Open Medicine最新文献

筛选
英文 中文
Correlation between albumin levels during the third trimester and the risk of postpartum levator ani muscle rupture. 妊娠晚期白蛋白水平与产后提肛肌破裂风险的相关性
IF 1.7 4区 医学
Open Medicine Pub Date : 2025-06-09 eCollection Date: 2025-01-01 DOI: 10.1515/med-2025-1209
Yueyun Cai, Yuting Cai, Yuanling Hu, Shengkai Lu, Yueqing Lin
{"title":"Correlation between albumin levels during the third trimester and the risk of postpartum levator ani muscle rupture.","authors":"Yueyun Cai, Yuting Cai, Yuanling Hu, Shengkai Lu, Yueqing Lin","doi":"10.1515/med-2025-1209","DOIUrl":"10.1515/med-2025-1209","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the correlation between albumin levels during the third trimester and the risk of postpartum levator ani muscle rupture.</p><p><strong>Methods: </strong>A retrospective analysis of 410 parturients undergoing vaginal delivery at Zhangzhou Hospital Affiliated to Fujian Medical University was conducted. Parturients were classified into low-albumin (<35 g/L) and normal-albumin (≥35 g/L) groups based on their albumin levels during the third trimester. Data on levator ani muscle rupture and various clinical parameters were collected and analyzed using multivariate binary logistic regression.</p><p><strong>Results: </strong>The low-albumin group comprised 38.29% of participants and had a significantly higher incidence of levator ani muscle rupture (53.50%) compared to the normal-albumin group (33.20%; <i>P</i> < 0.05). Albumin levels strongly correlated with rupture risk (<i>r</i> = 0.193, <i>P</i> < 0.001). Multivariate analysis showed low albumin levels were an independent risk factor (OR = 2.286, 95% CI: 1.259-4.152). Other independent risk factors included forceps-assisted delivery, BMI ≥ 24 kg/m², age ≥ 35 years, and second stage of labor duration ≥ 120 min (all <i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Decreased albumin levels are an independent risk factor for postpartum levator ani muscle rupture, suggesting a potential role in increasing the risk of muscle injury.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20251209"},"PeriodicalIF":1.7,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163573/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanisms of hesperetin in treating metabolic dysfunction-associated steatosis liver disease via network pharmacology and in vitro experiments. 橙皮素治疗代谢功能障碍相关脂肪变性肝病的网络药理学及体外实验机制
IF 1.7 4区 医学
Open Medicine Pub Date : 2025-06-09 eCollection Date: 2025-01-01 DOI: 10.1515/med-2025-1215
Yi Wu, Ying Lin, Shan Xu, Dan Su, Hao Yang, Lidan Tang
{"title":"Mechanisms of hesperetin in treating metabolic dysfunction-associated steatosis liver disease <i>via</i> network pharmacology and <i>in vitro</i> experiments.","authors":"Yi Wu, Ying Lin, Shan Xu, Dan Su, Hao Yang, Lidan Tang","doi":"10.1515/med-2025-1215","DOIUrl":"10.1515/med-2025-1215","url":null,"abstract":"<p><strong>Purpose: </strong>Metabolic dysfunction-associated steatosic liver disease (MASLD) poses a global health challenge with limited therapeutic options. Hesperetin, a flavonoid extracted from citrus, exhibits multiple pharmacological properties, but its mechanisms in MASLD-associated lipid metabolism remain unclear. This study aimed to explore the mechanism of hesperetin for treating MASLD.</p><p><strong>Methods: </strong>Network pharmacology identified the therapeutic targets for MASLD. Key targets were selected based on network topology analysis. Subsequently, Kyoto Encyclopedia of genes and genomes (KEGG) pathways and gene ontology enrichment were conducted. Molecular docking was performed to evaluate the binding affinity between hesperetin and the identified key targets. <i>In vitro</i> validation included lipid accumulation assays and verification of core target modulation <i>via</i> western blotting.</p><p><strong>Results: </strong>Hesperetin significantly attenuated lipid accumulation in free fatty acid -induced HepG2 cells. Forty core targets of hesperetin for MASLD mitigation were identified. Notably, MYC, IL-6, IL1B, and PTGS2 had high network association values. KEGG analysis revealed predominant involvement in cancer-related pathways, non-alcoholic fatty liver disease, and JAK/STAT signaling. Biological processes included inflammatory response regulation and cytokine activity. Molecular docking confirmed strong hesperetin-IL-6 binding. Experimental data suggested that hesperetin may ameliorate lipid accumulation by modulating the IL-6-mediated STAT3-SOCS3 signaling pathway.</p><p><strong>Conclusion: </strong>Hesperetin may ameliorate MASLD by targeting the IL-6-STAT3-SOCS3 axis, underscoring its therapeutic potential.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20251215"},"PeriodicalIF":1.7,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dopamine attenuates ethanol-induced neuronal apoptosis by stimulating electrical activity in the developing rat retina. 多巴胺通过刺激发育中的大鼠视网膜的电活动来减弱乙醇诱导的神经元凋亡。
IF 1.7 4区 医学
Open Medicine Pub Date : 2025-06-05 eCollection Date: 2025-01-01 DOI: 10.1515/med-2025-1205
Junde Han, Shuli Ge, Kan Zhang, Jijian Zheng, Jing Dong
{"title":"Dopamine attenuates ethanol-induced neuronal apoptosis by stimulating electrical activity in the developing rat retina.","authors":"Junde Han, Shuli Ge, Kan Zhang, Jijian Zheng, Jing Dong","doi":"10.1515/med-2025-1205","DOIUrl":"10.1515/med-2025-1205","url":null,"abstract":"<p><strong>Background: </strong>Prenatal alcohol exposure causes fetal alcohol spectrum disorders (FASD), primarily through alcohol-induced apoptosis. This study explores the link between ethanol-induced neuronal apoptosis and neural network electrical activity in developing rat retinal ganglion cells, and examines dopamine's protective effects and influence on this activity.</p><p><strong>Methods: </strong>The study employed a combination of immunohistochemical techniques, terminal deoxynucleotidyl transferase dUTP nick-end labeling assay, and electrophysiological recordings to assess neuronal apoptosis and neural network activity in the developing rat retinal ganglion cell layer. Ethanol exposure was administered to model prenatal alcohol exposure, and dopamine was applied to evaluate its protective effects.</p><p><strong>Results: </strong>Ethanol exposure was found to disrupt the spatiotemporal properties of synchronized spontaneous neural network electrical activity and partially induce neuronal apoptosis. Conversely, dopamine treatment increased the frequency of neural network electrical activity and attenuated ethanol-induced apoptosis.</p><p><strong>Conclusion: </strong>The findings suggest that ethanol disrupts neural network activity and induces apoptosis in the developing nervous system, while dopamine exerts a protective effect by modulating neural network activity and reducing apoptosis. These results contribute to understanding the mechanisms underlying FASD and offer potential therapeutic avenues for prevention and treatment.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20251205"},"PeriodicalIF":1.7,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12144908/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relation of time in range to severity of coronary artery disease in patients with type 2 diabetes: A cross-sectional study. 2型糖尿病患者冠状动脉病变严重程度与时间范围的关系:一项横断面研究
IF 1.7 4区 医学
Open Medicine Pub Date : 2025-06-04 eCollection Date: 2025-01-01 DOI: 10.1515/med-2025-1158
Weiguo Ma, Jinfeng Li, Xiaojuan Shao, Xiaohong Yin, Chuanqing Xie, Fenfen Wang, Ya Li
{"title":"Relation of time in range to severity of coronary artery disease in patients with type 2 diabetes: A cross-sectional study.","authors":"Weiguo Ma, Jinfeng Li, Xiaojuan Shao, Xiaohong Yin, Chuanqing Xie, Fenfen Wang, Ya Li","doi":"10.1515/med-2025-1158","DOIUrl":"10.1515/med-2025-1158","url":null,"abstract":"<p><strong>Background: </strong>Despite the high prevalence and serious clinical implications of coronary artery disease (CAD) in patients with type 2 diabetes mellitus (T2DM), the relationship between glycemic control and CAD is usually overlooked. This study aimed to explore the relationship between time in range (TIR), a surrogate marker for glycemic control, and CAD in patients with T2DM.</p><p><strong>Methods: </strong>Overall, 334 patients with T2DM were included and analyzed in this cross-sectional study. The presence of CAD was determined angiographically and the Gensini score was applied to evaluate CAD severity. TIR was calculated from sensor glucose from continuous glucose monitoring. Multivariable-adjusted logistic regression analysis was used to evaluate the relationship between TIR and CAD presence.</p><p><strong>Results: </strong>T2DM with CAD had significantly lower TIR than those without (75.68 ± 13.74 vs 66.12 ± 11.87, <i>P</i> < 0.01). Moreover, TIR was correlated with CAD severity as indicated by the Gensini score. Multivariable-adjusted logistic regression analysis indicated that a higher TIR was an independent protective factor for CAD in patients with T2DM (OR = 0.919, 95% CI: 0.896-0.942).</p><p><strong>Conclusion: </strong>TIR is significantly and independently related to CAD severity in T2DM patients. Thus, TIR could be a promising biomarker for the noninvasive assessment of CAD presence and severity in T2DM.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20251158"},"PeriodicalIF":1.7,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12144907/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comprehensive biomedicine assessment of Apteranthes tuberculata extracts: Phytochemical analysis and multifaceted pharmacological evaluation in animal models. 无翼花提取物的综合生物医学评价:植物化学分析和动物模型的多方面药理评价。
IF 1.7 4区 医学
Open Medicine Pub Date : 2025-06-03 eCollection Date: 2025-01-01 DOI: 10.1515/med-2024-1092
Sajida Afzal, Siraj Khan, Muhammad Imam Ammarullah
{"title":"Comprehensive biomedicine assessment of <i>Apteranthes tuberculata</i> extracts: Phytochemical analysis and multifaceted pharmacological evaluation in animal models.","authors":"Sajida Afzal, Siraj Khan, Muhammad Imam Ammarullah","doi":"10.1515/med-2024-1092","DOIUrl":"10.1515/med-2024-1092","url":null,"abstract":"<p><strong>Background: </strong>This study comprehensively analyzes the pharmacological effects of ethanolic extract of <i>Apteranthes tuberculata</i> (EEAT) on various physiological parameters in mice.</p><p><strong>Objective: </strong>The research aimed to quantify flavonoid and phenol contents across different extraction methods, with a focus on the superior efficacy of the ethanolic extract.</p><p><strong>Methods: </strong><i>In vitro</i> assays were conducted to assess the antioxidant activity of EEAT, revealing dose-dependent effects and significant inhibition percentages.</p><p><strong>Results: </strong>EEAT exhibited notable analgesic effects in the writhing response test, particularly at 200 mg/kg, indicating its potential as a natural analgesic. Additionally, its anti-inflammatory effects were complex and dose-dependent in a carrageenan-induced paw edema model. The extract also showed significant changes in body temperature regulation following Brewer's yeast-induced fever, revealing a distinct pattern of initial hypothermia followed by gradual re-elevation. Furthermore, EEAT demonstrated regulatory effects on gastrointestinal motility, with higher doses enhancing intestinal transit in charcoal meal tests.</p><p><strong>Conclusion: </strong>This study highlights the pharmacological potential of EEAT as a natural therapeutic agent for antioxidant, analgesic, anti-inflammatory, and gastrointestinal regulation, warranting further investigation into its mechanisms of action and therapeutic applications.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20241092"},"PeriodicalIF":1.7,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12144909/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of a novel drainage catheter in the treatment of CSF leak after posterior spine surgery: A retrospective cohort study. 一种新型引流管治疗后路脊柱手术后脑脊液泄漏的疗效:一项回顾性队列研究。
IF 1.7 4区 医学
Open Medicine Pub Date : 2025-05-29 eCollection Date: 2025-01-01 DOI: 10.1515/med-2025-1211
Shu Yang, Zhengyuan Zhu, Gang Chen, Zhisheng Long
{"title":"Efficacy of a novel drainage catheter in the treatment of CSF leak after posterior spine surgery: A retrospective cohort study.","authors":"Shu Yang, Zhengyuan Zhu, Gang Chen, Zhisheng Long","doi":"10.1515/med-2025-1211","DOIUrl":"10.1515/med-2025-1211","url":null,"abstract":"<p><strong>Purpose: </strong>This work aimed to evaluate and analyze the efficacy and safety of modified drainage and catheterization in the treatment of cerebrospinal fluid leakage (CSFL) after posterior spinal surgery.</p><p><strong>Methods: </strong>A total of 12 patients with CSFL were selected from June 2020 to June 2023. The modified drainage technique was used to treat CSFL. The perioperative index, including the duration of drainage tube placement, was observed. The study also assessed the amount of cerebrospinal fluid (CSF) drainage, the healing time of the drainage wound, the occurrence of other complications, the effectiveness of the drainage procedure, and the length of hospital stay.</p><p><strong>Results: </strong>Among the patients with CSFL, the mean drainage time was 6.2 ± 0.8 days, the healing time of the drainage wound was 9.6 ± 1.7 days, and the hospital stay was 7.5 ± 1.0 days. The total volume of CSF drainage was 488.6 ± 55.3 mL. Furthermore, no cases of retrograde infection, drainage orifice exudate, or drainage wound nonunion were reported in this study.</p><p><strong>Conclusion: </strong>This preliminary study demonstrates that the modified catheterization technique is effective in reducing the duration of CSFL and promoting rapid wound healing. Additionally, the novel drainage catheter shows advantages in terms of reducing the incidence of infection and other related complications.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20251211"},"PeriodicalIF":1.7,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12130775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Laboratory medicine between technological innovation, rights safeguarding, and patient safety: A bioethical perspective. 检验医学在技术创新、权利维护和患者安全之间的关系:生物伦理学的视角。
IF 1.7 4区 医学
Open Medicine Pub Date : 2025-05-29 eCollection Date: 2025-01-01 DOI: 10.1515/med-2025-1153
Francesco De Micco, Gianmarco Di Palma, Flavia Giacomobono, Anna De Benedictis, Mariano Cingolani, Vittoradolfo Tambone, Luca Tomassini, Roberto Scendoni
{"title":"Laboratory medicine between technological innovation, rights safeguarding, and patient safety: A bioethical perspective.","authors":"Francesco De Micco, Gianmarco Di Palma, Flavia Giacomobono, Anna De Benedictis, Mariano Cingolani, Vittoradolfo Tambone, Luca Tomassini, Roberto Scendoni","doi":"10.1515/med-2025-1153","DOIUrl":"10.1515/med-2025-1153","url":null,"abstract":"<p><strong>Introduction: </strong>The evolution of Laboratory Medicine (LM) has expanded diagnostic and therapeutic horizons, yet ethical concerns pervade its advancements. This article explores the ethical challenges inherent in LM and advocates for a personalist bioethical framework as a guiding principle. It addresses issues such as patient data privacy, healthcare equity, communication of complex analysis results, genetic information management, and conflicts of interest.</p><p><strong>Objectives: </strong>The proposed framework emphasizes principles such as the defense of life, freedom, responsibility, totality in therapy, and sociality and subsidiarity, with a focus on human dignity.</p><p><strong>Results: </strong>Various bioethical theories address complex ethical issues in medicine and health sciences, often combined to guide clinical practice. This study focuses on personalist bioethics, prioritizing human dignity and intrinsic value, advocating for principles like defense of physical life, freedom, totality in therapy, and sociality. In LM, ethical analysis involves patient care, genetic testing, informed consent, and Artificial Intelligence integration, emphasizing transparency and patient autonomy.</p><p><strong>Conclusion: </strong>LM plays a crucial role in healthcare, necessitating ethical considerations amidst technological progress. Upholding ethical frameworks, such as the ethics of good work, can ensure equitable and quality healthcare delivery.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20251153"},"PeriodicalIF":1.7,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12130780/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CA199 and CEA expression levels, and minimally invasive postoperative prognosis analysis in esophageal squamous carcinoma patients. 食管鳞癌患者CA199、CEA表达水平与微创术后预后分析。
IF 1.7 4区 医学
Open Medicine Pub Date : 2025-05-27 eCollection Date: 2025-01-01 DOI: 10.1515/med-2024-1127
Cheng Ji, Lingjia Ji, Fei Wang, Anping Zhang, Liang Shen
{"title":"CA199 and CEA expression levels, and minimally invasive postoperative prognosis analysis in esophageal squamous carcinoma patients.","authors":"Cheng Ji, Lingjia Ji, Fei Wang, Anping Zhang, Liang Shen","doi":"10.1515/med-2024-1127","DOIUrl":"10.1515/med-2024-1127","url":null,"abstract":"<p><strong>Background: </strong>This study explores the factors related to the expression levels of carbohydrate antigen 199 (CA199) and carcinoembryonic antigen (CEA) and their association with poor postoperative prognosis in patients with esophageal squamous cell carcinoma (ESCC) who underwent minimally invasive resection.</p><p><strong>Methods: </strong>Eighty patients with ESCC who underwent minimally invasive surgery were divided into two groups: 40 with poor prognosis (recurrence) and 40 with good prognosis (no recurrence). Additionally, 80 healthy subjects were selected as a control group. Serum CA199 and CEA levels were measured before surgery and 3 and 6 months postoperatively.</p><p><strong>Results: </strong>The serum CA199 and CEA levels in the experimental group were significantly higher than in the control group (<i>P</i> < 0.05). Patients with poor prognoses within the experimental group had higher CA199 and CEA levels than those with good prognoses (<i>P</i> < 0.05). In the poor prognosis group, CA199 and CEA levels at 6 months were significantly higher than at 3 months post-surgery (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Poor prognosis in ESCC patients after minimally invasive resection may be influenced by factors such as lymph node metastasis, lesion length, and tumor location. Elevated CA199 and CEA levels postoperatively can serve as predictors of poor prognosis in patients with ESCC.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20241127"},"PeriodicalIF":1.7,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12120403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interleukin-37 mediates the anti-oral tumor activity in oral cancer through STAT3. 白细胞介素-37通过STAT3介导口腔癌的抗口腔肿瘤活性。
IF 1.7 4区 医学
Open Medicine Pub Date : 2025-05-26 eCollection Date: 2025-01-01 DOI: 10.1515/med-2025-1173
Jing Fang, Kunshan Li, Liyuan Zhang, Ying Zhang, Yifan Wang, Jing Zhang
{"title":"Interleukin-37 mediates the anti-oral tumor activity in oral cancer through STAT3.","authors":"Jing Fang, Kunshan Li, Liyuan Zhang, Ying Zhang, Yifan Wang, Jing Zhang","doi":"10.1515/med-2025-1173","DOIUrl":"10.1515/med-2025-1173","url":null,"abstract":"<p><p>Oral cancer constitutes a significant public health challenge, and gaining insights into the pathogenesis of oral cancer is crucial for the development of innovative therapeutic approaches. To address this objective, this study investigates the impact of interleukin-37 (IL-37) on oral cancer and its underlying mechanisms. Two oral cancer cell lines, HN13 and HSC-6, were employed in the study. Our findings reveal that IL-37 markedly inhibits cell viability and induces apoptosis in oral cancer cells. IL-37 attenuates the proliferation of oral cancer cells induced by lipopolysaccharide and tumor necrosis factor-alpha, while knockdown of <i>IL-37</i> exacerbates this induction. Furthermore, IL-37 demonstrates anti-inflammatory effects on oral cancer cells. The modulation of inflammation, proliferation, apoptosis, and migration by IL-37 is mediated through the STAT3 pathway. The outcomes of this study contribute valuable insights to a deeper understanding of oral cancer pathogenesis and pave the way for the development of novel drugs for the treatment of this disease.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20251173"},"PeriodicalIF":1.7,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12120405/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute pancreatitis risk in the diagnosis and management of inflammatory bowel disease: A critical focus. 急性胰腺炎风险在炎症性肠病的诊断和管理:一个关键的焦点。
IF 1.7 4区 医学
Open Medicine Pub Date : 2025-05-22 eCollection Date: 2025-01-01 DOI: 10.1515/med-2025-1189
Feibo Zheng, Jinan Li, Lina Ma, Yu Zhang, Zhengwei Tu, Yunfeng Cui
{"title":"Acute pancreatitis risk in the diagnosis and management of inflammatory bowel disease: A critical focus.","authors":"Feibo Zheng, Jinan Li, Lina Ma, Yu Zhang, Zhengwei Tu, Yunfeng Cui","doi":"10.1515/med-2025-1189","DOIUrl":"10.1515/med-2025-1189","url":null,"abstract":"<p><strong>Objective: </strong>We explored the causal relationship between pancreatitis and various autoimmune diseases using bidirectional Mendelian randomization (MR).</p><p><strong>Methods: </strong>We collected genome-wide association study summary data for four pancreatitis types and five autoimmune diseases to conduct our bidirectional MR analysis. The primary analysis was performed using the inverse variance weighted (IVW) method, complemented by MR Egger, weighted median, and weighted mode methods. Sensitivity analyses included Cochran's <i>Q</i> test for heterogeneity, MR-Egger regression for pleiotropy, and MR-PRESSO and leave-one-out analyses for outliers.</p><p><strong>Results: </strong>The result of IVW revealed a significant association between genetically predicted inflammatory bowel disease (IBD) and an increased risk of acute pancreatitis (AP) (odds ratio [OR] = 1.07, 95% confidence interval [CI] = 1.03-1.12, <i>P</i> = 0.0015). Subsequent analyses further confirmed this association in IBD subtypes, with genetically predicted ulcerative colitis (UC) and Crohn's disease (CD) also showing increased risks of AP (UC: OR = 1.07, 95% CI = 1.02-1.13, <i>P</i> = 0.01; CD: OR = 1.05, 95% CI = 1-1.09, <i>P</i> = 0.03), affirming IBD as a risk factor for pancreatitis. Reverse analysis ruled out reverse causality and did not find a causal relationship between other immune diseases and pancreatitis.</p><p><strong>Conclusion: </strong>These findings suggest that pancreatitis in IBD patients may arise from the disease itself, necessitating increased vigilance for AP during diagnosis and treatment.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20251189"},"PeriodicalIF":1.7,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103105/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信