapies preferred in children with end-stage renal disease (ESRD) worldwide. \u0000Methods: This single-center, retrospective study was conducted at Pamukkale University, Faculty of Medicine, Organ Transplantation Center. The PKTx was performed in 11 patients between December 2014 and November 2019. \u0000Results: The mean time from the beginning of the first dialysis session to transplantation was 40.2 months, and two patients were transplanted preemptively. The mean age of LD and DD transplants was 41.6 years and 17.1 years, respectively. This was attributed to the fact that, in the donation of cadaveric organs, donors under the age of 18 years are only registered for the waiting list for the recipients under the age of 18 years in our country. \u0000Conclusion: Our study showed that patients who used basiliximab for induction treatment were more advantageous in terms of infections than patients using ATG.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80353782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is There a Relationship Between TP-e/QT Ratio and Spinal Anesthesia-Related Cardiovascular Events in Pregnant Women?","authors":"Ilker Coskun","doi":"10.31362/patd.1346427","DOIUrl":"https://doi.org/10.31362/patd.1346427","url":null,"abstract":"Introduction and Objective: Prolonged TPe interval has been reported to reflect the abnormal distribution of ventricular repolarization which can be used as a marker of ventricular arrhythmias. Since prolonged TPe/QT ratio is associated with cardiac pathologies, it is thought that it may also be associated with cardiovascular adverse events that occur during and after spinal anesthesia. The aim of this study is to investigate whether there is a relationship between prolonged TPe/QT ratio, which is routine preoperative non-invasive patient data that can be evaluated easily, and perioperative adverse cardiovascular events during cesarean section in pregnant women undergoing spinal anesthesia. \u0000Materials and Methods: Voluntary consent was obtained for our study in which 144 pregnant women who were planned for elective cesarean section were included. QT interval was measured based on the initial point where the Q wave or the R wave in the absence of the Q wave started to the last point where the T wave ended. TPe interval measurement was based on the peak point of the T wave and the end point of the T wave convexity. Lead V5 was primarily used for TPe measurement. TPe/QT ratios were calculated in Microsoft office excel program. Patients' demographic characteristics, heart rate, systolic, diastolic and mean arterial pressures were recorded every five minutes intraoperatively. \u0000Results: A weak positive correlation was found between the height variable and the Tpe/QT ratio (p=0.022, r=0.191). As the height increased, the TPe/QT ratio increased. Although it did not reach the level of statistical significance, we found that the TPe/QT ratio was longerin cases with intraoperative bradycardia and hypotension than in cases without complications. The TPe/QT ratio was above 0.21 in patients who developed bradycardia and hypotension. Examination of the correlation between the amount of ephedrine use and TPe/QT ratio revealed a weak positive correlation (p=0.012, r=0.208). \u0000Conclusion: TPe/QT ratio is a novel cardiac marker with high predictive power, is non-invasive, quite inexpensive, and very practical to measure in the early detection of cardiac events, especially arrhythmia. This novel predictive marker can be used in anesthesia practice, preoperative examination and patient follow-up in the intraoperative operating room to predict fatal cardiac arrhythmias or intraoperative hypo/hypertension. \u0000Keywords: Spinal anesthesia, pregnancy, TPe/QT ratio, cardiovascular event","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81995875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ÜST VE ALT EKSTREMİTEDE AYNI SİNİR TARAFINDAN İNERVE OLAN PROKSİMAL VE DİSTAL KASLARDAN KAYDEDİLEN F DALGASI: YENİ BİR YÖNTEM OLABİLİR Mİ?","authors":"Zeynep Ünlütürk","doi":"10.31362/patd.1351377","DOIUrl":"https://doi.org/10.31362/patd.1351377","url":null,"abstract":"Purpose \u0000The F- wave is a valuable measurement that provides information about both the proximal and distal parts of the nerve. Classical F-wave recording methods are performed from the distal muscles of the limb and so are affected from distal pathologies. Nerve conduction velocity of a nerve is affected by the diameter of the nerve. The diameter of a nerve gets thinner as it gives branches and travels distally. So it is expected that the nerve conduction velocity of a nerve is faster in proximal segment of the nerve than the distal part even they are the parts of the same nerve. The aim of this study is to compare the nerve conduction parameters of F waves recorded in proximal and distal muscles innervated by the same nerve. Which will provide additional information and may be valuable in detecting proximal pathologies accompanying background pathologies affecting the distal nerve \u0000Materials and Methods \u0000Twenty –six healthy volunteers who have normal routine nerve conduction studies are included in this study. The latencies of ulnar and peroneal F-waves of all participants were recorded from the proximal and distal muscles innervated by the same nerve. \u0000Results \u0000F-wave latencies recorded from proximal muscles were significantly later than the ones recorded from distal muscles. \u0000Conclusion \u0000Although the distances travelled by stimulation are shorter in F latencies recorded from proximal muscles , and the segment /branch of the nerve is expected to be thicker and faster however the latencies recorded from proximal muscles were longer than the ones recorded from distal muscles . This may be due to the distance of the recording electrodes effected by subcutaneous tissues in the proximal large mass muscles. One reason for this difference may be that the proximal relatively large mass muscles have higher desynchronization and temporal dispersions.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86587407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of personality types and coping styles on coronavirus anxiety levels of the healthcare workers","authors":"Osman Zülkif Topak","doi":"10.31362/patd.1348940","DOIUrl":"https://doi.org/10.31362/patd.1348940","url":null,"abstract":"Purpose: Healthcare workers are exposed to long and stressful work shifts in pandemics. It was aimed to evaluate the coronavirus related anxiety levels of the healthcare workers, and to evaluate the relationship between their personality types and coping strategies. \u0000Materials and Methods: Study included 213 medical healthcare workers who were randomly selected and agreed to participate in the study on a voluntary basis. Sociodemographic data form, Coronavirus anxiety scale, Type A Behavior Test, and Coping styles scale was applied to the all participants. \u0000Results: The total coronavirus anxiety scores of the participants with type A personality traits were found to be significantly higher than with type B personality traits (p=0.006). The mean scores of helpless approach and seeking social support of were found to be significantly higher in participants with Type A personality (p=0.002, p=0.007, respectively). Self-confident and optimistic approach were found to be higher in participants with Type B personality (p=0.041, p=0.023, respectively). Participants with helpless approach had higher anxiety scores (p=0.033). A negative correlation was found between coronavirus anxiety and self-confident approach (p=0.002, r=-0.212) and optimistic approach (p=0.002, r=- 0.209), and positive correlation with helpless approach (p=0.044, r=0.138). \u0000Conclusion: The results of this study showed that those who approached self confident and optimistic can cope with stress better. Individuals with Type A personality are at greater risk for anxiety in the pandemic. Monitoring and ensuring the mental health of healthcare workers is crucial to global health in other possible pandemics.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82524149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}