{"title":"<i>Commiphora gileadensis</i> ameliorate infertility and erectile dysfunction in diabetic male mice.","authors":"Ayman Saeed Alhazmi","doi":"10.1515/med-2025-1166","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The <i>Commiphora gileadensis</i> (<i>C. gileadensis</i>) is a tree belonging to the genus <i>Commiphora.</i> Aim of the study: This study investigates the effect of <i>C. gileadensis</i> on erectile dysfunction and infertility in male mice.</p><p><strong>Methods: </strong>Fifty male BALB/c mice are divided into five groups: control, untreated diabetic, diabetic <i>C. gileadensis</i> sap-treated, methanol extract-treated, and acetone extract-treated. All groups were assessed for body weight, testicular weight, serum follicle-stimulating hormone, luteinizing hormone, testosterone, prolactin, nitric oxide, adropin, endothelin levels, semen analysis, CD4<sup>+</sup>, CD8<sup>+</sup>, CD25<sup>+</sup>, and testicular nitric oxide synthase (NOS) immunoreactivity.</p><p><strong>Outcome: </strong><i>C. gileade</i>nsis maintains sexual integrity and infertility in mice.</p><p><strong>Results: </strong>Diabetic groups treated with <i>C. gileadensis</i> had significantly higher body weight than the untreated group. Furthermore, the diabetic group treated with <i>C. gileadensis</i> sap had significantly increased testicular weight than the untreated groups. Diabetic groups treated with <i>C. gileadensis</i> had significantly greater testosterone levels than the untreated groups. Additionally, these groups exhibit considerably higher nitric oxide and adropin levels than the untreated diabetic group. Endothelin levels were considerably lower in diabetic groups treated with <i>C. gileadensis</i> than in the untreated group. Semen analysis shows that the diabetic group treated with <i>C. gileadensis</i> sap had considerably more sperm count than the untreated group (<i>P</i> < 0.05). CD4<sup>+</sup>, CD8<sup>+</sup>, CD4<sup>+</sup>, CD25<sup>+</sup>, and CD8<sup>+</sup> CD25<sup>+</sup> were reduced significantly in diabetic mice treated with <i>C. gileadnesis</i>. In addition, the NOS immunoreactivity is greater in diabetic <i>C. gileadensis</i> treated groups than in the untreated group.</p><p><strong>Clinical implications: </strong><i>C. gileadensis</i> induces mice erectile function and fertility.</p><p><strong>Strength and limitations: </strong>The study does not use laser Doppler flowmetry for the measurement of erectile dysfunction.</p><p><strong>Conclusion: </strong><i>C. gileadensis</i> ameliorates infertility and erectile dysfunction in diabetic mice.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20251166"},"PeriodicalIF":1.7000,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909575/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Open Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1515/med-2025-1166","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
Abstract
Background: The Commiphora gileadensis (C. gileadensis) is a tree belonging to the genus Commiphora. Aim of the study: This study investigates the effect of C. gileadensis on erectile dysfunction and infertility in male mice.
Methods: Fifty male BALB/c mice are divided into five groups: control, untreated diabetic, diabetic C. gileadensis sap-treated, methanol extract-treated, and acetone extract-treated. All groups were assessed for body weight, testicular weight, serum follicle-stimulating hormone, luteinizing hormone, testosterone, prolactin, nitric oxide, adropin, endothelin levels, semen analysis, CD4+, CD8+, CD25+, and testicular nitric oxide synthase (NOS) immunoreactivity.
Outcome: C. gileadensis maintains sexual integrity and infertility in mice.
Results: Diabetic groups treated with C. gileadensis had significantly higher body weight than the untreated group. Furthermore, the diabetic group treated with C. gileadensis sap had significantly increased testicular weight than the untreated groups. Diabetic groups treated with C. gileadensis had significantly greater testosterone levels than the untreated groups. Additionally, these groups exhibit considerably higher nitric oxide and adropin levels than the untreated diabetic group. Endothelin levels were considerably lower in diabetic groups treated with C. gileadensis than in the untreated group. Semen analysis shows that the diabetic group treated with C. gileadensis sap had considerably more sperm count than the untreated group (P < 0.05). CD4+, CD8+, CD4+, CD25+, and CD8+ CD25+ were reduced significantly in diabetic mice treated with C. gileadnesis. In addition, the NOS immunoreactivity is greater in diabetic C. gileadensis treated groups than in the untreated group.
Clinical implications: C. gileadensis induces mice erectile function and fertility.
Strength and limitations: The study does not use laser Doppler flowmetry for the measurement of erectile dysfunction.
Conclusion: C. gileadensis ameliorates infertility and erectile dysfunction in diabetic mice.
期刊介绍：
Open Medicine is an open access journal that provides users with free, instant, and continued access to all content worldwide. The primary goal of the journal has always been a focus on maintaining the high quality of its published content. Its mission is to facilitate the exchange of ideas between medical science researchers from different countries. Papers connected to all fields of medicine and public health are welcomed. Open Medicine accepts submissions of research articles, reviews, case reports, letters to editor and book reviews.
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