Open Medicine最新文献_第4页

Review of mechanisms and frontier applications in IL-17A-induced hypertension.

IF 1.7 4区医学

Open Medicine Pub Date : 2025-02-27 eCollection Date: 2025-01-01 DOI: 10.1515/med-2025-1159

Ruiyuan Li, Lipeng Guo, Bin Liang, Wei Sun, Feng Hai

{"title":"Review of mechanisms and frontier applications in IL-17A-induced hypertension.","authors":"Ruiyuan Li, Lipeng Guo, Bin Liang, Wei Sun, Feng Hai","doi":"10.1515/med-2025-1159","DOIUrl":"https://doi.org/10.1515/med-2025-1159","url":null,"abstract":"Background: The immune system is closely related to hypertension. Hypertension is an immune disorder to a certain extent, and inflammation is the basis of abnormally elevated blood pressure (BP). The accumulation of T cells and their cytokines can increase BP and end organ damage. T cells are activated by antigen-presenting cells of the innate immune system or by the influence of a high-sodium diet, the self-environment, or the gut microbiota. These cells produce inflammatory factors and cytokines, such as interleukin-17A (IL-17A) in T helper 17 cells, causing vascular inflammation, hypertension, and target organ damage.Methods: In this article, we provide an insightful review of the research progress regarding the role of IL-17A in the pathogenesis of hypertension and its effects on different organs while emphasizing the role of IL-17A and its mediated functions in the kidneys, brain, intestines, and vascular system in the development and progression of hypertension.Results: At the organ level, IL-17A is involved in the development and progression of hypertension in the kidneys, brain, intestines, and blood vessels, interacting with multiple signal pathway.Conclusions: These findings have significant implications for developing future immunomodulatory therapies, which may lead to the development of potential treatments for hypertension.","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20251159"},"PeriodicalIF":1.7,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11868716/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic value of ratio of blood inflammation to coagulation markers in periprosthetic joint infection.

IF 1.7 4区医学

Open Medicine Pub Date : 2025-02-27 eCollection Date: 2025-01-01 DOI: 10.1515/med-2025-1150

Jincheng Huang, Xu Li, Yajun Chen, Meng Zhang, Zongyan Gao, Zhipeng Dai, Tao Liu, Yi Jin

{"title":"Diagnostic value of ratio of blood inflammation to coagulation markers in periprosthetic joint infection.","authors":"Jincheng Huang, Xu Li, Yajun Chen, Meng Zhang, Zongyan Gao, Zhipeng Dai, Tao Liu, Yi Jin","doi":"10.1515/med-2025-1150","DOIUrl":"https://doi.org/10.1515/med-2025-1150","url":null,"abstract":"Introduction: Assess the feasibility of utilizing the ratio of blood inflammation to coagulation markers as a potential periprosthetic joint infection (PJI) diagnostic tool.Materials and methods: A retrospective analysis was conducted, involving 133 PJI and 93 aseptic loosening patients. Levels of C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), platelet count, mean platelet volume, fibrinogen, D-dimer, and ratios of CRP to fibrinogen, ESR to fibrinogen, platelet count and mean platelet volume ratio (PC/MPV), and D-dimer were compared. Receiver operating characteristic curves and Youden's index were employed to assess the diagnostic efficacy of these biomarkers.Results: PJI patients had significantly higher levels of CRP, ESR, PC/MPV ratio, fibrinogen, D-dimer, CRP/(PC/MPV) ratio (CPR), CRP/D-dimer, CRP/fibrinogen (CFR), ESR/(PC/MPV) ratio, ESR/D-dimer, and ESR/fibrinogen. Area under the curve (AUC) values for fibrinogen, CRP, and ESR in diagnosing PJI were comparable. AUC values for CPR and CFR were akin to those of ESR. AUC values for combined CRP and CPR, combined CRP and fibrinogen, combined CRP and CFR, and combined ESR and fibrinogen in diagnosing PJI were akin to that of combined CRP and ESR.Conclusions: Fibrinogen, CPR, CFR, combined CRP and CPR, combined CRP and fibrinogen, combined CRP and CFR, and combined ESR and fibrinogen could be considered as new adjunct markers for diagnosing PJI.","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20251150"},"PeriodicalIF":1.7,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11868709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical observation of probiotics combined with mesalazine and Yiyi Baitouweng Decoction retention enema in treating mild-to-moderate ulcerative colitis. 益生菌联合美沙拉嗪和益母草白头翁煎剂保留灌肠治疗轻中度溃疡性结肠炎的临床观察。

IF 1.7 4区医学

Open Medicine Pub Date : 2025-02-25 eCollection Date: 2025-01-01 DOI: 10.1515/med-2024-1126

Yanlong Li, Baoyu Li, Yuqin Gou, Xudong Tian, Lijun Chang, Chaoxu Qu

{"title":"Clinical observation of probiotics combined with mesalazine and Yiyi Baitouweng Decoction retention enema in treating mild-to-moderate ulcerative colitis.","authors":"Yanlong Li, Baoyu Li, Yuqin Gou, Xudong Tian, Lijun Chang, Chaoxu Qu","doi":"10.1515/med-2024-1126","DOIUrl":"https://doi.org/10.1515/med-2024-1126","url":null,"abstract":"Objective: The purpose of this article was to unravel the clinical efficacy of probiotics combined with mesalazine and Yiyi Baitouweng Decoction retention enema in the treatment of mild-to-moderate ulcerative colitis (UC).Methods: Eighty-six mild-to-moderate UC patients were selected as study subjects and randomized into the control group (treated with mesalazine enteric-coated tablets [Salofalk]) and the observation group (treated with mesalazine enteric-coated tablets, Bifidobacterium Tetravaccine Tablets, and Yiyi Baitouweng Decoction retention enema). The clinical efficacy, colonoscopy score, serum levels of inflammatory factors, and the incidence of adverse reactions were compared.Results: The clinical efficacy of patients in the observation group was better in contrast to the control group. After 8 weeks of treatment, the colonoscopy score, and levels of TNF-α, IFN-γ, CRP, and ESR were lower, while IL-10 levels were higher in patients of both groups than those before treatment; lower colonoscopy score and levels of TNF-α, IFN-γ, CRP, and ESR and higher IL-10 levels were observed in the observation group versus the control group.Conclusion: Probiotics combined with mesalazine and Yiyi Baitouweng Decoction retention enema have remarkable clinical effects in treating mild-to-moderate UC.","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20241126"},"PeriodicalIF":1.7,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11868706/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical analysis of ten cases of HIV infection combined with acute leukemia.

IF 1.7 4区医学

Open Medicine Pub Date : 2025-02-24 eCollection Date: 2025-01-01 DOI: 10.1515/med-2024-1081

Shanshan Fan, Chuan Qian, Pengfei Tao, Qiwen Zhou, Sen Lin, Konglong Li, Xi Wang, Haiyan Min

{"title":"Clinical analysis of ten cases of HIV infection combined with acute leukemia.","authors":"Shanshan Fan, Chuan Qian, Pengfei Tao, Qiwen Zhou, Sen Lin, Konglong Li, Xi Wang, Haiyan Min","doi":"10.1515/med-2024-1081","DOIUrl":"https://doi.org/10.1515/med-2024-1081","url":null,"abstract":"Objective: To summarize the clinical characteristics, diagnosis, and treatment experience of human immunodeficiency virus (HIV) infection combined with acute leukemia.Methods: Ten patients with HIV infection (eight males, two females; mean age of 40 years) were diagnosed with acute leukemia. Clinical features, diagnosis, treatment, and outcomes of these patients were retrospectively analyzed.Results: Among these ten patients, eight acute myeloid leukemia cases and two acute lymphoblastic leukemia cases were L3; three cases of M3 were positive for the promyelocytic leukemia and Vitamin A acid receptor alpha (PML/RARA) fusion genes, and four cases presented multiple chromosomal structural and numerical abnormalities. CD4+ T cell counts of the ten patients ranged from 84 to 389 cells/μL with a mean of 253.5 cells/μL. Among six patients who received chemotherapy, three cases were alive, two died of sepsis secondary to myelosuppression after chemotherapy, and one was lost to follow-up. Among four patients who did not receive chemotherapy, three died, one had M3 treatment and died with cerebral hemorrhage, and one was lost to follow-up. The maximum survival time was 74 months.Conclusion: HIV combined with acute leukemia has a complex presentation and rapid progression, early diagnosis and timely initiation of standard chemotherapy along with active antiviral therapy can improve patient's survival.","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20241081"},"PeriodicalIF":1.7,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11868711/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the cardioprotective potential of quercetin against tacrolimus-induced cardiotoxicity in Wistar rats: A mechanistic insights. 研究槲皮素对他克莫司诱导的 Wistar 大鼠心脏毒性的潜在保护作用：机理研究

IF 1.7 4区医学

Open Medicine Pub Date : 2025-02-24 eCollection Date: 2025-01-01 DOI: 10.1515/med-2024-1130

Ankit Verma, Tarique Anwer, Muzaffar Iqbal, Vinod Gahlot, Roshi Khan, Manju Sharma, Mohammad Sohail Akhtar

{"title":"Investigating the cardioprotective potential of quercetin against tacrolimus-induced cardiotoxicity in Wistar rats: A mechanistic insights.","authors":"Ankit Verma, Tarique Anwer, Muzaffar Iqbal, Vinod Gahlot, Roshi Khan, Manju Sharma, Mohammad Sohail Akhtar","doi":"10.1515/med-2024-1130","DOIUrl":"https://doi.org/10.1515/med-2024-1130","url":null,"abstract":"Purpose: The aim of this research study is to assess the ability of quercetin to protect the heart from the negative consequences of tacrolimus-induced cardiotoxicity.Methods: A total of 30 rats were divided into 5 groups. Tacrolimus was used to induce cardiotoxicity, whereas quercetin was employed as a protective agent.Results: Tacrolimus administration significantly raised the levels of serum cardiac biomarkers (Lactate dehydrogenase, creatine kinase-myocardial band, and troponin-I) as well as inflammatory biomarkers (tumor necrosis alpha and interleukin 6). The administration of quercetin reduced raised levels of cardiac and inflammatory biomarkers significantly. In addition, treatment with tacrolimus resulted in higher malondialdehyde (MDA) (lipid peroxidation marker) levels and falling in the levels of reduced glutathione (GSH) as well as antioxidant enzymes such as superoxide dismutase (SOD), glutathione reductase (GR), and catalase (CAT). Quercetin treatment significantly reduced MDA levels and increased GSH and antioxidant enzyme (SOD, GR, and CAT) levels. Moreover, the tacrolimus-administered group exhibited histological changes in cardiac tissue cited as vacuole formation, large and uncondensed nucleus, and cardiomyocyte hypertrophy. The quercetin treatment reduced the inflammatory cell infiltration in cardiac tissue and thus reduced vacuole formation and hypertrophy.Conclusions: The outcome showed quercetin's cardioprotective potential against tacrolimus-administered cardiotoxicity. Consequently, it is concluded that quercetin may be used as add-on therapy with tacrolimus to reduce cardiac adverse effects.","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20241130"},"PeriodicalIF":1.7,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11868710/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Examination of the causal role of immune cells in non-alcoholic fatty liver disease by a bidirectional Mendelian randomization study.

IF 1.7 4区医学

Open Medicine Pub Date : 2025-02-19 eCollection Date: 2025-01-01 DOI: 10.1515/med-2025-1154

Yu Li, Xiaodan Lv, Jianing Lin, Shiquan Li, Guangfu Lin, Zhixi Huang, Deyi Chen, Lichun Han, Lingling Zhan, Xiaoping Lv

{"title":"Examination of the causal role of immune cells in non-alcoholic fatty liver disease by a bidirectional Mendelian randomization study.","authors":"Yu Li, Xiaodan Lv, Jianing Lin, Shiquan Li, Guangfu Lin, Zhixi Huang, Deyi Chen, Lichun Han, Lingling Zhan, Xiaoping Lv","doi":"10.1515/med-2025-1154","DOIUrl":"10.1515/med-2025-1154","url":null,"abstract":"Background: Non-alcoholic fatty liver disease (NAFLD) is a globally widespread disease. Recent investigations have highlighted a close association between immunity and NAFLD, but the causality between them has not been thoroughly examined.Methods: A total of 731 immunological traits and NAFLD cohorts were derived from genome-wide association study summary data, and single nucleotide polymorphisms significantly associated with immune traits were identified as instrumental variables. Moreover, 731 phenotypes include absolute cell counts, median fluorescence intensity (MFI), morphological parameters, and relative cell counts. The bidirectional two-sample Mendelian randomization (MR) was performed primarily using the inverse-variance weighted methods, and sensitivity analysis was carried out simultaneously.Results: Four immunophenotypes were identified to exert a protective effect against NAFLD, including HLA-DR+ CD4+ %lymphocytes, SSC-A on CD4+, CD24 MFI on IgD-CD38-, and CD8 MFI on CD28-CD8br. Seven immunophenotypes were identified to be hazardous, including CD28+ CD45RA+ CD8dim%CD8dim, CD127 MFI on CD28+ DN (CD4-CD8-), CD20 MFI on IgD+ CD38br, CD20 MFI on transitional, IgD MFI on transitional, CD3 MFI on central memory CD8br, and CD45 MFI on CD33brHLA-DR+ CD14-. However, reverse MR showed NAFLD had no causal effect on immunophenotypes.Conclusion: The study demonstrated a potential causal link between several immunophenotypes and NAFLD, which contributes to advancing research and treatment of NAFLD based on immune-mediated mechanisms.","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20251154"},"PeriodicalIF":1.7,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11843165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bone scintigraphy and positron emission tomography in the early diagnosis of MRONJ.

IF 1.7 4区医学

Open Medicine Pub Date : 2025-02-18 eCollection Date: 2025-01-01 DOI: 10.1515/med-2025-1143

Daniele Pergolini, Mohamed Mohsen, Gianluca Tenore, Gaspare Palaia, Lorenzo Magnifico, Alessandro Del Vecchio, Umberto Romeo

{"title":"Bone scintigraphy and positron emission tomography in the early diagnosis of MRONJ.","authors":"Daniele Pergolini, Mohamed Mohsen, Gianluca Tenore, Gaspare Palaia, Lorenzo Magnifico, Alessandro Del Vecchio, Umberto Romeo","doi":"10.1515/med-2025-1143","DOIUrl":"10.1515/med-2025-1143","url":null,"abstract":"Objectives: The aim of this study is to evaluate the bone scintigraphy (BS) and positron emission tomography (PET) in the early diagnosis of medication-related osteonecrosis of the jaws (MRONJ) and their possible use in the identification of patients at risk for MRONJ.Material and methods: Thirty-one patients treated with ONJ-related drugs and who had undergone BS or PET for the evaluation of bone lesions were included in the study. The jaws of each patient were divided into four areas. For each area, the presence of pathological tracer uptake was evaluated and related to the eventual MRONJ development. Sensitivity, specificity, and predictive values of both techniques were determined. The latency from the finding of pathological tracer uptake in BS or PET to the clinical diagnosis of MRONJ and the odds ratio were also calculated.Results: Sensitivity and specificity of BS for MRONJ prediction were, respectively, 83.3 and 87.5%. Positive and negative predictive values were, respectively, 73.2 and 92.8%. The odds ratio was 35. Sensitivity of PET was 33.3%, specificity was 94.9%, and positive and negative predictive values were 70.0 and 80.0%, respectively. The odds ratio was 9.333. All values were statistically significant.Conclusions: BS and PET may be accurate techniques for an early prediction of MRONJ.","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20251143"},"PeriodicalIF":1.7,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11843161/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanism research on inhibition of gastric cancer in vitro by the extract of Pinellia ternata based on network pharmacology and cellular metabolomics.

IF 1.7 4区医学

Open Medicine Pub Date : 2025-02-18 eCollection Date: 2025-01-01 DOI: 10.1515/med-2024-1131

Fan Feng, Ping Hu, Jun Chen, Lei Peng, Luyao Wang, Xingkui Tao, Chaoqun Lian

{"title":"Mechanism research on inhibition of gastric cancer in vitro by the extract of Pinellia ternata based on network pharmacology and cellular metabolomics.","authors":"Fan Feng, Ping Hu, Jun Chen, Lei Peng, Luyao Wang, Xingkui Tao, Chaoqun Lian","doi":"10.1515/med-2024-1131","DOIUrl":"10.1515/med-2024-1131","url":null,"abstract":"Background and purpose: Gastric cancer is a kind of malignant tumor with high incidence and high mortality, which has strong tumor heterogeneity. A classic Chinese medicine, Pinellia ternata (PT), was shown to exert therapeutic effects on gastric cancer cells. However, its chemical and pharmacological profiles remain to be elucidated. In the current study, we aimed to reveal the mechanism of PT in treating gastric cancer cells through metabolomic analysis and network pharmacology.Methods: Metabolomic analysis of two strains of gastric cancer cells treated with the Pinellia ternata extract (PTE) was used to identify differential metabolites, and the metabolic pathways were enriched by MetaboAnalyst. Then, network pharmacology was applied to dig out the potential targets against gastric cancer cells induced by PTE. The integrated network of metabolomics and network pharmacology was constructed based on Cytoscape.Results: The PTE was confirmed to significantly inhibit cell proliferation, migration, and invasion of HGC-27 and BGC-823 cells. The results of cellular metabolomics showed that 61 metabolites were differently expressed in gastric cancer cells of the experimental and control groups. Through pathway enrichment analysis, 16 metabolites were found to be involved in the glycerophospholipid metabolism, purine metabolism, sphingolipid metabolism, and tryptophan metabolism. Combined with network pharmacology, seven bioactive compounds were found in PT, and the networks of bioactive compound-target gene-metabolic enzyme-metabolite interactions were constructed.Conclusions: In conclusion, this study revealed the complicated mechanisms of PT against gastric cancer. Our work provides a novel paradigm to identify the potential mechanisms of pharmacological effects derived from a natural compound.","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20241131"},"PeriodicalIF":1.7,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11843166/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modulatory effects of Lycium barbarum polysaccharide on bone cell dynamics in osteoporosis.

IF 1.7 4区医学

Open Medicine Pub Date : 2025-02-18 eCollection Date: 2025-01-01 DOI: 10.1515/med-2024-1104

Qing Wang, Ting Zhang, Xinting Feng, Peng Chen, Ye Feng, Haoqiang Huang, Yinhua Qian, Yang Guo, Zifei Yin

{"title":"Modulatory effects of Lycium barbarum polysaccharide on bone cell dynamics in osteoporosis.","authors":"Qing Wang, Ting Zhang, Xinting Feng, Peng Chen, Ye Feng, Haoqiang Huang, Yinhua Qian, Yang Guo, Zifei Yin","doi":"10.1515/med-2024-1104","DOIUrl":"10.1515/med-2024-1104","url":null,"abstract":"Background: Osteoporosis (OP) is a systemic bone disorder marked by reduced bone mass and disrupted microstructure, leading to higher fracture risk. Epidemiological data from China show a 20.7% prevalence in women and 14.4% in men over 50, underscoring a pressing health issue given the aging population. More drugs to inhibit OP progression should be explored, and their biological mechanisms confirmed in preclinical studies.Methods: In this study, we utilized Lycium barbarum polysaccharide (LBP), an extract from the traditional Chinese medicine Goji Berry. LBP, known for its range of pharmacological activities, was assessed for its potential therapeutic effects on OP. We specifically investigated its influence on the proliferation, apoptosis, migration, and functional differentiation of osteoblasts and osteoclasts.Results: LBP significantly promotes osteoblast proliferation, migration, and osteogenic differentiation. Conversely, it inhibits the intrinsic apoptotic response in osteoblasts. For osteoclasts, LBP suppressed their proliferation, migration, and osteoclastic differentiation while enhancing their natural apoptosis. These results were confirmed by classical protein pathway detection experiments.Conclusion: LBP showcases potential therapeutic properties against OP, particularly in modulating osteoblast/osteoclast activities. While its exact mechanisms through vital signaling pathways remain to be fully elucidated, LBP's prominent effects suggest that it is a promising agent for OP intervention, warranting further in-depth studies.","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20241104"},"PeriodicalIF":1.7,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11843162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to "Empagliflozin improves aortic injury in obese mice by regulating fatty acid metabolism".

IF 1.7 4区医学

Open Medicine Pub Date : 2025-02-18 eCollection Date: 2025-01-01 DOI: 10.1515/med-2025-9999

Lin Yue, Yue Wang, Cuiying Wang, Shu Niu, Xihong Dong, Yaqing Guan, Shuchun Chen

引用次数: 0