Mian Wang, JiHong Lian, Bin Kuang, ChaoHui Zhang, MingHui Zhang
{"title":"横断面研究：维持透析患者血清氧化应激水平与动静脉瘘成熟的关系。","authors":"Mian Wang, JiHong Lian, Bin Kuang, ChaoHui Zhang, MingHui Zhang","doi":"10.1515/med-2025-1149","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>This study was to investigate the relationship between serum superoxide dismutase (SOD) and malondialdehyde (MDA) and arteriovenous fistula (AVF) maturation in maintenance hemodialysis (MHD) patients.</p><p><strong>Methods: </strong>A total of 120 MHD patients were divided into a maturation group (72 patients) and a maturation failure group (48 patients). General information and ultrasound data were collected and venous blood was drawn for routine blood tests. General data and serum SOD and MDA were compared. Independent variables with statistically significant (<i>P</i> < 0.05) differences in univariate analysis were included in multivariate logistic regression. Serum SOD and MDA in predicting maturation failure of AVF were analyzed using receiver operating characteristic curves.</p><p><strong>Results: </strong>The internal diameter of the cephalic vein, internal diameter of the cephalic vein after tourniquet binding, internal diameter of the radial artery, and serum SOD level were lower and serum MDA level was higher in the maturation failure group. Reduced SOD and elevated MDA were independent risk factors for maturation failure of AVF. The area under the curve (AUC) for serum SOD and MDA was 0.68 each. When combined, their AUC for predicting AVF maturation failure was 0.79.</p><p><strong>Conclusion: </strong>Reduced serum SOD and increased MDA are risk factors affecting AVF maturation in MHD patients.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20251149"},"PeriodicalIF":1.7000,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11920762/pdf/","citationCount":"0","resultStr":"{\"title\":\"A cross-sectional study: Relationship between serum oxidative stress levels and arteriovenous fistula maturation in maintenance dialysis patients.\",\"authors\":\"Mian Wang, JiHong Lian, Bin Kuang, ChaoHui Zhang, MingHui Zhang\",\"doi\":\"10.1515/med-2025-1149\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>This study was to investigate the relationship between serum superoxide dismutase (SOD) and malondialdehyde (MDA) and arteriovenous fistula (AVF) maturation in maintenance hemodialysis (MHD) patients.</p><p><strong>Methods: </strong>A total of 120 MHD patients were divided into a maturation group (72 patients) and a maturation failure group (48 patients). General information and ultrasound data were collected and venous blood was drawn for routine blood tests. General data and serum SOD and MDA were compared. Independent variables with statistically significant (<i>P</i> < 0.05) differences in univariate analysis were included in multivariate logistic regression. Serum SOD and MDA in predicting maturation failure of AVF were analyzed using receiver operating characteristic curves.</p><p><strong>Results: </strong>The internal diameter of the cephalic vein, internal diameter of the cephalic vein after tourniquet binding, internal diameter of the radial artery, and serum SOD level were lower and serum MDA level was higher in the maturation failure group. Reduced SOD and elevated MDA were independent risk factors for maturation failure of AVF. The area under the curve (AUC) for serum SOD and MDA was 0.68 each. When combined, their AUC for predicting AVF maturation failure was 0.79.</p><p><strong>Conclusion: </strong>Reduced serum SOD and increased MDA are risk factors affecting AVF maturation in MHD patients.</p>\",\"PeriodicalId\":19715,\"journal\":{\"name\":\"Open Medicine\",\"volume\":\"20 1\",\"pages\":\"20251149\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2025-03-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11920762/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Open Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1515/med-2025-1149\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Open Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1515/med-2025-1149","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
A cross-sectional study: Relationship between serum oxidative stress levels and arteriovenous fistula maturation in maintenance dialysis patients.
Objective: This study was to investigate the relationship between serum superoxide dismutase (SOD) and malondialdehyde (MDA) and arteriovenous fistula (AVF) maturation in maintenance hemodialysis (MHD) patients.
Methods: A total of 120 MHD patients were divided into a maturation group (72 patients) and a maturation failure group (48 patients). General information and ultrasound data were collected and venous blood was drawn for routine blood tests. General data and serum SOD and MDA were compared. Independent variables with statistically significant (P < 0.05) differences in univariate analysis were included in multivariate logistic regression. Serum SOD and MDA in predicting maturation failure of AVF were analyzed using receiver operating characteristic curves.
Results: The internal diameter of the cephalic vein, internal diameter of the cephalic vein after tourniquet binding, internal diameter of the radial artery, and serum SOD level were lower and serum MDA level was higher in the maturation failure group. Reduced SOD and elevated MDA were independent risk factors for maturation failure of AVF. The area under the curve (AUC) for serum SOD and MDA was 0.68 each. When combined, their AUC for predicting AVF maturation failure was 0.79.
Conclusion: Reduced serum SOD and increased MDA are risk factors affecting AVF maturation in MHD patients.
期刊介绍：
Open Medicine is an open access journal that provides users with free, instant, and continued access to all content worldwide. The primary goal of the journal has always been a focus on maintaining the high quality of its published content. Its mission is to facilitate the exchange of ideas between medical science researchers from different countries. Papers connected to all fields of medicine and public health are welcomed. Open Medicine accepts submissions of research articles, reviews, case reports, letters to editor and book reviews.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
