Pain Processing and Vegetative Dysfunction in Fibromyalgia: A Study by Sympathetic Skin Response and Laser Evoked Potentials.

Q2 Medicine

Pain Research and Treatment Pub Date : 2017-01-01 Epub Date: 2017-09-28 DOI:10.1155/2017/9747148

Marina de Tommaso, Katia Ricci, Giuseppe Libro, Eleonora Vecchio, Marianna Delussi, Anna Montemurno, Giuseppe Lopalco, Florenzo Iannone

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引用次数: 29

Abstract

Background: A dysfunction of pain processing at central and peripheral levels was reported in fibromyalgia (FM). We aimed to correlate laser evoked potentials (LEPs), Sympathetic Skin Response (SSR), and clinical features in FM patients.

Methods: Fifty FM patients and 30 age-matched controls underwent LEPs and SSR by the right hand and foot. The clinical evaluation included FM disability (FIQ) and severity scores (WPI), anxiety (SAS) and depression (SDS) scales, and questionnaires for neuropathic pain (DN4).

Results: The LEP P2 latency and amplitude and the SSR latency were increased in FM group. This latter feature was more evident in anxious patients. The LEPs habituation was reduced in FM patients and correlated to pain severity scores. In a significant number of patients (32%) with higher DN4 and FIQ scores, SSR or LEP responses were absent.

Conclusions: LEPs and SSR might contribute to clarifying the peripheral and central nervous system involvement in FM patients.

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纤维肌痛的疼痛加工和植物功能障碍:交感皮肤反应和激光诱发电位的研究。

背景:据报道，纤维肌痛(FM)中存在中枢和外周水平的疼痛加工功能障碍。我们的目的是将激光诱发电位(LEPs)、交感皮肤反应(SSR)和FM患者的临床特征联系起来。方法:50例FM患者和30例年龄相匹配的对照组分别行右手和足部LEPs和SSR。临床评价包括FM残疾(FIQ)和严重程度评分(WPI)，焦虑(SAS)和抑郁(SDS)量表，神经性疼痛(DN4)问卷。结果:FM组LEP P2潜伏期、振幅和SSR潜伏期均增加。后一种特征在焦虑患者中更为明显。FM患者的lep习惯化程度降低，并与疼痛严重程度评分相关。在DN4和FIQ评分较高的大量患者(32%)中，没有SSR或LEP反应。结论:LEPs和SSR可能有助于明确FM患者的外周和中枢神经系统受累情况。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pain Research and Treatment Medicine-Anesthesiology and Pain Medicine

CiteScore

3.60

自引率

0.00%

发文量