单剂量帕瑞昔布对失血性休克大鼠炎症反应及缺血性小管损伤的影响。

Q2 Medicine
Pain Research and Treatment Pub Date : 2018-02-04 eCollection Date: 2018-01-01 DOI:10.1155/2018/8375746
Mariana Takaku, Andre Carnevali da Silva, Nathalie Izumi Iritsu, Pedro Thadeu Galvao Vianna, Yara Marcondes Machado Castiglia
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引用次数: 5

摘要

帕瑞昔布是一种选择性COX-2抑制剂,用于改善术后手术的镇痛。在这里,我们评估了单剂量帕瑞昔布预处理是否会影响急性出血大鼠的肾脏功能、细胞损伤和炎症反应。根据血清和肾组织细胞因子(IL-1α、IL-1β、IL-6、IL-10和TNF-α)水平测定炎症反应。将44只七氟醚麻醉的成年Wistar大鼠随机分为四组:安慰剂组/无出血组(Plc/NH);帕瑞昔布/无出血(Pcx/NH);安慰剂/出血(Plc) / H);帕瑞昔布/出血(Pcx/H)。Pcx组给予单剂量静脉注射帕瑞昔布,Plc组给予单剂量安慰剂(等渗盐水)。出血组的动物出血量为血容量的30%。然后评估肾功能和肾脏组织学。Plc/H显示出最高的血清细胞因子水平,表明帕瑞昔布预处理可以降低出血大鼠的炎症反应。各组间组织细胞因子水平无差异。Plc/H显示肾小管扩张和退变的比例较高,表明帕瑞昔布抑制肾灌注不足引起的肾小管损伤。我们的研究结果表明,单剂量帕瑞昔布预处理可以减轻急性出血大鼠的炎症反应和肾小管损伤,而不会改变肾功能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Effects of a Single Dose of Parecoxib on Inflammatory Response and Ischemic Tubular Injury Caused by Hemorrhagic Shock in Rats.

Effects of a Single Dose of Parecoxib on Inflammatory Response and Ischemic Tubular Injury Caused by Hemorrhagic Shock in Rats.

Effects of a Single Dose of Parecoxib on Inflammatory Response and Ischemic Tubular Injury Caused by Hemorrhagic Shock in Rats.

Effects of a Single Dose of Parecoxib on Inflammatory Response and Ischemic Tubular Injury Caused by Hemorrhagic Shock in Rats.

Parecoxib, a selective COX-2 inhibitor, is used to improve analgesia in postoperative procedures. Here we evaluated whether pretreatment with a single dose of parecoxib affects the function, cell injury, and inflammatory response of the kidney of rats subjected to acute hemorrhage. Inflammatory response was determined according to serum and renal tissue cytokine levels (IL-1α, IL-1β, IL-6, IL-10, and TNF-α). Forty-four adult Wistar rats anesthetized with sevoflurane were randomized into four groups: placebo/no hemorrhage (Plc/NH); parecoxib/no hemorrhage (Pcx/NH); placebo/hemorrhage (Plc/H); and parecoxib/hemorrhage (Pcx/H). Pcx groups received a single dose of intravenous parecoxib while Plc groups received a single dose of placebo (isotonic saline). Animals in hemorrhage groups underwent bleeding of 30% of blood volume. Renal function and renal histology were then evaluated. Plc/H showed the highest serum levels of cytokines, suggesting that pretreatment with parecoxib reduced the inflammatory response in rats subjected to hemorrhage. No difference in tissue cytokine levels between groups was observed. Plc/H showed higher percentage of tubular dilation and degeneration, indicating that parecoxib inhibited tubular injury resulting from renal hypoperfusion. Our findings indicate that pretreatment with a single dose of parecoxib reduced the inflammatory response and tubular renal injury without altering renal function in rats undergoing acute hemorrhage.

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来源期刊
Pain Research and Treatment
Pain Research and Treatment Medicine-Anesthesiology and Pain Medicine
CiteScore
3.60
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