Open Medicine最新文献

{"title":"Dioscin protects against chronic prostatitis through the TLR4/NF-κB pathway","authors":"Yan Long, Xiaodong Ge, Liangliang Ma, Junhua Guo, Yong Zhu","doi":"10.1515/med-2024-1036","DOIUrl":"https://doi.org/10.1515/med-2024-1036","url":null,"abstract":"This study aimed to elucidate the effects and potential mechanisms of dioscin on chronic prostatitis (CP) <jats:italic>in vivo</jats:italic> and <jats:italic>in vitro</jats:italic>. CP models were constructed <jats:italic>in vivo</jats:italic> and <jats:italic>in vitro</jats:italic> and treated with different concentrations of dioscin. Hematoxylin and eosin staining was used to investigate the morphology of the prostate tissues. The concentration of inflammatory factors in prostate tissues was determined by enzyme-linked immunosorbent assay. The release of reactive oxygen species, malondialdehyde, superoxide dismutase, and catalase was measured using detection kits. P69 cell proliferation was assessed by 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide. Furthermore, the activity of the TLR4/NF-κB signaling pathway was determined by quantitative reverse transcriptase polymerase chain reaction or Western blot assay. Histopathological data suggested that dioscin exerted protective effects against prostate morphological changes. Dioscin inhibits inflammatory cytokines and oxidative stress (OS) in prostate tissues in a concentration-dependent manner. Moreover, dioscin notably inhibited the activation of the TLR4/NF-κB signaling pathway in CP rats. <jats:italic>In vitro</jats:italic>, dioscin remarkably reduced lipopolysaccharide-induced P69 proliferation, inflammation, OS, and TLR4/NF-κB pathway activation in a dose-dependent manner. In conclusion, dioscin exerts a protective effect in CP by decreasing the inflammatory response and OS through the TLR4/NF-κB pathways. Our findings provide a novel latent therapy for dioscin for the treatment and prevention of CP.","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"42 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142252412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laboratory variables‐based artificial neural network models for predicting fatty liver disease: A retrospective study","authors":"Panpan Lv, Zhen Cao, Zhengqi Zhu, Xiaoqin Xu, Zhen Zhao","doi":"10.1515/med-2024-1031","DOIUrl":"https://doi.org/10.1515/med-2024-1031","url":null,"abstract":"Background The efficacy of artificial neural network (ANN) models employing laboratory variables for predicting fatty liver disease (FLD) remains inadequately established. The study aimed to develop ANN models to precisely predict FLD. Methods Of 12,058 participants undergoing the initial FLD screening, 7,990 eligible participants were included. A total of 6,309 participants were divided randomly into the training (4,415 participants, 70%) and validation (1,894 participants, 30%) sets for developing prediction models. The performance of ANNs was additionally tested in the testing set (1,681 participants). The area under the receiver operating characteristic curve (AUROC) was employed to assess the models’ performance. Results The 18-variable, 11-variable, 3-variable, and 2-variable models each achieved robust FLD prediction performance, with AUROCs over 0.92, 0.91, and 0.89 in the training, validation, and testing, respectively. Although slightly inferior to the other three models in performance (AUROC ranges: 0.89–0.92 vs 0.91–0.95), the 2-variable model showed 80.3% accuracy and 89.7% positive predictive value in the testing. Incorporating age and gender increased the AUROCs of the resulting 20-variable, 13-variable, 5-variable, and 4-variable models each to over 0.93, 0.92, and 0.91 in the training, validation, and testing, respectively. Conclusions Implementation of the ANN models could effectively predict FLD, with enhanced predictive performance via the inclusion of age and gender.","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"65 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142252414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of polymorphisms in FBN1, MYH11, and TGF-β signaling-related genes with susceptibility of sporadic thoracic aortic aneurysm and dissection in the Zhejiang Han population","authors":"Shasha Yu, Lujie Huang, Jianfei Ren, Xiaoying Zhang","doi":"10.1515/med-2024-1025","DOIUrl":"https://doi.org/10.1515/med-2024-1025","url":null,"abstract":"Background Sporadic thoracic aortic aneurysm and dissection (sTAAD) is a complicated vascular disease with a high mortality rate. And its genetic basis has not been fully explored. Method Here, 122 sTAAD patients and 98 healthy individuals were recruited, and 10 single nucleotide polymorphisms were selected and analyzed (FBN1 rs10519177, rs1036477, rs2118181, MYH11 rs115364997, rs117593370, TGFβ1 rs1800469, TGFβ2 rs900, TGFβR2 rs764522, rs1036095, and rs6785385). Moreover, multiple logistic regression analysis was used to evaluate gene–environment interactions. Results We identified that TGFβR2 rs1036095 dominant model CC + CG genotype (GT) (<jats:italic>P</jats:italic> = 0.004) may be a factor of increased risk of sTAAD, especially for women. FBN1 rs1036477 recessive model AA GT (<jats:italic>P</jats:italic> = 0.009) and FBN1 rs2118181 dominant model CC + CT GT (<jats:italic>P</jats:italic> = 0.009) were correlated to an increased death rate in sTAAD men patients. Gene–environment interactions indicated TGFβR2 rs1036095 dominant model (CC + CG)/GG to be a higher-risk factor for sTAAD (odds ratio = 3.255; 95% confidence interval: 1.324–8.000, <jats:italic>P</jats:italic> = 0.01). Conclusions TGFβR2 rs1036095, FBN1 rs1036477, and FBN1 rs2118181 were identified as factors of increased risk of sTAAD. Gene–environment interactions were associated with the risk of sTAAD.","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142252465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application value of multi-parameter magnetic resonance image-transrectal ultrasound cognitive fusion in prostate biopsy","authors":"Haichuan Yuan, Min Huang, Tao Liu, Wu Song, Chengpeng Luo","doi":"10.1515/med-2024-1026","DOIUrl":"https://doi.org/10.1515/med-2024-1026","url":null,"abstract":"Objective To investigate the effect of three-dimensional (3D) reconstruction-assisted cognitive fusion in targeted prostate biopsy. Results There was no significant difference in the detection rate of prostate cancer (PCa) between targeted biopsy and systematic biopsy, and there was significant difference in the detection rate of clinically significant prostate cancer (csPCa) between targeted biopsy and systematic biopsy. In the low prostate total specific antigen (tPSA) group, there was no statistically significant difference in the detection rate of prostate cancer between the two biopsy modalities. However, compared with systematic puncture, targeted puncture had a higher detection rate for csPCa and a lower detection rate for clinically insignificant prostate cancer (ciPCa), and the difference was statistically significant. In the high tPSA group, there was no significant difference in the detection rate of PCa, csPCa, and ciPCa between the two biopsy types. Single needle positive rate of targeted puncture (29.77%) was significantly higher than that of systematic puncture (10.28%). Conclusions The detection rate of csPCa in 3D reconstruction-assisted cognitive fusion targeted prostate biopsy is better than that of 12-needle systematic biopsy, which markedly improved the positive rate of prostate biopsy.","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"23 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142252415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep quality associate with the increased prevalence of cognitive impairment in coronary artery disease patients: A retrospective case–control study","authors":"Min Liu, Jianning Ma, Kena Bao, Ye Gu, Jing Zhao, Dongmei Ren, Fang Zhu, Xiangdong Xu","doi":"10.1515/med-2024-1034","DOIUrl":"https://doi.org/10.1515/med-2024-1034","url":null,"abstract":"Background The pathogenesis of cognitive impairment (CI) in coronary artery disease (CAD) patients is still unclear and numerous influence factors could affect the CI status. The current studies suggest that sleep quality and behavior pattern are significant influence factors associated with CAD susceptibility. Methods A total of 223 participants including 90 CAD patients with CI and 133 controls were enrolled into this retrospective study. Demographic information, laboratory test results, clinical diagnostic data, and questionnaire survey were collected to recognize the influencing factors of CI in CAD patients. Appropriate statistical methods are used to analyze these collected data. Results Univariate analysis results of demographic information, laboratory test results, and questionnaire survey data revealed that the differences in fatigue symptom, age, HDL, TG, and sleep quality were statistically significant (<jats:italic>p</jats:italic> = 0.006, <jats:italic>p</jats:italic> = 0.000, <jats:italic>p</jats:italic> = 0.019, <jats:italic>p</jats:italic> = 0.028, and <jats:italic>p</jats:italic> = 0.037, respectively). Logistic regression analysis showed that age, fatigue, and sleep quality were the influence factors for CI in CAD population (<jats:italic>p</jats:italic> = 0.000, <jats:italic>p</jats:italic> = 0.035, and <jats:italic>p</jats:italic> = 0.017). Conclusions Sleep quality, fatigue, and age were associated with the increased susceptibility of CI in CAD patients. Both CI state and its related factors were involved in the pathological process of CAD, these findings could offer additional information for the prevention and control of CAD.","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"2 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142201003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paraquat disrupts the blood–brain barrier by increasing IL-6 expression and oxidative stress through the activation of PI3K/AKT signaling pathway","authors":"Tao Liu, Fenshuang Zheng, Lin Liu, Hua Zhou, Tao Shen, Yanping Li, Wei Zhang","doi":"10.1515/med-2024-1020","DOIUrl":"https://doi.org/10.1515/med-2024-1020","url":null,"abstract":"Background Paraquat (PQ) is a frequently used herbicide with neurotoxic effects after acute or chronic exposure. Although <jats:italic>in vitro</jats:italic> evidence supports the PQ toxicity to dopamine cells, its <jats:italic>in vivo</jats:italic> effects (especially the chronic exposure) remain ambiguous. In this study, we investigated the effect of chronic PQ exposure on the blood–brain barrier (BBB) damage and the underlying mechanisms. Methods Adult male Sprague Dawley rats and primary human brain microvascular endothelial (PHBME) cells were exposed to PQ as the animal and cell models. Evans Blue staining and hematoxylin &amp; eosin staining were conducted to examine the BBB and brain tissue damages. The inflammatory cytokines were quantified via enzyme linked immunosorbent assay. The changes of PI3K/AKT signaling pathway were detected by western blot. Results PQ exposure can cause significant pathological lesions in the brain tissues and the BBB. IL-6 and reactive oxygen species levels were found to be significantly upregulated after PQ exposure in both the animal and cell models. PQ treatment could arrest the cell proliferation and migration in PHBME cells. PQ treatment promoted the phosphorylation of PI3K and AKT, and the application of PI3K inhibitor could attenuate PQ-induced IL-6 production, oxidative stress, BBB disruption, and brain tissue damage. Conclusion Our study demonstrated that chronic PQ exposure could impair the BBB function and induce brain tissue damage. The overactivation of the PI3K/AKT pathway, consequent upregulation of IL-6 production, and increased oxidative stress appear to mediate the inflammatory damage resulting from PQ exposure.","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"16 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142201002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between IFN-γ, IL-10, IL-6 cytokines, and severity of the condition with serum zinc and Fe in children infected with Mycoplasma pneumoniae","authors":"Yi Xu, Xiangyong Fei","doi":"10.1515/med-2024-0987","DOIUrl":"https://doi.org/10.1515/med-2024-0987","url":null,"abstract":"Objective To explore the relationship between cytokines such as interferon γ (IFN-γ), interleukin-10 (IL-10), and interleukin-6 (IL-6), as well as the severity of the condition, and serum zinc (Zn) and Fe levels in children with <jats:italic>Mycoplasma pneumoniae</jats:italic> infection. Methods A simple random sampling method was used to select 108 children with <jats:italic>Mycoplasma pneumoniae</jats:italic> infection admitted to the hospital from January to December 2022 as the study subjects. Collect demographic data such as gender, age, and course of disease from all patients, as well as inflammatory cytokines (InCs) such as IFN-γ, IL-10, and IL-6, the severity of the condition, and serum trace element information such as Zn, Fe, calcium (Ca), and potassium (K) from all patients. Spearman correlation analysis was used to examine the relationship between IFN-γ, IL-10, IL-6, severity of illness, and Zn, Fe, Ca, K in children infected with <jats:italic>Mycoplasma pneumoniae</jats:italic>. Additionally, receiver operating characteristic (ROC) curve analysis was used to test the predictive efficacy of Zn, Fe, Ca, and K on the severity of the patient’s condition. Results This study included 108 children infected with <jats:italic>Mycoplasma pneumoniae</jats:italic>, of whom 6 had clinical data missing &gt;10% and were all excluded. Finally, 102 complete clinical data were collected, with a data recovery efficiency of 94.44%. The differences in IFN-γ, IL-10, IL-6 levels, severity of the condition, as well as Zn, Fe, Ca, K levels among children of different ages, disease courses, body mass, and body temperature showed <jats:italic>P</jats:italic> &lt; 0. 05. Spearman correlation analysis showed that the levels of IFN-γ, IL-10, IL-6, and severity of the condition in children with <jats:italic>Mycoplasma pneumoniae</jats:italic> infection were negatively correlated with Zn, Fe, Ca, and K (<jats:italic>ρ</jats:italic> = −0.319 to −0.827, <jats:italic>P</jats:italic> &lt; 0.05). The ROC curve analysis results indicate that Zn, Fe, Ca, and K can all be used as indicators to predict the severity of the patient’s condition (AUC = 0.710–0.759, <jats:italic>P</jats:italic> &lt; 0.05). Conclusion There is a close relationship between InCs and the severity of the condition in children with <jats:italic>Mycoplasma pneumoniae</jats:italic> and serum trace elements. Therefore, clinical attention should be paid to monitoring the serum trace element levels of children, and reasonable measures should be taken to regulate them to accelerate the progress of disease treatment.","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"31 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142201004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced neuroimaging and criminal interrogation in lie detection.","authors":"Valentina Opancina, Vladimir Sebek, Vladimir Janjic","doi":"10.1515/med-2024-1032","DOIUrl":"10.1515/med-2024-1032","url":null,"abstract":"<p><p>Hidden information is the key to many security issues. If there is a reliable method to determine whether someone withholds information, many issues of this type can be resolved. However, until now, no method has proven to be reliable, but technical discoveries in the field of neuroimaging have caused a surge of new research in this area. Many neuroimaging techniques can be used, but functional magnetic resonance is the newest method, and its use in extracting and evaluating information from subjects could be the most significant, given that it records brain states in parallel with current mental activity/behavior, enabling the establishment of correlational links between them. Because the brain state displayed during fMRI imaging is the dependent variable measured during stimulus/task condition manipulation, it is necessary to use fMRI data in combination with complementary criminal interrogation techniques to gather information. This could be particularly important when standard interrogational techniques are not enough in order to preserve the common good, especially in \"ticking bomb\" situations. In this study, we review aspects of the possibility of utilizing advanced neuroimaging in combination with criminal interrogation in cases of serious criminal acts that threaten public safety.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"19 1","pages":"20241032"},"PeriodicalIF":1.7,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11377981/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142154658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-HMGCR myopathy mimicking facioscapulohumeral muscular dystrophy.","authors":"Andreas Albert Braun, Monika Atiya, Katja Göhner, Tibor Hortobagyi, Tobias Burkhardt, Bettina Schreiner","doi":"10.1515/med-2024-1033","DOIUrl":"10.1515/med-2024-1033","url":null,"abstract":"<p><strong>Introduction: </strong>Statin use can lead to various muscle-related issues, including benign creatine kinase (CK) elevations, myalgias, toxic myopathies, rhabdomyolysis, and immune-mediated necrotizing myositis (IMNM), which primarily affects older males. IMNM presents with proximal muscle weakness, elevated CK levels, and specific antibodies.</p><p><strong>Case presentation: </strong>We describe a 72-year-old patient with muscle weakness persisting for over 3 years after statin therapy. Initially suspected to have a genetic disorder, further testing revealed elevated anti-3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) antibodies, indicating immune-mediated myopathy. Despite the absence of inflammatory changes on biopsy, the patient responded positively to immune therapy.</p><p><strong>Conclusion: </strong>This case highlights challenges in diagnosing immune-mediated myopathy, especially in older patients with atypical presentations. Testing for HMGCR antibodies can aid in diagnosis, particularly when inflammatory markers are absent. Awareness of red flags, such as delayed symptom onset and response to prednisone, is crucial for accurate diagnosis and management.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"19 1","pages":"20241033"},"PeriodicalIF":1.7,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11377977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142154660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of nutritional support for clinical outcomes in gastric cancer patients: A meta-analysis of randomized controlled trials.","authors":"Juping Zhang, Qian Kong, Jibo Zhang, Jun Guo","doi":"10.1515/med-2024-1023","DOIUrl":"10.1515/med-2024-1023","url":null,"abstract":"<p><strong>Background: </strong>Gastric cancer (GC) is a leading cause of cancer-related morbidity and mortality globally. This meta-analysis was conducted to assess the impact of nutritional interventions on clinical outcomes in GC patients.</p><p><strong>Methods: </strong>Comprehensive search was conducted across four medical databases to identify randomized controlled trials (RCTs) that examined nutritional interventions in GC patients. The outcomes assessed included hospitalization duration, nutritional status, immune function, and complications.</p><p><strong>Results: </strong>A total of 11 studies were included. Enteral nutrition (EN) significantly reduce hospital stay duration compared to no nutritional intervention (SMD = -1.22, 95% CI [-1.72, -0.73], <i>P</i> < 0.001) and parenteral nutrition (PN) (SMD = -1.30, 95% CI [-1.78, -0.82], <i>P</i> < 0.001), but showed no significant difference compared to immunonutrition (IN). EN also improved nutritional status, indicated by higher albumin prealbumin levels, and improved immune function by elevating CD4+ levels (SMD = 1.09, 95% CI [0.61, 1.57], <i>P</i> < 0.001). However, IN showed superior effects on immunoglobulin levels (IgG and IgM). No significant differences were observed in complication rates among EN, IN, and PN interventions.</p><p><strong>Conclusion: </strong>Nutritional support, particularly EN and IN, can significantly improve hospitalization outcomes, nutritional status, and immune function. Customizing interventions according to patient requirements can optimize therapeutic outcomes, highlighting the need for further research in this area.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"19 1","pages":"20241023"},"PeriodicalIF":1.7,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11377983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142154661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}