Pediatric Radiology最新文献

{"title":"Quantitative evaluation of placental microvascular blood flow and microstructure in fetal growth restriction with IVIM MRI.","authors":"Caroline J Walsh, Mariana L Meyers, Neal Chandnani, Alex J Barker, Takashi Fujiwara, David M Mirsky, Erin K Englund","doi":"10.1007/s00247-024-06151-9","DOIUrl":"10.1007/s00247-024-06151-9","url":null,"abstract":"<p><strong>Background: </strong>Intravoxel incoherent motion (IVIM) MRI uses diffusion-weighted (DW) MRI acquisitions to evaluate the microvascular and cellular environments of tissue. Due to these properties, IVIM has been increasingly utilized to evaluate abnormal placentation.</p><p><strong>Objective: </strong>Our primary objective was to compare IVIM parameters in the placenta of patients with fetal growth restriction and appropriate for gestational age controls across gestational ages. Our secondary aim was to quantify IVIM parameters in fetal versus maternal placental aspects to evaluate microvascular and parenchymal differences.</p><p><strong>Materials and methods: </strong>With IRB approval, pregnant individuals with a diagnosis of fetal growth restriction (n=24) and controls (n=22) were retrospectively analyzed. DW-MRI data were collected at 1.5 T with nine b-values (range, 0 s/mm² to 1,000 s/mm²). Data were processed by one non-blinded reader to obtain mean perfusion fraction (f), pseudo-diffusion coefficient (D*), their product fD*, and diffusion coefficient (D) in maternal and fetal aspects of the placenta, defined by bisecting the thickness of the placenta. Repeated measures of two-way ANOVAs were used to compare IVIM parameters in fetal and maternal placental aspects between participant groups. Correlations between IVIM parameters and gestational age were also evaluated in both groups.</p><p><strong>Results: </strong>The average gestational age at MRI was 27±4 weeks for both groups. The percentile estimated fetal weight was 5.4±5.9% for the fetal growth restriction group and 42.8±28.5% for controls (P<0.001). The parameters D* and fD*, related to microvascular blood flow and tissue perfusion, were significantly lower in participants with fetal growth restriction compared to controls (D*, 40.5 vs. 52.4×10^-3 mm²/s, P=0.043; fD*, 14.7 vs. 21.0×10^-3 mm²/s, P=0.019). No other differences were observed, nor associations between gestational age and IVIM parameters in either group.</p><p><strong>Conclusion: </strong>Our results suggest reduced microvascular flow in placentas of patients with fetal growth restriction compared to controls.</p>","PeriodicalId":19755,"journal":{"name":"Pediatric Radiology","volume":" ","pages":"546-555"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Displaced cortical vein sign on CT in infants: a reliable predictor to distinguish low-attenuation subdural collections from benign enlargement of subarachnoid spaces.","authors":"Danika Baskar, Selima Siala, William W Pryor, Thad Benefield, Carolina V Guimaraes","doi":"10.1007/s00247-024-06160-8","DOIUrl":"10.1007/s00247-024-06160-8","url":null,"abstract":"<p><p>Differentiating benign enlargement of subarachnoid spaces (BESS) from low-attenuation subdural collections on CT imaging of infants can be challenging. This distinction is crucial in infants, as subdural collections may raise the concern for abusive head trauma (AHT). To evaluate the utilization of the displaced cortical vein sign on CT as a predictor of pathological subdural collections confirmed by MRI and to assess the reproducibility of this finding among radiologists with different levels of clinical experience. A total of 104 imaging exams were independently reviewed by junior- and senior-level radiologists (52 head CTs and 52 corresponding brain MRI exams). These exams included 43 MRI-confirmed cases of subdural collections and 9 MRI-confirmed cases of BESS from patients aged 0-2 years. The presence of pathological collections and sulcal flattening, and the displaced cortical vein sign were recorded for both reviewers along with attenuation and signal characteristics of the collections. Confirmed diagnosis of AHT was determined by chart review. The sensitivity, specificity, and inter-observer reliability were analyzed between reviewers. The average patient age was 6.4 months with a median age of 4 months. The sensitivity values of the displaced cortical vein sign on CT for the presence of subdural collections were 69.6% and 79.0% for the two reviewers, respectively. The specificity of this finding was 100% for both reviewers, with no false negative cases. Interobserver reliability was the highest for the depiction of the displaced cortical vein sign on CT (κ=0.63, 95% CI 0.45-0.82) and MRI (κ=0.96, 95% CI 0.87-1.00). All cases where at least 1 reviewer noted the displaced cortical vein sign on CT and were later confirmed to be traumatic subdural collection on MRI were concluded to have high concern for AHT upon chart review. In total, 23.3% (11 out of 52) of cases confirmed to have subdural collections on MRI were found to have calvarial fractures associated with their presentation. The displaced cortical vein sign on head CT is a specific and reproducible finding associated with subdural collections. Our data suggest that this sign is a more reliable and readily identifiable indicator of pathological subdural collections compared to other traditional imaging findings, such as flattening of the cerebral sulci.</p>","PeriodicalId":19755,"journal":{"name":"Pediatric Radiology","volume":" ","pages":"459-465"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The publication fate of abstracts awarded prizes at European Society of Paediatric Radiology annual scientific meetings.","authors":"Michael Paddock, Parasdeep S Bains, Ola Kvist, Savvas Andronikou, Stephanie Franchi-Abella, Rick R van Rijn, Owen J Arthurs, Amaka C Offiah","doi":"10.1007/s00247-024-06152-8","DOIUrl":"10.1007/s00247-024-06152-8","url":null,"abstract":"<p><strong>Background: </strong>The European Society of Paediatric Radiology (ESPR) awards prizes for outstanding work presented at their annual scientific meetings. The proportion of ESPR prize-winning abstracts to journal publications is not known. Contextualising abstract-to-publication proportions by evaluating publication experience can yield valuable insights and actionable outcomes to support researchers in overcoming barriers to journal publication.</p><p><strong>Objective: </strong>To assess the abstract-to-publication proportion of prize-winning ESPR abstracts and prize-winning authors' experience of publishing in Pediatric Radiology, the affiliated journal of the ESPR and other specialist international paediatric radiology societies.</p><p><strong>Materials and methods: </strong>PubMed was searched for titles of ESPR prize-winning abstracts from 1977 (the year of first award) up to and including 2021, where the presenter was either first or co-author, and the article was published 2 years before or after the presentation year. If not found, a general internet search was performed. Titles of all retrieved articles were evaluated for inclusion. A survey was distributed to all ESPR prize winners to better understand their experiences around journal submission.</p><p><strong>Results: </strong>Over 44 years, 108 prizes were awarded. The prize-winning abstract-to-publication proportion was significantly higher (59.3%, OR=2.10, P=0.012) than the recently published pediatric radiology \"abstract to publication rate\" (41.9% from 2013-2016). Moreover, prize winners were more than twice as likely than to achieve journal publication (OR=2.10), and as first author (OR=1.33). The majority of awardees published their work as first author (52/64, 81.3%): the first-author abstract-to-publication proportion was not significantly higher than the paediatric radiology \"abstract-to-publication rate\" (48.1%, OR=0.33, P=0.330). Sixty-four survey responses were received (59.3%, out of a total 108 awarded prizes). Just over 20% of prize-winning work was published in Pediatric Radiology, with 41.5% of respondents reporting a good to excellent submission experience.</p><p><strong>Conclusion: </strong>Prize-winning and first-author abstract-to-publication proportions are higher for ESPR-awarded abstracts than the most recently reported paediatric radiology \"abstract-to-publication rate\", suggesting that prizes are either awarded to work most likely to be published or that being awarded a prize encourages publication. Given that just over 40% of prize-winning abstracts remain unpublished, the ESPR should do more to support and encourage all authors to publish their work.</p>","PeriodicalId":19755,"journal":{"name":"Pediatric Radiology","volume":" ","pages":"578-584"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"International standardization of pediatric magnetic resonance imaging protocols: creation of the World Federation of Pediatric Imaging MR Protocols Committee.","authors":"Suely Fazio Ferraciolli, Maria Ines Boechat, Yunhong Shu, Meaza Anu, Christine Harris, Elizabeth Van Vorstenbosch-Lynn, Tracy Kilborn, Wendy Lam, Mai-Lan Ho, Joanna Kasznia-Brown, Camilo Jaimes, Michael S Gee","doi":"10.1007/s00247-024-06154-6","DOIUrl":"10.1007/s00247-024-06154-6","url":null,"abstract":"<p><p>The World Federation of Pediatric Imaging (WFPI) MR Protocols Committee was formed in response to the critical need for standardized magnetic resonance imaging (MRI) protocols tailored specifically for pediatric populations. This initiative addresses the inherent challenges and variabilities in pediatric MRI practices due to the unique physiological and anatomical characteristics of children, which often result in extended scan times, increased costs, and greater need for sedation. The committee, comprising a diverse group of international radiologists, pediatric imaging societies, and major MRI vendors, collaboratively developed a comprehensive set of MRI protocols. These protocols are designed to enhance diagnostic accuracy, reduce sedation use, and streamline workflows, thereby minimizing healthcare disparities across global regions. Protocols cover a wide range of applications, including neuroradiology, abdominal imaging, and musculoskeletal conditions, with specific focus on practical implementation in both high-resource and resource-limited settings. After rigorous development and refinement through global feedback, these protocols have been made accessible through the WFPI website and will be directly integrated into MRI systems via vendor collaborations. These protocols provide a flexible, foundational approach that can be adapted to suit the needs of centers worldwide. This ensures that even basic protocols are accessible across different settings, allowing customization based on available resources and specific clinical demands.</p>","PeriodicalId":19755,"journal":{"name":"Pediatric Radiology","volume":" ","pages":"375-383"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MRI features of hepatocellular adenomas in children: clinical and radiological review.","authors":"Musab Almushayqih, Rose Chami, Caroline Rutten, Aleena Malik, Govind B Chavhan","doi":"10.1007/s00247-025-06177-7","DOIUrl":"10.1007/s00247-025-06177-7","url":null,"abstract":"<p><strong>Background: </strong>Hepatocellular adenomas (HCAs) are rare, benign hepatic tumors in children, with limited imaging data available for pediatric cases.</p><p><strong>Objective: </strong>To describe the magnetic resonance imaging (MRI) and clinical features of histologically proven HCAs in children.</p><p><strong>Materials and methods: </strong>Single-center retrospective review of pathology-proven HCA from January 2004 to February 2024. Patients with available pre-intervention imaging in our PACS were included. Two independent readers reviewed the imaging studies. The features were summarized using descriptive statistics and inter-reader agreement was assessed using Cohen's kappa.</p><p><strong>Results: </strong>This study included 11 children (6 boys and 5 girls; median age 15 years) with 13 pathologically proven HCAs. Three patients had type 1a glycogen storage disease. Five patients had a single lesion, while six had multiple lesions. The lesions were well-defined with a median average diameter of 3.6 cm. Most were homogenously T1 iso-intense (61.5%) and mildly hyperintense (76.9%) on T2-w fat saturated images. The atoll sign was present in two lesions. Intralesional fat was observed in 69.2% of cases: microscopic in eight lesions and macroscopic in one. Hemorrhage occurred in three (23.07%) lesions and necrosis in one (7.7%). Nine out of 10 (90%) lesions showed arterial phase hyperenhancement, and only 3/10 (30%) lesions retained contrast on hepatobiliary phase. In total, 6/13 (46.1%) lesions showed washout, and all received hepatobiliary agent. One lesion ruptured with the hemoperitoneum. Of the 11, 63.6% of patients underwent percutaneous biopsy and 36.4% underwent surgical resection.</p><p><strong>Conclusion: </strong>MR imaging features are nonspecific, but homogenous slight T2 hyperintensity, arterial phase hyperenhancement, and intralesional fat content are common features. Hepatobiliary contrast uptake is variable.</p>","PeriodicalId":19755,"journal":{"name":"Pediatric Radiology","volume":" ","pages":"488-498"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ovarian volume estimation in girls using rapid MR imaging for right lower quadrant pain.","authors":"Sharon Gould, Tejal Mody, Mary Gould, Heidi Kecskemethy, Simone Veale, Arabinda Choudhary","doi":"10.1007/s00247-025-06170-0","DOIUrl":"10.1007/s00247-025-06170-0","url":null,"abstract":"<p><strong>Background: </strong>MRI provides adequate ovarian imaging to permit accurate measurement. More normative data for children and adolescents is needed as MRI is being used for evaluation of right lower quadrant pain that could be due to ovarian torsion.</p><p><strong>Objective: </strong>To determine normative data for ovarian size by MRI using a rapid protocol for right lower quadrant pain.</p><p><strong>Materials and methods: </strong>Retrospective evaluation of MRI examinations of girls obtained between 2013 and 2019 was performed including chart and image review. Normative data was determined by age.</p><p><strong>Results: </strong>Mean patient age was 12.8 years (range 1-18 years). Six hundred forty-four scans were included in the study. Thirty-three ovaries contained cysts measuring greater than 3 cm and 8 additional ovaries were torsed. These ovaries were not included in the normal ovary measurements. Patients with known or suspected polycystic ovarian syndrome or torsion also were excluded. Ovarian volumes of normal-appearing ovaries are reported by patient age.</p><p><strong>Conclusion: </strong>Normative data for girls and adolescents utilizing a rapid MRI protocol for right lower quadrant pain is provided for increased confidence in assessing ovarian size in girls on MRI.</p>","PeriodicalId":19755,"journal":{"name":"Pediatric Radiology","volume":" ","pages":"499-504"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Collaborating with non-radiological clinical colleagues.","authors":"Maria Raissaki, Samuel Stafrace, Androniki Kozana, Rutger A J Nievelstein, Georgia Papaioannou","doi":"10.1007/s00247-024-06027-y","DOIUrl":"10.1007/s00247-024-06027-y","url":null,"abstract":"<p><p>Paediatric radiology is a challenging and intriguing subspecialty, dealing with children, guardians and non-radiological clinical colleagues. Paediatric radiologists are routinely in contact with numerous paediatric and surgical subspecialties, all having different needs, perceptions, prioritisations and expectations. Moreover, the radiologist is part of the team of radiographers, sonographers, nurses and secretaries, assisted by appropriate equipment and electronic tools. The framework of good collaboration to ensure safety and effectiveness for the imaged child is a shared responsibility among all medical practitioners involved. Communication in routine practice has many forms and includes appropriately filled radiology requests in accordance to the patient's medical records, routine and timely production of structured, problem-solving radiology reports, face-to-face or electronic-assisted communications and discussions on a pre-defined framework, mutually-agreed and evidence-based protocols adjusted to local availability, skills and national and international guidelines. Mutual understanding of advantages and limitations of imaging is paramount. Well-meant discussions, professionalism and empathy should promote soft skills, bidirectional communication and good collaboration for the benefit of added-value paediatric radiology. International societies, health authorities, medical directors and senior consultants have the responsibility to suggest and safeguard frameworks and recommendations. Regular multidisciplinary meetings and multidisciplinary research projects under openness, honesty and transparency are pathways favouring good collaboration.</p>","PeriodicalId":19755,"journal":{"name":"Pediatric Radiology","volume":" ","pages":"397-410"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142018260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of trauma center status on radiology resident performance in detecting non-accidental trauma on the WIDI SIM exam.","authors":"Kevin Pierre, Abheek Raviprasad, Jay Talati, Isabella Amador, Alexandria Iakovidis, Christopher Sistrom, Roberta Slater, Linda Lanier, Evelyn Anthony, Anthony Mancuso, Dhanashree Rajderkar, Priya Sharma","doi":"10.1007/s00247-024-06158-2","DOIUrl":"10.1007/s00247-024-06158-2","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate whether adult and pediatric trauma center status, as well as the presence of dedicated child protection teams, influences radiology resident performance in detecting non-accidental trauma on the Emergent/Critical Care Imaging Simulation (WIDI SIM) exam.</p><p><strong>Materials and methods: </strong>We retrospectively analyzed 639 WIDI SIM exam scores for four pediatric non-accidental trauma cases completed by radiology residents across 33 programs. Residents were stratified by level (R1-R4) and institutional factors, including adult trauma center status, pediatric trauma center status, and child protection team presence. Additionally, 2022 pediatric physical abuse counts per state were obtained from the National Child Abuse and Neglect Data System and normalized between 0 and 1. We employed a negative binomial generalized linear model (GLM). The outcome was regressed on resident level, trauma center status variables, child protection team presence, and normalized abuse counts.</p><p><strong>Results: </strong>Higher resident training level was significantly associated with better performance (R1=3.6, R2=5, R3=6.1, R4=7.9; P<0.001). Adult trauma center accreditation was also associated with higher scores (4.6 vs. 3.3; P<0.001). In contrast, pediatric trauma center status, child protection team presence, and normalized state-level abuse counts were not significantly associated with resident performance (all P>0.05).</p><p><strong>Conclusion: </strong>Resident experience and adult trauma center accreditation were significantly associated with better radiology resident performance in detecting non-accidental trauma in a simulated call environment. Pediatric trauma center status, child protection team presence, and statewide abuse prevalence were not associated with detection performance. These findings suggest the need for targeted educational interventions at non-adult trauma centers and emphasize the importance of experience in developing diagnostic proficiency for non-accidental trauma.</p>","PeriodicalId":19755,"journal":{"name":"Pediatric Radiology","volume":" ","pages":"540-545"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142979541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skeletal surveys for suspected infant abuse: patient-specific radiation dose estimation using a hybrid computational phantom.","authors":"Danielle Beaulieu, Da Zhang, Jeannette M Pérez-Rosselló, Reyhaneh Nosrati, Choonsik Lee, Andy Tsai","doi":"10.1007/s00247-024-06157-3","DOIUrl":"10.1007/s00247-024-06157-3","url":null,"abstract":"<p><strong>Background: </strong>Radiographic skeletal survey plays an important role in the diagnosis of infant abuse. Some practitioners have expressed concerns about the radiation exposure from this examination.</p><p><strong>Objective: </strong>To utilize state-of-the-art hybrid computational phantoms to more accurately estimate radiation doses of skeletal surveys performed for suspected infant abuse.</p><p><strong>Materials and methods: </strong>We searched our imaging database to identify skeletal surveys performed for suspected infant abuse (5/2020-5/2022). Initial skeletal surveys consisted of 25 standardized radiographs while follow-up skeletal surveys consisted of 16 standardized radiographs (no frontal or lateral views of the skull; or lateral views of the spine, knees, and ankles). To estimate the patient-specific organ and effective dose, we applied the National Cancer Institute dosimetry system for Radiography and Fluoroscopy (with on-the-fly 3D Monte Carlo simulation) to the male and female infant hybrid computational phantoms.</p><p><strong>Results: </strong>The mean total effective radiation dose was 0.627 mSv (initial survey) and 0.495 mSv (follow-up survey). For both surveys, the anteroposterior chest radiograph was the largest contributor to effective dose (contributing 0.101 mSv and 0.108 mSv, respectively). In the initial skeletal survey, the lens and the eyeballs received the highest organ absorbed doses (with the skull radiographs as the major contributors); and in the follow-up skeletal survey, the breasts received the highest organ absorbed dose (with the chest radiographs as the major contributors).</p><p><strong>Conclusions: </strong>We employed hybrid computational phantoms to better estimate the radiation profile of skeletal surveys performed for suspected infant abuse, thus enabling us to update and optimize this life-saving imaging protocol.</p>","PeriodicalId":19755,"journal":{"name":"Pediatric Radiology","volume":" ","pages":"530-539"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142978798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Significance of left ventricular strain in cardiac magnetic resonance for short-term prognosis in pediatric patients with acute lymphoblastic leukemia.","authors":"Wenfeng Jin, Yang Jia, Yi Liao, Linjun Xie, Xiangao Lei, Yingkun Guo, Lini Liu, Yilei Wang, Zhigang Yang, Chao Lin, Rong Xu","doi":"10.1007/s00247-025-06168-8","DOIUrl":"https://doi.org/10.1007/s00247-025-06168-8","url":null,"abstract":"<p><strong>Background: </strong>The survival rate of pediatric leukemia patients has remarkably increased. Early identification of cardiotoxicity associated with chemotherapy and the detection of prognostic factors are essential for effective patient management.</p><p><strong>Objective: </strong>To evaluate the prognostic value of parameters assessed by cardiac magnetic resonance imaging (MRI) in pediatric patients with acute lymphoblastic leukemia (ALL).</p><p><strong>Materials and methods: </strong>A total of 217 children diagnosed with ALL (study group) and 65 healthy (control group) were recruited for the study and underwent cardiac MRI. Follow-up was conducted after the cardiac MRI to monitor adverse clinical events and adverse cardiac events. Cox and Kaplan-Meier (K-M) analyses were used to investigate the predictive value of cardiac MRI parameters.</p><p><strong>Results: </strong>All strain parameters including global radial strain, global circumferential strain, and global longitudinal strain were significantly lower in the study group compared to the control group. Global radial strain (hazard ratio (HR) = 0.89; 95% confidence interval (CI) 0.79-0.99) and global longitudinal strain (HR = 1.31; 95% CI 1.01-1.71) were indicators of adverse clinical outcomes (P < 0.05). Left ventricular remodeling index (LVRI, HR = 1.11; 95% CI 1.00-1.23) was the risk predictor for adverse cardiac events (P < 0.05). Patients with global longitudinal strain of < 18% had worse clinical outcomes (HR = 6.97, 95% CI 1.07-62.39, P = 0.04) and higher risk of adverse cardiac events (HR = 5.94, 95% CI 1.23-28.58, P = 0.03) compared with those with global longitudinal strain of ≥ 18%.</p><p><strong>Conclusion: </strong>Cardiac MRI-derived parameters, including global longitudinal strain, global radial strain, and LVRI, are effective prognostic tools for predicting adverse events in children diagnosed with ALL who underwent chemotherapy with anthracyclines.</p>","PeriodicalId":19755,"journal":{"name":"Pediatric Radiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}