Pediatric Radiology最新文献

{"title":"Imaging paediatric bone marrow in immunocompromised patients.","authors":"Sara I Sirvent Cerdá, Inés Solís Muñiz, Elena García Esparza","doi":"10.1007/s00247-024-06153-7","DOIUrl":"https://doi.org/10.1007/s00247-024-06153-7","url":null,"abstract":"<p><p>The bone marrow of immunocompromised patients may exhibit abnormalities due to the underlying disease, adverse treatment effects, and/or complications arising from either source. Such complexity poses a significant diagnostic challenge, particularly in children. Magnetic resonance imaging (MRI) is the modality of choice when evaluating bone marrow in these patients. The high soft tissue contrast of MRI studies allows for detailed evaluation of bone marrow composition, including fat content, cellularity, and vascularisation. During the early years of life, bone marrow undergoes physiological maturation manifesting as a wide range of MRI findings. Understanding the most common MRI features during this phase of development is essential. However, it is equally critical to recognise physiological variations that can mimic pathological changes, as distinguishing between variations and truly pathological abnormalities is crucial for accurate diagnosis and management. This article reviews normal bone marrow and its variations during childhood, as well as the most common alterations presenting in immunocompromised patients.</p>","PeriodicalId":19755,"journal":{"name":"Pediatric Radiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spleen stiffness in a healthy pediatric population undergoing liver magnetic resonance elastography.","authors":"Suraj D Serai, Alexandra Glenn, Andrew T Trout, Wondwossen T Lerebo, Michael S Gee, Geetika Khanna, Sudha A Anupindi","doi":"10.1007/s00247-024-06107-z","DOIUrl":"https://doi.org/10.1007/s00247-024-06107-z","url":null,"abstract":"<p><strong>Background: </strong>Splenic stiffness is a potential imaging marker of portal hypertension. Normative spleen stiffness values are needed to define diagnostic thresholds.</p><p><strong>Objective: </strong>To report stiffness measurements of the spleen in healthy children undergoing liver magnetic resonance (MR) elastography across MRI vendors and field strengths.</p><p><strong>Materials and methods: </strong>This was a post-hoc analysis of data collected under a prospective multicenter cross-sectional study. Volunteers aged 7-17.9 years without a known history of liver or spleen disease were recruited for a research MRI between February 2018 and October 2019. Gradient recalled echo (GRE) or spin-echo-echo-planar imaging (SE-EPI) MR elastography was performed on a total of three vendor platforms and at two field strengths (1.5 T (T) and 3 T) with standard right upper quadrant passive driver placement (frequency of 60 Hz). Two independent reviewers measured spleen stiffness, length, and volume. Descriptive statistics, independent sample t-tests or Mann-Whitney test, and Pearson's or Spearman's correlation were used.</p><p><strong>Results: </strong>From 101 study volunteers, 72 (34 female) had measurable splenic stiffness. Median age was 12 years (interquartile range [IQR], 9.9-14.9 years). Mean (± SD) spleen stiffness was 4.7 ± 0.9 kPa (IQR, 3.8-5.4 kPa) with 6.1 kPa reflecting the 95th percentile. Strong correlation was observed between reviewers (ICC = 0.89 [95%CI, 0.71-0.93; P < 0.001]). Male volunteers had slightly higher splenic stiffness compared to females: 4.9 ± 0.9 vs. 4.3 ± 0.8 kPa (P = 0.014). There was significant correlation between spleen stiffness and body mass index (r = 0.33 [95%CI, 0.06-0.56; P = 0.024]) but no other measure of patient size (r = 0.15-0.29). No significant difference in spleen stiffness was observed across vendors (P = 0.089) or field strengths (P = 0.236).</p><p><strong>Conclusion: </strong>MR elastography-based spleen stiffness, measured as part of a liver MR elastography acquisition, is < 6.1 kPa in a healthy pediatric population and does not vary with MRI vendor or field strength.</p>","PeriodicalId":19755,"journal":{"name":"Pediatric Radiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The publication fate of abstracts awarded prizes at European Society of Paediatric Radiology annual scientific meetings.","authors":"Michael Paddock, Parasdeep S Bains, Ola Kvist, Savvas Andronikou, Stephanie Franchi-Abella, Rick R van Rijn, Owen J Arthurs, Amaka C Offiah","doi":"10.1007/s00247-024-06152-8","DOIUrl":"https://doi.org/10.1007/s00247-024-06152-8","url":null,"abstract":"<p><strong>Background: </strong>The European Society of Paediatric Radiology (ESPR) awards prizes for outstanding work presented at their annual scientific meetings. The proportion of ESPR prize-winning abstracts to journal publications is not known. Contextualising abstract-to-publication proportions by evaluating publication experience can yield valuable insights and actionable outcomes to support researchers in overcoming barriers to journal publication.</p><p><strong>Objective: </strong>To assess the abstract-to-publication proportion of prize-winning ESPR abstracts and prize-winning authors' experience of publishing in Pediatric Radiology, the affiliated journal of the ESPR and other specialist international paediatric radiology societies.</p><p><strong>Materials and methods: </strong>PubMed was searched for titles of ESPR prize-winning abstracts from 1977 (the year of first award) up to and including 2021, where the presenter was either first or co-author, and the article was published 2 years before or after the presentation year. If not found, a general internet search was performed. Titles of all retrieved articles were evaluated for inclusion. A survey was distributed to all ESPR prize winners to better understand their experiences around journal submission.</p><p><strong>Results: </strong>Over 44 years, 108 prizes were awarded. The prize-winning abstract-to-publication proportion was significantly higher (59.3%, OR=2.10, P=0.012) than the recently published pediatric radiology \"abstract to publication rate\" (41.9% from 2013-2016). Moreover, prize winners were more than twice as likely than to achieve journal publication (OR=2.10), and as first author (OR=1.33). The majority of awardees published their work as first author (52/64, 81.3%): the first-author abstract-to-publication proportion was not significantly higher than the paediatric radiology \"abstract-to-publication rate\" (48.1%, OR=0.33, P=0.330). Sixty-four survey responses were received (59.3%, out of a total 108 awarded prizes). Just over 20% of prize-winning work was published in Pediatric Radiology, with 41.5% of respondents reporting a good to excellent submission experience.</p><p><strong>Conclusion: </strong>Prize-winning and first-author abstract-to-publication proportions are higher for ESPR-awarded abstracts than the most recently reported paediatric radiology \"abstract-to-publication rate\", suggesting that prizes are either awarded to work most likely to be published or that being awarded a prize encourages publication. Given that just over 40% of prize-winning abstracts remain unpublished, the ESPR should do more to support and encourage all authors to publish their work.</p>","PeriodicalId":19755,"journal":{"name":"Pediatric Radiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic imaging of Bacillus cereus brain infection in newborns.","authors":"Benjamin Feferman, Valentina Fernandez, Elsa Tavernier, Julie Fuseau, Catherine Sembély-Taveau, Ronan Boennec, Agathe Cremades, Zoha Maakaroun-Vermesse, Christelle Follet, Delphine Mitanchez, Philippe Lanotte, Cécile Le Brun, Laurent Brunereau, Laurent Mereghetti, Baptiste Morel","doi":"10.1007/s00247-025-06169-7","DOIUrl":"https://doi.org/10.1007/s00247-025-06169-7","url":null,"abstract":"<p><strong>Background: </strong>Cerebral infection with the opportunistic pathogen Bacillus cereus can lead to severe lesions, especially in premature newborns. Early diagnosis would be highly beneficial. The aim of this study was to describe the imaging findings associated with B. cereus infections.</p><p><strong>Materials and methods: </strong>We included all newborns with a positive B. cereus blood culture and transfontanellar ultrasound between 2012 and 2022 at the Tours University Hospital. Imaging was assessed by both a junior and a senior radiologist to differentiate between hemorrhages, leukomalacia, and lesions attributed to B. cereus.</p><p><strong>Results: </strong>Nineteen patients were enrolled (12 girls), of whom 18 were premature. Three patients did not survive. Six patients had normal ultrasound and brain magnetic resonance imaging (MRI) scans. Thirteen patients had ultrasound-detected lesions: 7 hemorrhages, 1 case of leukomalacia, 1 focal ischemic lesion, and 5 lesions attributed to B. cereus. The B. cereus lesions appeared as irregular (5/5), bilateral (4/5), asymmetric (5/5), and hyperechoic patches in the subcortical white matter. They were extensive, asynchronous, and rapidly progressive over a few days (central necrosis with peripheral enhancement, referred to as the \"bear scratch sign\"), while respecting the cortex and basal ganglia.</p><p><strong>Conclusion: </strong>The presence of rapidly evolving white matter lesions should raise suspicion of B. cereus infection in newborns' brains. Imaging plays a crucial role in estimating the progression of this pathology.</p>","PeriodicalId":19755,"journal":{"name":"Pediatric Radiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Twenty years of the SPR Cardiac Imaging Course.","authors":"Taylor Chung, Gordon Culham, Shi-Joon Yoo","doi":"10.1007/s00247-024-06122-0","DOIUrl":"https://doi.org/10.1007/s00247-024-06122-0","url":null,"abstract":"","PeriodicalId":19755,"journal":{"name":"Pediatric Radiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular imaging in children with cardiac implantable electronic devices.","authors":"Benjamin Zielonka, Ashwin Prakash, Douglas Y Mah, David Annese, Robert Smalley, Daniel A Castellanos","doi":"10.1007/s00247-024-06144-8","DOIUrl":"https://doi.org/10.1007/s00247-024-06144-8","url":null,"abstract":"<p><p>The number of children with cardiac implantable electronic devices (CIEDs) is increasing at a time of rapid growth in cardiac magnetic resonance (MR) and cardiac computed tomography (CT) utilization. The presence of CIEDs poses challenges with respect to imaging safety and quality. A thoughtful approach to cardiovascular imaging in patients with CIEDs begins with an awareness of the clinical indications to determine the most appropriate imaging modality. Understanding device characteristics allows one to ensure that the proper safety measures are taken before and during cardiac MR and cardiac CT examinations. Despite the propensity of CIEDs to cause image artifact, several techniques are available to counteract these artifacts and preserve imaging quality.</p>","PeriodicalId":19755,"journal":{"name":"Pediatric Radiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Femur osteoid osteoma in children: are there location-dependent differences in MRI findings?","authors":"Dov Rosenbaum, Vandan Patel, Wudbhav N Sankar, Alexandre Arkadre, Jie C Nguyen","doi":"10.1007/s00247-024-06149-3","DOIUrl":"https://doi.org/10.1007/s00247-024-06149-3","url":null,"abstract":"<p><strong>Background: </strong>Osteoid osteomas are most commonly found in the femur and preferentially affect the pediatric population. Magnetic resonance imaging (MRI) findings of femoral osteoid osteomas are not well described.</p><p><strong>Objective: </strong>To systematically characterize pretreatment MRI findings of clinically confirmed femur osteoid osteomas in children and determine location-dependent differences.</p><p><strong>Materials and method: </strong>The current study included children (< 18 years) with clinically confirmed femoral osteoid osteomas, who underwent pretreatment MRI in the last 14 years (2009-2023). Two radiologists retrospectively reviewed all examinations and recorded skeletal maturity, lesion size, epicenter, perilesional dark rim, and concomitant subjacent findings. Chi-squared, Mann-Whitney U, and Kruskal-Wallis tests were used to compare MRI findings between femoral neck and shaft lesions and for subgroup analyses among lesions along the proximal, mid, and distal femoral neck.</p><p><strong>Results: </strong>Our study group included 35 pediatric patients (19 boys, 16 girls, mean age 10.1 ± 3.7; range 4.0-17.3 years) with 23 femoral neck and 12 femoral shaft lesions. Radiologists' agreement on MRI findings ranged between 49-100%. Neck lesions were more common among older patients while shaft lesions were more common among younger patients (11.6 ± 3.2 vs. 7.0 ± 2.8 years, P < 0.01). Complete perilesional dark rim sign was more common in the femoral shaft than in the femoral neck (92%, 11/12 vs. 17%, 4/23, P < 0.01). Within the femoral neck, a complete dark rim was more commonly observed with lesions in the distal third compared to mid and proximal third (50% vs. 0%, 0%, P = 0.04). Concomitant findings were common, but only effusion-synovitis was significantly more common in femoral neck lesions than in shaft lesions (65% vs. 0%, P < 0.01). And within the neck, effusion-synovitis was more common with proximal and mid than distal neck lesions (100%, 85% vs. 25%, P = 0.01).</p><p><strong>Conclusion: </strong>Differential MRI findings were observed not only between osteoid osteomas in the femoral neck and shaft, but also between lesions located within the proximal and distal neck. Patterns of findings follow the known anatomic boundary of the femoral neck/shaft and these findings can help improve pretreatment diagnostic accuracy.</p>","PeriodicalId":19755,"journal":{"name":"Pediatric Radiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Displaced cortical vein sign on CT in infants: a reliable predictor to distinguish low-attenuation subdural collections from benign enlargement of subarachnoid spaces.","authors":"Danika Baskar, Selima Siala, William W Pryor, Thad Benefield, Carolina V Guimaraes","doi":"10.1007/s00247-024-06160-8","DOIUrl":"https://doi.org/10.1007/s00247-024-06160-8","url":null,"abstract":"<p><p>Differentiating benign enlargement of subarachnoid spaces (BESS) from low-attenuation subdural collections on CT imaging of infants can be challenging. This distinction is crucial in infants, as subdural collections may raise the concern for abusive head trauma (AHT). To evaluate the utilization of the displaced cortical vein sign on CT as a predictor of pathological subdural collections confirmed by MRI and to assess the reproducibility of this finding among radiologists with different levels of clinical experience. A total of 104 imaging exams were independently reviewed by junior- and senior-level radiologists (52 head CTs and 52 corresponding brain MRI exams). These exams included 43 MRI-confirmed cases of subdural collections and 9 MRI-confirmed cases of BESS from patients aged 0-2 years. The presence of pathological collections and sulcal flattening, and the displaced cortical vein sign were recorded for both reviewers along with attenuation and signal characteristics of the collections. Confirmed diagnosis of AHT was determined by chart review. The sensitivity, specificity, and inter-observer reliability were analyzed between reviewers. The average patient age was 6.4 months with a median age of 4 months. The sensitivity values of the displaced cortical vein sign on CT for the presence of subdural collections were 69.6% and 79.0% for the two reviewers, respectively. The specificity of this finding was 100% for both reviewers, with no false negative cases. Interobserver reliability was the highest for the depiction of the displaced cortical vein sign on CT (κ=0.63, 95% CI 0.45-0.82) and MRI (κ=0.96, 95% CI 0.87-1.00). All cases where at least 1 reviewer noted the displaced cortical vein sign on CT and were later confirmed to be traumatic subdural collection on MRI were concluded to have high concern for AHT upon chart review. In total, 23.3% (11 out of 52) of cases confirmed to have subdural collections on MRI were found to have calvarial fractures associated with their presentation. The displaced cortical vein sign on head CT is a specific and reproducible finding associated with subdural collections. Our data suggest that this sign is a more reliable and readily identifiable indicator of pathological subdural collections compared to other traditional imaging findings, such as flattening of the cerebral sulci.</p>","PeriodicalId":19755,"journal":{"name":"Pediatric Radiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the natural course of clinical and radiologic features in 13 patients with TRPV4-related skeletal dysplasias.","authors":"Nilay Güneş, Dilek Uludağ Alkaya, Sebuh Kurugoğlu, Nuri Özyalvaç, Ayşegül Bursalı, Nursel H Elçioğlu, Beyhan Tüysüz","doi":"10.1007/s00247-024-06145-7","DOIUrl":"https://doi.org/10.1007/s00247-024-06145-7","url":null,"abstract":"<p><strong>Background: </strong>Heterozygous TRPV4 mutations cause a group of skeletal dysplasias characterized by short stature, short trunk, and skeletal deformities.</p><p><strong>Objective: </strong>The aim of this study is to compare the natural history of clinical and radiologic features of patients with different TRPV4-related skeletal dysplasias.</p><p><strong>Materials and methods: </strong>Thirteen patients with a mutation in TRPV4 were included in the study, and 11 were followed for a median of 6.5 years. The clinical phenotype of five patients was compatible with spondylometaphyseal dysplasia Kozlowski type, three each with metatropic dysplasia and brachyolmia type 3, and one each with spondyloepiphyseal dysplasia Maroteaux type and congenital distal spinal muscular atrophy.</p><p><strong>Results: </strong>Short stature and bone pain when running, walking, and climbing stairs occurred in patients with spondylometaphyseal dysplasia Kozlowski type and metatropic dysplasia from the age of 5 years and worsened with increasing age. Kyphosis was more pronounced with increasing age in these two groups of patients, while severe scoliosis occurred in brachyolmia type 3. In the radiographs of patients with spondylometaphyseal dysplasia Kozlowski type and metatropic dysplasia, severe platyspondyly persisted into adulthood or puberty. The patients with spondylometaphyseal dysplasia Kozlowski type exhibited irregular proximal femora leading to destruction of the femoral head towards the end of puberty, whereas metatropic dysplasia showed marked irregularity and widening of the femoral neck. We also observed that metaphyseal dysplasia in long bones other than the proximal femur was so inconspicuous that it could be ignored in patients with spondylometaphyseal dysplasia Kozlowski type.</p><p><strong>Conclusion: </strong>Comparison of radiologic features that change with age in five different TRPV4-related skeletal dysplasias will be of great benefit in the management of this patient group.</p>","PeriodicalId":19755,"journal":{"name":"Pediatric Radiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Practical approach to extracardiac findings in CT and MR for the non-radiologist.","authors":"Alan V Godfrey, Erin K Opfer, Neil J Mardis","doi":"10.1007/s00247-024-06150-w","DOIUrl":"https://doi.org/10.1007/s00247-024-06150-w","url":null,"abstract":"<p><p>Cross-sectional cardiac imaging plays an essential role in the evaluation of pediatric patients with congenital and acquired heart disease. While the focus of cardiac imaging is primarily on evaluating cardiac structures, it also provides valuable insights into extracardiac structures and associated abnormalities. The radiologists and cardiologists interpreting these exams play a critical role in recognizing these findings and providing recommendations for follow-up testing when indicated. Due to the excellent soft tissue resolution of cardiac magnetic resonance imaging (MRI) and computed tomography (CT), incidental findings can often be diagnosed without further imaging. Incidental findings are generally defined as lesions or masses detected by imaging that is performed for a different reason. In other cases, further imaging evaluation and testing may be necessary. This article aims to explore the spectrum of extracardiac findings encountered in pediatric cardiac imaging studies, their clinical significance, and the potential implications for patient care.</p>","PeriodicalId":19755,"journal":{"name":"Pediatric Radiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}