Open Medicine最新文献

{"title":"CBD's potential impact on Parkinson's disease: An updated overview.","authors":"El Ghachi Hafida, Soulimani Rachid, Gamrani Halima, Kissani Najib","doi":"10.1515/med-2024-1075","DOIUrl":"10.1515/med-2024-1075","url":null,"abstract":"<p><strong>Background: </strong>Parkinson's disease (PD) is primarily known as a motor disorder; however, its debilitating non-motor symptoms have a significant impact on patients' quality of life. The current standard treatment, l-DOPA, is used to relieve motor symptoms, but prolonged use is often associated with severe side effects. This creates an urgent need for effective alternatives targeting both motor and non-motor symptoms.</p><p><strong>Objectives: </strong>Over the past decade, <i>Cannabis sativa</i> and its cannabinoids have been widely studied across various health conditions. Among these compounds, cannabidiol (CBD), a non-psychoactive component, is garnering growing interest due to its multi-targeted pleiotropic properties. This work aims to provide a comprehensive overview of CBD's efficacy in PD.</p><p><strong>Methods: </strong>This review compiles data on both motor and non-motor symptoms of PD, integrating results from preclinical animal studies and available clinical trials.</p><p><strong>Results: </strong>Preclinical research has demonstrated promising results regarding CBD's potential benefits in PD; however, the total number of clinical trials is limited (with only seven studies to date), making it difficult to draw definitive conclusions on its efficacy.</p><p><strong>Conclusions: </strong>While preclinical findings suggest that CBD may have therapeutic potential in PD, the limited number of clinical trials highlights the need for further research. This review emphasizes the gaps that need to be addressed in future studies to fully understand CBD's role in treating both motor and non-motor symptoms of PD.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"19 1","pages":"20241075"},"PeriodicalIF":1.7,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11524397/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142546657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progress in cytokine research for ARDS: A comprehensive review.","authors":"Kaihuan Zhou, Junyu Lu","doi":"10.1515/med-2024-1076","DOIUrl":"10.1515/med-2024-1076","url":null,"abstract":"<p><strong>Introduction: </strong>Acute respiratory distress syndrome (ARDS) is a critical form of acute respiratory failure characterized by diffuse alveolar damage, refractory hypoxemia, and non-cardiogenic pulmonary edema, resulting in high mortality. Dysregulated inflammation, driven by cytokines, is central to ARDS pathogenesis, progression, and prognosis.</p><p><strong>Objective: </strong>This review synthesizes current knowledge on the role of cytokines in ARDS and evaluates their potential as therapeutic targets, offering new insights for clinical management.</p><p><strong>Methods: </strong>A comprehensive analysis of recent studies was conducted to explore the roles of pro-inflammatory cytokines (e.g., IL-1β, IL-6, IL-8) and anti-inflammatory cytokines (e.g., IL-10, IL-22) in ARDS pathogenesis and to assess current and emerging therapies targeting these cytokines.</p><p><strong>Results: </strong>Pro-inflammatory cytokines are crucial in initiating inflammatory responses and lung injury in early ARDS, while anti-inflammatory cytokines help regulate and resolve inflammation. Targeted therapies, such as IL-1 and IL-6 inhibitors, show potential in managing ARDS, particularly in COVID-19, but their clinical efficacy is still debated. Combination therapy strategies may enhance outcomes, but further large-scale, multicenter randomized controlled trials are required to establish their safety and efficacy.</p><p><strong>Conclusion: </strong>Understanding cytokine regulation in ARDS could lead to innovative therapeutic approaches. Future research should focus on cytokine roles across ARDS subtypes and stages and develop biomarker-driven, individualized treatments.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"19 1","pages":"20241076"},"PeriodicalIF":1.7,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11524396/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142546658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of COVID-19 lockdown on admission rates in Maternity Hospital.","authors":"Jehad Abdullah Al-Harmi, Baydaa Alsannan, Fatemah Alhadhoud, Zahraa Akbar, Eman Alazmi, Khaled AlMuzayen, Eelaf Hussain, Mariam Aldarweesh, Basilio Pecorino, Antonio Simone Laganà, Antonio D'Amato, Vittorio Agrifoglio, Andrea Etrusco","doi":"10.1515/med-2024-1062","DOIUrl":"10.1515/med-2024-1062","url":null,"abstract":"<p><strong>Objectives: </strong>The COVID-19 pandemic had adverse health outcomes on individuals and communities. In this cross-sectional study we evaluated the admission rates in a tertiary-level hospital during the first wave of the pandemic (March 22, 2020 to August 31, 2020).</p><p><strong>Methods: </strong>We compared the indications for admission during the first wave of the pandemic to a control period prior to the lockdown (November 9, 2019 to March 22, 2020).</p><p><strong>Results: </strong>Most hospital admissions during the curfew period were obstetric emergencies (46.88%), which were significantly higher than the control group (38.19%) <i>p</i> ≤ 0.0001. Among the obstetric emergencies, cases in active labor (65.63%) were dominant. Significant rises in car deliveries (2.46%, <i>p</i> ≤ 0.0001) and admissions during the second stage of labor (6.43%, <i>p</i> ≤ 0.001) were noted. There was also an increased rate of admissions for early pregnancy complications, induction of labor, elective obstetric cases, and medical obstetric cases.</p><p><strong>Conclusions: </strong>This study demonstrates that lockdown precautions implemented had a significant impact on the rate of admissions to Maternity Hospital. The data obtained may be a used to aid in designing robust policies for future pandemics to avoid adverse health outcomes.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"19 1","pages":"20241062"},"PeriodicalIF":1.7,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11524393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142550080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NSUN6 and HTR7 disturbed the stability of carotid atherosclerotic plaques by regulating the immune responses of macrophages.","authors":"Tingyu Jin, Han Gao, Danyang Meng, Man Luo, Jin Hu","doi":"10.1515/med-2024-1072","DOIUrl":"https://doi.org/10.1515/med-2024-1072","url":null,"abstract":"<p><strong>Background: </strong>Ischemic stroke associated with atherosclerosis is globally named atherothrombotic stroke. Presently, the underlying pathogenic genes promoting carotid atherosclerotic plaques transfer from a stable to unstable state remains elusive. This study aims to find the hub genes disturbing the stability of plaques and explore the primary cells affected by these hub genes.</p><p><strong>Methods: </strong>The optimal hub genes from five datasets for unstable plaques were identified by overlapping genes derived from Boruta and LASSO algorithms. The hub genes' expression levels in stroke patients were confirmed through RT-qPCR. Visualization of the hub genes' expression across various cell clusters was achieved with the aid of the Seurat R package. Then, hub genes were overexpressed or knock-down by lentivirus and siRNA, respectively. The inflammatory factors in the culture medium were detected using an ELISA assay.</p><p><strong>Results: </strong>Eight genes (APOD, ASXL1, COL4A5, HTR7, INF2, NSUN6, PDSS2, and RBBP7) were identified and confirmed by RT-qPCR. The prognostic model was built upon this eight-gene composite foundation, and the area under the curve was 0.98. Based on CIBERSORT findings, unstable plaques displayed a higher macrophage proportion compared to stable ones (<i>P</i> < 0.05). These eight genes also correlated with infiltrated immune cells, especially macrophages. Then, according to single-cell RNA-seq analysis, we found that the eight hub genes mainly expressed in macrophages. The cellular localization of two hub genes (NSUN6 and HTR7) with high distinguishability was confirmed, and gene set enrichment analysis also clarified the possible biological pathways regulated by them. The findings from the <i>in vitro</i> investigation revealed that TNF-α and IL-6 were reduced in macrophages with NSUN6 overexpression or HTR7 knockdown.</p><p><strong>Conclusion: </strong>Eight hub genes, especially NSUN6 and HTR7, were found to promote the progression of plaques by regulating the immune responses of macrophages.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"19 1","pages":"20241072"},"PeriodicalIF":1.7,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11500533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142505365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The chemoprotective hormetic effects of rosmarinic acid.","authors":"Edward J Calabrese, Peter Pressman, A Wallace Hayes, Gaurav Dhawan, Rachna Kapoor, Evgenios Agathokleous, Linda A Baldwin, Vittorio Calabrese","doi":"10.1515/med-2024-1065","DOIUrl":"https://doi.org/10.1515/med-2024-1065","url":null,"abstract":"<p><p>Rosmarinic acid is a polyphenol found in numerous fruits and vegetables, consumed in supplement form, and tested in numerous clinical trials for therapeutic applications due to its putative chemopreventive properties. Rosmarinic acid has been extensively studied at the cellular, whole animal, and molecular mechanism levels, presenting a complex array of multi-system biological effects. Rosmarinic acid-induced hormetic dose responses are widespread, occurring in numerous biological models and cell types for a broad range of endpoints. Consequently, this article provides the first assessment of rosmarinic acid-induced hormetic concentration/dose responses, their quantitative features, mechanistic foundations, extrapolative strengths/limitations, and their biomedical, clinical, and public health implications.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"19 1","pages":"20241065"},"PeriodicalIF":1.7,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11497216/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142505367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shikonin alleviates asthma phenotypes in mice via an airway epithelial STAT3-dependent mechanism.","authors":"Yao Zhang, Lizhan Chen, Haifeng Ouyang","doi":"10.1515/med-2024-1016","DOIUrl":"https://doi.org/10.1515/med-2024-1016","url":null,"abstract":"<p><strong>Background: </strong>Asthma is an inflammatory disease where the balance between Th1/Th2 and Th17/Treg plays a crucial role in its pathogenesis. Shikonin is used to treat a variety of autoimmune diseases due to its good anti-inflammatory activity. However, the effect and mechanism of shikonin on asthma remain unknown.</p><p><strong>Method: </strong>Mice were sensitized with ovalbumin (OVA)/house dust mite (HDM) and treated with shikonin. Lung inflammation was assessed histologically and via flow cytometry. Bronchoalveolar lavage fluid (BALF) was analyzed for cell counts and cytokines. Shikonin's impact on p-STAT3 was studied <i>in vivo</i> and <i>in vitro.</i></p><p><strong>Results: </strong>Shikonin inhibited OVA or HDM-induced inflammation and airway hyperresponsiveness. Upon treatment, a restoration of the Th1/Th2 and Th17/Treg balance was observed, evidenced by a reduction in IL-4 and IL-17A levels in BALF, alongside an elevation in interferon-gamma and IL-10. Furthermore, shikonin impeded the infiltration of eosinophils, neutrophils, macrophages, and lymphocytes into lung tissue. The observed decrease in STAT3 phosphorylation and diminished nuclear translocation of p-STAT3 confirmed that shikonin promotes the balance of Th1/Th2 and Th17/Treg by regulating airway epithelial STAT3.</p><p><strong>Conclusion: </strong>Shikonin mitigates asthma symptoms through a STAT3-dependent mechanism, indicating its potential as an anti-asthmatic therapeutic agent.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"19 1","pages":"20241016"},"PeriodicalIF":1.7,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11497215/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142505366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The unusual location of primary hydatid cyst: A case series study.","authors":"Seerwan Hama Shareef Qaradaghy, Diyaree Nihad Ismael, Shorsh Hama Hussein Ameen, Kawa Abdula Mahmood, Ismael Hama Amin Aghaways, Fadhluddin Nasruddin Shakor, Zana Othman Abdullah, Kawa M Ibrahim, Mohammed Amin Ali Omer, Sangar Abdullah Mohammed, Aram Ahmed Mohammed, Safeen Hama Rasheed","doi":"10.1515/med-2024-1030","DOIUrl":"10.1515/med-2024-1030","url":null,"abstract":"<p><strong>Background: </strong>Cystic echinococcosis mainly affects the liver and lungs, in which the larvae from the microvascular wall in the liver pass to the lungs and then to the blood circulation and settle in any tissue or organ.</p><p><strong>Objectives: </strong>The objective of this study was to report the unusual location of hydatid cysts in infected patients in Sulaimaniyah City, Iraq.</p><p><strong>Patients and methods: </strong>This retrospective case series study enrolled 13 patients. They underwent a surgical operation to excise their cyst after confirmed diagnosis with blood investigations, electrocardiogram, chest X-ray, computed tomography scan, and magnetic resonance imaging (when needed). After the operation, the cyst was confirmed with histopathological examination, and patients were advised to take an Albendazole tablet.</p><p><strong>Results: </strong>Most patients were females from rural areas, with a mean age of 38.93 ± 14.4 years. Patients presented with cysts on the skin of the anterior abdominal wall, gluteal region, mesenteric area, pericardium, tibia bone meta diaphysis, right inguinal region, right thigh, skin of the anterior neck, spleen, left suprarenal gland, right breast, and the iliopsoas muscle.</p><p><strong>Conclusions: </strong>The hydatid cyst can affect any body part with no site immune and often produces nonspecific symptoms.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"19 1","pages":"20241030"},"PeriodicalIF":1.7,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11491882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142471833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraoperative changes in electrophysiological monitoring can be used to predict clinical outcomes in patients with spinal cavernous malformation.","authors":"Xiaoyu Li, Hongqi Zhang, Jian Ren","doi":"10.1515/med-2024-1008","DOIUrl":"10.1515/med-2024-1008","url":null,"abstract":"<p><strong>Aim: </strong>The study aimed to evaluate the sensitivity and specificity of these monitoring parameters in predicting postoperative neurological dysfunction.</p><p><strong>Methods: </strong>In this study, a total of 85 patients with spinal cavernous malformations (SCMs) treated at Xuanwu Hospital, Capital Medical University, from November 2012 to August 2017 were included. During the surgical procedures, all patients underwent monitoring of motor evoked potentials (MEP) and somatosensory evoked potentials (SEP). The criteria for warning included a reduction of ≥80% in MEP amplitude and ≥50% in SEP amplitude.</p><p><strong>Results: </strong>Among 85 patients, 40 (47.1%) had SCMs located in the thoracic segment, 35 (41.2%) in the cervical segment, 6 (7.1%) in the cervical thoracic segment, and 4 (4.7%) in the lumbar segment. MEP recordings were obtained from 81 patients, and the preoperative McCormick score was 1.53 ± 0.69. The sensitivity of multimodal monitoring combined with the criteria of 80% reduction in MEP amplitude and SEP was 83.9%, with a specificity of 69%, a positive predictive value of 69%, and a negative predictive value of 90.4%.</p><p><strong>Conclusion: </strong>This study emphasizes the crucial role of electrophysiological monitoring, particularly MEP and SEP, during the surgical resection of SCMs. The findings demonstrate that this approach is effective in predicting and preventing postoperative neurological dysfunction, thereby improving patient outcomes.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"19 1","pages":"20241008"},"PeriodicalIF":1.7,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11491772/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142471830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity and risk of placenta accreta spectrum: A meta-analysis.","authors":"Ensiyeh Jenabi, Roya Najafi-Vosough, Arshia Nazari","doi":"10.1515/med-2024-1047","DOIUrl":"10.1515/med-2024-1047","url":null,"abstract":"<p><strong>Background: </strong>Some studies have indicated a notable association between obesity and placenta accreta spectrum (PAS), while others have not reported. Hence, we performed a meta-analysis to explore the association between obesity and the risk of PAS.</p><p><strong>Methods: </strong>To explore the association between obesity and PAS through observational studies, we conducted a systematic search across PubMed, Web of Science, Google scholar, and Scopus databases up to March 30, 2024. The meta-analysis utilized a random-effect model, with the quality of included studies assessed using the Newcastle-Ottawa scale. A significance level of less than 0.05 was considered statistically significant using Stata software, version 14 (StataCorp, College Station, TX, USA).</p><p><strong>Results: </strong>The association between obesity and PAS risk in crude studies showed significance (1.51 [95% CI: 1.19, 1.82; <i>I</i> ² = 0.0%]). However, in adjusted studies, the association was not significant (1.25 [95% CI: 0.45, 2.05; <i>I</i> ² = 52.0%]).</p><p><strong>Conclusion: </strong>These findings suggest that obesity has been proposed as potentially associated with a higher risk of PAS, particularly evident in crude studies. However, it is imperative to conduct prospective cohort studies with a large sample size and meticulous control of confounding variables to further elucidate this relationship.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"19 1","pages":"20241047"},"PeriodicalIF":1.7,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11491883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142471832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The risk of cancer among insulin glargine users in Lithuania: A retrospective population-based study.","authors":"Justinas Jonusas, Mingailė Drevinskaitė, Donata Linkeviciute-Ulinskiene, Adomas Ladukas, Aušvydas Patašius, Lina Zabulienė, Giedrė Smailytė","doi":"10.1515/med-2024-1017","DOIUrl":"10.1515/med-2024-1017","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this study was to determine the association between insulin glargine usage and the potential increase in cancer risk among the Lithuanian population diagnosed with type 2 diabetes mellitus (T2DM).</p><p><strong>Methods: </strong>A retrospective cohort study was conducted. The cohort of insulin users was established by identifying all male and female patients diagnosed with T2DM, as recorded in the National Health Insurance Fund database between 1 January 2000 and 31 December 2012. The risk of cancer among insulin glargine users was compared with the risk in non-glargine insulin users. Cox proportional hazard models were used to estimate hazard ratios (HR) and their 95% confidence intervals (CI).</p><p><strong>Results: </strong>The overall cancer risk for all sites combined showed no significant difference (HR 0.84, 95% CI 0.67-1.05). Although a general decrease in the risk of cancers was observed at most sites for glargine users, the use of insulin glargine was associated with a non-significant increase in the risk of mouth and pharynx, stomach, non-melanoma skin, breast, cervical, ovarian, and central nervous system cancers. There was a tendency for a lower risk of colon, rectum, rectosigmoid, and anus cancer among glargine users (HR 0.45, 95% CI 0.18-1.12, <i>p</i> = 0.09).</p><p><strong>Conclusions: </strong>Our research contributes to the growing body of evidence showing that insulin glargine is not associated with an increased risk of all cancers or specific types of cancer.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"19 1","pages":"20241017"},"PeriodicalIF":1.7,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11491771/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142485817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}