L Feller, R A G Khammissa, J Fourie, M Bouckaert, J Lemmer
{"title":"Postherpetic Neuralgia and Trigeminal Neuralgia.","authors":"L Feller, R A G Khammissa, J Fourie, M Bouckaert, J Lemmer","doi":"10.1155/2017/1681765","DOIUrl":"10.1155/2017/1681765","url":null,"abstract":"<p><p>Postherpetic neuralgia (PHN) is an unpredictable complication of varicella zoster virus- (VZV-) induced herpes zoster (HZ) which often occurs in elderly and immunocompromised persons and which can induce psychosocial dysfunction and can negatively impact on quality of life. Preventive options for PHN include vaccination of high-risk persons against HZ, early use of antiviral agents, and robust management of pain during the early stage of acute herpes zoster. If it does occur, PHN may persist for months or even years after resolution of the HZ mucocutaneous eruptions, and treatment is often only partially effective. Classical trigeminal neuralgia is a severe orofacial neuropathic pain condition characterized by unilateral, brief but recurrent, lancinating paroxysmal pain confined to the distribution of one or more of the branches of the trigeminal nerve. It may be idiopathic or causally associated with vascular compression of the trigeminal nerve root. The anticonvulsive agents, carbamazepine or oxcarbazepine, constitute the first-line treatment. Microvascular decompression or ablative procedures should be considered when pharmacotherapy is ineffective or intolerable. The aim of this short review is briefly to discuss the etiopathogenesis, clinical features, and treatment of PHN and classical trigeminal neuralgia.</p>","PeriodicalId":19786,"journal":{"name":"Pain Research and Treatment","volume":"2017 ","pages":"1681765"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35759330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maria Beatrice Passavanti, Vincenzo Pota, Pasquale Sansone, Caterina Aurilio, Lorenzo De Nardis, Maria Caterina Pace
{"title":"Chronic Pelvic Pain: Assessment, Evaluation, and Objectivation.","authors":"Maria Beatrice Passavanti, Vincenzo Pota, Pasquale Sansone, Caterina Aurilio, Lorenzo De Nardis, Maria Caterina Pace","doi":"10.1155/2017/9472925","DOIUrl":"10.1155/2017/9472925","url":null,"abstract":"<p><p>Chronic Pelvic Pain (CPP) and Chronic Pelvic Pain Syndrome (CPPS) have a significant impact on men and women of reproductive and nonreproductive age, with a considerable burden on overall quality of life (QoL) and on psychological, functional, and behavioural status. Moreover, diagnostic and therapeutic difficulties are remarkable features in many patients. Therefore evaluation, assessment and objectivation tools are often necessary to properly address each patient and consequently his/her clinical needs. Here we review the different tools for pain assessment, evaluation, and objectivation; specific features regarding CPP/CPPS will be highlighted. Also, recent findings disclosed with neuroimaging investigations will be reviewed as they provide new insights into CPP/CPPS pathophysiology and may serve as a tool for CPP assessment and objectivation.</p>","PeriodicalId":19786,"journal":{"name":"Pain Research and Treatment","volume":"2017 ","pages":"9472925"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/9472925","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35759332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A Serrano, D Torres, M Veciana, C Caro, J Montero, V Mayoral
{"title":"Quantitative Thermal Testing Profiles as a Predictor of Treatment Response to Topical Capsaicin in Patients with Localized Neuropathic Pain.","authors":"A Serrano, D Torres, M Veciana, C Caro, J Montero, V Mayoral","doi":"10.1155/2017/7425907","DOIUrl":"https://doi.org/10.1155/2017/7425907","url":null,"abstract":"There are no reliable predictors of response to treatment with capsaicin. Given that capsaicin application causes heat sensation, differences in quantitative thermal testing (QTT) profiles may predict treatment response. The aim of this study was to determine whether different QTT profiles could predict treatment outcomes in patients with localized peripheral neuropathic pain (PeLNP). We obtained from medical records QTT results and treatment outcomes of 55 patients treated between 2010 and 2013. Warm sensation threshold (WST) and heat pain threshold (HPT) values were assessed at baseline at the treatment site and in the asymptomatic, contralateral area. Responders were defined as those who achieved a > 30% decrease in pain lasting > 30 days. Two distinct groups were identified based on differences in QTT profiles. Most patients (27/31; 87.1%) with a homogenous profile were nonresponders. By contrast, more than half of the patients (13/24, 54.2%) with a nonhomogenous profile were responders (p = 0.0028). A nonhomogenous QTT profile appears to be predictive of response to capsaicin. We hypothesize patients with a partial loss of cutaneous nerve fibers or receptors are more likely to respond. By contrast, when severe nerve damage or normal cutaneous sensations are present, the pain is likely due to central sensitization and thus not responsive to capsaicin. Prospective studies with larger patient samples are needed to confirm this hypothesis.","PeriodicalId":19786,"journal":{"name":"Pain Research and Treatment","volume":"2017 ","pages":"7425907"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/7425907","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34835905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
David Jonsson, Lage Burström, Tohr Nilsson, Jens Wahlström, Hans Pettersson
{"title":"Association between Pain in Adolescence and Low Back Pain in Adulthood: Studying a Cohort of Mine Workers.","authors":"David Jonsson, Lage Burström, Tohr Nilsson, Jens Wahlström, Hans Pettersson","doi":"10.1155/2017/3569231","DOIUrl":"https://doi.org/10.1155/2017/3569231","url":null,"abstract":"<p><p><i>Purpose.</i> To study the association of self-reported pain in adolescence with low back pain (LBP) in adulthood among mine workers and, also, study associations between the presence of LBP over 12-month or one-month LBP intensity during a health examination and daily ratings of LBP three and nine months later. <i>Methods.</i> Mixed design with data collected retrospectively, cross-sectionally, and prospectively. Data was collected using a questionnaire during a health examination and by using self-reported daily ratings of LBP three and nine months after the examination. <i>Results.</i> Pain prevalence during teenage years was 55% and it was 59% at age 20. Pain during teenage years had a relative risk of 1.33 (95% confidence interval 1.03-1.73) of LBP 12 months prior to the health examination, but with no associations with LBP intensity or LBP assessed by text messaging. Pain at age 20 years was not associated with any measure of LBP in adulthood. Daily ratings of LBP were associated with LBP during the health examination three and nine months earlier. <i>Conclusions.</i> There were no clear associations between self-reported pain in adolescence and LBP in adulthood. Self-reported daily ratings of LBP were associated with LBP from the health examination. Possible limitations for this study were the retrospective design and few participants.</p>","PeriodicalId":19786,"journal":{"name":"Pain Research and Treatment","volume":"2017 ","pages":"3569231"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/3569231","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34877245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Robert Jank, Alexander Gallee, Markus Boeckle, Sabine Fiegl, Christoph Pieh
{"title":"Chronic Pain and Sleep Disorders in Primary Care.","authors":"Robert Jank, Alexander Gallee, Markus Boeckle, Sabine Fiegl, Christoph Pieh","doi":"10.1155/2017/9081802","DOIUrl":"10.1155/2017/9081802","url":null,"abstract":"<p><strong>Background: </strong>Chronic pain (CP) and sleep disorders (SD) are highly prevalent in the general population. However, comprehensive data regarding the prevalence and characteristics of pain and SD in primary care are rare.</p><p><strong>Methods: </strong>From <i>N</i> = 578 patients <i>N</i> = 570 were included within 8 weeks (mean age: 50.8 ± 18.7 years, females: 289). Sociodemographic data, Insomnia Severity Index (ISI), and parts of a self-report questionnaire for pain (Multidimensional German Pain Questionnaire) were recorded and additional medical information (pain medication, sleep medication) was gathered from the patient charts.</p><p><strong>Results: </strong>Of the total sample, 33.2% (<i>n</i> = 189) suffer from CP (pain ≥ 6 months) and 29.1% (<i>n</i> = 166) from SD. 45.5% of the CP patients suffer from SD and 26.5% from clinical insomnia (ISI ≥ 15). SD (<i>β</i> = 0.872, SE = 0.191, <i>t</i> = 4,572, <i>p</i> < 0.001, CI [0.497; 1.246]) and older age (<i>β</i> = 0.025, SE = 0.005, <i>t</i> = 5.135, <i>p</i> < 0.001, CI [0.015; 0.035]) were significantly associated with pain experience.</p><p><strong>Conclusion: </strong>About a quarter of CP patients suffer from clinical insomnia. The suggested bidirectional relation should be considered during comprehensive assessment and treatment of patients.</p>","PeriodicalId":19786,"journal":{"name":"Pain Research and Treatment","volume":"2017 ","pages":"9081802"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35802051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pain and Stress Response during Intravenous Access in Children with Congenital Adrenal Hyperplasia: Effects of EMLA and Nitrous Oxide Treatment.","authors":"K Ekbom","doi":"10.1155/2017/1793241","DOIUrl":"https://doi.org/10.1155/2017/1793241","url":null,"abstract":"<p><strong>Background: </strong>Congenital adrenal hyperplasia (CAH) is an endocrine condition that requires regularly blood samples for optimal treatment. The management of CAH in children is complex when intravenous access is one of the most stressful procedures for children. The purpose of this pilot study was to investigate the effects of nitrous oxide inhalation (N2O) in combination with cutaneous application of local anesthetics (EMLA) for improving intravenous access in children with CAH.</p><p><strong>Method: </strong>Ten children (7-14 years) were studied. The children received two intravenous procedures: one with EMLA and one with EMLA + N2O. The order of priority was randomized. The outcomes were the children's pain experience (0-10) and an evaluation of satisfaction (1-5) after the procedure. Heart rate, blood pressure, saturation, and analyses of 17-hydroxyprogesterone (17-OHP), norepinephrine, and glucose were analyzed.</p><p><strong>Results: </strong>Higher pain scores, heart rate, and glucose levels were reported after EMLA, compared to EMLA + N2O, but 17-OHP levels remained unchanged. The children's satisfaction with the intravenous procedure was more positive for EMLA + N2O.</p><p><strong>Conclusions: </strong>EMLA + N2O offers the possibility of improving the intravenous procedure for anxious children with CAH. Although the quality of care was better with N2O treatment, it was not possible to demonstrate that this is a prerequisite for valid 17-OHP measurements.</p>","PeriodicalId":19786,"journal":{"name":"Pain Research and Treatment","volume":"2017 ","pages":"1793241"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/1793241","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35849382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Effectiveness of Aromatherapy in Reducing Pain: A Systematic Review and Meta-Analysis","authors":"S. Lakhan, Heather Sheafer, Deborah E. Tepper","doi":"10.1155/2016/8158693","DOIUrl":"https://doi.org/10.1155/2016/8158693","url":null,"abstract":"Background. Aromatherapy refers to the medicinal or therapeutic use of essential oils absorbed through the skin or olfactory system. Recent literature has examined the effectiveness of aromatherapy in treating pain. Methods. 12 studies examining the use of aromatherapy for pain management were identified through an electronic database search. A meta-analysis was performed to determine the effects of aromatherapy on pain. Results. There is a significant positive effect of aromatherapy (compared to placebo or treatments as usual controls) in reducing pain reported on a visual analog scale (SMD = −1.18, 95% CI: −1.33, −1.03; p < 0.0001). Secondary analyses found that aromatherapy is more consistent for treating nociceptive (SMD = −1.57, 95% CI: −1.76, −1.39, p < 0.0001) and acute pain (SMD = −1.58, 95% CI: −1.75, −1.40, p < 0.0001) than inflammatory (SMD = −0.53, 95% CI: −0.77, −0.29, p < 0.0001) and chronic pain (SMD = −0.22, 95% CI: −0.49, 0.05, p = 0.001), respectively. Based on the available research, aromatherapy is most effective in treating postoperative pain (SMD = −1.79, 95% CI: −2.08, −1.51, p < 0.0001) and obstetrical and gynecological pain (SMD = −1.14, 95% CI: −2.10, −0.19, p < 0.0001). Conclusion. The findings of this study indicate that aromatherapy can successfully treat pain when combined with conventional treatments.","PeriodicalId":19786,"journal":{"name":"Pain Research and Treatment","volume":"2016 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/8158693","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64552844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Somers, S. Kelleher, K. Westbrook, G. Kimmick, R. Shelby, A. Abernethy, F. Keefe
{"title":"A Small Randomized Controlled Pilot Trial Comparing Mobile and Traditional Pain Coping Skills Training Protocols for Cancer Patients with Pain","authors":"T. Somers, S. Kelleher, K. Westbrook, G. Kimmick, R. Shelby, A. Abernethy, F. Keefe","doi":"10.1155/2016/2473629","DOIUrl":"https://doi.org/10.1155/2016/2473629","url":null,"abstract":"Psychosocial pain management interventions are efficacious for cancer pain but are underutilized. Recent advances in mobile health (mHealth) technologies provide new opportunities to decrease barriers to access psychosocial pain management interventions. The objective of this study was to gain information about the accessibility and efficacy of mobile pain coping skills training (mPCST) intervention delivered to cancer patients with pain compared to traditional in-person pain coping skills training intervention. This study randomly assigned participants (N = 30) to receive either mobile health pain coping skills training intervention delivered via Skype or traditional pain coping skills training delivered face-to-face (PCST-trad). This pilot trial suggests that mPCST is feasible, presents low burden to patients, may lead to high patient engagement, and appears to be acceptable to patients. Cancer patients with pain in the mPCST group reported decreases in pain severity and physical symptoms as well as increases in self-efficacy for pain management that were comparable to changes in the PCST-trad group (p's < 0.05). These findings suggest that mPCST, which is a highly accessible intervention, may provide benefits similar to an in-person intervention and shows promise for being feasible, acceptable, and engaging to cancer patients with pain.","PeriodicalId":19786,"journal":{"name":"Pain Research and Treatment","volume":"2016 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/2473629","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64275352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jinguo Wang, Honglan Zhou, W. An, Na Wang, Yang Gao
{"title":"Effective Concentration of Lidocaine Plus Fentanyl for Caudal Block in Patients Undergoing Transrectal Ultrasound Guided Prostate Biopsy","authors":"Jinguo Wang, Honglan Zhou, W. An, Na Wang, Yang Gao","doi":"10.1155/2016/5862931","DOIUrl":"https://doi.org/10.1155/2016/5862931","url":null,"abstract":"Objective. This study determined the effective concentration (EC) of lidocaine plus 75 μg fentanyl for caudal block in patients undergoing transrectal ultrasound (TRUS) guided prostate biopsy. Methods. Consecutive male patients scheduled for TRUS guided prostate biopsy were enrolled. The mixed solution for caudal block contained lidocaine and 75 μg fentanyl, in total 20 mL. The concentration of lidocaine was determined using the up-and-down method, starting at 0.8% (a step size of 0.1%). A successful caudal block was defined by no pain perception during biopsy. The EC50 of lidocaine for successful caudal block was calculated and side effects were evaluated. Results. A total of 23 patients were recruited. The EC50 of lidocaine for successful caudal block was 0.53%. Conclusions. Lidocaine of 0.53% combined with 75 μg fentanyl resulted in excellent caudal block in 50% of male patients undergoing transrectal ultrasound guided prostate biopsy.","PeriodicalId":19786,"journal":{"name":"Pain Research and Treatment","volume":"136 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/5862931","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64443154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comment on “Cost-Saving Early Diagnosis of Functional Pain in Nonmalignant Pain: A Noninferiority Study of Diagnostic Accuracy”","authors":"K. Toda","doi":"10.1155/2016/8542491","DOIUrl":"https://doi.org/10.1155/2016/8542491","url":null,"abstract":"Dr. Cámara et al. published a diagnostic testing that distinguishes functional pain from neuropathic and nociceptive pain [1]. It is very important to distinguish between neuropathic pain and nociceptive pain, because treatment of the two kinds of pain is completely different. However, distinction between neuropathic pain and functional pain provides little clinical value, because treatment of the two kinds of pain is almost the same. Functional pain corresponds to central sensitivity syndromes such as fibromyalgia (FM) and its incomplete forms. To my knowledge, if FM is neuropathic pain, FM is the disorder that has the highest number of science-based treatments among neuropathic pain. Effective treatment for FM is effective for other neuropathic pain. From the viewpoint of treatment, we do not have to distinguish neuropathic pain from functional pain. Continuance of any kinds of pain causes central sensitization in the brain and/or spinal cord, and central sensitization itself causes pain. I believe that pain due to central sensitization is central neuropathic pain and functional pain is central neuropathic pain. FM has a feature of central neuropathic pain. I believe that we do not have to distinguish neuropathic pain from functional pain.","PeriodicalId":19786,"journal":{"name":"Pain Research and Treatment","volume":"2016 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/8542491","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64573503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}