{"title":"Clinical Features of Idiopathic Parotid Pain Triggered by the First Bite in Japanese Patients with Type 2 Diabetes: A Case Study of Nine Patients.","authors":"Masatoshi Chiba, Hiroaki Hirotani, Tetsu Takahashi","doi":"10.1155/2018/7861451","DOIUrl":"https://doi.org/10.1155/2018/7861451","url":null,"abstract":"<p><strong>Objective: </strong>First bite syndrome, characterized by pain in the parotid region after the first bite of each meal, predominantly develops in patients who have had head and neck surgery. Idiopathic parotid pain (IPP) that mimics first bite syndrome may present in patients without a history of surgery or evidence of an underlying tumor, but its clinical features are unclear. This study characterized the clinical characteristics of IPP in patients with diabetes.</p><p><strong>Study design: </strong>A retrospective case review involving the clinical findings and pain characteristics of nine patients with IPP and diabetes who presented to our department between 2013 and 2016.</p><p><strong>Results: </strong>All the patients were men diagnosed with type 2 diabetes (median age, 43 years). IPP developed unilaterally in seven patients and bilaterally in two. The median intensity of the first bite pain was 8 on a numerical rating scale of 0-10. The trigger factor was gustatory stimuli, and the trigger area was the posterior section of the tongue. Postprandial pain occurred within 1-10 min after meals in six patients.</p><p><strong>Conclusions: </strong>IPP may be considered a separate disorder, in which the pain characteristics are similar to those of first bite syndrome but the clinical features and pathophysiology are different.</p>","PeriodicalId":19786,"journal":{"name":"Pain Research and Treatment","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2018/7861451","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36127278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mariana Takaku, Andre Carnevali da Silva, Nathalie Izumi Iritsu, Pedro Thadeu Galvao Vianna, Yara Marcondes Machado Castiglia
{"title":"Effects of a Single Dose of Parecoxib on Inflammatory Response and Ischemic Tubular Injury Caused by Hemorrhagic Shock in Rats.","authors":"Mariana Takaku, Andre Carnevali da Silva, Nathalie Izumi Iritsu, Pedro Thadeu Galvao Vianna, Yara Marcondes Machado Castiglia","doi":"10.1155/2018/8375746","DOIUrl":"https://doi.org/10.1155/2018/8375746","url":null,"abstract":"<p><p>Parecoxib, a selective COX-2 inhibitor, is used to improve analgesia in postoperative procedures. Here we evaluated whether pretreatment with a single dose of parecoxib affects the function, cell injury, and inflammatory response of the kidney of rats subjected to acute hemorrhage. Inflammatory response was determined according to serum and renal tissue cytokine levels (IL-1<i>α</i>, IL-1<i>β</i>, IL-6, IL-10, and TNF-<i>α</i>). Forty-four adult Wistar rats anesthetized with sevoflurane were randomized into four groups: placebo/no hemorrhage (Plc/NH); parecoxib/no hemorrhage (Pcx/NH); placebo/hemorrhage (Plc/H); and parecoxib/hemorrhage (Pcx/H). Pcx groups received a single dose of intravenous parecoxib while Plc groups received a single dose of placebo (isotonic saline). Animals in hemorrhage groups underwent bleeding of 30% of blood volume. Renal function and renal histology were then evaluated. Plc/H showed the highest serum levels of cytokines, suggesting that pretreatment with parecoxib reduced the inflammatory response in rats subjected to hemorrhage. No difference in tissue cytokine levels between groups was observed. Plc/H showed higher percentage of tubular dilation and degeneration, indicating that parecoxib inhibited tubular injury resulting from renal hypoperfusion. Our findings indicate that pretreatment with a single dose of parecoxib reduced the inflammatory response and tubular renal injury without altering renal function in rats undergoing acute hemorrhage.</p>","PeriodicalId":19786,"journal":{"name":"Pain Research and Treatment","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2018/8375746","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35910217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. V. van Nooten, D. Trundell, D. Staniewska, Jun Chen, E. Davies, D. Revicki
{"title":"Evaluating the Measurement Properties of the Self-Assessment of Treatment Version II, Follow-Up Version, in Patients with Painful Diabetic Peripheral Neuropathy","authors":"F. V. van Nooten, D. Trundell, D. Staniewska, Jun Chen, E. Davies, D. Revicki","doi":"10.1155/2017/6080648","DOIUrl":"https://doi.org/10.1155/2017/6080648","url":null,"abstract":"Background. The Self-Assessment of Treatment version II (SAT II) measures treatment-related improvements in pain and impacts and impressions of treatment in neuropathic pain patients. The measure has baseline and follow-up versions. This study assesses the measurement properties of the SAT II. Methods. Data from 369 painful diabetic peripheral neuropathy (PDPN) patients from a phase III trial assessing capsaicin 8% patch (Qutenza®) efficacy and safety were used in these analyses. Reliability, convergent validity, known-groups validity, and responsiveness (using the Brief Pain Inventory-Diabetic Neuropathy [BPI-DN] and Patient Global Impression of Change [PGIC]) analyses were conducted, and minimally important differences (MID) were estimated. Results. Exploratory factor analysis supported a one-factor solution for the six impact items. The SAT II has good internal consistency (Cronbach's alpha: 0.96) and test-retest reliability (intraclass correlation coefficients: 0.62–0.88). Assessment of convergent validity showed moderate to strong correlations with change in other study endpoints. Scores varied significantly by level of pain intensity and sleep interference (p < 0.05) defined by the BPI-DN. Responsiveness was shown based on the PGIC. MID estimates ranged from 1.2 to 2.4 (pain improvement) and 1.0 to 2.0 (impact scores). Conclusions. The SAT II is a reliable and valid measure for assessing treatment improvement in PDPN patients.","PeriodicalId":19786,"journal":{"name":"Pain Research and Treatment","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/6080648","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48026224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Antonella Paladini, Giustino Varrassi, Giuseppe Bentivegna, Sandro Carletti, Alba Piroli, Stefano Coaccioli
{"title":"Palmitoylethanolamide in the Treatment of Failed Back Surgery Syndrome.","authors":"Antonella Paladini, Giustino Varrassi, Giuseppe Bentivegna, Sandro Carletti, Alba Piroli, Stefano Coaccioli","doi":"10.1155/2017/1486010","DOIUrl":"https://doi.org/10.1155/2017/1486010","url":null,"abstract":"Introduction This observational study was designed to evaluate the efficacy of ultramicronized palmitoylethanolamide (um-PEA) (Normast®) administration, as add-on therapy for chronic pain, in the management of pain-resistant patients affected by failed back surgery syndrome. Methods A total of 35 patients were treated with tapentadol (TPD) and pregabalin (PGB). One month after the start of standard treatment, um-PEA was added for the next two months. Pain was evaluated by the Visual Analogue Scale (VAS) at the time of enrollment (T0) and after one (T1), two (T2), and three (T3) months. Results After the first month with TDP + PGB treatment only, VAS score decreased significantly from 5.7 ± 0.12 at the time of enrollment (T0) to 4.3 ± 0.11 (T1) (p < 0.0001); however, it failed to provide significant subjective improvement in pain symptoms. Addition of um-PEA led to a further and significant decrease in pain intensity, reaching VAS scores of 2.7 ± 0.09 (T2) and 1.7 ± 0.11 (T3, end of treatment) (p < 0.0001) without showing any side effects. Conclusions This observational study provides evidence, albeit preliminary, for the efficacy and safety of um-PEA (Normast) as part of a multimodal therapeutic regimen in the treatment of pain-resistant patients suffering from failed back surgery syndrome.","PeriodicalId":19786,"journal":{"name":"Pain Research and Treatment","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/1486010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35475752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Kinesiophobia, Pain, Muscle Functions, and Functional Performances among Older Persons with Low Back Pain.","authors":"Nor Azizah Ishak, Zarina Zahari, Maria Justine","doi":"10.1155/2017/3489617","DOIUrl":"https://doi.org/10.1155/2017/3489617","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims (1) to determine the association between kinesiophobia and pain, muscle functions, and functional performances and (2) to determine whether kinesiophobia predicts pain, muscle functions, and functional performance among older persons with low back pain (LBP).</p><p><strong>Methods: </strong>This is a correlational study, involving 63 institutionalized older persons (age = 70.98 ± 7.90 years) diagnosed with LBP. Anthropometric characteristics (BMI) and functional performances (lower limb function, balance and mobility, and hand grip strength) were measured. Muscle strength (abdominal and back muscle strength) was assessed using the Baseline® Mechanical Push/Pull Dynamometer, while muscle control (transverse abdominus and multifidus) was measured by using the Pressure Biofeedback Unit. The pain intensity and the level of kinesiophobia were measured using Numerical Rating Scale and Tampa Scale of Kinesiophobia, respectively. Data were analyzed using Pearson's correlation coefficients and multivariate linear regressions.</p><p><strong>Results: </strong>No significant correlations were found between kinesiophobia and pain and muscle functions (all <i>p</i> > 0.05). Kinesiophobia was significantly correlated with mobility and balance (<i>p</i> = 0.038, <i>r</i> = 0.263). Regressions analysis showed that kinesiophobia was a significant predictor of mobility and balance (<i>p</i> = 0.038).</p><p><strong>Conclusion: </strong>We can conclude that kinesiophobia predicted mobility and balance in older persons with LBP. Kinesiophobia should be continuously assessed in clinical settings to recognize the obstacles that may affect patient's compliance towards a rehabilitation program in older persons with LBP.</p>","PeriodicalId":19786,"journal":{"name":"Pain Research and Treatment","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/3489617","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35105955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"iACT-CEL: A Feasibility Trial of a Face-to-Face and Internet-Based Acceptance and Commitment Therapy Intervention for Chronic Pain in Singapore.","authors":"Su-Yin Yang, Rona Moss-Morris, Lance M McCracken","doi":"10.1155/2017/6916915","DOIUrl":"https://doi.org/10.1155/2017/6916915","url":null,"abstract":"<p><p>Psychological interventions are increasingly utilising online or mobile phone based platforms to deliver treatment, including that for people with chronic pain. The aims of this study were to develop an adapted form of Acceptance and Commitment Therapy (ACT) for chronic pain in Singapore and to test the feasibility of elements of this treatment delivered via the internet and email. <i>Methods</i>. Thirty-three participants recruited from a tertiary pain management clinic and via the clinic website participated in this program over a period of five weeks with a 3-month follow-up. Treatment outcomes were assessed at three assessment time points. <i>Results</i>. 90.9% of participants completed the program, with 81.8% reporting high treatment satisfaction. Significant changes in depression, <i>t</i> = 3.08, <i>p</i> = 0.002 (baseline to posttreatment), <i>t</i> = 3.28, <i>p</i> = 0.001 (baseline to follow-up), and pain intensity, <i>t</i> = 2.15, <i>p</i> = 0.03 (baseline to follow-up) were found. Mainly small effect sizes (<i>d</i> = 0.09-0.39) with a moderate effect size (<i>d</i> = 0.51) for depression were found at posttreatment. Clinically meaningful improvement in at least one outcome was demonstrated in 75.8% of participants. <i>Conclusions</i>. An adaptation of ACT for people with chronic pain in Singapore appears promising. Optimal treatment design and more effective ways to target outcomes and processes measured here are required.</p>","PeriodicalId":19786,"journal":{"name":"Pain Research and Treatment","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/6916915","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34841179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marina de Tommaso, Katia Ricci, Giuseppe Libro, Eleonora Vecchio, Marianna Delussi, Anna Montemurno, Giuseppe Lopalco, Florenzo Iannone
{"title":"Pain Processing and Vegetative Dysfunction in Fibromyalgia: A Study by Sympathetic Skin Response and Laser Evoked Potentials.","authors":"Marina de Tommaso, Katia Ricci, Giuseppe Libro, Eleonora Vecchio, Marianna Delussi, Anna Montemurno, Giuseppe Lopalco, Florenzo Iannone","doi":"10.1155/2017/9747148","DOIUrl":"10.1155/2017/9747148","url":null,"abstract":"<p><strong>Background: </strong>A dysfunction of pain processing at central and peripheral levels was reported in fibromyalgia (FM). We aimed to correlate laser evoked potentials (LEPs), Sympathetic Skin Response (SSR), and clinical features in FM patients.</p><p><strong>Methods: </strong>Fifty FM patients and 30 age-matched controls underwent LEPs and SSR by the right hand and foot. The clinical evaluation included FM disability (FIQ) and severity scores (WPI), anxiety (SAS) and depression (SDS) scales, and questionnaires for neuropathic pain (DN4).</p><p><strong>Results: </strong>The LEP P2 latency and amplitude and the SSR latency were increased in FM group. This latter feature was more evident in anxious patients. The LEPs habituation was reduced in FM patients and correlated to pain severity scores. In a significant number of patients (32%) with higher DN4 and FIQ scores, SSR or LEP responses were absent.</p><p><strong>Conclusions: </strong>LEPs and SSR might contribute to clarifying the peripheral and central nervous system involvement in FM patients.</p>","PeriodicalId":19786,"journal":{"name":"Pain Research and Treatment","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/9747148","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35563463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cláudia Gouvinhas, Dalila Veiga, Liliane Mendonça, Rute Sampaio, Luís Filipe Azevedo, José Manuel Castro-Lopes
{"title":"Interventional Pain Management in Multidisciplinary Chronic Pain Clinics: A Prospective Multicenter Cohort Study with One-Year Follow-Up.","authors":"Cláudia Gouvinhas, Dalila Veiga, Liliane Mendonça, Rute Sampaio, Luís Filipe Azevedo, José Manuel Castro-Lopes","doi":"10.1155/2017/8402413","DOIUrl":"https://doi.org/10.1155/2017/8402413","url":null,"abstract":"<p><strong>Background: </strong>Interventional Pain Management (IPM) is performed in multidisciplinary chronic pain clinics (MCPC), including a range of invasive techniques to diagnose and treat chronic pain (CP) conditions. Current patterns of use of those techniques in MCPC have not yet been reported.</p><p><strong>Objective: </strong>We aimed to describe quantitatively and qualitatively the use of IPM and other therapeutic procedures performed on-site at four Portuguese MCPC.</p><p><strong>Methods: </strong>A prospective cohort study with one-year follow-up was performed in adult patients. A structured case report form was systematically completed at baseline and six and 12 months.</p><p><strong>Results: </strong>Among 808 patients referred to the MCPC, 17.2% had been prescribed IPM. Patients with IPM were on average younger and had longer CP duration and lower levels of maximum pain and pain interference/disability. The three main diagnoses were low back pain (<i>n</i> = 28), postoperative CP, and knee pain (<i>n</i> = 16 each). From 195 IPM prescribed, nerve blocks (<i>n</i> = 108), radiofrequency (<i>n</i> = 31), and viscosupplementation (<i>n</i> = 22) were the most prevalent. Some IPM techniques were only available in few MCPC. One MCPC did not provide IPM.</p><p><strong>Conclusions: </strong>IPM are seldom prescribed in Portuguese MCPC. Further studies on IPM safety and effectiveness are necessary for clear understanding the role of these techniques in CP management.</p>","PeriodicalId":19786,"journal":{"name":"Pain Research and Treatment","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/8402413","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35575657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abdulrahman D Algarni, Yazeed Al-Saran, Ahlam Al-Moawi, Abdullah Bin Dous, Abdulaziz Al-Ahaideb, Shaji John Kachanathu
{"title":"The Prevalence of and Factors Associated with Neck, Shoulder, and Low-Back Pains among Medical Students at University Hospitals in Central Saudi Arabia.","authors":"Abdulrahman D Algarni, Yazeed Al-Saran, Ahlam Al-Moawi, Abdullah Bin Dous, Abdulaziz Al-Ahaideb, Shaji John Kachanathu","doi":"10.1155/2017/1235706","DOIUrl":"https://doi.org/10.1155/2017/1235706","url":null,"abstract":"<p><strong>Aim: </strong>The study aim was to determine the prevalence of neck, shoulder, and low-back pains and to explore the factors associated with musculoskeletal pain (MSP) among medical students at university hospitals in central Saudi Arabia.</p><p><strong>Method: </strong>This cross-sectional study was conducted at a government institution using an online self-administered, modified version of the Standardised Nordic Questionnaire in the English language.</p><p><strong>Results: </strong>A total of 469 students responded to our survey. The prevalence of MSP in at least one body site at any time, in the past week, and in the past year was 85.3%, 54.4%, and 81.9%, respectively. Factors significantly associated with MSP in at least one body site at any time were being in the clinical year (<i>P</i> = 0.032), history of trauma (<i>P</i> = 0.036), history of depressive symptoms (<i>P</i> < 0.001), and history of psychosomatic symptoms (<i>P</i> < 0.001). On multivariable regression analysis, factors associated with MSP were history of trauma (<i>P</i> = 0.016) and depressive (<i>P</i> = 0.002) or psychosomatic symptoms (<i>P</i> = 0.004).</p><p><strong>Conclusion: </strong>MSP among Saudi medical students is high, particularly among those in the clinical years and those with history of trauma and with depressive or psychosomatic symptoms. Medical institutions should be aware of this serious health issue and preventive measures are warranted.</p>","PeriodicalId":19786,"journal":{"name":"Pain Research and Treatment","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/1235706","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35654756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Corrigendum to \"The Role of Descending Modulation in Manual Therapy and Its Analgesic Implications: A Narrative Review\".","authors":"Andrew D Vigotsky, Ryan P Bruhns","doi":"10.1155/2017/1535473","DOIUrl":"https://doi.org/10.1155/2017/1535473","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1155/2015/292805.].</p>","PeriodicalId":19786,"journal":{"name":"Pain Research and Treatment","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/1535473","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35634642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}