Open Medicine最新文献

{"title":"Effect of adalimumab on anxiety-depression-like behaviors and learning in rats receiving cisplatin.","authors":"Durmuş Ali Aslanlar, Mehmet Öz, F Hümeyra Yerlikaya Aydemir, K Esra Nurullahoglu Atalik","doi":"10.1515/med-2026-1406","DOIUrl":"10.1515/med-2026-1406","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the neuroprotective effects of adalimumab against cisplatin-induced cognitive impairment (CICI) and to evaluate its potential to ameliorate anxiety- and depression-like behaviors as well as learning and memory deficits through modulation of Tumor necrosis factor-α (TNF-α)-mediated neuroinflammation, cholinergic homeostasis, and apoptosis.</p><p><strong>Methods: </strong>Adult male Wistar rats were divided into four groups (n=6/group): Control, Cisplatin (2 mg/kg/day, i.p., 10 days), ADA (10 mg/kg, i.p., three doses), and Cisplatin + ADA. Anxiety-, depression-like behaviors and memory performance were assessed using the open field test, elevated plus maze, forced swim test, and novel object recognition test. Serum and hippocampal TNF-α, nitric oxide (NO), acetylcholinesterase (AChE), acetylcholine (ACh), and p53 levels were measured by ELISA.</p><p><strong>Results: </strong>Cisplatin induced anxiety- and depression-like behaviors and impaired recognition memory without affecting locomotor activity. These behavioral alterations were accompanied by increased TNF-α, NO, AChE, and p53 levels in the hippocampus. ADA treatment significantly reversed behavioral deficits and normalized inflammatory, cholinergic, and stress-related markers.</p><p><strong>Conclusions: </strong>Adalimumab attenuates cisplatin-induced cognitive and mood disturbances, likely through modulation of TNF-α-mediated neuroinflammation, cholinergic imbalance, and stress-related signaling pathways.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"21 1","pages":"20261406"},"PeriodicalIF":1.8,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13295197/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148345940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meta-analysis on the safety and efficacy of different dressings in the treatment of diabetic foot ulcers.","authors":"Xinxin Huang, Xubiao Meng","doi":"10.1515/med-2026-1459","DOIUrl":"10.1515/med-2026-1459","url":null,"abstract":"<p><strong>Introduction: </strong>Diabetic foot ulcers (DFU) are a common and severe complication of diabetes, associated with high morbidity, infection risk, and amputation rates. Various dressings have been applied in clinical practice, yet their comparative safety and efficacy remain unclear. This study aimed to systematically evaluate different dressings for DFU treatment through meta-analysis.</p><p><strong>Content: </strong>Relevant studies from Chinese and English databases were retrieved and analyzed. A total of 25 studies involving 2,421 patients were included. Dichotomous data analysis showed that the experimental group had a significantly higher complete wound healing rate than the control group (OR=4.62, 95 % CI: 3.10-6.90, p<0.01), a significantly lower incidence of wound infection (OR=0.63, 95 % CI: 0.43-0.93, p=0.02), and no significant difference in amputation rate (OR=0.62, 95 % CI: 0.34-1.14, p=0.12). Continuous data analysis indicated that the experimental group had higher wound healing scores (MD=25.77, 95 % CI: 2.33-49.20, p=0.03), greater ulcer area reduction (MD=27.96, 95 % CI: 21.93-34.00, p<0.01), and shorter healing time (MD=-11.41, 95 % CI: -14.35 to -8.47, p<0.01). Meta-regression analysis suggested that publication year, blinding, and outcome indicators contributed to heterogeneity (p<0.05).</p><p><strong>Summary: </strong>Activated carbon cloth (ACC), negative pressure wound therapy (NPWT), and olive oil dressings demonstrated favorable safety and efficacy, although each has distinct advantages. Clinical selection should therefore be individualized according to patient conditions and wound characteristics.</p><p><strong>Outlook: </strong>Future studies with larger sample sizes and higher methodological quality are needed to further validate these findings and reduce heterogeneity, thereby providing more robust evidence for clinical decision-making.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"21 1","pages":"20261459"},"PeriodicalIF":1.8,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13296375/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148345978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occurrence of portal venous gas following routine endoscopy: a case report.","authors":"Liping Yang, Chao Lu","doi":"10.1515/med-2026-1474","DOIUrl":"10.1515/med-2026-1474","url":null,"abstract":"<p><strong>Objectives: </strong>Portal venous gas (PVG) is commonly associated with severe gastrointestinal disease, whereas benign causes related to endoscopic procedures are uncommon. We report an unusual mechanism of PVG occurring in the setting of chronic gastric outlet obstruction after carbon dioxide (CO₂)-insufflated upper gastrointestinal endoscopy.</p><p><strong>Case presentation: </strong>A 25-year-old Asian woman presented with recurrent vomiting. She had undergone surgery for duodenal perforation six months earlier and was subsequently lost to follow-up. Her symptoms recently worsened, with significant abdominal distension and vomiting for 3 weeks. A computed tomography (CT) revealed marked gastric dilatation and fibrotic duodenal bulb stenosis. After gastric decompression, CO₂-insufflated gastroscopy was performed while she remained conscious. Severe gastric distension, retained contents, and limited procedural tolerance and cooperation limited visualization, and an ultrathin gastroscope could not pass <1 mm stenosis. The procedure was terminated without any immediate complications. Later that night, she developed abdominal pain. CT demonstrated extensive PVG and submucosal gastric wall air, with normal inflammatory markers and no signs of perforation. Conservative treatment with continued decompression and acid suppression led to rapid clinical improvement, and repeat CT two days later showed complete resolution of PVG. Endoscopy used standard low-flow CO₂ insufflation, total procedure duration was approximately 20 min, and intermittent suctioning was performed for content removal.</p><p><strong>Conclusions: </strong>In the setting of chronic gastric outlet obstruction and prolonged gastric distension, impaired mucosal integrity together with increased intragastric pressure may predispose to abnormal CO₂ migration into the portal venous system during endoscopy. Possible partial-thickness or submucosal injury during manipulation may further facilitate portal venous gas formation. Recognition of etiologies of PVG that do not require surgery is essential, as many stable patients can be managed conservatively, preventing unnecessary operative intervention.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"21 1","pages":"20261474"},"PeriodicalIF":1.8,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13293325/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148332052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"6PPD-quinone exposure and Alzheimer's disease: insights from integrative network pharmacology, transcriptomics, machine learning, and molecular docking.","authors":"Chun Zhang, Jingqi Zhang","doi":"10.1515/med-2026-1477","DOIUrl":"10.1515/med-2026-1477","url":null,"abstract":"<p><strong>Objectives: </strong>To systematically investigate the molecular associations between 6PPD-quinone (6PPD-Q), an environmental transformation product of the tire antioxidant 6PPD, and Alzheimer's disease (AD) pathogenesis.</p><p><strong>Methods: </strong>An integrative strategy combining network pharmacology, transcriptomic validation, and machine learning was employed. Intersecting targets were identified through multi-database mining, followed by functional enrichment and protein-protein interaction (PPI) network analyses. Transcriptomic validation, SHAP-based XGBoost analysis, Mendelian randomization, and molecular docking were performed to evaluate target expression, diagnostic value, causal associations, and binding affinities.</p><p><strong>Results: </strong>A total of 92 intersecting targets were identified, enriched in synaptic structures, kinase activity, neuroinflammation, and apoptotic pathways. PPI analysis revealed 23 core targets, with <i>NFKB1</i>, <i>GSK3B</i>, and <i>PIK3CA</i> as key hub genes enriched in the cerebral cortex and basal ganglia. Transcriptomic data confirmed differential expression of core targets in AD. SHAP analysis identified <i>PTGS2</i>, <i>KIT</i>, <i>PIK3CA</i>, <i>NFE2L2</i>, and <i>NFKB1</i> as high-value diagnostic predictors. Mendelian randomization supported a causal association between <i>NFKB1</i> brain expression and AD risk. Molecular docking confirmed strong binding of 6PPD-Q to <i>PTGS2</i>, <i>GSK3B</i>, and <i>NFE2L2</i>.</p><p><strong>Conclusions: </strong>This study provides the first systematic characterization of the molecular mechanisms by which 6PPD-Q may contribute to AD pathogenesis, potentially through inducing oxidative stress, activating neuroinflammation, and disrupting kinase signaling networks.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"21 1","pages":"20261477"},"PeriodicalIF":1.8,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13290095/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148318331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discovery and validation of key genes and potential mechanisms linked to endothelial cell senescence and carbohydrate metabolism in recurrent spontaneous abortion.","authors":"Lin Chen, Yu Shao, Xianshun Pan, Ting Lai","doi":"10.1515/med-2026-1464","DOIUrl":"10.1515/med-2026-1464","url":null,"abstract":"<p><strong>Objectives: </strong>Recurrent spontaneous abortion (RSA) is a major pregnancy complication with largely unknown causes. Carbohydrate metabolism (CM) disorders can affect the progression of endothelial cell senescence (ES), thereby leading to placental dysfunction. However, research on the interplay between CM and ES in RSA is limited. This study aims to identify key genes at the intersection of CM- and ES-related pathways in RSA via various bioinformatics methods.</p><p><strong>Methods: </strong>Datasets GSE165004 (training) and GSE26787 (validation) were downloaded from the GEO database. ES- and CM-related genes were obtained from previous literature. Key genes were obtained through WGCNA, two machine learning algorithms, gene expression analysis in the training and validation datasets, and RT-qPCR analysis. A comprehensive evaluation was conducted to assess the diagnostic potential of key genes.</p><p><strong>Results: </strong>Two genes (BDH1, PIK3C2G) were recognized as key genes in RSA, which were upregulated in RSA. Immune infiltration analysis revealed that the key genes were negatively correlated with three distinct immune cell types. Both genes are linked to the cytokine-cytokine receptor interaction pathway. They were predicted to interact with two transcription factors (FOXL1 and YY1) and several chemicals.</p><p><strong>Conclusions: </strong>This study identifies BDH1 and PIK3C2G as candidate genes associated with CM and ES-related pathways in RSA.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"21 1","pages":"20261464"},"PeriodicalIF":1.8,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13293328/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148331959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TyG index combined with BMI predicts metabolism dysfunction-associated fatty liver disease in patients with type 2 diabetes.","authors":"Qian Gao, Lei Feng, Weiling Zhou, Xiaoli Li, Lanzi Yin, Xiaojuan Hou, Yuan Wang","doi":"10.1515/med-2026-1457","DOIUrl":"10.1515/med-2026-1457","url":null,"abstract":"<p><strong>Objectives: </strong>To explore the predictive capacity of the TyG index (triacylglycerol-glucose index) in conjunction with BMI for diagnosing MAFLD among patients with type 2 diabetes mellitus (T2DM).</p><p><strong>Methods: </strong>A retrospective study of 356 consecutive type-2 diabetes patients followed by the Endocrinology Department from May 2022 to May 2024 was studied. Participants were divided into MAFLD and non-MAFLD groups, and the association and predictive accuracy of the TyG index were evaluated using logistic regression and ROC curve analyses.</p><p><strong>Results: </strong>Significant variations in the incidence of MAFLD were observed across the quartiles Q1 (TyG<8.98), Q2 (8.98≤TyG<9.36), Q3 (9.36≤TyG<9.94), and Q4 (TyG≥9.94) (p<0.001). The formula log (p)=-22.549+0.385 * BMI + 1.3708 * TyG index illustrated that the TyG index and BMI are predictive of the likelihood of MAFLD in patients with T2DM. Furthermore, the TyG index and BMI were strongly correlated with MAFLD, evidenced by an area under the curve of 0.868 (95 % CI [0.829, 0.907], p<0.001), a sensitivity of 83.0 %, and a specificity of 77.8 %.</p><p><strong>Conclusions: </strong>The TyG index is significantly associated with the risk of developing MAFLD in individuals with type 2 diabetes, and its predictive utility is markedly enhanced when BMI is incorporated.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"21 1","pages":"20261457"},"PeriodicalIF":1.8,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13274720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148278287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Designing a multi-epitope vaccine against yellow fever virus using immunoinformatics approaches.","authors":"Muhammad Naveed, Muhammad Asim, Tariq Aziz, Muhammad Toheed, Aroosa Athar, Muhammad Nouman Majeed, Ayaz Ali Khan, Maha Alharbi, Ashwag Shami, Maher S Alwethaynani, Mai M Almsaud, Fakhria A Al-Joufi","doi":"10.1515/med-2026-1453","DOIUrl":"10.1515/med-2026-1453","url":null,"abstract":"<p><strong>Objectives: </strong>Yellow fever virus (YFV) is a mosquito-borne pathogen causing severe hemorrhagic fever in tropical and subtropical regions. This study aimed to design and evaluated a multi-epitope subunit vaccine against yellow fever virus using immunoinformatics and computational approaches.</p><p><strong>Methods: </strong>The yellow fever virus envelope glycoprotein was selected as the target antigen. Antigenic, non-allergenic, and non-toxic B-cell, MHC-I, and MHC-II epitopes were predicted and assembled into a vaccine construct using linkers and β-defensin-3 as an adjuvant. Structural modeling and validation were performed using AlphaFold3 and quality assessment tools. Molecular docking with TLR2 and TLR8 was conducted using ClusPro, followed by molecular dynamics simulations to assess structural stability. Disulfide engineering was applied to enhance rigidity, immune simulation was performed to predict host immune responses, and <i>in silico</i> cloning was carried out using the pBR322 vector.</p><p><strong>Results: </strong>Six conserved epitopes with strong antigenic potential were identified. The vaccine construct showed favorable docking interactions with TLR2 and TLR8, yielding ClusPro weighted interaction scores of -1105.52 and -1152.9, respectively. Molecular dynamics simulations revealed structural stability, supported by stable RMSD and compact radius of gyration profiles. Immune simulation indicated robust humoral and cellular immune responses.</p><p><strong>Conclusions: </strong>The designed multi-epitope vaccine showed promising immunogenic and structural properties, supporting its potential as a potential vaccine candidate against yellow fever virus. However, experimental validation through <i>in vitro</i> and <i>in vivo</i> studies is required.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"21 1","pages":"20261453"},"PeriodicalIF":1.8,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13274724/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148278285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic yield of real-time PCR vs. NGS in pediatric FMF: insights from a Turkish cohort.","authors":"Emine Göktaş, Tuğba Deniz Kurnaz Demir, Ayşe Gül Zamani, Mahmut Selman Yildirim","doi":"10.1515/med-2026-1451","DOIUrl":"10.1515/med-2026-1451","url":null,"abstract":"<p><strong>Objectives: </strong>Familial Mediterranean Fever (FMF) is the most common monogenic autoinflammatory disease, especially in Mediterranean populations. This study compares the diagnostic value of real-time PCR and next-generation sequencing (NGS) in a Turkish pediatric cohort and assesses the benefits of comprehensive genetic panels.</p><p><strong>Methods: </strong>A total of 478 children with suspected FMF, seen between January 2022 and July 2024, were retrospectively analyzed. All underwent initial <i>MEFV</i> mutation screening via real-time PCR. Patients with negative or inconclusive results (n=39) were further tested using targeted NGS, covering <i>MEFV</i> and other autoinflammatory genes.</p><p><strong>Results: </strong>Real-time PCR detected at least one <i>MEFV</i> variant in 211 patients (44.1 %). The most common variants were M694V (41.6 %), E148Q (24.4 %), V726A (12.4 %), and M680I (10.9 %). Among the 39 patients further evaluated with NGS, some had additional or rare variants in <i>MEFV</i> or other genes such as <i>MVK, NOD2, STAT3</i>, and <i>NLRP12</i>, providing additional genetic findings, particularly in PCR-negative cases.</p><p><strong>Conclusions: </strong>Real-time PCR is effective for initial <i>MEFV</i> screening. However, NGS enhances diagnostic accuracy by identifying rare or complex variants, supporting its use in unresolved or atypical FMF cases.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"21 1","pages":"20261451"},"PeriodicalIF":1.8,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13274722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148278270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the effects of pure vitamin E and combined conservative therapy for precancerous cervical lesions cultivated on a microfluidic chip.","authors":"Anđela Perić, Ana N Mirić, Jelena V Košarić, Nevena N Milivojević, Marko N Živanović, Miloš N Milosavljević, Simona Protrka, Petar S Arsenijević","doi":"10.1515/med-2026-1413","DOIUrl":"10.1515/med-2026-1413","url":null,"abstract":"<p><strong>Objectives: </strong>We aimed to examine the effect of vitamin E on preinvasive cervical squamous epithelium lesions on a microfluidic chip model.</p><p><strong>Methods: </strong>The research was conducted on 60 women, previously determined for a biopsy of the cervix due to an abnormal screening cytological test. The control group consisted of patients who were not treated with vaginal tablets Ialuna^® or pure vitamin E. Samples were cultivated on a microfluidic chip, treated with Ialuna^® vaginal tablets containing vitamin E combined with other ingredients or pure vitamin E, and then relative gene expression of BAX and BCL2 genes was measured.</p><p><strong>Results: </strong>In tissues from women with chronic cervicitis, treatment with Ialuna^® vaginal tablets induced a significant increase in BAX expression and the BAX/BCL2 ratio, while no significant changes were observed in BCL2 expression. In LSIL tissues, Ialuna^® treatment resulted in a significant decrease in BCL2 expression, accompanied by increased BAX expression and an elevated BAX/BCL2 ratio. Conversely, pure vitamin E treatment did not produce significant changes in apoptotic markers in either group.</p><p><strong>Conclusions: </strong>This study has shown that conservative therapy is an important part of the treatment of cervical precancerous lesions and can potentially lead to diminishing radical interventions.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"21 1","pages":"20261413"},"PeriodicalIF":1.8,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13274721/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148278233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The value of predictive models assisted diagnosis of benign and malignant lacrimal gland tumor based on dynamic contrast-enhanced combined with conventional MRI.","authors":"Tianming Jian, Fei Gao, Mei Yang, Tong Wu, Xiaodong Ji, Shuang Xia, Fengyuan Sun","doi":"10.1515/med-2026-1437","DOIUrl":"10.1515/med-2026-1437","url":null,"abstract":"<p><strong>Background or purpose: </strong>To explore the value of predictive models assisted diagnosis of benign and malignant lacrimal gland tumor based on dynamic contrast enhanced (DCE) combined with conventional MRI.</p><p><strong>Methods: </strong>This study retrospectively analyzed the patients with primary lacrimal gland tumors using conventional and DCE-MRI. 15 base predictive models were conducted to compare the diagnostic value.</p><p><strong>Results: </strong>A total number of 76 patients were enrolled, including 41 were malignant, 35 were benign. Compared with the benign and malignant tumors, MRI parameters including tumor diameter, tumor shape, adjacent bone damage, K^trans, K_ep, V_e and TIC were selected into predictive models. Six-performance metrics of models with DCE quantitative parameters was significantly better than the models without. According to the test results, Extra Trees Classifier (ET) showed the highest MCC and F1 score, the accuracy was 91 %, precision was 100 %, and the recall was 83 %, based on DCE quantitative parameters plus conventional MRI features.</p><p><strong>Discussion or conclusions: </strong>Our findings indicate that the predictive models based on DCE quantitative parameters plus conventional MRI features have shown better performance than the models based on conventional MRI features alone. ET could be selected as the best model in the diagnosis of benign and malignant lacrimal tumors.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"21 1","pages":"20261437"},"PeriodicalIF":1.8,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13267938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148265373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}