一过性新生儿糖尿病

Gülay SÖNMEZ DEMİR, Didem YILDIRIM ÇAKAR, Murat Öcal, Ö. Özdemi̇r, Selda Ayça Altincik, Hacer Ergi̇n
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引用次数: 0

摘要

新生儿糖尿病(NDM)是指新生儿在出生后头六个月内出现至少两周的高血糖,并需要胰岛素治疗。虽然其发病率为每 9-16 万活产婴儿中就有 1 例,但在我国等近亲结婚现象普遍的社会中,其发病率上升至 1/3000000。NDM 可表现为一过性(50%-60%)、永久性或作为综合征的一部分。NDM 的临床表现为宫内发育迟缓、生长停止、多尿、脱水和酮症酸中毒。一些早产儿或低出生体重儿可能会因多种原因出现高血糖,因此诊断可能会有困难和延误。在排除其他原因引起的一过性高血糖后,如果高血糖持续时间超过 7-10 天,建议怀疑为 NDM 并进行基因检查,尤其是血糖超过 250 毫克/分升的婴儿。本文介绍了一名因出生后第 15 天出现持续高血糖而转诊至我院新生儿科的新生儿,在排除其他高血糖原因后被诊断为一过性 NDM。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Geçici neonatal diyabetes mellitus
Neonatal diabetes mellitus (NDM) is defined as hyperglycemia in the first six months of life for at least two weeks and requiring insulin therapy. Although its incidence is 1 in 90000-160000 live births, its frequency rises to 1/30000 in societies such as our country where consanguineous marriages are common. NDM may be seen as transient (50-60%), permanent or as a part of syndromes. Clinical manifestations of NDM are intrauterine growth retardation, growth cessation, excessive urination, dehydration, and ketoacidosis. Some of the premature or low birth weight infants may develop hyperglycemia due to many different reasons, so there may be difficulties and delay in diagnosis. If the high blood glucose level lasts longer than 7-10 days after excluding other causes of transient hyperglycemia, it is recommended to suspect NDM and perform genetic examination, especially in infants with blood glucose above 250mg/dL. Herein, a newborn, referred to our neonatal unit due to persistent hyperglycemia on the postnatal 15th day and diagnosed as transient NDM after excluding other causes of hyperglycemia, is presented due to the rarity of the disease.
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