Open Medicine最新文献

{"title":"MZB1 regulates the immune microenvironment and inhibits ovarian cancer cell migration.","authors":"Mingyue Zhu, Guxin Zhou, Fangyuan Chang, Jin Liu","doi":"10.1515/med-2025-1174","DOIUrl":"10.1515/med-2025-1174","url":null,"abstract":"<p><strong>Background: </strong>The immune microenvironment of ovarian cancer is crucial in its progression. Recent studies highlight the significant role of MZB1 in shaping the tumor immune microenvironment (TIME), although its specific function in ovarian cancer remains unclear.</p><p><strong>Materials and methods: </strong>We analyzed 381 ovarian cancer samples from the TCGA database, along with additional samples from GEO and single-cell datasets. Differentially expressed genes (DEGs) were identified using DESeq2. Various algorithms were applied to assess the relationship between MZB1 and the TIME. Cell proliferation was measured using the CCK-8 assay, while cell migration was evaluated using the wound healing assay. Furthermore, a nomogram predicting overall survival was developed based on multivariable Cox regression results.</p><p><strong>Results: </strong>Our results indicated a positive correlation between high MZB1 expression and improved clinical prognosis. Additionally, higher MZB1 expression was linked to increased immune cell infiltration within the TIME. Elevated MZB1 levels inhibited the migration and proliferation of SKOV3 cells. The nomogram's C-index was 0.702, and its calibration curve demonstrated good calibration, indicating satisfactory discrimination and accuracy in predicting patient outcomes.</p><p><strong>Conclusions: </strong>This study comprehensively analyzes MZB1's role in the TIME of ovarian cancer. MZB1 is a promising prognostic marker and a potential target for personalized treatment.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20251174"},"PeriodicalIF":1.7,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12086629/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cord-lamina angle and foraminal diameter as key predictors of C5 palsy after anterior cervical decompression and fusion surgery.","authors":"Wenchao Zhou, Baifeng Sun, Zichuan Wu, Aochen Xu, Hanlin Song, Xuhong Zhang, Junbin Liu, Junzhe Sheng, Yang Liu","doi":"10.1515/med-2025-1162","DOIUrl":"10.1515/med-2025-1162","url":null,"abstract":"<p><strong>Background: </strong>C5 nerve root palsy (C5P) is a rare but documented complication after cervical decompression surgery. Despite multiple proposed mechanisms, research on risk factors for C5P after anterior cervical discectomy and fusion (ACDF) remains insufficient.</p><p><strong>Objective: </strong>The aim of this study was to identify specific risk factors associated with C5 nerve root palsy after ACDF.</p><p><strong>Methods: </strong>A total of 108 patients who underwent ACDF surgery were divided into C5P and non-C5P groups. The basic data, preoperative Japanese Orthopaedic Association score, cervical curvature correction at C2-7 and C4-5, anterior-posterior diameter (APD) at C4/5, spinal-cord-lumbar angle (CLA) at C4/5, foramen magnum occipitalis at C4/5, and the presence of preoperative high-signal areas in the C4/5 spinal cord on T2-weighted magnetic resonance imaging, were present. Risk factors associated with C5P were identified using logistic regression analysis.</p><p><strong>Results: </strong>There were no significant differences between the two groups in terms of age, gender, disease duration, diagnosis, preoperative Japanese Orthopaedic Association score, number of operated segments, APD, or high-intensity zone. LRA showed that a larger CLA and narrower FD at C4/5 were the main risk factors for the development of C5P (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>A larger cord-lamina angle and a narrower foraminal diameter at C4/5 are significant risk factors associated with the development of C5 palsy following ACDF.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20251162"},"PeriodicalIF":1.7,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12086625/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GATA1: A key biomarker for predicting the prognosis of patients with diffuse large B-cell lymphoma.","authors":"Yuxin Zhang, Yue Wang, Shifen Wang, Dawei Cui, Zheng Wei","doi":"10.1515/med-2025-1185","DOIUrl":"10.1515/med-2025-1185","url":null,"abstract":"<p><strong>Objectives: </strong>Diffuse large B-cell lymphoma (DLBCL) is a common and highly aggressive type of lymphoma. Iron metabolism plays a critical role in human diseases, however, which remains unclear in DLBCL patients. The study is to explore the genetic characteristics and molecular mechanisms underlying ferroptosis in DLBCL patients.</p><p><strong>Methods: </strong>Based on the GEO, GeneCards database, weighted gene co-expression network analysis was performed on the DLBCL sample and iron metabolism-related datasets. Enrichment analysis (Gene Ontology/Kyoto Encyclopedia of Genes and Genomes and gene set enrichment analysis) was used to analyze the expression and possible mechanism of key genes in DLBCL patients. The key genes were identified by quantitative real-time PCR.</p><p><strong>Results: </strong>The results showed that GATA-binding factor 1 (GATA1), as a key gene of iron metabolism in DLBCL patients, was related to the myeloid cell differentiation and granulocyte differentiation pathways to affect CD4⁺ T cells, B cells, and monocytes. GATA1 was strongly positively or negatively correlated with sensitivity to multiple targeted drugs. The patients with high GATA1 expression had shorter overall survival and worse prognosis than the patients with low expression. Additionally, high expression of the GATA1 gene was confirmed in DLBCL patients.</p><p><strong>Conclusions: </strong>GATA1 as one of the important genes of ferroptosis suggested a significant biomarker for predicting the prognosis of DLBCL patients.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20251185"},"PeriodicalIF":1.7,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12086623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influencing factors of false lumen thrombosis in type B aortic dissection: A single-center retrospective study.","authors":"Qian-Hui Tang, Han Yang, Zhong Qin, Qiu-Ning Lin, Ming Hu, Xiao Qin, Jing Chen","doi":"10.1515/med-2025-1179","DOIUrl":"10.1515/med-2025-1179","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the factors associated with false lumen thrombosis in preoperative type B aortic dissection (TBAD) patients.</p><p><strong>Methods: </strong>Between January 2008 and December 2017, TBAD patients were evaluated. Participants were divided into patent, partial thrombosis, and complete thrombosis groups according to the status of the false lumen. Univariate analysis and logistic regression analysis were used to identify the factors associated with false lumen thrombosis.</p><p><strong>Results: </strong>A total of 285 participants fulfilled our inclusion criteria. Patients in the complete thrombosis group were significantly older than those in the partial thrombosis and patent groups (59 ± 10 vs 53 ± 11 and 50 ± 11 years, respectively), and combined shorter dissection lengths (290 ± 101 vs 354 ± 92 and 351 ± 102 mm, respectively). The following factors were associated with partial thrombosis of the false lumen with an odds ratio (OR) <1: primary tear size (OR, 0.96; 95% confidence interval [CI], 0.93-0.99; <i>p</i> = 0.03), last tear size (OR, 0.93; 95% CI, 0.87-0.99; <i>p</i> = 0.04), and the total number of tears (OR, 0.87; 95% CI, 0.78-0.98; <i>p</i> = 0.02).</p><p><strong>Conclusions: </strong>TBAD patients older than 59 years or with aortic dissection lengths of less than 290 mm were more likely to have a thrombosed false lumen.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20251179"},"PeriodicalIF":1.7,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12086627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Celastrol suppresses neovascularization in rat aortic vascular endothelial cells stimulated by inflammatory tenocytes via modulating the NLRP3 pathway.","authors":"Yong Yang, Huajun Wang, Huige Hou, Jiwen Chen, Xiaolei Chen, Hongjian Zheng, Kai Zheng, Baofei Ye, Chunhui Wu, Xiaofei Zheng, Shiguo Yuan, Boyuan Zheng","doi":"10.1515/med-2024-1121","DOIUrl":"10.1515/med-2024-1121","url":null,"abstract":"<p><p>Appropriate formation of blood vessels is critical for tendon-bone healing during tendon injury, as excessive angiogenesis would exacerbate scar formation and lead to chronic pain and dysfunction. The mechanism to regulate inflammatory angiogenesis during tendon-bone healing remains to be elucidated. Here, we utilized lipopolysaccharide (LPS) to induce tenocyte inflammation and applied the conditioned medium from inflammatory tenocytes to treat rat aortic vascular endothelial cells (RAOECs). The results that indicated LPS treatment significantly induced the mRNA and protein upregulation of NLRP3, tumor necrosis factor α, IL-1β, and vascular endothelial growth factor A (VEGFA), as well as the secretion of VEGFA. Furthermore, the conditioned medium stimulated RAOEC angiogenesis. Celastrol, a quinone-methylated triterpenoid from <i>Tripterygium wilfordii</i>, has been reported to treat osteoarthritis. Here, celastrol could suppress LPS-induced upregulation of NLRP3 and IL-1β, and the secretion of VEGFA. Celastrol treatment also suppressed the conditioned medium-induced angiogenesis in RAOEC. Moreover, we established a rotator cuff tear rat model to stimulate tendon injury. Celastrol administration at the lesion significantly promoted tendon healing and functional recovery in injured mice by regulating NLRP3 and VEGFA levels. Taken together, these data suggest that the inflammation-induced tenocyte injury leads to angiogenesis, and that celastrol administration could suppress the inflammatory tenocyte-induced angiogenesis to promote tendon-bone healing via the NLRP3 pathway.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20241121"},"PeriodicalIF":1.7,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12086628/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Necroptosis of hippocampal neurons in paclitaxel chemotherapy-induced cognitive impairment mediates microglial activation via TLR4/MyD88 signaling pathway.","authors":"Lan-Lan Liu, Xin Liu, Shuang Zhao, Zhao Li, Jia-Xin Liu, Dong-Yang Ma, Xiu-Li Wang","doi":"10.1515/med-2025-1182","DOIUrl":"https://doi.org/10.1515/med-2025-1182","url":null,"abstract":"<p><strong>Background: </strong>Paclitaxel (PTX) chemotherapy frequently induces cognitive impairment, which is closely associated with two key pathological processes: necroptosis of hippocampal neurons and microglial polarization. Necroptotic neurons release damage-associated molecular patterns, triggering inflammatory responses. As the primary immune cells in the central nervous system, microglia can exhibit either pro-inflammatory or anti-inflammatory activity depending on their polarization state. However, the relationship between PTX-induced neuronal necroptosis and microglial activation remains unclear.</p><p><strong>Methods: </strong>In this study, both <i>in vivo</i> and <i>in vitro</i> experiments were conducted. <i>In vivo</i>, an adult male C57BL/6N mouse model of PTX-induced cognitive impairment was established and divided into three groups: Veh (vehicle control), PTX (paclitaxel only), and P + N (paclitaxel with Nec-1 treatment). Necrostatin-1 (Nec-1), a specific inhibitor of RIPK1, was used to inhibit necroptosis. <i>In vitro</i>, HT22 cells were used to prepare necroptosis-conditioned medium, and BV-2 cells were treated with this medium. TAK-242, a TLR4 inhibitor, was used to explore the role of the TLR4/MyD88 signaling pathway. Immunofluorescence staining, western blot, and ELISA were employed to detect relevant markers and cytokines.</p><p><strong>Results: </strong>The results demonstrated that PTX-induced necroptosis of hippocampal neurons activated microglia. Nec-1 effectively suppressed neuronal necroptosis and reduced M1 polarization of microglia. The TLR4/MyD88 signaling pathway was involved in microglial polarization induced by the necroptotic-conditioned medium of PTX-treated HT22 cells. TAK-242 significantly blocked the regulatory effect of PTX-induced neuronal necroptosis on BV-2 microglial polarization.</p><p><strong>Conclusion: </strong>This study reveals that hippocampal neuron necroptosis activates microglia through the TLR4/MyD88 signaling pathway in PTX-induced cognitive impairment, promoting M1 polarization and neuroinflammation. Inhibiting necroptosis promotes M2 polarization and neuroprotection. These findings uncover a novel mechanism of PTX-induced cognitive impairment and suggest potential therapeutic targets.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20251182"},"PeriodicalIF":1.7,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12048903/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathogen surveillance and risk factors for pulmonary infection in patients with lung cancer: A retrospective single-center study.","authors":"Hu Shan, Jing Wang, Qiuhong Zhang, Zongjuan Ming, Yonghong Zhang, Ping He, Ping Fang, Ming Zhang, Wei Li, Hongyang Shi, Yuanlin Guan, Shuanying Yang","doi":"10.1515/med-2025-1180","DOIUrl":"https://doi.org/10.1515/med-2025-1180","url":null,"abstract":"<p><strong>Background: </strong>Early and accurate diagnosis of pulmonary infection (PI) is crucial for the timely implementation of appropriate treatment strategies in lung cancer patients.</p><p><strong>Methods: </strong>Metagenomic next-generation sequencing and conventional testing were performed in lung cancer patients with and without PI. The pathogen profiles were analyzed, and risk factors for PI were explored using univariate and multivariate logistic regression models.</p><p><strong>Results: </strong>A total of 55 lung cancer patients with PI and 59 non-infected lung cancer patients were included. There were 41 underlying pathogens identified by both methods in lung cancer patients with PI. The coexistence of different pathogen types was common, particularly between fungi and viruses, which was observed in 28.57% of cases. The incidence of <i>Streptococcus pneumoniae</i> and <i>Pneumocystis jirovecii</i> is significantly higher in small-cell lung carcinoma patients compared to that in non-small-cell lung carcinoma patients. Besides, cytomegalovirus, <i>P. jirovecii</i>, and <i>Aspergillus</i> were more likely to be found in advanced-stage patients. Risk factor analysis revealed that Karnofsky Performance Status <90 and chemotherapy were strongly associated with PI in lung cancer patients.</p><p><strong>Conclusions: </strong>This study highlights the complexity of PI in lung cancer patients, emphasizing the need for tailored diagnostic and therapeutic strategies based on cancer type and stage.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20251180"},"PeriodicalIF":1.7,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12048904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of smoking and smoking cessation on hematological parameters in polycythemic patients.","authors":"Kadir Ilkkilic, Dilek Karadogan, Tahsin Gökhan Telatar, Osman Cure, Aleksandra Klisic","doi":"10.1515/med-2025-1181","DOIUrl":"https://doi.org/10.1515/med-2025-1181","url":null,"abstract":"<p><strong>Background: </strong>The number of studies on the effect of smoking cessation interventions in polycythemic patients is limited. Our aim was to examine the effects of quitting smoking on hematological parameters in patients with polycythemia and to evaluate the outcomes of smoking cessation interventions in polycythemic patients.</p><p><strong>Methods: </strong>The prospective study was conducted in the hematology outpatient clinic between November 2022 and May 2023. Patients with polycythemia were grouped according to their smoking status. Smoking cessation interventions were applied to current smokers. Blood parameters were compared according to smoking status at the baseline and third month follow up.</p><p><strong>Results: </strong>At first presentation, 65.4% (<i>N</i> = 93) of 142 patients were current smokers and 34.5% (<i>N</i> = 49) were non-smokers. Fifty-one percent (<i>N</i> = 47) of active smokers quit smoking at the 3-month follow-up after the intervention. Hemoglobin (Hb), hematocrit (Hct), mean corpuscular volume, very low density lipoprotein cholesterol, and immature granulocytes were found to be higher in active smokers compared to non-smokers at initial presentation (<i>p</i> < 0.05). Hb and Hct values decreased in smokers who quit smoking compared to baseline values at 3 months (<i>p</i> < 0.05).</p><p><strong>Conclusions: </strong>Of the patients with polycythemia, 65% were current smokers and about half of them were successful in quitting smoking at 3 months with effective implementation of smoking cessation interventions.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20251181"},"PeriodicalIF":1.7,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12048899/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diverse electrophysiological demyelinating features in a late-onset glycogen storage disease type IIIa case.","authors":"Xiajun Zhou, Xingxing Zhong, Mingshi Gao, Dongyue Yue, Kai Qiao, Min Wang, Nan Zhi, Wenwei Cao, Lu Han, Jiahong Lu, Wenhua Zhu, Chongbo Zhao, Yangtai Guan","doi":"10.1515/med-2025-1172","DOIUrl":"https://doi.org/10.1515/med-2025-1172","url":null,"abstract":"<p><p>Glycogen storage disease type IIIa (GSD IIIa) is a rare etiology among patients with adult-onset myopathy, which is typically associated with axonopathy rather than demyelination. We report a genetically and pathologically confirmed case that exhibited prominent electrophysiological hallmarks of demyelination, including prolonged distal motor latency, temporal dispersion, prolonged F-waves, and conduction block. The presence of these diverse demyelinating characteristics in this context, excluding other factors, is infrequently reported, suggesting that glycogen accumulation may influence not only muscles but also potentially the myelin, thereby broadening our comprehension of this rare disease spectrum.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20251172"},"PeriodicalIF":1.7,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12048896/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Semaglutide treatment for type 2 diabetes in a patient with chronic myeloid leukemia: A case report and review of the literature.","authors":"Yuchen Zhang, Anxin Li","doi":"10.1515/med-2025-1184","DOIUrl":"https://doi.org/10.1515/med-2025-1184","url":null,"abstract":"<p><strong>Background: </strong>Comorbid type 2 diabetes mellitus (T2DM), severe obesity, and chronic myeloid leukemia (CML) present therapeutic challenges, especially given the limited data on glucagon-like peptide-1 (GLP-1) receptor agonists in this setting.</p><p><strong>Methods: </strong>We describe a 33-year-old female with poorly controlled T2DM (HbA1c 10.7%), severe obesity (BMI 47.05 kg/m²), and stable CML on tyrosine kinase inhibitor therapy. She received once-weekly semaglutide (0.5-1.5 mg) for 6 months, alongside insulin glargine and dapagliflozin/metformin. Clinical, biochemical, and molecular parameters were monitored.</p><p><strong>Results: </strong>After 6 months, her HbA1c declined from 10.7 to 5.5%, fasting plasma glucose from 16.2 to 5.3 mmol/L, and body weight decreased by 18 kg. Lipid parameters improved, and molecular analysis confirmed continued CML remission (undetectable BCR-ABL1). The patient experienced only mild, transient gastrointestinal side effects.</p><p><strong>Conclusion: </strong>In this complex case, semaglutide proved safe and effective for achieving glycemic control and weight reduction without compromising CML stability. These findings suggest that GLP-1 receptor agonists may be a viable therapeutic option for patients with coexisting T2DM, severe obesity, and stable CML, warranting further investigation in broader populations.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20251184"},"PeriodicalIF":1.7,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12032985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}