Pediatric Radiology最新文献

{"title":"Hermes.","authors":"","doi":"10.1007/s00247-025-06360-w","DOIUrl":"https://doi.org/10.1007/s00247-025-06360-w","url":null,"abstract":"","PeriodicalId":19755,"journal":{"name":"Pediatric Radiology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144760752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Faulty fetal packing: a case series and literature review.","authors":"Sakura M Noda, Jeffrey Otjen, Ajay S Koti, Adrienne Schlatter, Matthew Blessing, Ken Feldman, Sarah Menashe","doi":"10.1007/s00247-025-06318-y","DOIUrl":"10.1007/s00247-025-06318-y","url":null,"abstract":"<p><strong>Background: </strong>Faulty fetal packing is an under-recognized nontraumatic entity often confused with depressed skull fracture.</p><p><strong>Objective: </strong>To describe cases of faulty fetal packing at our institution and their common features, management, and outcomes compared to existing literature.</p><p><strong>Materials and methods: </strong>Institutional review board approval was obtained for this retrospective study. A retrospective search through a radiology database at a quaternary freestanding children's hospital from 2014-2022 was performed for cases of faulty fetal packing. Clinical characteristics, imaging findings, management, and outcome were recorded.</p><p><strong>Results: </strong>Five cases of faulty fetal packing were identified. These neonates were born at 37-41 weeks, one by vaginal delivery and four by Cesarean section, all after long labor or difficult extraction. Parietal skull depressions were noted at birth or by 16 days after birth, and no associated traumatic findings were identified on imaging. The depressions were initially diagnosed as fractures. All patients were managed by observation, and depressions significantly improved by 2-4 months in four cases; one case was lost to follow-up after 16 days. No adverse outcomes were reported.</p><p><strong>Conclusion: </strong>Skull depressions seen in faulty fetal packing should be considered in the differential diagnosis of depressed skull fracture. They typically resolve with conservative management.</p>","PeriodicalId":19755,"journal":{"name":"Pediatric Radiology","volume":" ","pages":"1811-1819"},"PeriodicalIF":2.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility study of fully automatic measurement of adenoid size on lateral neck and head radiographs using deep learning.","authors":"Dapeng Hao, Limin Tang, Da Li, Sheng Miao, Cheng Dong, Jiufa Cui, Chuanping Gao, Jie Li","doi":"10.1007/s00247-025-06332-0","DOIUrl":"10.1007/s00247-025-06332-0","url":null,"abstract":"<p><strong>Background: </strong>The objective and reliable quantification of adenoid size is pivotal for precise clinical diagnosis and the formulation of effective treatment strategies. Conventional manual measurement techniques, however, are often labor-intensive and time-consuming.</p><p><strong>Objective: </strong>To develop and validate a fully automated system for measuring adenoid size using deep learning (DL) on lateral head and neck radiographs.</p><p><strong>Materials and methods: </strong>In this retrospective study, we analyzed 711 lateral head and neck radiographs collected from two centers between February and July 2023. A DL-based adenoid size measurement system was developed, utilizing Fujioka's method. The system employed the RTMDet network and RTMPose networks for accurate landmark detection, and mathematical formulas were applied to determine adenoid size. To evaluate consistency and reliability of the system, we employed the intra-class correlation coefficient (ICC), mean absolute difference (MAD), and Bland-Altman plots as key assessment metrics.</p><p><strong>Results: </strong>The DL-based system exhibited high reliability in the prediction of adenoid, nasopharynx, and adenoid-nasopharyngeal ratio measurements, showcasing strong agreement with the reference standard. The results indicated an ICC for adenoid measurements of 0.902 [95%CI, 0.872-0.925], with a MAD of 1.189 and a root mean square (RMS) of 1.974. For nasopharynx measurements, the ICC was 0.868 [95%CI, 0.828-0.899], with a MAD of 1.671 and an RMS of 1.916. Additionally, the adenoid-nasopharyngeal ratio measurements yielded an ICC of 0.911 [95%CI, 0.883-0.932], a MAD of 0.054, and an RMS of 0.076.</p><p><strong>Conclusions: </strong>The developed DL-based system effectively automates the measurement of the adenoid-nasopharyngeal ratio, adenoid, and nasopharynx on lateral neck or head radiographs, showcasing high reliability.</p>","PeriodicalId":19755,"journal":{"name":"Pediatric Radiology","volume":" ","pages":"1891-1902"},"PeriodicalIF":2.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accelerated brain magnetic resonance imaging with deep learning reconstruction: a comparative study on image quality in pediatric neuroimaging.","authors":"Jae Won Choi, Yeon Jin Cho, Seul Bi Lee, Seunghyun Lee, Jae-Yeon Hwang, Young Hun Choi, Jung-Eun Cheon, Joonsung Lee","doi":"10.1007/s00247-025-06314-2","DOIUrl":"10.1007/s00247-025-06314-2","url":null,"abstract":"<p><strong>Background: </strong>Magnetic resonance imaging (MRI) is crucial in pediatric radiology; however, the prolonged scan time is a major drawback that often requires sedation. Deep learning reconstruction (DLR) is a promising method for accelerating MRI acquisition.</p><p><strong>Objective: </strong>To evaluate the clinical feasibility of accelerated brain MRI with DLR in pediatric neuroimaging, focusing on image quality compared to conventional MRI.</p><p><strong>Materials and methods: </strong>In this retrospective study, 116 pediatric participants (mean age 7.9 ± 5.4 years) underwent routine brain MRI with three reconstruction methods: conventional MRI without DLR (C-MRI), conventional MRI with DLR (DLC-MRI), and accelerated MRI with DLR (DLA-MRI). Two pediatric radiologists independently assessed the overall image quality, sharpness, artifacts, noise, and lesion conspicuity. Quantitative image analysis included the measurement of image noise and coefficient of variation (CoV).</p><p><strong>Results: </strong>DLA-MRI reduced the scan time by 43% compared with C-MRI. Compared with C-MRI, DLA-MRI demonstrated higher scores for overall image quality, noise, and artifacts, as well as similar or higher scores for lesion conspicuity, but similar or lower scores for sharpness. DLC-MRI demonstrated the highest scores for all the parameters. Despite variations in image quality and lesion conspicuity, the lesion detection rates were 100% across all three reconstructions. Quantitative analysis revealed lower noise and CoV for DLA-MRI than those for C-MRI. Interobserver agreement was substantial to almost perfect (weighted Cohen's kappa = 0.72-0.97).</p><p><strong>Conclusion: </strong>DLR enabled faster MRI with improved image quality compared with conventional MRI, highlighting its potential to address prolonged MRI scan times in pediatric neuroimaging and optimize clinical workflows.</p>","PeriodicalId":19755,"journal":{"name":"Pediatric Radiology","volume":" ","pages":"1903-1914"},"PeriodicalIF":2.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144619727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic performance and reproducibility of shear wave elastography techniques for liver stiffness assessment in children with biliary atresia.","authors":"Manli Fu, Chao Geng, Liqiong Shi, Jiaoyan Tan, Han Jing, Xueqiang Yan, Li Yuan","doi":"10.1007/s00247-025-06333-z","DOIUrl":"10.1007/s00247-025-06333-z","url":null,"abstract":"<p><strong>Background: </strong>Biliary atresia casuses progressive liver fibrosis in infants. After Kasai portoenterostomy (KPE), non-invasive liver monitoring is essential. Shear wave elastography (SWE) offers a promising alternative to biopsy.</p><p><strong>Objectives: </strong>To evaluate the diagnostic performance, reproducibility, and inter-technique consistency of three shear wave elastography (SWE) modalities-point-SWE (p-SWE), two-dimensional SWE (2D-SWE), and supersonic shear imaging (supersonic-SWE)-in children with biliary atresia post-KPE.</p><p><strong>Materials and methods: </strong>This prospective study (March 2024-November 2024) recruited 76 children: 47 biliary atresia patients (mean age, 5.7 ± 3.3 years; 24 girls) post-KPE and 29 healthy controls (mean age, 6.9 ± 3.2 years; 12 girls). Liver stiffness values were obtained using three SWE techniques. Statistical methods included the Mann-Whitney U test, Friedman test, intraclass correlation coefficients (ICCs), Spearman correlation, and generalized liner model analysis.</p><p><strong>Results: </strong>Biliary atresia group showed significantly higher liver stiffness values than controls across all techniques (supersonic-SWE: 8.20 vs. 5.20 kPa, p-SWE: 6.60 vs. 3.50 kPa, 2D-SWE: 4.90 vs. 2.90 kPa; all P< 0.001). Supersonic-SWE yielded higher liver stiffness values than p-SWE and 2D-SWE (P< 0.05). Strong correlations were observed. Reproducibility was good to excellent (ICCs: 0.74 to 0.90), with supersonic-SWE demonstrating the highest ICC. Anteroposterior diameter of the left lobe was an independent predictor significantly associated with liver stiffness values (P< 0.001). Supersonic-SWE required longer measurement time than other techniques (P< 0.001).</p><p><strong>Conclusion: </strong>SWE is a reliable tool for liver stiffness assessment in biliary atresia patients, however, inter-technique and inter-vendor discrepancies highlight the need for standardized protocol and techniques should not be used interchangeably.</p>","PeriodicalId":19755,"journal":{"name":"Pediatric Radiology","volume":" ","pages":"1820-1828"},"PeriodicalIF":2.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12464065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Echoes of change: lung ultrasound revolutionizing neonatal and pediatric respiratory care.","authors":"Yoshino Tamaki Sameshima, Andrés García-Bayce, Fabiana Gual Oranges, Marcelo Assis Rocha, Márcia Wang Matsuoka, Jovan Lovrenski","doi":"10.1007/s00247-025-06300-8","DOIUrl":"10.1007/s00247-025-06300-8","url":null,"abstract":"<p><p>Lung ultrasound has emerged as a transformative imaging modality in neonatal and pediatric pulmonary care, offering a radiation-free, bedside, and versatile tool that complements traditional chest radiography. Despite its recognized value in the detection, monitoring, and management of various conditions in neonatal and pediatric intensive care units, the routine application of lung ultrasound for monitoring pneumonia remains underutilized by radiologists. In recent years, lung ultrasound has demonstrated its effectiveness in monitoring disease progression without the need for repeated chest computed tomography scans, particularly in cases of complicated pneumonia. This essay reviews the fundamental principles, key sonographic patterns, and essential applications of lung ultrasound in neonatal and pediatric intensive care units. Case-based experiences are shared to illustrate how lung ultrasound is shaping clinical decision-making and redefining best practices in pulmonary care by minimizing invasive procedures and reducing radiation exposure.</p>","PeriodicalId":19755,"journal":{"name":"Pediatric Radiology","volume":" ","pages":"1767-1782"},"PeriodicalIF":2.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144541814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interobserver variability in assessing preoperative imaging biomarkers for cerebellar mutism syndrome: a multiobserver pilot study.","authors":"Aske Foldbjerg Laustsen, Rob Dineen, Jurgita Ilginiene, Jonathan Kjær Grønbæk, Astrid Marie Sehested, Kjeld Schmiegelow, René Mathiasen, Marianne Juhler, Shivaram Avula","doi":"10.1007/s00247-025-06326-y","DOIUrl":"10.1007/s00247-025-06326-y","url":null,"abstract":"<p><strong>Background: </strong>Cerebellar mutism syndrome is a well-known complication of paediatric posterior fossa tumour surgery. In recent years, several imaging biomarkers have been suggested to predict cerebellar mutism syndrome based on its probable pathoanatomical causes.</p><p><strong>Objective: </strong>This study investigates the reliability of preoperative imaging biomarkers for cerebellar mutism syndrome in paediatric posterior fossa tumours. Specifically, it examines the interobserver agreement on the size, invasion, and compression of selected regions of interest with structured magnetic resonance imaging (MRI) reporting.</p><p><strong>Materials and methods: </strong>Preoperative brain MRI scans from ten paediatric patients with posterior fossa tumours, conducted at a single institution, were analysed. The scans were evaluated by three neuroradiologists from three different institutions across two countries using a structured reporting format. The interobserver agreement was assessed using intraclass correlation coefficient and Fleiss' kappa. All estimates were reported with a 95% confidence interval.</p><p><strong>Results: </strong>The study found good to excellent agreement in measuring tumour size, tumour volume, and the Evans index. Substantial agreement was found in tumour pathology and location. However, the interobserver agreement was unreliable for invasion and compression of the included anatomical structures.</p><p><strong>Conclusion: </strong>Findings from this study challenge the reliability of preoperative imaging biomarkers for cerebellar mutism syndrome, emphasising the need for further investigation into consistent and reproducible biomarkers relevant to this syndrome.</p>","PeriodicalId":19755,"journal":{"name":"Pediatric Radiology","volume":" ","pages":"1915-1926"},"PeriodicalIF":2.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12394353/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment outcome of ultrasound-guided hydrostatic reduction of intussusception and its associated factors among pediatric patients in a resource-limited setting.","authors":"Chala Takele Ayana, Tesfahunegn Feleke, Anduamlak Bazezew, Zelalem Mehari, Yodit Abraham Yaynishet, Tewodros Getinet, Merga Belina, Samuel Sisay Hailu","doi":"10.1007/s00247-025-06305-3","DOIUrl":"10.1007/s00247-025-06305-3","url":null,"abstract":"<p><strong>Background: </strong>Ultrasound (US)-guided hydrostatic reduction of intussusception was recently introduced and adopted as the first-line management for intussusception in children at Tibebe Ghion Specialized Hospital. Knowledge of the treatment outcome and associated factors will enhance the expansion of this technique to hospitals in Sub-Saharan Africa, where surgery largely remains the exclusive treatment strategy.</p><p><strong>Methods: </strong>An institution-based cross-sectional study was conducted at Tibebe Ghion Specialized Hospital, Bahir Dar, Ethiopia. We consecutively enrolled children with US-confirmed intussusception for whom US-guided hydrostatic reduction with normal saline was performed by a general radiologist and/or final-year residents under supervision after ruling out contraindications. Firth's logistic regression analysis was undertaken to determine odds ratios (ORs) and 95% confidence intervals (CIs) of factors predictive of successful outcomes.</p><p><strong>Results: </strong>A total of 145 children with a mean age of 24 months were enrolled in the current study. Most patients (123, 84.8%) presented within 24 h of symptom onset, with colicky abdominal pain being the main complaint (79, 54.5%). Ileocolic type and short-length intussusception were visualized more on US, 135 (93.1) and 118 (81.4%), respectively. The overall reduction rate was 93.1% (95% CI [89.0-97.2]). Ten patients (6.9%) underwent surgery after a failed hydrostatic reduction, with good postoperative outcomes. Reported duration of illness of less than 24 h, adjusted odds ratio (AOR) of 6.77 (95% CI [1.25-30.42]), and length of intussusception of less than 3 cm (AOR, 6.24; 95% CI [1.18-33.00]) were significantly associated with successful hydrostatic reduction outcomes.</p><p><strong>Conclusion: </strong>We have found a high US-guided hydrostatic reduction rate of intussusception in an implementation phase and a relatively low resource setup. Early presentation and short intussusception segment were favorably associated with successful outcomes.</p>","PeriodicalId":19755,"journal":{"name":"Pediatric Radiology","volume":" ","pages":"1829-1837"},"PeriodicalIF":2.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144541815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequency and outcomes of gastrojejunostomy tube replacement in children - a single-centre experience.","authors":"Swetha S Yatham, Lara Herbert, Angela Rogers","doi":"10.1007/s00247-025-06310-6","DOIUrl":"10.1007/s00247-025-06310-6","url":null,"abstract":"<p><strong>Background: </strong>At present, there is no consensus on whether gastrojejunostomy tubes should be routinely changed and if so, on what timescale.</p><p><strong>Objective: </strong>We describe our 5-year experience following the 2018 introduction of an interventional radiology lead service of four to six monthly elective changes. We focused on the impact this had on the number and length of hospital admissions, and radiation dose.</p><p><strong>Materials and methods: </strong>Retrospective review of gastrojejunostomy tube exchanges performed from 2011-2022 in a single centre.</p><p><strong>Results: </strong>Over 11 years, 89 gastrojejunostomy tube exchanges were performed in ten patients. Following the introduction of the interventional radiology-led elective service in 2018, 50 gastrojejunostomy tube exchanges were done electively vs 25 done as emergencies. On average, gastrojejunostomy tubes were replaced every 5.6 months (elective 6.4 months, emergency 3.3 months). The median was 4 months. The most cited reasons for an emergency replacement were a malfunctioning tube or displaced tube. General anaesthetic was required for 61 exchanges. Admission time was shorter for elective exchanges (1.2 days vs 3.1 days). There was no significant difference in the average dose area product for elective vs emergency procedures.</p><p><strong>Conclusion: </strong>Our results suggest that an optimal time for gastrojejunostomy tube replacement is 4 months. Elective replacement of gastrojejunostomy tubes results in a reduced number and length of admissions.</p>","PeriodicalId":19755,"journal":{"name":"Pediatric Radiology","volume":" ","pages":"1838-1845"},"PeriodicalIF":2.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic resonance imaging related anxiety and workflow: impact of a child-friendly audio-visual intervention.","authors":"Sanae van der Vleuten-Chraibi, Sanne Nauts, Dobromiła Barańska, Emilio J Inarejos Clemente, Jonas Sterup Bovin, Nadia Najafi, Julian A Luetkens, Marianne Alison, Hilla M Biermann, Fabian Peckman, Privender Saini","doi":"10.1007/s00247-025-06308-0","DOIUrl":"10.1007/s00247-025-06308-0","url":null,"abstract":"<p><strong>Background: </strong>Magnetic resonance imaging (MRI) is the diagnostic imaging modality of choice for pediatric patients. However, it can be challenging to scan young children awake while maintaining a high image quality with an efficient, patient-friendly workflow.</p><p><strong>Objective: </strong>We investigated if an audio-visual intervention with specially designed pediatric content could reduce MRI-related patient anxiety and workflow-issues in children during an awake MRI.</p><p><strong>Materials and methods: </strong>In six European hospitals, children (n = 175; aged 6-12 years) were scanned with child-friendly content (intervention) or without (control). Staff recorded children's stress levels before, during, and after the MRI on a 6-point Likert scale. Scan issues (i.e., repeat scans and interruptions) were recorded by staff and extracted from the MRI logfiles.</p><p><strong>Results: </strong>The stress level of young children (aged 6-10 years) in the intervention group decreased more strongly from before to after the MRI compared to the control group, F_(2,96) = 7.84, P < 0.001. They also had significantly fewer scan issues as reported by staff, F_(1,169) = 8.36, P = 0.004, Cohen's d = 0.58, and as logged by the MRI system, F_(1,156) = 8.10, P = 0.005, Cohen's d = 0.45. The used pediatric content showed no significant effects on older children (aged 10 + years).</p><p><strong>Conclusion: </strong>A child-friendly audio-visual intervention can help reduce stress levels of young children (aged 6-10 years) and support a smooth workflow.</p><p><strong>Trial registration number: </strong>NCT05089955, date: 2021-10-22.</p>","PeriodicalId":19755,"journal":{"name":"Pediatric Radiology","volume":" ","pages":"1934-1942"},"PeriodicalIF":2.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12394259/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}